pyrazinamide and Gout
pyrazinamide has been researched along with Gout in 32 studies
pyrazinecarboxamide : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis.
Gout: Metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of URIC ACID calculi.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Benzbromarone1 is a benzofuran derivative which lowers serum urate and increases urinary urate excretion in normal, hyperuricaemic and gouty subjects." | 8.75 | Benzbromarone: a review of its pharmacological properties and therapeutic use in gout and hyperuricaemia. ( Avery, GS; Brogden, RN; Heel, RC; Speight, TM, 1977) |
| "A number of pharmacological agents can induce hyperuricaemia, and sometimes gout, usually by interfering with the renal tubular excretion of urate but also in some instances by increasing the formation of uric acid." | 4.78 | Drug-induced gout. ( Scott, JT, 1991) |
| "Benzbromarone1 is a benzofuran derivative which lowers serum urate and increases urinary urate excretion in normal, hyperuricaemic and gouty subjects." | 4.75 | Benzbromarone: a review of its pharmacological properties and therapeutic use in gout and hyperuricaemia. ( Avery, GS; Brogden, RN; Heel, RC; Speight, TM, 1977) |
| "Pyrazinamide, an antituberculous drug discovered in 1952, was first considered as a toxic drug." | 2.36 | [Toxicity of pyrazinamide in antituberculous treatments (author's transl)]. ( Perdrizet, S; Pretet, S, 1980) |
Research
Studies (32)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (75.00) | 18.7374 |
| 1990's | 6 (18.75) | 18.2507 |
| 2000's | 2 (6.25) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Ichida, K | 1 |
| Hosoyamada, M | 1 |
| Kimura, H | 1 |
| Takeda, M | 1 |
| Utsunomiya, Y | 1 |
| Hosoya, T | 1 |
| Endou, H | 1 |
| Yamamoto, T | 1 |
| SCOTT, JT | 2 |
| DIXON, AS | 1 |
| BYWATERS, EG | 1 |
| Podevin, R | 1 |
| Paillard, F | 1 |
| Amiel, C | 1 |
| Richet, G | 1 |
| Pretet, S | 1 |
| Perdrizet, S | 1 |
| Puig, JG | 1 |
| Mateos, F | 1 |
| Muñoz, A | 1 |
| Gaspar, G | 1 |
| Ramos, T | 1 |
| Gijón Baños, J | 1 |
| Levinson, DJ | 1 |
| Sorensen, LB | 2 |
| Hisatome, I | 1 |
| Kosaka, H | 1 |
| Ohtahara, K | 1 |
| Tsuboi, M | 1 |
| Manabe, I | 1 |
| Ohtahara, A | 1 |
| Sawaguchi, M | 1 |
| Igawa, O | 1 |
| Tanaka, Y | 1 |
| Fujimoto, Y | 1 |
| Yoshida, A | 1 |
| Takeda, A | 1 |
| Shigemasa, C | 1 |
| Rao, TP | 1 |
| Schmitt, JK | 1 |
| Decaux, G | 1 |
| Soupart, A | 1 |
| Musch, W | 1 |
| Hannotier, P | 1 |
| Prospert, F | 1 |
| Boss, GR | 1 |
| Seegmiller, JE | 1 |
| Rieselbach, RE | 3 |
| Heel, RC | 1 |
| Brogden, RN | 1 |
| Speight, TM | 1 |
| Avery, GS | 1 |
| Sinclair, DS | 1 |
| Fox, IH | 2 |
| Amodio, MI | 1 |
| Bengualid, V | 1 |
| Lowy, FD | 1 |
| Dong, SQ | 1 |
| Garyfallos, A | 1 |
| Magoula, I | 1 |
| Tsapas, G | 1 |
| García Puig, J | 1 |
| Mateos Antón, F | 1 |
| López Jiménez, M | 1 |
| Conthe Gutiérrez, P | 1 |
| Holmes, EW | 1 |
| Kelley, WN | 3 |
| Wyngaarden, JB | 1 |
| Gershon, SL | 1 |
| Hart, FD | 1 |
| Steele, TH | 3 |
| de Gery, A | 1 |
| Auscher, C | 1 |
| Saporta, L | 1 |
| Delbarre, F | 1 |
| Postlethwaite, AE | 2 |
| Ramsdell, CM | 1 |
| Bartel, AG | 1 |
| Rodnan, GP | 1 |
| Gutman, AB | 1 |
| Yü, TF | 1 |
| Berger, L | 1 |
| Shelp, WD | 1 |
| Emmerson, BT | 1 |
| Mirosch, W | 1 |
| Douglas, JB | 1 |
Reviews
10 reviews available for pyrazinamide and Gout
| Article | Year |
|---|---|
[Effect of ethanol on uric acid level].
Topics: Acetaldehyde; Animals; Erythrocytes; Ethanol; Gout; Humans; Hyperuricemia; Purines; Pyrazinamide; Ur | 2003 |
[Toxicity of pyrazinamide in antituberculous treatments (author's transl)].
Topics: Chemical and Drug Induced Liver Injury; Diarrhea; Drug Eruptions; Gout; Humans; Isoniazid; Nausea; P | 1980 |
Hyperuricemia and gout. Classification, complications and management.
Topics: Acute Disease; Allopurinol; Arthritis; Aspirin; Colchicine; Coronary Disease; Diuretics; Gout; Human | 1979 |
Renal handling of uric acid.
Topics: Biological Transport; Glomerular Filtration Rate; Gout; Humans; Kidney; Kidney Tubules; Models, Biol | 1977 |
Benzbromarone: a review of its pharmacological properties and therapeutic use in gout and hyperuricaemia.
Topics: Aspirin; Benzbromarone; Benzofurans; Drug Interactions; Fasting; Gout; Humans; Kidney Diseases; Kine | 1977 |
Drug-induced gout.
Topics: Cyclosporins; Cytotoxins; Diuretics; Drug-Related Side Effects and Adverse Reactions; Ethambutol; Et | 1991 |
Editorial: The kidney and uric acid excretion in man.
Topics: Angiotensin II; Animals; Biological Transport, Active; Blood Proteins; Diabetes Insipidus; Diet, Sod | 1972 |
Influence of the kidney upon urate homeostasis in health and disease.
Topics: Acute Kidney Injury; Female; Glomerular Filtration Rate; Gout; Homeostasis; Humans; Hypertension; Hy | 1974 |
Invitation to the gout. A consideration of the role of various predisposing and provocative factors in the genesis of acute gouty arthritis.
Topics: Acute Disease; Alcoholic Beverages; Arthritis; Fasting; Food; Gout; Humans; Mercury; Organomercury C | 1967 |
Control of uric acid excretion.
Topics: Animals; Dogs; Glycine; Gout; Humans; Kidney; Kidney Diseases; Kidney Tubules; Pyrazinamide; Uric Ac | 1971 |
Trials
2 trials available for pyrazinamide and Gout
| Article | Year |
|---|---|
Treatment of gout and hyperuricaemia by benzbromarone, ethyl 2 (dibromo-3,5 hydroxy-4 benzoyl)-3 benzofuran.
Topics: Benzoates; Bromine; Clinical Trials as Topic; Creatinine; Gout; Humans; Hypoxanthines; Probenecid; P | 1974 |
Renal function in gout. 3. Estimation of tubular secretion and reabsorption of uric acid by use of pyrazinamide (pyrazinoic acid).
Topics: Adult; Allopurinol; Clinical Trials as Topic; Gout; Humans; Kidney Tubules; Metabolic Clearance Rate | 1969 |
Other Studies
20 other studies available for pyrazinamide and Gout
| Article | Year |
|---|---|
Urate transport via human PAH transporter hOAT1 and its gene structure.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Benzbromarone; Biological Transport; Blotting, Western; Car | 2003 |
ASSOCIATION OF HYPERURICAEMIA AND GOUT WITH HYPERPARATHYROIDISM.
Topics: Adenoma; Blood Chemical Analysis; Diagnosis; Gout; Humans; Hyperparathyroidism; Hyperuricemia; Nephr | 1964 |
[Effect of benziodarone on the renal excretion of uric acid].
Topics: Gout; Humans; Probenecid; Pyrazinamide; Uricosuric Agents | 1967 |
Renal handling of uric acid in gout by means of the pyrazinamide and probenecid tests.
Topics: Adult; Gout; Humans; Kidney; Kidney Tubules; Probenecid; Pyrazinamide; Reference Values; Uric Acid | 1984 |
Renal handling of uric acid in normal and gouty subject: evidence for a 4-component system.
Topics: Absorption; Benzbromarone; Blood Proteins; Female; Gout; Humans; In Vitro Techniques; Kidney; Kidney | 1980 |
Renal handling of urate in a patient with familial juvenile gouty nephropathy.
Topics: Adolescent; Benzbromarone; Female; Genes, Dominant; Gout; Gout Suppressants; Humans; Kidney; Kidney | 1996 |
Gout secondary to pyrazinamide and ethambutol.
Topics: Diuretics; Ethambutol; Gout; Humans; Male; Middle Aged; Pyrazinamide | 1996 |
[First-time standard setting for therapy of pulmonary tuberculosis after revision of the Medical Treatment Standard--special reference to results of questionnaire survey on reality of early stage short-term PZA therapy and occurrence of the adverse effect
Topics: Antitubercular Agents; Chemical and Drug Induced Liver Injury; Drug Therapy; Gout; Humans; Japan; Li | 1997 |
Restoration of the uricosuric effect of probenecid after triglycylvasopressine administration in a gouty patient.
Topics: Absorption; Acute Kidney Injury; Adult; Anti-Inflammatory Agents; Benzbromarone; Fludrocortisone; Go | 1998 |
The pharmacology of hypouricemic effect of benzbromarone.
Topics: Adult; Aspirin; Benzbromarone; Benzofurans; Blood Proteins; Creatinine; Female; Gout; Humans; Male; | 1975 |
Development of acute gout secondary to pyrazinamide in a patient without a prior history of gout.
Topics: Aged; Allopurinol; Colchicine; Gout; Humans; Male; Pyrazinamide | 1990 |
[Observations on the effect of PZA, EB and RFP on uric acid metabolism].
Topics: Adolescent; Adult; Arthritis; Drug Therapy, Combination; Ethambutol; Female; Gout; Humans; Male; Mid | 1986 |
Evaluation of the renal mechanisms for urate homeostasis in uremic patients by probenecid and pyrazinamide test.
Topics: Absorption; Creatinine; Female; Glomerular Filtration Rate; Gout; Homeostasis; Humans; Kidney Failur | 1987 |
Renal handling of uric acid in gout: impaired tubular transport of urate not dependent on serum urate levels.
Topics: Adult; Aged; Biological Transport, Active; Gout; Humans; Kidney Tubules; Kinetics; Male; Middle Aged | 1986 |
Pharmacologic effects of nicotinic acid on human purine metabolism.
Topics: Adult; Aspirin; Creatinine; Erythrocytes; Female; Gout; Humans; Iopanoic Acid; Kidney Tubules; Male; | 1974 |
Drug-induced arthritis.
Topics: Acute Disease; Anticoagulants; Antihypertensive Agents; Arteritis; Arthritis; Barbiturates; Contrace | 1974 |
Uricosuric effect of an anticholinergic agent in hyperuricemic subjects.
Topics: Creatinine; Cyclohexanes; Glycopyrrolate; Gout; Humans; Parasympatholytics; Propanolamines; Purine-P | 1974 |
Hyperuricemia induced by ethambutol.
Topics: Allopurinol; Creatinine; Diuretics; Ethambutol; Ethanol; Gout; Humans; Isoniazid; Lactates; Pyrazina | 1974 |
Diminished renal urate secretion per nephron as a basis for primary gout.
Topics: Adult; Allopurinol; Carbon Isotopes; Computers; Dietary Proteins; Gout; Humans; Inulin; Kidney Funct | 1970 |
The relative contributions of tubular reabsorption and secretion to urate excretion in lead nephropathy.
Topics: Absorption; Adult; Female; Glomerular Filtration Rate; Gout; Humans; Insulin; Kidney Failure, Chroni | 1971 |