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pyrazinamide and Gout

pyrazinamide has been researched along with Gout in 32 studies

pyrazinecarboxamide : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis.

Gout: Metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of URIC ACID calculi.

Research Excerpts

ExcerptRelevanceReference
"Benzbromarone1 is a benzofuran derivative which lowers serum urate and increases urinary urate excretion in normal, hyperuricaemic and gouty subjects."8.75Benzbromarone: a review of its pharmacological properties and therapeutic use in gout and hyperuricaemia. ( Avery, GS; Brogden, RN; Heel, RC; Speight, TM, 1977)
"A number of pharmacological agents can induce hyperuricaemia, and sometimes gout, usually by interfering with the renal tubular excretion of urate but also in some instances by increasing the formation of uric acid."4.78Drug-induced gout. ( Scott, JT, 1991)
"Benzbromarone1 is a benzofuran derivative which lowers serum urate and increases urinary urate excretion in normal, hyperuricaemic and gouty subjects."4.75Benzbromarone: a review of its pharmacological properties and therapeutic use in gout and hyperuricaemia. ( Avery, GS; Brogden, RN; Heel, RC; Speight, TM, 1977)
"Pyrazinamide, an antituberculous drug discovered in 1952, was first considered as a toxic drug."2.36[Toxicity of pyrazinamide in antituberculous treatments (author's transl)]. ( Perdrizet, S; Pretet, S, 1980)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-199024 (75.00)18.7374
1990's6 (18.75)18.2507
2000's2 (6.25)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ichida, K1
Hosoyamada, M1
Kimura, H1
Takeda, M1
Utsunomiya, Y1
Hosoya, T1
Endou, H1
Yamamoto, T1
SCOTT, JT2
DIXON, AS1
BYWATERS, EG1
Podevin, R1
Paillard, F1
Amiel, C1
Richet, G1
Pretet, S1
Perdrizet, S1
Puig, JG1
Mateos, F1
Muñoz, A1
Gaspar, G1
Ramos, T1
Gijón Baños, J1
Levinson, DJ1
Sorensen, LB2
Hisatome, I1
Kosaka, H1
Ohtahara, K1
Tsuboi, M1
Manabe, I1
Ohtahara, A1
Sawaguchi, M1
Igawa, O1
Tanaka, Y1
Fujimoto, Y1
Yoshida, A1
Takeda, A1
Shigemasa, C1
Rao, TP1
Schmitt, JK1
Decaux, G1
Soupart, A1
Musch, W1
Hannotier, P1
Prospert, F1
Boss, GR1
Seegmiller, JE1
Rieselbach, RE3
Heel, RC1
Brogden, RN1
Speight, TM1
Avery, GS1
Sinclair, DS1
Fox, IH2
Amodio, MI1
Bengualid, V1
Lowy, FD1
Dong, SQ1
Garyfallos, A1
Magoula, I1
Tsapas, G1
García Puig, J1
Mateos Antón, F1
López Jiménez, M1
Conthe Gutiérrez, P1
Holmes, EW1
Kelley, WN3
Wyngaarden, JB1
Gershon, SL1
Hart, FD1
Steele, TH3
de Gery, A1
Auscher, C1
Saporta, L1
Delbarre, F1
Postlethwaite, AE2
Ramsdell, CM1
Bartel, AG1
Rodnan, GP1
Gutman, AB1
Yü, TF1
Berger, L1
Shelp, WD1
Emmerson, BT1
Mirosch, W1
Douglas, JB1

Reviews

10 reviews available for pyrazinamide and Gout

ArticleYear
[Effect of ethanol on uric acid level].
    Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61 Suppl 1

    Topics: Acetaldehyde; Animals; Erythrocytes; Ethanol; Gout; Humans; Hyperuricemia; Purines; Pyrazinamide; Ur

2003
[Toxicity of pyrazinamide in antituberculous treatments (author's transl)].
    Revue francaise des maladies respiratoires, 1980, Volume: 8, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Diarrhea; Drug Eruptions; Gout; Humans; Isoniazid; Nausea; P

1980
Hyperuricemia and gout. Classification, complications and management.
    The New England journal of medicine, 1979, Jun-28, Volume: 300, Issue:26

    Topics: Acute Disease; Allopurinol; Arthritis; Aspirin; Colchicine; Coronary Disease; Diuretics; Gout; Human

1979
Renal handling of uric acid.
    Advances in experimental medicine and biology, 1977, Volume: 76B

    Topics: Biological Transport; Glomerular Filtration Rate; Gout; Humans; Kidney; Kidney Tubules; Models, Biol

1977
Benzbromarone: a review of its pharmacological properties and therapeutic use in gout and hyperuricaemia.
    Drugs, 1977, Volume: 14, Issue:5

    Topics: Aspirin; Benzbromarone; Benzofurans; Drug Interactions; Fasting; Gout; Humans; Kidney Diseases; Kine

1977
Drug-induced gout.
    Bailliere's clinical rheumatology, 1991, Volume: 5, Issue:1

    Topics: Cyclosporins; Cytotoxins; Diuretics; Drug-Related Side Effects and Adverse Reactions; Ethambutol; Et

1991
Editorial: The kidney and uric acid excretion in man.
    Kidney international, 1972, Volume: 2, Issue:3

    Topics: Angiotensin II; Animals; Biological Transport, Active; Blood Proteins; Diabetes Insipidus; Diet, Sod

1972
Influence of the kidney upon urate homeostasis in health and disease.
    The American journal of medicine, 1974, Volume: 56, Issue:5

    Topics: Acute Kidney Injury; Female; Glomerular Filtration Rate; Gout; Homeostasis; Humans; Hypertension; Hy

1974
Invitation to the gout. A consideration of the role of various predisposing and provocative factors in the genesis of acute gouty arthritis.
    Transactions & studies of the College of Physicians of Philadelphia, 1967, Volume: 35, Issue:2

    Topics: Acute Disease; Alcoholic Beverages; Arthritis; Fasting; Food; Gout; Humans; Mercury; Organomercury C

1967
Control of uric acid excretion.
    The New England journal of medicine, 1971, May-27, Volume: 284, Issue:21

    Topics: Animals; Dogs; Glycine; Gout; Humans; Kidney; Kidney Diseases; Kidney Tubules; Pyrazinamide; Uric Ac

1971

Trials

2 trials available for pyrazinamide and Gout

ArticleYear
Treatment of gout and hyperuricaemia by benzbromarone, ethyl 2 (dibromo-3,5 hydroxy-4 benzoyl)-3 benzofuran.
    Advances in experimental medicine and biology, 1974, Volume: 41

    Topics: Benzoates; Bromine; Clinical Trials as Topic; Creatinine; Gout; Humans; Hypoxanthines; Probenecid; P

1974
Renal function in gout. 3. Estimation of tubular secretion and reabsorption of uric acid by use of pyrazinamide (pyrazinoic acid).
    The American journal of medicine, 1969, Volume: 47, Issue:4

    Topics: Adult; Allopurinol; Clinical Trials as Topic; Gout; Humans; Kidney Tubules; Metabolic Clearance Rate

1969

Other Studies

20 other studies available for pyrazinamide and Gout

ArticleYear
Urate transport via human PAH transporter hOAT1 and its gene structure.
    Kidney international, 2003, Volume: 63, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Benzbromarone; Biological Transport; Blotting, Western; Car

2003
ASSOCIATION OF HYPERURICAEMIA AND GOUT WITH HYPERPARATHYROIDISM.
    British medical journal, 1964, Apr-25, Volume: 1, Issue:5390

    Topics: Adenoma; Blood Chemical Analysis; Diagnosis; Gout; Humans; Hyperparathyroidism; Hyperuricemia; Nephr

1964
[Effect of benziodarone on the renal excretion of uric acid].
    Revue francaise d'etudes cliniques et biologiques, 1967, Volume: 12, Issue:4

    Topics: Gout; Humans; Probenecid; Pyrazinamide; Uricosuric Agents

1967
Renal handling of uric acid in gout by means of the pyrazinamide and probenecid tests.
    Advances in experimental medicine and biology, 1984, Volume: 165 Pt A

    Topics: Adult; Gout; Humans; Kidney; Kidney Tubules; Probenecid; Pyrazinamide; Reference Values; Uric Acid

1984
Renal handling of uric acid in normal and gouty subject: evidence for a 4-component system.
    Annals of the rheumatic diseases, 1980, Volume: 39, Issue:2

    Topics: Absorption; Benzbromarone; Blood Proteins; Female; Gout; Humans; In Vitro Techniques; Kidney; Kidney

1980
Renal handling of urate in a patient with familial juvenile gouty nephropathy.
    Internal medicine (Tokyo, Japan), 1996, Volume: 35, Issue:7

    Topics: Adolescent; Benzbromarone; Female; Genes, Dominant; Gout; Gout Suppressants; Humans; Kidney; Kidney

1996
Gout secondary to pyrazinamide and ethambutol.
    Virginia medical quarterly : VMQ, 1996,Fall, Volume: 123, Issue:4

    Topics: Diuretics; Ethambutol; Gout; Humans; Male; Middle Aged; Pyrazinamide

1996
[First-time standard setting for therapy of pulmonary tuberculosis after revision of the Medical Treatment Standard--special reference to results of questionnaire survey on reality of early stage short-term PZA therapy and occurrence of the adverse effect
    Kekkaku : [Tuberculosis], 1997, Volume: 72, Issue:11

    Topics: Antitubercular Agents; Chemical and Drug Induced Liver Injury; Drug Therapy; Gout; Humans; Japan; Li

1997
Restoration of the uricosuric effect of probenecid after triglycylvasopressine administration in a gouty patient.
    Clinical nephrology, 1998, Volume: 50, Issue:4

    Topics: Absorption; Acute Kidney Injury; Adult; Anti-Inflammatory Agents; Benzbromarone; Fludrocortisone; Go

1998
The pharmacology of hypouricemic effect of benzbromarone.
    The Journal of rheumatology, 1975, Volume: 2, Issue:4

    Topics: Adult; Aspirin; Benzbromarone; Benzofurans; Blood Proteins; Creatinine; Female; Gout; Humans; Male;

1975
Development of acute gout secondary to pyrazinamide in a patient without a prior history of gout.
    DICP : the annals of pharmacotherapy, 1990, Volume: 24, Issue:11

    Topics: Aged; Allopurinol; Colchicine; Gout; Humans; Male; Pyrazinamide

1990
[Observations on the effect of PZA, EB and RFP on uric acid metabolism].
    Zhonghua jie he he hu xi xi ji bing za zhi = Chinese journal of tuberculosis and respiratory diseases, 1986, Volume: 9, Issue:4

    Topics: Adolescent; Adult; Arthritis; Drug Therapy, Combination; Ethambutol; Female; Gout; Humans; Male; Mid

1986
Evaluation of the renal mechanisms for urate homeostasis in uremic patients by probenecid and pyrazinamide test.
    Nephron, 1987, Volume: 46, Issue:3

    Topics: Absorption; Creatinine; Female; Glomerular Filtration Rate; Gout; Homeostasis; Humans; Kidney Failur

1987
Renal handling of uric acid in gout: impaired tubular transport of urate not dependent on serum urate levels.
    Metabolism: clinical and experimental, 1986, Volume: 35, Issue:12

    Topics: Adult; Aged; Biological Transport, Active; Gout; Humans; Kidney Tubules; Kinetics; Male; Middle Aged

1986
Pharmacologic effects of nicotinic acid on human purine metabolism.
    The Journal of laboratory and clinical medicine, 1974, Volume: 84, Issue:2

    Topics: Adult; Aspirin; Creatinine; Erythrocytes; Female; Gout; Humans; Iopanoic Acid; Kidney Tubules; Male;

1974
Drug-induced arthritis.
    Current medical research and opinion, 1974, Volume: 2, Issue:9

    Topics: Acute Disease; Anticoagulants; Antihypertensive Agents; Arteritis; Arthritis; Barbiturates; Contrace

1974
Uricosuric effect of an anticholinergic agent in hyperuricemic subjects.
    Advances in experimental medicine and biology, 1974, Volume: 41

    Topics: Creatinine; Cyclohexanes; Glycopyrrolate; Gout; Humans; Parasympatholytics; Propanolamines; Purine-P

1974
Hyperuricemia induced by ethambutol.
    Advances in experimental medicine and biology, 1974, Volume: 41

    Topics: Allopurinol; Creatinine; Diuretics; Ethambutol; Ethanol; Gout; Humans; Isoniazid; Lactates; Pyrazina

1974
Diminished renal urate secretion per nephron as a basis for primary gout.
    Annals of internal medicine, 1970, Volume: 73, Issue:3

    Topics: Adult; Allopurinol; Carbon Isotopes; Computers; Dietary Proteins; Gout; Humans; Inulin; Kidney Funct

1970
The relative contributions of tubular reabsorption and secretion to urate excretion in lead nephropathy.
    Australian and New Zealand journal of medicine, 1971, Volume: 1, Issue:4

    Topics: Absorption; Adult; Female; Glomerular Filtration Rate; Gout; Humans; Insulin; Kidney Failure, Chroni

1971