y-700 and Gout

y-700 has been researched along with Gout* in 1 studies

Other Studies

1 other study(ies) available for y-700 and Gout

Article	Year
Synthesis and structure-activity relationships of 1-phenylpyrazoles as xanthine oxidase inhibitors. Bioorganic & medicinal chemistry letters, 2001, Apr-09, Volume: 11, Issue:7 A series of 1-phenylpyrazoles was evaluated for inhibitory activity against xanthine oxidase in vitro. Of the compounds prepared, 1-(3-cyano-4-neopentyloxyphenyl)pyrazole-4-carboxylic acid (Y-700) had the most potent enzyme inhibition and displayed longer-lasting hypouricemic action than did allopurinol in a rat model of hyperuricemia induced by the uricase inhibitor potassium oxonate. Topics: Allopurinol; Animals; Area Under Curve; Gout; Gout Suppressants; Male; Metabolic Diseases; Models, Animal; Pyrazoles; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Urate Oxidase; Uric Acid; Xanthine Oxidase	2001

Article

Year

Synthesis and structure-activity relationships of 1-phenylpyrazoles as xanthine oxidase inhibitors.

Bioorganic & medicinal chemistry letters, 2001, Apr-09, Volume: 11, Issue:7

A series of 1-phenylpyrazoles was evaluated for inhibitory activity against xanthine oxidase in vitro. Of the compounds prepared, 1-(3-cyano-4-neopentyloxyphenyl)pyrazole-4-carboxylic acid (Y-700) had the most potent enzyme inhibition and displayed longer-lasting hypouricemic action than did allopurinol in a rat model of hyperuricemia induced by the uricase inhibitor potassium oxonate.

Topics: Allopurinol; Animals; Area Under Curve; Gout; Gout Suppressants; Male; Metabolic Diseases; Models, Animal; Pyrazoles; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Urate Oxidase; Uric Acid; Xanthine Oxidase

2001