Page last updated: 2024-10-22

amitriptyline and Gout

amitriptyline has been researched along with Gout in 2 studies

Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.

Gout: Metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of URIC ACID calculi.

Research Excerpts

ExcerptRelevanceReference
"Using in silico docking analysis, RT-PCR, siRNA, elisa, proteomics and clinical data mining of drug consumption, we explored the clinical relevance of amitriptyline blockade of TLR4-mediated innate immune responses in human osteoarthritis chondrocytes."8.12Amitriptyline blocks innate immune responses mediated by toll-like receptor 4 and IL-1 receptor: Preclinical and clinical evidence in osteoarthritis and gout. ( Alonso-Pérez, A; Belén Bravo, S; Crespo-Golmar, A; Franco-Trepat, E; Gómez Bahamonde, R; Gualillo, O; Guillán-Fresco, M; Jorge-Mora, A; López-Fagúndez, M; Pazos-Pérez, A, 2022)
"Using in silico docking analysis, RT-PCR, siRNA, elisa, proteomics and clinical data mining of drug consumption, we explored the clinical relevance of amitriptyline blockade of TLR4-mediated innate immune responses in human osteoarthritis chondrocytes."4.12Amitriptyline blocks innate immune responses mediated by toll-like receptor 4 and IL-1 receptor: Preclinical and clinical evidence in osteoarthritis and gout. ( Alonso-Pérez, A; Belén Bravo, S; Crespo-Golmar, A; Franco-Trepat, E; Gómez Bahamonde, R; Gualillo, O; Guillán-Fresco, M; Jorge-Mora, A; López-Fagúndez, M; Pazos-Pérez, A, 2022)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19901 (50.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's1 (50.00)2.80

Authors

AuthorsStudies
Franco-Trepat, E1
Alonso-Pérez, A1
Guillán-Fresco, M1
Jorge-Mora, A1
Crespo-Golmar, A1
López-Fagúndez, M1
Pazos-Pérez, A1
Gualillo, O1
Belén Bravo, S1
Gómez Bahamonde, R1
Kilpatrick, R1
Smith, AJ1

Reviews

1 review available for amitriptyline and Gout

ArticleYear
Advances in medicine.
    The Practitioner, 1971, Volume: 207, Issue:240

    Topics: Amitriptyline; Cholera; Coronary Disease; Crohn Disease; Diabetes Mellitus; Diet Therapy; Diverticul

1971

Other Studies

1 other study available for amitriptyline and Gout

ArticleYear
Amitriptyline blocks innate immune responses mediated by toll-like receptor 4 and IL-1 receptor: Preclinical and clinical evidence in osteoarthritis and gout.
    British journal of pharmacology, 2022, Volume: 179, Issue:2

    Topics: Aged; Amitriptyline; Chondrocytes; Gout; Humans; Immunity, Innate; NLR Family, Pyrin Domain-Containi

2022