oxonic acid and Gout
oxonic acid has been researched along with Gout in 19 studies
Oxonic Acid: Antagonist of urate oxidase.
Gout: Metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of URIC ACID calculi.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " It suppressed liver xanthine oxidase activity to decrease uric acid synthesis and modulated renal urate transporters to stimulate uric acid excretion, alleviating kidney damage caused by hyperuricemia." | 8.31 | Paeonia × suffruticosa Andrews leaf extract and its main component apigenin 7-O-glucoside ameliorate hyperuricemia by inhibiting xanthine oxidase activity and regulating renal urate transporters. ( An, J; Li, C; Li, Y; Lin, F; Ma, S; Wang, S; Xie, Y; Xu, L; Zhang, Y; Zhao, Y, 2023) |
| " In this study, the xanthine oxidase (XO) inhibition and uric acid-lowering effect of corni fructus extract (CFE) were evaluated in mice with potassium oxonate-induced hyperuricemia." | 8.12 | Protective effects of corni fructus extract in mice with potassium oxonate-induced hyperuricemia. ( Chen, C; Chen, FA; Chen, HC; Chiu, PY; Li, YL; Wang, CC, 2022) |
| " The RSGE treatment dose-dependently reduced PO- and MSU-induced paw edema, serum TNF-α, IL-1β, IL-6, IL-12, uric acid, and BUN, while significantly elevated serum IL-10, urinary uric acid and creatinine levels as compared with the respective values in the hyperuricemic and gouty mice group (vehicle group)." | 7.91 | Protective effects of Rhizoma smilacis glabrae extracts on potassium oxonate- and monosodium urate-induced hyperuricemia and gout in mice. ( Chang, Y; Liang, C; Liang, G; Nie, Y; Xiao, D; Zeng, S; Zhan, S; Zheng, Q; Zheng, X, 2019) |
| " It suppressed liver xanthine oxidase activity to decrease uric acid synthesis and modulated renal urate transporters to stimulate uric acid excretion, alleviating kidney damage caused by hyperuricemia." | 4.31 | Paeonia × suffruticosa Andrews leaf extract and its main component apigenin 7-O-glucoside ameliorate hyperuricemia by inhibiting xanthine oxidase activity and regulating renal urate transporters. ( An, J; Li, C; Li, Y; Lin, F; Ma, S; Wang, S; Xie, Y; Xu, L; Zhang, Y; Zhao, Y, 2023) |
| " In this study, the xanthine oxidase (XO) inhibition and uric acid-lowering effect of corni fructus extract (CFE) were evaluated in mice with potassium oxonate-induced hyperuricemia." | 4.12 | Protective effects of corni fructus extract in mice with potassium oxonate-induced hyperuricemia. ( Chen, C; Chen, FA; Chen, HC; Chiu, PY; Li, YL; Wang, CC, 2022) |
| " The RSGE treatment dose-dependently reduced PO- and MSU-induced paw edema, serum TNF-α, IL-1β, IL-6, IL-12, uric acid, and BUN, while significantly elevated serum IL-10, urinary uric acid and creatinine levels as compared with the respective values in the hyperuricemic and gouty mice group (vehicle group)." | 3.91 | Protective effects of Rhizoma smilacis glabrae extracts on potassium oxonate- and monosodium urate-induced hyperuricemia and gout in mice. ( Chang, Y; Liang, C; Liang, G; Nie, Y; Xiao, D; Zeng, S; Zhan, S; Zheng, Q; Zheng, X, 2019) |
| "Benzbromarone (BBR) is effective in the treatment of gout; however, clinical findings have shown it can also cause fatal hepatic failure." | 3.85 | Metabolic Epoxidation Is a Critical Step for the Development of Benzbromarone-Induced Hepatotoxicity. ( Lan, Q; Pang, J; Peng, Y; Wang, H; Wang, S; Wang, W; Wang, X; Zhang, T; Zhao, H; Zhao, Y; Zheng, J, 2017) |
| " riparia in reducing serum uric acid levels in a potassium oxonate-induced hyperuricemia mouse model." | 3.80 | Smilax riparia reduces hyperuricemia in mice as a potential treatment of gout. ( Anderson, S; Wu, XH; Yu, CH; Zhang, CF; Zhang, YW, 2014) |
| "These findings demonstrate that mangiferin has the potential to be developed as a new therapeutic agent for the treatment of hyperuricemia and gout." | 3.78 | Reducing effect of mangiferin on serum uric acid levels in mice. ( Gao, L; Li, L; Lin, H; Liu, X; Lu, W; Niu, Y, 2012) |
| " We evaluated the hypouricemic effect of propolis from China on hyperuricemia induced by the uricase inhibitor, oxonic acid (500 mg/kg p." | 3.73 | [Xanthine oxidase inhibitory activity and hypouricemia effect of propolis in rats]. ( Nishioka, N; Tsuji, T; Yoshizumi, K, 2005) |
| " The ideal uricase inhibitor for induction of hyperuricemia would be one which is irreversible, noncompetitive, and relatively nontoxic, so that its activity would be independent of high levels of uric acid, and effective inhibition could be attained at low dosage levels." | 2.36 | Use of the uricase-inhibited rat as an animal model in toxicology. ( Nera, EA; Stavric, B, 1978) |
| "Currently, the treatment of gout mainly includes two basic methods: reducing uric acid and alleviating inflammation." | 1.56 | Development of novel NLRP3-XOD dual inhibitors for the treatment of gout. ( Ha, EH; Hu, Q; Li, H; Li, Z; Pang, J; Tian, S; Wang, W; Zhou, M, 2020) |
| "Thus, AE may be a potential treatment for hyperuricemia and gout." | 1.51 | Anti-hyperuricemic effect of Alpinia oxyphylla seed extract by enhancing uric acid excretion in the kidney. ( Kim, DS; Kim, JS; Lee, S; Lee, YS; Son, E; Sung, YY; Yuk, HJ, 2019) |
Research
Studies (19)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (31.58) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (10.53) | 29.6817 |
| 2010's | 8 (42.11) | 24.3611 |
| 2020's | 3 (15.79) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Wang, CC | 1 |
| Li, YL | 1 |
| Chiu, PY | 1 |
| Chen, C | 1 |
| Chen, HC | 1 |
| Chen, FA | 1 |
| Zhang, Y | 1 |
| Li, Y | 1 |
| Li, C | 1 |
| Zhao, Y | 2 |
| Xu, L | 1 |
| Ma, S | 1 |
| Lin, F | 1 |
| Xie, Y | 1 |
| An, J | 1 |
| Wang, S | 2 |
| Wang, W | 2 |
| Pang, J | 2 |
| Ha, EH | 1 |
| Zhou, M | 1 |
| Li, Z | 1 |
| Tian, S | 1 |
| Li, H | 1 |
| Hu, Q | 1 |
| Wang, H | 1 |
| Peng, Y | 1 |
| Zhang, T | 1 |
| Lan, Q | 1 |
| Zhao, H | 1 |
| Wang, X | 2 |
| Zheng, J | 1 |
| Liang, G | 1 |
| Nie, Y | 1 |
| Chang, Y | 1 |
| Zeng, S | 1 |
| Liang, C | 1 |
| Zheng, X | 1 |
| Xiao, D | 1 |
| Zhan, S | 1 |
| Zheng, Q | 1 |
| Lee, YS | 1 |
| Sung, YY | 1 |
| Yuk, HJ | 1 |
| Son, E | 1 |
| Lee, S | 1 |
| Kim, JS | 1 |
| Kim, DS | 1 |
| Wu, XH | 1 |
| Yu, CH | 1 |
| Zhang, CF | 1 |
| Anderson, S | 1 |
| Zhang, YW | 1 |
| Kodithuwakku, ND | 1 |
| Feng, YD | 1 |
| Zhang, YY | 1 |
| Pan, M | 1 |
| Fang, WR | 1 |
| Li, YM | 1 |
| Hu, QH | 1 |
| Jiao, RQ | 1 |
| Lv, YZ | 1 |
| Kong, LD | 1 |
| Niu, Y | 1 |
| Lu, W | 1 |
| Gao, L | 1 |
| Lin, H | 1 |
| Liu, X | 1 |
| Li, L | 1 |
| Hou, CW | 1 |
| Lee, YC | 1 |
| Hung, HF | 1 |
| Fu, HW | 1 |
| Jeng, KC | 1 |
| Yoshizumi, K | 1 |
| Nishioka, N | 1 |
| Tsuji, T | 1 |
| Sarawek, S | 1 |
| Feistel, B | 1 |
| Pischel, I | 1 |
| Butterweck, V | 1 |
| Hirai, A | 1 |
| Kumagai, A | 1 |
| Musil, J | 1 |
| Stavric, B | 1 |
| Nera, EA | 1 |
| Winocour, PD | 1 |
| Munday, KA | 1 |
| Taylor, TG | 1 |
| Tuner, MR | 1 |
| Bluestone, R | 1 |
| Waisman, J | 1 |
| Klinenberg, JR | 1 |
| Holländer, E | 1 |
Reviews
2 reviews available for oxonic acid and Gout
| Article | Year |
|---|---|
[Animal model for gout].
Topics: Animals; Chickens; Disease Models, Animal; Female; Gout; Male; Mice; Oxonic Acid; Poultry Diseases; | 1982 |
Use of the uricase-inhibited rat as an animal model in toxicology.
Topics: Aggression; Animals; Diet; Disease Models, Animal; Dogs; Embryo, Mammalian; Female; Gout; Humans; Ki | 1978 |
Other Studies
17 other studies available for oxonic acid and Gout
| Article | Year |
|---|---|
Protective effects of corni fructus extract in mice with potassium oxonate-induced hyperuricemia.
Topics: Animals; Antioxidants; Cornus; Gout; Hyperuricemia; Mice; Oxonic Acid; Plant Extracts; Uric Acid; Xa | 2022 |
Paeonia × suffruticosa Andrews leaf extract and its main component apigenin 7-O-glucoside ameliorate hyperuricemia by inhibiting xanthine oxidase activity and regulating renal urate transporters.
Topics: Animals; Apigenin; Creatinine; Glucosides; Gout; Hyperuricemia; Kidney; Malondialdehyde; Mice; Molec | 2023 |
Development of novel NLRP3-XOD dual inhibitors for the treatment of gout.
Topics: Animals; Benzimidazoles; Benzoxazoles; Cell Line; Disease Models, Animal; Gout; Humans; Hyperuricemi | 2020 |
Metabolic Epoxidation Is a Critical Step for the Development of Benzbromarone-Induced Hepatotoxicity.
Topics: Activation, Metabolic; Animals; Benzbromarone; Chemical and Drug Induced Liver Injury; Cytochrome P- | 2017 |
Protective effects of Rhizoma smilacis glabrae extracts on potassium oxonate- and monosodium urate-induced hyperuricemia and gout in mice.
Topics: Animals; Antioxidants; Arthritis, Gouty; Disease Models, Animal; Drugs, Chinese Herbal; Edema; Flavo | 2019 |
Anti-hyperuricemic effect of Alpinia oxyphylla seed extract by enhancing uric acid excretion in the kidney.
Topics: Alpinia; Animals; China; Gout; Humans; Hyperuricemia; Kidney; Male; Organic Anion Transport Protein | 2019 |
Smilax riparia reduces hyperuricemia in mice as a potential treatment of gout.
Topics: Animals; Disease Models, Animal; Down-Regulation; Drugs, Chinese Herbal; Gout; Gout Suppressants; Hy | 2014 |
The molecular insight into the antihyperuricemic and renoprotective effect of Shuang Qi gout capsule in mice.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; | 2015 |
Simiao pill ameliorates urate underexcretion and renal dysfunction in hyperuricemic mice.
Topics: Allopurinol; Animals; Biological Transport; Gout; Hyperuricemia; Kidney; Male; Mice; Mice, Inbred St | 2010 |
Reducing effect of mangiferin on serum uric acid levels in mice.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gout; | 2012 |
Longan seed extract reduces hyperuricemia via modulating urate transporters and suppressing xanthine oxidase activity.
Topics: Allopurinol; Animals; Glucose Transporter Type 1; Gout; Gout Suppressants; Hyperuricemia; Hypoxanthi | 2012 |
[Xanthine oxidase inhibitory activity and hypouricemia effect of propolis in rats].
Topics: Animals; Anti-Infective Agents; Brazil; Caffeic Acids; China; Coumaric Acids; Disease Models, Animal | 2005 |
Flavonoids of Cynara scolymus possess potent xanthinoxidase inhibitory activity in vitro but are devoid of hypouricemic effects in rats after oral application.
Topics: Administration, Oral; Animals; Cynara scolymus; Flavonoids; Gout; Hyperuricemia; Male; Oxonic Acid; | 2008 |
Physiological characteristics of various experimental models for the study of disorders in purine metabolism.
Topics: Acidosis; Alkalosis; Allopurinol; Animals; Cholesterol; Disease Models, Animal; Diuresis; Fructose; | 1977 |
Platelet aggregation in rats made hyperuricaemic with nucleic adid-rich diets containing oxonate, and inhibitor of uricase [proceedings].
Topics: Animals; Diet; Disease Models, Animal; Female; Fusarium; Gout; Nucleic Acids; Oxonic Acid; Platelet | 1976 |
Chronic experimental hyperuricemic nephropathy.
Topics: Animals; Disease Models, Animal; Gout; Kidney; Kidney Calculi; Nephritis, Interstitial; Oxonic Acid; | 1975 |
[The effect of fructose on uric acid metabolism].
Topics: Allopurinol; Animals; Diuresis; Fasting; Fructose; Gout; Humans; Male; Oxonic Acid; Rats; Urate Oxid | 1974 |