guanfacine has been researched along with Cocaine Abuse in 7 studies
Guanfacine: A centrally acting antihypertensive agent with specificity towards ADRENERGIC ALPHA-2 RECEPTORS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cocaine dependence is associated with increased stress and drug cue-induced craving and physiological arousal but decreased prefrontal activity to emotional and cognitive challenge." | 2.77 | Guanfacine effects on stress, drug craving and prefrontal activation in cocaine dependent individuals: preliminary findings. ( Fox, HC; Hansen, J; Kimmerling, A; Morgan, PT; Seo, D; Sinha, R; Tuit, K, 2012) |
| "The pathophysiology of cocaine addiction is linked to changes within neural systems and brain regions that are critical mediators of stress system sensitivity and behavioral processes associated with the regulation of adaptive goal-directed behavior." | 2.50 | The role of guanfacine as a therapeutic agent to address stress-related pathophysiology in cocaine-dependent individuals. ( Fox, H; Sinha, R, 2014) |
| "Guanfacine treated women improved their performance on the Stroop task following exposure to all 3 imagery conditions compared with placebo women (p=0." | 1.46 | Sex differences in guanfacine effects on stress-induced stroop performance in cocaine dependence. ( Fox, HC; Hermes, G; Jayaram-Lindstrom, N; Milivojevic, V; Sinha, R, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (85.71) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Lustberg, D | 1 |
| Weinshenker, D | 1 |
| Milivojevic, V | 1 |
| Fox, HC | 3 |
| Jayaram-Lindstrom, N | 1 |
| Hermes, G | 1 |
| Sinha, R | 5 |
| Morgan, PT | 2 |
| Fox, H | 2 |
| Moran-Santa Maria, MM | 1 |
| Baker, NL | 1 |
| Ramakrishnan, V | 1 |
| Brady, KT | 1 |
| McRae-Clark, A | 1 |
| Sofuoglu, M | 1 |
| Seo, D | 1 |
| Tuit, K | 1 |
| Hansen, J | 1 |
| Kimmerling, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Guanfacine to Reduce Stress-Induced Cocaine/Alcohol Craving and Relapse[NCT00585754] | Phase 1 | 75 participants (Actual) | Interventional | 2006-04-30 | Completed | ||
| Guanfacine to Reduce Relapse Risk in Women With Alcohol Use Disorder (AUD)[NCT03137082] | Phase 1/Phase 2 | 60 participants (Anticipated) | Interventional | 2017-01-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for guanfacine and Cocaine Abuse
| Article | Year |
|---|---|
The role of guanfacine as a therapeutic agent to address stress-related pathophysiology in cocaine-dependent individuals.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Cocaine-Related Disorders; Guanfacine; Humans; Stress | 2014 |
4 trials available for guanfacine and Cocaine Abuse
| Article | Year |
|---|---|
Sex differences in guanfacine effects on drug craving and stress arousal in cocaine-dependent individuals.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Affect; Anxiety; Arousal; Blood Pressure; Cocaine-Relat | 2014 |
Sex differences in guanfacine effects on drug craving and stress arousal in cocaine-dependent individuals.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Affect; Anxiety; Arousal; Blood Pressure; Cocaine-Relat | 2014 |
Sex differences in guanfacine effects on drug craving and stress arousal in cocaine-dependent individuals.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Affect; Anxiety; Arousal; Blood Pressure; Cocaine-Relat | 2014 |
Sex differences in guanfacine effects on drug craving and stress arousal in cocaine-dependent individuals.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Affect; Anxiety; Arousal; Blood Pressure; Cocaine-Relat | 2014 |
Impact of acute guanfacine administration on stress and cue reactivity in cocaine-dependent individuals.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Cocaine-Related Disorders; Cues; Double-Blind Method; F | 2015 |
Guanfacine enhances inhibitory control and attentional shifting in early abstinent cocaine-dependent individuals.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Attention; Cocaine-Related Disorders; Cognition; Double | 2015 |
Guanfacine effects on stress, drug craving and prefrontal activation in cocaine dependent individuals: preliminary findings.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Cocaine-Related Disorders; Combined Modality Therapy; C | 2012 |
2 other studies available for guanfacine and Cocaine Abuse
| Article | Year |
|---|---|
Stressing the potential of guanfacine as a treatment for cocaine use disorder.
Topics: Adrenergic alpha-2 Receptor Agonists; Cocaine; Cocaine-Related Disorders; Conditioning, Classical; G | 2020 |
Sex differences in guanfacine effects on stress-induced stroop performance in cocaine dependence.
Topics: Cocaine; Cocaine-Related Disorders; Cues; Female; Guanfacine; Humans; Male; Sex Characteristics; Str | 2017 |