gbr 12935 and Cocaine Abuse studies

gbr 12935 and Cocaine Abuse

gbr 12935 has been researched along with Cocaine Abuse in 2 studies

1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine : An N-alkylpiperazine that consists of piperazine bearing 2-(benzhydryloxy)ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent and selective inhibitor of dopamine uptake (KD = 5.5 nM in rat striatal membranes).

Research Excerpts

Excerpt	Relevance	Reference
"In our search for long-acting agents for the treatment of cocaine abuse, a series of optically pure hydroxylated derivatives of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (1) and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (2) (GBR 12909 and GBR 12935, respectively) were synthesized and evaluated in vitro and in vivo."	3.71	Development of long-acting dopamine transporter ligands as potential cocaine-abuse therapeutic agents: chiral hydroxyl-containing derivatives of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phe ( Baumann, MH; Dersch, CM; Glowa, JR; Hsin, LW; Jacobson, AE; Rice, KC; Rothman, RB; Stafford, D, 2002)

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (50.00)	18.2507
2000's	1 (50.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

0 (0.00)

18.7374

1990's

1 (50.00)

18.2507

2000's

1 (50.00)

29.6817

2010's

0 (0.00)

24.3611

2020's

0 (0.00)

2.80

Authors

Authors	Studies
Lewis, DB	1
Matecka, D	1
Zhang, Y	1
Hsin, LW	2
Dersch, CM	2
Stafford, D	2
Glowa, JR	2
Rothman, RB	2
Rice, KC	2
Baumann, MH	1
Jacobson, AE	1

Studies

Lewis, DB

Matecka, D

Zhang, Y

Hsin, LW

Dersch, CM

Stafford, D

Glowa, JR

Rothman, RB

Rice, KC

Baumann, MH

Jacobson, AE

Other Studies

2 other studies available for gbr 12935 and Cocaine Abuse

Article	Year
Oxygenated analogues of 1-[2-(Diphenylmethoxy)ethyl]- and 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as potential extended-action cocaine-abuse therapeutic agents. Journal of medicinal chemistry, 1999, Dec-02, Volume: 42, Issue:24 Topics: Animals; Carrier Proteins; Cocaine-Related Disorders; Delayed-Action Preparations; Dopamine; Dopamin	1999
Development of long-acting dopamine transporter ligands as potential cocaine-abuse therapeutic agents: chiral hydroxyl-containing derivatives of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phe Journal of medicinal chemistry, 2002, Mar-14, Volume: 45, Issue:6 Topics: Animals; Behavior, Animal; Benzhydryl Compounds; Cocaine-Related Disorders; Dopamine Plasma Membrane	2002

Article

Year

Oxygenated analogues of 1-[2-(Diphenylmethoxy)ethyl]- and 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as potential extended-action cocaine-abuse therapeutic agents.

Journal of medicinal chemistry, 1999, Dec-02, Volume: 42, Issue:24

Topics: Animals; Carrier Proteins; Cocaine-Related Disorders; Delayed-Action Preparations; Dopamine; Dopamin

1999

Development of long-acting dopamine transporter ligands as potential cocaine-abuse therapeutic agents: chiral hydroxyl-containing derivatives of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phe

Journal of medicinal chemistry, 2002, Mar-14, Volume: 45, Issue:6

Topics: Animals; Behavior, Animal; Benzhydryl Compounds; Cocaine-Related Disorders; Dopamine Plasma Membrane

2002