Page last updated: 2024-11-13

davallialactone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

davallialactone: from Davallia mariesii; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
Davalliagenus[no description available]Davalliaceae[no description available]

Cross-References

ID SourceID
PubMed CID54715402
CHEMBL ID205945
MeSH IDM0187967

Synonyms (4)

Synonym
davallialactone
CHEMBL205945
bdbm50498535
DTXSID401045722
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Neuraminidase Influenza A virus (A/Wilson-Smith/1933(H1N1))IC50 (µMol)19.03330.00000.503510.0000AID1241697; AID1241698; AID1241699
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (38)

Assay IDTitleYearJournalArticle
AID1241698Inhibition of recombinant Influenza A virus H5N1 neuraminidase2015Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16
Anti-influenza activities of polyphenols from the medicinal mushroom Phellinus baumii.
AID705522Hepatoprotective activity in CCL4-induced FVB mouse assessed as reduction in liver necrosis at 2.5 to 10 mg/kg, sc administered for 3 consecutive days prior CCL4 challenge measured 12 to 24 hrs post challenge by hematoxylin/eosin-staining method relative 2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Hispidin analogue davallialactone attenuates carbon tetrachloride-induced hepatotoxicity in mice.
AID277800Cytotoxicity against human A549 cells2007Journal of natural products, Feb, Volume: 70, Issue:2
Structures, biogenesis, and biological activities of pyrano[4,3-c]isochromen-4-one derivatives from the Fungus Phellinus igniarius.
AID502563Antioxidant activity assessed as ABTS radical scavenging activity2010Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18
Styrylpyrones from the medicinal fungus Phellinus baumii and their antioxidant properties.
AID1241697Inhibition of recombinant Influenza A virus H1N1 neuraminidase2015Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16
Anti-influenza activities of polyphenols from the medicinal mushroom Phellinus baumii.
AID705515Hepatoprotective activity in CCL4-induced FVB mouse assessed as decrease in serum TNFalpha level at 2.5 to 10 mg/kg, sc administered for 3 consecutive days prior CCL4 challenge measured 12 to 24 hrs post challenge by ELISA relative to control2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Hispidin analogue davallialactone attenuates carbon tetrachloride-induced hepatotoxicity in mice.
AID705514Hepatoprotective activity in CCL4-induced FVB mouse assessed as decrease in iNOS expression at 2.5 to 10 mg/kg, sc administered for 3 consecutive days prior CCL4 challenge measured 12 to 24 hrs post challenge by Western blot method relative to control2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Hispidin analogue davallialactone attenuates carbon tetrachloride-induced hepatotoxicity in mice.
AID705331Hepatoprotective activity in CCL4-induced FVB mouse assessed as increase in HO-1 expression at 2.5 to 10 mg/kg, sc administered for 3 consecutive days prior CCL4 challenge measured 12 to 24 hrs post challenge by Western blot method relative to control2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Hispidin analogue davallialactone attenuates carbon tetrachloride-induced hepatotoxicity in mice.
AID263927ABTS radical scavenging activity2006Bioorganic & medicinal chemistry letters, May-01, Volume: 16, Issue:9
Hispidin analogs from the mushroom Inonotus xeranticus and their free radical scavenging activity.
AID705518Hepatoprotective activity in CCL4-induced FVB mouse assessed as reduction in serum MDA level at 2.5 to 10 mg/kg, sc administered for 3 consecutive days prior CCL4 challenge measured 12 to 24 hrs post challenge relative to control2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Hispidin analogue davallialactone attenuates carbon tetrachloride-induced hepatotoxicity in mice.
AID705521Hepatoprotective activity in CCL4-induced FVB mouse assessed as reduction in liver necrosis at 10 mg/kg, sc administered for 3 consecutive days prior CCL4 challenge measured 12 hrs post challenge by hematoxylin/eosin-staining method relative to control2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Hispidin analogue davallialactone attenuates carbon tetrachloride-induced hepatotoxicity in mice.
AID263926Superoxide radical scavenging activity2006Bioorganic & medicinal chemistry letters, May-01, Volume: 16, Issue:9
Hispidin analogs from the mushroom Inonotus xeranticus and their free radical scavenging activity.
AID277801Cytotoxicity against human Bel7402 cells2007Journal of natural products, Feb, Volume: 70, Issue:2
Structures, biogenesis, and biological activities of pyrano[4,3-c]isochromen-4-one derivatives from the Fungus Phellinus igniarius.
AID705328Hepatoprotective activity in CCL4-induced FVB mouse assessed as effect on CYP2E1 expression at 2.5 to 10 mg/kg, sc administered for 3 consecutive days prior CCL4 challenge measured 12 to 24 hrs post challenge by Western blot method relative to control2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Hispidin analogue davallialactone attenuates carbon tetrachloride-induced hepatotoxicity in mice.
AID1241700Noncompetitive inhibition of recombinant Influenza A virus H1N1 neuraminidase using MU-NANA as substrate2015Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16
Anti-influenza activities of polyphenols from the medicinal mushroom Phellinus baumii.
AID277798Antioxidant activity assessed as inhibition of rat liver microsomal lipid peroxidation2007Journal of natural products, Feb, Volume: 70, Issue:2
Structures, biogenesis, and biological activities of pyrano[4,3-c]isochromen-4-one derivatives from the Fungus Phellinus igniarius.
AID705513Hepatoprotective activity in CCL4-induced FVB mouse assessed as decrease in COX2 expression at 2.5 to 10 mg/kg, sc administered for 3 consecutive days prior CCL4 challenge measured 12 to 24 hrs post challenge by Western blot method relative to control2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Hispidin analogue davallialactone attenuates carbon tetrachloride-induced hepatotoxicity in mice.
AID705519Hepatoprotective activity in CCL4-induced FVB mouse assessed as reduction in ROS level at 10 mg/kg, sc administered for 3 consecutive days prior CCL4 challenge measured 12 to 24 hrs post challenge by DHE-labeling method relative to control2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Hispidin analogue davallialactone attenuates carbon tetrachloride-induced hepatotoxicity in mice.
AID277799Cytotoxicity against human A2708 cells2007Journal of natural products, Feb, Volume: 70, Issue:2
Structures, biogenesis, and biological activities of pyrano[4,3-c]isochromen-4-one derivatives from the Fungus Phellinus igniarius.
AID1241703Cytotoxicity against MDCK cells by SRB assay2015Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16
Anti-influenza activities of polyphenols from the medicinal mushroom Phellinus baumii.
AID705330Hepatoprotective activity in CCL4-induced FVB mouse assessed as decrease in liver macrophages at 2.5 to 10 mg/kg, sc administered for 3 consecutive days prior CCL4 challenge measured 24 hrs post challenge by immunofluorescence staining method relative to 2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Hispidin analogue davallialactone attenuates carbon tetrachloride-induced hepatotoxicity in mice.
AID502564Antioxidant activity assessed as inhibition of fenton reaction-induced pBR322 DNA single strand break by agarose gel electrophoresis2010Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18
Styrylpyrones from the medicinal fungus Phellinus baumii and their antioxidant properties.
AID1241705Therapeutic index, ratio of CC50 for MDCK cells to IC50 for Influenza A virus H1N12015Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16
Anti-influenza activities of polyphenols from the medicinal mushroom Phellinus baumii.
AID705329Hepatoprotective activity in CCL4-induced FVB mouse assessed as decrease in cleaved caspase3-positive hepatocytes at 2.5 to 10 mg/kg, sc administered for 3 consecutive days prior CCL4 challenge measured 24 hrs post challenge by immunofluorescence staining2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Hispidin analogue davallialactone attenuates carbon tetrachloride-induced hepatotoxicity in mice.
AID502565Antioxidant activity assessed as inhibition of fenton reaction-induced pBR322 DNA single strand break by CAS assay2010Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18
Styrylpyrones from the medicinal fungus Phellinus baumii and their antioxidant properties.
AID1241702Ratio of hispidin IC50 to compound IC50 for recombinant Influenza A virus H1N1 neuraminidase2015Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16
Anti-influenza activities of polyphenols from the medicinal mushroom Phellinus baumii.
AID502562Antioxidant activity assessed as DPPH radical scavenging activity2010Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18
Styrylpyrones from the medicinal fungus Phellinus baumii and their antioxidant properties.
AID1241696Retention time of the compound2015Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16
Anti-influenza activities of polyphenols from the medicinal mushroom Phellinus baumii.
AID1241707Antiviral activity against Influenza A virus H1N1 infected in MDCK cells assessed as inhibition of virus-induced change in cell morphology at 10 ug/ml after 2 days by microscopic analysis2015Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16
Anti-influenza activities of polyphenols from the medicinal mushroom Phellinus baumii.
AID705520Hepatoprotective activity in sc dosed CCL4-induced FVB mouse assessed as reduction in liver necrosis at administered for 3 consecutive days prior CCL4 challenge measured 24 hrs post challenge by hematoxylin/eosin-staining method relative to control2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Hispidin analogue davallialactone attenuates carbon tetrachloride-induced hepatotoxicity in mice.
AID705524Hepatoprotective activity in FVB mouse assessed as reduction of CCL4-induced increase of serum ALT level at 2.5 to 10 mg/kg, sc administered for 3 consecutive days prior CCL4 challenge measured 12 to 24 hrs post challenge2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Hispidin analogue davallialactone attenuates carbon tetrachloride-induced hepatotoxicity in mice.
AID705517Hepatoprotective activity in CCL4-induced FVB mouse assessed as restoration of Cu/Zn SOD expression at 2.5 to 10 mg/kg, sc administered for 3 consecutive days prior CCL4 challenge measured 12 to 24 hrs post challenge by Western blot method relative to con2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Hispidin analogue davallialactone attenuates carbon tetrachloride-induced hepatotoxicity in mice.
AID263928DPPH radical scavenging activity2006Bioorganic & medicinal chemistry letters, May-01, Volume: 16, Issue:9
Hispidin analogs from the mushroom Inonotus xeranticus and their free radical scavenging activity.
AID705516Hepatoprotective activity in CCL4-induced FVB mouse assessed as increase in CYP2E1 p-nitrophenol activity at 2.5 to 10 mg/kg, sc administered for 3 consecutive days prior CCL4 challenge measured 12 to 24 hrs post challenge relative to control2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Hispidin analogue davallialactone attenuates carbon tetrachloride-induced hepatotoxicity in mice.
AID705523Hepatoprotective activity in FVB mouse assessed as reduction of CCL4-induced increase of serum AST level at 2.5 to 10 mg/kg, sc administered for 3 consecutive days prior CCL4 challenge measured 12 to 24 hrs post challenge2012Journal of natural products, Oct-26, Volume: 75, Issue:10
Hispidin analogue davallialactone attenuates carbon tetrachloride-induced hepatotoxicity in mice.
AID1241704Antiviral activity against Influenza A virus H1N1 infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect by SRB assay2015Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16
Anti-influenza activities of polyphenols from the medicinal mushroom Phellinus baumii.
AID277802Cytotoxicity against human HCT8 cells2007Journal of natural products, Feb, Volume: 70, Issue:2
Structures, biogenesis, and biological activities of pyrano[4,3-c]isochromen-4-one derivatives from the Fungus Phellinus igniarius.
AID1241699Inhibition of recombinant Influenza A virus H3N2 neuraminidase2015Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16
Anti-influenza activities of polyphenols from the medicinal mushroom Phellinus baumii.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (14)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (7.14)18.2507
2000's4 (28.57)29.6817
2010's8 (57.14)24.3611
2020's1 (7.14)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other14 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]