salicylates and Gout

A number of pharmacological agents can induce hyperuricaemia, and sometimes gout, usually by interfering with the renal tubular excretion of urate but also in some instances by increasing the formation of uric acid. Alcohol is well known to have this property and in recent years diuretic-induced hyperuricaemia has become a global phenomenon. Other drugs which can cause hyperuricaemia are salicylates, pyrazinamide, ethambutol, nicotinic acid, cyclosporin, 2-ethylamino-1,3,4-thiadiazole, fructose and cytotoxic agents. A special type of 'drug-induced gout' can follow the rapid lowering of serum uric acid by allopurinol or uricosuric drugs.

Topics: Cyclosporins; Cytotoxins; Diuretics; Drug-Related Side Effects and Adverse Reactions; Ethambutol; Ethanol; Fructose; Gout; Humans; Niacin; Pyrazinamide; Salicylates; Uric Acid

Topics: Allopurinol; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Gold; Gout; Humans; Lupus Erythematosus, Systemic; Osteoarthritis; Penicillamine; Rheumatic Diseases; Salicylates; Spondylitis, Ankylosing; Vasculitis

Topics: Adrenal Cortex Hormones; Ambulatory Care; Antimalarials; Gold; Gout; Humans; Immunosuppressive Agents; Indomethacin; Injections, Intra-Articular; Muscle Relaxants, Central; ortho-Aminobenzoates; Phenylacetates; Phenylbutazone; Pyrazoles; Rheumatic Diseases; Salicylates; Tissue Extracts; Tranquilizing Agents

Topics: Acetaminophen; Aged; Anti-Inflammatory Agents; Aspirin; Bone Marrow; Drug Hypersensitivity; Gastric Mucosa; Gout; Humans; Phenacetin; Phenylbutazone; Rheumatic Diseases; Salicylates; Stomach Diseases

Topics: Activities of Daily Living; Arthritis, Rheumatoid; Bursitis; Chloroquine; Diagnosis, Differential; Finger Joint; Gold; Gout; Hot Temperature; Humans; Hydroxychloroquine; Methylprednisolone; Neuralgia; Osteoarthritis; Pain; Physical Examination; Physical Exertion; Physical Therapy Modalities; Prednisolone; Rest; Salicylates; Synovectomy; Triamcinolone; Wrist Joint

Topics: Arthritis, Gouty; Colchicine; Crystallization; Gout; Gout Suppressants; History, 20th Century; Humans; Phenylbutazone; Salicylates; Uric Acid

20 patients with elevated serum uric acid levels and osteoarthritis of the hip or knee were given diflunisal 500 mg b.i.d. The joint complaints were influenced good to excellent in all patients. The uric acid levels were decreased from 7.37 to 6.22 mg/dl for the duration of this eight week open study. Diflunisal can be advocated also for the treatment of gout.

Topics: Adolescent; Adult; Aged; Arthritis; Diflunisal; Female; Gout; Humans; Male; Middle Aged; Salicylates; Uric Acid

The urate lowering effect of diflunisal, a fluorinated salicylate with an antiinflammatory action, was compared with that of allopurinol in a crossover study. When patients took diflunisal the mean serum urate was significantly greater than on allopurinol but still was within the optimal range in 6 of 8 patients studied. This effect was consistent with its uricosuric action. No inhibition of xanthine oxidase activity by diflunisal was found. Diflunisal could be particularly useful in patients who require a drug with both a uricosuric and an antiinflammatory effect.

Topics: Allopurinol; Diflunisal; Gout; Humans; Osmolar Concentration; Salicylates; Uric Acid; Xanthine; Xanthines

Topics: Adrenal Cortex Hormones; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Chondrocalcinosis; Female; Giant Cell Arteritis; Gout; Humans; Male; Middle Aged; Osteoarthritis; Osteoporosis; Rheumatic Diseases; Salicylates

Topics: Adult; Aged; Diflunisal; Dose-Response Relationship, Drug; Female; Gout; Humans; Male; Middle Aged; Salicylates; Uric Acid

Topics: Adult; Aged; Diflunisal; Female; Gout; Humans; Male; Middle Aged; Salicylates; Uric Acid

Sixteen hyperuricemic gouty patients were treated with diflunisal, a novel salicylate, 500 mg BID. Serum and urine uric acid along with uric acid clearances were studied before and after a 7-day treatment. A clear hypouricemic action was observed, but 2 different mechanisms of action were seen when overexcretor patients and normoexcretor patients were analyzed separately. In overexcretors an allopurinol-like action was evident, whereas in normoexcretors a uricosuric action occurred. In vitro experiments showed a competitive inhibition of xanthine-oxidase exerted by diflunisal at low concentrations.

Topics: Adult; Aged; Creatinine; Diflunisal; Enzyme Inhibitors; Gout; Humans; In Vitro Techniques; Middle Aged; Salicylates; Uric Acid; Xanthine Oxidase; Xanthines

Topics: Acetates; Adult; Aged; Analgesics; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Child; Drug Interactions; Female; Gout; Humans; Phenylbutazone; Pregnancy; Propionates; Salicylates

In clinical rheumatology, the hazardousness of mixed preparations containing cortisone is being stressed even more, their use is only recommended in very special cases and only for short periods. Dolo Visano Supp. sine codeino and Dolo Visano Supp. are remedies which are indicated, like other mixed preparations not containing steroids, in cases of painful muscular overstrain and psychomuscular kinesalgia (symptom range of non-articular rheumatism). In our study, they were used in acute and severe pain conditions in intermediate or short-term therapy until complaints improved. Dolo Visano Supp. sine codeino and Dolo Visano Supp. (with codeine) can contribute in limiting the use of the risky preparations containing cortisone, which have hitherto been applied so frequently.

Topics: Aspirin; Codeine; Diphenhydramine; Drug Combinations; Female; Gout; Humans; Male; Meprobamate; Middle Aged; Muscle Rigidity; Nerve Compression Syndromes; Nicotinic Acids; Osteoarthritis; Pain; Plant Extracts; Salicylamides; Salicylates; Spinal Nerve Roots; Suppositories

Topics: Allopurinol; Diflunisal; Gout; Humans; Salicylates

The various stages in the diagnostic process are discussed with particular reference to rheumatology. Consideration is given to recent "early" and "preclinical" diagnosis concepts, and these are applied to the aircrew category. The main "rheumatological emergencies" are listed and described for the purposes of that "specialised" prevention constantly needed to a greater extent, not only in the complex, demanding activity of aircrew, but also in the wider "world of labour", as currently conceived.

Topics: Aerospace Medicine; Collagen Diseases; Emergencies; Gout; Humans; Hydrarthrosis; Salicylates; Sciatica

Topics: Adult; Child, Preschool; Female; Gout; Humans; Male; Middle Aged; Phenylbutazone; Salicylates; Uric Acid

Topics: Acetaminophen; Acetanilides; Administration, Oral; Arthritis, Rheumatoid; Aspirin; Foot; Gout; Hand; Humans; Indomethacin; Injections, Intra-Articular; Knee; Prednisolone; Salicylates; Thermography

Topics: Aged; Ankle Joint; Arthritis; Arthritis, Rheumatoid; Arthroplasty; Bursitis; Gout; Hip Joint; Humans; Indomethacin; Knee Joint; Laminectomy; Middle Aged; Osteoarthritis; Osteotomy; Phenylbutazone; Physical Therapy Modalities; Radiography; Salicylates; Shoulder Joint; Spinal Diseases; Tarsal Joints; Wrist Joint

Topics: Adrenal Cortex Hormones; Adult; Arthritis; Cartilage, Articular; Chondrocalcinosis; Chronic Disease; Diagnosis, Differential; Female; Gout; Humans; Knee; Male; Middle Aged; Phenylbutazone; Prognosis; Pubic Symphysis; Radiography; Salicylates; Synovial Fluid; Synovial Membrane; Synovitis; Wrist

Topics: Allopurinol; Creatinine; Diuretics; Ethambutol; Ethanol; Gout; Humans; Isoniazid; Lactates; Pyrazinamide; Pyridoxine; Salicylates; Stimulation, Chemical; Streptomycin; Time Factors; Tuberculosis; Uric Acid

Topics: Adult; Aged; Allopurinol; Female; Gout; Humans; Hydrocortisone; Indomethacin; Male; Middle Aged; Phenylbutazone; Salicylates

Topics: Anti-Inflammatory Agents; Binding Sites; Dansyl Compounds; Dialysis; Fatty Acids; Gout; Humans; Kidney Tubules; Mefenamic Acid; Phenylbutazone; Protein Binding; Salicylates; Serum Albumin; Sulfathiazoles; Ultrafiltration; Uric Acid; Uricosuric Agents

Topics: Diuretics; Gout; Humans; Hypertension; Hypothyroidism; Kidney Diseases; Nicotinic Acids; Nucleoproteins; Proteins; Purines; Salicylates; Thioridazine; Uric Acid

Topics: Antibodies, Antinuclear; Arthritis, Rheumatoid; Biopsy; Connective Tissue; Dermatomyositis; Diphosphates; Gout; Humans; Hyperparathyroidism; Inflammation; Joint Diseases; Lupus Erythematosus, Systemic; Neutrophils; Polyarteritis Nodosa; Psoriasis; Rheumatoid Factor; Salicylates; Sarcoidosis; Spondylitis, Ankylosing; Synovial Fluid; Synovial Membrane; Uric Acid

Topics: Acetaminophen; Adrenal Cortex Hormones; Arthritis; Arthritis, Rheumatoid; Aspirin; Chloroquine; Codeine; Cortisone; Cyclophosphamide; Dextropropoxyphene; Gold; Gout; Humans; Indomethacin; Mefenamic Acid; Pentazocine; Phenylbutazone; Salicylates; Spondylitis, Ankylosing

Topics: Fingers; Gout; Humans; Male; Middle Aged; Probenecid; Radiography; Salicylates

Topics: Acute Disease; Allopurinol; Chronic Disease; Colchicine; Gout; Humans; Indomethacin; Metabolic Diseases; Phenylbutazone; Salicylates; Uric Acid; Uricosuric Agents

The plasma levels of the urate-binding alpha(1)-alpha(2)-globulin, as determined by its urate-binding capacity, have been recorded in 19 individuals from two gouty kindreds. A significantly reduced binding capacity, accounting for 13-30% of the mean value obtained in healthy, unrelated control subjects, was found in all cases of gout and in the single case of essential hyperuricemia included in the present study. In addition, six apparently healthy members of one of these kindreds also exhibited this characteristic. The distribution of the characteristic in three subsequent generations from this kindred further supported the hypothesis that the reduced binding capacity was inherited as an autosomal trait for which affected subjects were heterozygous. Based on the present observation, the mechanisms of inheritance in primary gout are discussed with special emphasis on the possible cooperation of genetic and environmental factors.

Topics: Adult; Alpha-Globulins; Arthritis; Autoradiography; Chromatography, Gel; Epilepsy; Female; Gout; Heterozygote; Humans; Immunoelectrophoresis; Kidney; Male; Middle Aged; Migraine Disorders; Narcolepsy; Pedigree; Protein Binding; Puberty; Salicylates; Spectrophotometry; Uric Acid

Topics: Allopurinol; Colchicine; Crystallization; Diagnosis, Differential; Diet Therapy; Gout; Humans; Indomethacin; Joint Diseases; Kidney Diseases; Kidneys, Artificial; Phenylbutazone; Probenecid; Proteinuria; Purines; Radiography; Salicylates; Steroids; Sulfinpyrazone; Uric Acid

Topics: Adrenal Cortex Hormones; Ambulatory Care; Arthritis, Rheumatoid; Chloroquine; Chronic Disease; Family Practice; Gold; Gout; Humans; Mineral Waters; Physical Therapy Modalities; Prednisone; Rheumatic Diseases; Salicylates; Spondylitis, Ankylosing

Topics: Allopurinol; Gout; Humans; Phenylbutazone; Salicylates; Uricosuric Agents; Xanthine Oxidase

Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticoagulants; Benzofurans; Colchicine; Gout; Griseofulvin; Humans; Indomethacin; Oxyphenbutazone; Phenylbutazone; Probenecid; Salicylates; Sulfinpyrazone

Topics: Allopurinol; Blood Urea Nitrogen; Enzyme Therapy; Female; Gout; Humans; Kidney Calculi; Kidney Diseases; Male; Salicylates; Sulfinpyrazone; Uric Acid; Xanthine Oxidase

Topics: Enzyme Inhibitors; Fluids and Secretions; Gout; Hypoxanthines; Kidney; Pharmacology; Physiology; Probenecid; Purines; Pyrimidines; Renal Elimination; Salicylates; Spectrophotometry; Sulfinpyrazone; Uricosuric Agents; Urine; Xanthine Oxidase; Xanthines

Topics: Adolescent; Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Colchicine; Genetics, Medical; Gout; Intestinal Diseases; Intestinal Obstruction; Intestine, Small; Kidney Diseases; Pathology; Salicylates; Substance Withdrawal Syndrome; Substance-Related Disorders; Toxicology; Uremia; Uricosuric Agents

Topics: Aged; Colchicine; Diagnosis; Diet; Diet Therapy; Drug Therapy; Geriatrics; Gout; History; Humans; Phenylbutazone; Probenecid; Salicylates; Toxicology; Uric Acid

Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Colchicine; Diuretics; Gout; Griseofulvin; Humans; Oxyphenbutazone; Phenylbutazone; Probenecid; Salicylates; Uricosuric Agents

Topics: Abdomen; Abdomen, Acute; Adrenal Cortex Hormones; Colchicine; Gastrointestinal Hemorrhage; Gout; Kidney Diseases; Phenylbutazone; Salicylates; Shock; Toxicology; Uricosuric Agents; Zoxazolamine

Topics: Adrenocorticotropic Hormone; Blood; Body Fluids; Colchicine; Diet; Diet Therapy; Disease Management; Drug Therapy; Gout; Indoles; Phenylbutazone; Probenecid; Salicylates; Sulfinpyrazone; Surgical Procedures, Operative; Toxicology; Uricosuric Agents; Urine

Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Analgesics; Analgesics, Non-Narcotic; Antimalarials; Antipyretics; Arthritis; Arthritis, Rheumatoid; Gout; Pyrazoles; Rheumatic Fever; Salicylates; Spondylitis; Spondylitis, Ankylosing

Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Antimalarials; Arthritis; Arthritis, Rheumatoid; Gold; Gout; Humans; Pyrazoles; Rheumatic Diseases; Rheumatic Fever; Salicylates; Spondylitis; Spondylitis, Ankylosing; Uricosuric Agents

Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Balneology; Colchicine; Drug Therapy; Gout; Humans; Quinolines; Salicylates; Uricosuric Agents

Topics: Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Colchicine; Diet; Diet Therapy; Drug Therapy; Geriatrics; Gout; Kidney Diseases; Metabolism; Phenylbutazone; Probenecid; Salicylates; Sulfinpyrazone; Surgical Procedures, Operative; Toxicology; Uric Acid; Uricosuric Agents; Zoxazolamine

Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Colchicine; Diagnosis, Differential; Diet; Diet Therapy; Drug Therapy; Epidemiology; Genetics, Medical; Gout; Humans; Indomethacin; Kidney Diseases; Kidneys, Artificial; Phenylbutazone; Probenecid; Salicylates; Sulfinpyrazone; Uric Acid; Urine

Topics: Adolescent; Aging; Blood; Drug Therapy; Geriatrics; Gout; Longitudinal Studies; Metabolism; Phenylbutazone; Probenecid; Salicylates; Sex; Sulfinpyrazone; Toxicology; Uric Acid

Topics: Colchicine; Gout; Humans; Kidney Diseases; Phenylbutazone; Renal Insufficiency; Salicylates; Uric Acid

Topics: Arthritis; Arthritis, Rheumatoid; Gout; Humans; Salicylates

Topics: Arthritis; Aspirin; Chlorothiazide; Colchicine; Gout; Hydrochlorothiazide; Mecamylamine; Pempidine; Phenylbutazone; Probenecid; Pyrazoles; Salicylates

Topics: Arthritis, Gouty; Gout; Phenylbutazone; Probenecid; Pyrazoles; Salicylates; Uricosuric Agents; Zoxazolamine

Topics: Chlorthalidone; Colchicine; Diagnosis; Gout; Humans; Oxyphenbutazone; Phenylbutazone; Probenecid; Pyrazoles; Salicylates; Sulfinpyrazone; Uricosuric Agents

Topics: Gout; Phenylbutazone; Probenecid; Salicylates; Uric Acid; Zoxazolamine

Topics: Gout; Phenylbutazone; Prednisolone; Probenecid; Pyrazoles; Salicylates; Zoxazolamine

Topics: Diet; Disease Management; Gout; Humans; Probenecid; Salicylates

Topics: Gout; Humans; Salicylates

Topics: Body Fluids; Gout; Probenecid; Salicylates; Uric Acid; Urine

Topics: Gout; Salicylates; Sodium Salicylate

Topics: Arthritis, Gouty; Blood; Chronic Disease; Gout; Humans; Probenecid; Salicylates; Sodium Salicylate; Uric Acid

Topics: Gout; Salicylates; Sodium Salicylate

Topics: Adrenocorticotropic Hormone; Body Fluids; Gout; Humans; Salicylates; Uric Acid; Urine