desipramine and Cocaine Abuse studies

Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.

Research Excerpts

Excerpt	Relevance	Reference
"This 13-week, randomized, double-blind, placebo-controlled trial evaluated the efficacy of desipramine hydrochloride (0 or 150 mg/d) plus buprenorphine hydrochloride (12 mg/d) or methadone hydrochloride (65 mg/d) in 180 opioid-dependent cocaine abusers (124 men, 56 women)."	9.09	Desipramine in opioid-dependent cocaine abusers maintained on buprenorphine vs methadone. ( Feingold, A; Jatlow, P; Kosten, TR; Oliveto, AH; Schottenfeld, R, 1999)
"The aim of this study was to test the hypothesis that desipramine would be an effective treatment in cocaine abusers with current depressive disorders."	5.11	Desipramine treatment of cocaine-dependent patients with depression: a placebo-controlled trial. ( Ma, GJ; McDowell, D; Nunes, EV; Petkova, E; Rothenberg, J; Seracini, AM; Vosburg, SK, 2005)
"This 13-week, randomized, double-blind, placebo-controlled trial evaluated the efficacy of desipramine hydrochloride (0 or 150 mg/d) plus buprenorphine hydrochloride (12 mg/d) or methadone hydrochloride (65 mg/d) in 180 opioid-dependent cocaine abusers (124 men, 56 women)."	5.09	Desipramine in opioid-dependent cocaine abusers maintained on buprenorphine vs methadone. ( Feingold, A; Jatlow, P; Kosten, TR; Oliveto, AH; Schottenfeld, R, 1999)
"We concluded that cocaine abuse counseling is a powerful intervention for reducing HIV-related sexual behaviors in this group at high risk for exposure to HIV."	1.30	Cocaine abuse counseling as HIV prevention. ( Frosch, D; Ling, W; Rawson, RA; Shoptaw, S, 1997)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (23.08)	18.2507
2000's	10 (76.92)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Carroll, FI	1
Howell, LL	1
Kuhar, MJ	1
Kosten, T	2
Poling, J	3
Oliveto, A	4
Feingold, A	4
Sevarino, K	1
McCance-Katz, E	1
Stine, S	1
Gonzalez, G	3
Gonsai, K	2
Oliveto, AH	1
Schottenfeld, R	2
Jatlow, P	1
Kosten, TR	4
Sofuoglu, M	1
Milligan, CO	1
Nich, C	1
Carroll, KM	1
Williams, JM	1
Steketee, JD	1
Ma, G	1
Troxel, AB	1
Heitjan, DF	1
McDowell, D	1
Nunes, EV	2
Seracini, AM	2
Rothenberg, J	1
Vosburg, SK	1
Ma, GJ	1
Petkova, E	1
Shoptaw, S	1
Frosch, D	1
Rawson, RA	1
Ling, W	1
McDowell, DM	1
Levin, FR	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
The Women In Steady Exercise Research (WISER) Survivor Trial & Cost of Illness and Cost Effectiveness of Alternative Management Strategies[NCT01515124]		450 participants (Actual)	Interventional	2012-01-31	Completed
[NCT00037362]		0 participants	Observational	2001-09-30	Completed
New Approaches to Cocaine Abuse Medications (A)[NCT00000271]	Phase 2	111 participants (Actual)	Interventional	1995-01-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Effects of reducing contingency management values on heroin and cocaine use for buprenorphine- and desipramine-treated patients. Addiction (Abingdon, England), 2003, Volume: 98, Issue:5 Topics: Adult; Antidepressive Agents, Tricyclic; Behavior Control; Buprenorphine; Cocaine-Related Disorders;	2003
Desipramine and contingency management for cocaine and opiate dependence in buprenorphine maintained patients. Drug and alcohol dependence, 2003, Jun-05, Volume: 70, Issue:3 Topics: Adult; Aged; Ambulatory Care; Analysis of Variance; Antidepressive Agents, Tricyclic; Buprenorphine;	2003
Desipramine in opioid-dependent cocaine abusers maintained on buprenorphine vs methadone. Archives of general psychiatry, 1999, Volume: 56, Issue:9 Topics: Adult; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Buprenorphine; Cocaine-Related Disorder	1999
Comorbid major depressive disorder as a prognostic factor in cocaine-abusing buprenorphine-maintained patients treated with desipramine and contingency management. The American journal of drug and alcohol abuse, 2003, Volume: 29, Issue:3 Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Buprenorphine; Cocaine-Related Disorders; Comorbidity	2003
Prediction of treatment outcome by baseline urine cocaine results and self-reported cocaine use for cocaine and opioid dependence. The American journal of drug and alcohol abuse, 2003, Volume: 29, Issue:4 Topics: Adult; Analysis of Variance; Antidepressive Agents, Tricyclic; Buprenorphine; Cocaine-Related Disord	2003
Desipramine treatment of cocaine-dependent patients with depression: a placebo-controlled trial. Drug and alcohol dependence, 2005, Nov-01, Volume: 80, Issue:2 Topics: Adult; Antidepressive Agents, Tricyclic; Cocaine-Related Disorders; Cognitive Behavioral Therapy; Co	2005
Venlafaxine treatment of cocaine abusers with depressive disorders. The American journal of drug and alcohol abuse, 2000, Volume: 26, Issue:1 Topics: Adult; Antidepressive Agents, Second-Generation; Cocaine-Related Disorders; Comorbidity; Cyclohexano	2000
Utility of crossover designs in clinical trials: efficacy of desipramine vs. placebo in opioid-dependent cocaine abusers. The American journal on addictions, 2002,Spring, Volume: 11, Issue:2 Topics: Adult; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Buprenorphine; Clinical Trials as Topic	2002

Article	Year
Ethnic differences in substance abuse treatment retention, compliance, and outcome from two clinical trials. Psychiatric services (Washington, D.C.), 2004, Volume: 55, Issue:2 Topics: Adult; Analysis of Variance; Antidepressive Agents, Tricyclic; Black People; Cocaine-Related Disorde	2004
Effects of repeated cocaine on the release and clearance of dopamine within the rat medial prefrontal cortex. Synapse (New York, N.Y.), 2005, Volume: 55, Issue:2 Topics: Adrenergic Agents; Analysis of Variance; Animals; Behavior, Animal; Blotting, Western; Brain Chemist	2005
An index of local sensitivity to nonignorable drop-out in longitudinal modelling. Statistics in medicine, 2005, Jul-30, Volume: 24, Issue:14 Topics: Animal Feed; Animals; Antidepressive Agents, Tricyclic; Antineoplastic Agents, Hormonal; Cattle; Coc	2005
An index of local sensitivity to nonignorable drop-out in longitudinal modelling. Statistics in medicine, 2005, Jul-30, Volume: 24, Issue:14 Topics: Animal Feed; Animals; Antidepressive Agents, Tricyclic; Antineoplastic Agents, Hormonal; Cattle; Coc	2005
An index of local sensitivity to nonignorable drop-out in longitudinal modelling. Statistics in medicine, 2005, Jul-30, Volume: 24, Issue:14 Topics: Animal Feed; Animals; Antidepressive Agents, Tricyclic; Antineoplastic Agents, Hormonal; Cattle; Coc	2005
An index of local sensitivity to nonignorable drop-out in longitudinal modelling. Statistics in medicine, 2005, Jul-30, Volume: 24, Issue:14 Topics: Animal Feed; Animals; Antidepressive Agents, Tricyclic; Antineoplastic Agents, Hormonal; Cattle; Coc	2005
Cocaine abuse counseling as HIV prevention. AIDS education and prevention : official publication of the International Society for AIDS Education, 1997, Volume: 9, Issue:6 Topics: Adult; Analysis of Variance; Antidepressive Agents, Tricyclic; Chi-Square Distribution; Cocaine-Rela	1997

desipramine and Cocaine Abuse

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