naltrexone and Cocaine Abuse

naltrexone has been researched along with Cocaine Abuse in 54 studies

Research

Studies (54)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	7 (12.96)	18.2507
2000's	20 (37.04)	29.6817
2010's	22 (40.74)	24.3611
2020's	5 (9.26)	2.80

Authors

Authors	Studies
Graham, DP; Hamon, SC; Hillhouse, M; Kosten, TR; Lawson, WB; Ling, W; Nielsen, DA; Nielsen, EM; Rotrosen, J; Saxon, AJ; Settles-Reaves, BD; Shmueli-Blumberg, D; Shores-Wilson, K; Trivedi, MH; Walker, R	1
Cippitelli, A; Toll, L; Zribi, G	1
Bachtell, RK; Brown, KT; Levis, SC; Levy, C; O'Neill, CE; Rice, KC; Watkins, LR	1
Kenny, PJ; O'Brien, CP; Pierce, RC; Swinford-Jackson, SE; Unterwald, EM; Vanderschuren, LJMJ	1
Ayers, C; Chan, B; Freeman, M; Kansagara, D; Kondo, K; Korthuis, PT; Paynter, R	1
George, O; Kallupi, M; Martin-Fardon, R; Matzeu, A; Schweitzer, P	1
Buchholz, J; Saxon, AJ	1
Carson, RE; Chang, D; Foltin, R; Grassetti, A; Huang, Y; Lin, SF; Martinez, D; Matuskey, D; Nabulsi, N; Ropchan, J; Salling, M; Slifstein, M; Urban, N; Zheng, MQ	1
Briand, LA; Graziane, NM; Kauer, JA; Pierce, RC; Polter, AM	1
Askalsky, P; Berkower, EL; Comer, SD; Cooper, ZD; Foltin, RW; Haney, M; Jones, JD; Manubay, JM; Martinez, D; Mogali, S; Pines, A; Roux, P; Rubin, E; Saccone, PA; Sullivan, MA; Vosburg, SK; Walker, EA	1
Grabowski, J; Green, CE; Lindsay, JA; Moeller, FG; Rathnayaka, NS; Schmitz, JM; Stotts, AL	1
Aklin, WM; Bigelow, GE; DeFulio, A; Donlin, WD; Dunn, K; Everly, JJ; Fingerhood, M; Leoutsakos, JM; Nuzzo, PA; Silverman, K; Umbricht, A	1
Grosshans, M; Kiefer, F; Mutschler, J	1
Willyard, C	1
Eans, SO; Ganno, ML; Hunkele, A; Le Rouzic, V; Majumdar, S; Marrone, GF; McLaughlin, JP; Pasternak, GW; Subrath, JJ; Váradi, A	1
Sushchyk, S; Wang, JB; Xi, ZX	1
Ang, A; Annon, J; Brigham, GS; Church, S; Dawes, M; Drexler, K; Hasson, A; Hillhouse, MP; Knox, PC; Korthuis, PT; Lawson, W; Ling, W; Liu, DS; Matthews, AG; McCormack, J; Mooney, LJ; Ross, S; Rotrosen, J; Saxon, AJ; Schuman, C; Sparenborg, S; Swafford, W; Thomas, CM; Wiest, K	1
Correia, M; Deakin, JF; Elliott, R; Ersche, KD; Flechais, RS; Lingford-Hughes, AR; McGonigle, J; Murphy, A; Nutt, DJ; Orban, C; Passamonti, L; Paterson, LM; Reed, LJ; Riccelli, R; Robbins, TW; Sahakian, BJ; Savulich, G; Smith, DG; Suckling, J; Tait, R; Taylor, EM	1
Batki, SL; Dimmock, JA; Leontieva, L; Ploutz-Snyder, R	1
Achat-Mendes, C; Platt, DM; Rowlett, JK; Spealman, RD; Valdez, GR	1
Kampman, KM; Oslin, DW; Pettinati, HM; Plebani, JG; Tirado, CF; Volpicelli, JR	1
Platt, DM; Rowlett, JK; Rüedi-Bettschen, D; Spealman, RD	1
Amato, L; Davoli, M; Pani, PP; Trogu, E; Vacca, R; Vecchi, S	1
Kjome, KL; Kramer, LA; Liu, S; Ma, L; Moeller, FG; Narayana, PA; Rathnayaka, N; Schmitz, JM; Steinberg, JL	1
Beardsley, PM; Carroll, FI; Howard, JL; Pollard, GT	1
Koob, GF; Misra, KK; Schlosburg, JE; Vendruscolo, LF; Wee, S	1
Aklin, WM; Bigelow, GE; Fingerhood, M; Lejuez, CW; Severtson, SG; Silverman, K; Umbricht, A	1
Hasson, A; Hillhouse, M; Lindblad, R; Ling, W; McCormack, J; Mooney, LJ; Nielsen, S; Saxon, A; Stablein, D; Thomas, C	1
Aklin, WM; Bigelow, GE; Defulio, A; Donlin, WD; Dunn, KE; Everly, JJ; Fingerhood, M; Leoutsakos, JM; Nuzzo, PA; Silverman, K; Umbricht, A	1
Modesto-Lowe, V; Van Kirk, J	1
Kleber, HD	1
Kosten, TR; McCance-Katz, FE; Oliveto, A; Petrakis, I; Singha, A; Sofuoglu, M	1
Hagan, JJ; Heidbreder, CA	1
Gerrits, MA; Kuzmin, AV; van Ree, JM	1
O'Brien, CP	1
Fantoma, A; Gerra, G; Zaimovic, A	1
Antonilli, L; Cioce, AM; Giudici, FD; Grassi, MC; Nencini, P	1
Aicardi, G; Burattini, C; Burbassi, S; Cervo, L	1
Carroll, K; Levinson, C; Nich, C; Petrakis, I; Poling, J; Ralevski, E; Rounsaville, B	1
McGeary, JE; Miranda, R; Monti, PM; Rohsenow, DJ	1
Dackis, CA; Kampman, KM; Lynch, KG; O'Brien, CP; Oslin, DW; Pettinati, HM; Suh, JJ	1
Platt, DM; Rowlett, JK; Rüedi-Bettschen, D; Spealman, RD; Valdez, GR	1
Dackis, C; Kampman, KM; Lynch, KG; O'Brien, CP; Pettinati, HM; Rabinowitz, AR; Xie, H	1
Stitzer, ML; Vandrey, R	1
Braida, D; Gori, E; Paladini, E; Sala, M	1
Bauer, LO; Burleson, JA; Hersh, D; Kranzler, HR; Modesto-Lowe, V	1
Barringer, TM; Cavallaro, CA; Hubbell, CL; Mendez, JJ; Pabello, NG; Reid, LD	1
Hersh, D; Kranzler, HR; Van Kirk, JR	1
Borg, L; Gunduz, M; Ho, A; Kreek, MJ; Schluger, J	1
Kampman, KM; O'Brien, CP; Oslin, DW; Pettinati, HM; Volpicelli, JR; Wolf, AL	1
Hersh, D; Kranzler, HR; Mulgrew, CL; Van Kirk, J	1
Mello, NK; Negus, SS	1
Bornstein, G; Church, SH; Nunes, EV; Rothenberg, JL; Sullivan, MA	1
Dhopesh, V; Fudala, PJ; Yu, E	1

Reviews

9 review(s) available for naltrexone and Cocaine Abuse

Article	Year
A systematic review and meta-analysis of medications for stimulant use disorders in patients with co-occurring opioid use disorders. Drug and alcohol dependence, 2020, 11-01, Volume: 216 Topics: Analgesics, Opioid; Antidepressive Agents; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Female; Humans; Methadone; Naltrexone; Opioid-Related Disorders	2020
Medications to treat cocaine use disorders: current options. Current opinion in psychiatry, 2019, Volume: 32, Issue:4 Topics: Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Central Nervous System Stimulants; Cocaine-Related Disorders; Disulfiram; Humans; Naltrexone	2019
Disulfiram for the treatment of cocaine dependence. The Cochrane database of systematic reviews, 2010, Jan-20, Issue:1 Topics: Cocaine-Related Disorders; Disulfiram; Humans; Naltrexone; Narcotic Antagonists; Randomized Controlled Trials as Topic	2010
Clinical uses of naltrexone: a review of the evidence. Experimental and clinical psychopharmacology, 2002, Volume: 10, Issue:3 Topics: Alcoholism; Animals; Behavior, Addictive; Cocaine-Related Disorders; Feeding and Eating Disorders; Humans; Naltrexone; Narcotic Antagonists; Obsessive-Compulsive Disorder; Opioid-Related Disorders; Schizophrenia; Self-Injurious Behavior; Substance-Related Disorders; Tobacco Use Disorder	2002
Pharmacologic treatments for heroin and cocaine dependence. The American journal on addictions, 2003, Volume: 12, Issue:s2 Topics: Buprenorphine; Clonidine; Cocaine-Related Disorders; Comorbidity; Heroin Dependence; Humans; Mental Disorders; Methadone; Methadyl Acetate; Naltrexone; Narcotic Antagonists; Narcotics	2003
Novel pharmacotherapeutic approaches for the treatment of drug addiction and craving. Current opinion in pharmacology, 2005, Volume: 5, Issue:1 Topics: Alcoholism; Clinical Trials as Topic; Cocaine-Related Disorders; Humans; Naltrexone; Narcotic Antagonists; Nicotine; Opioid-Related Disorders; Structure-Activity Relationship; Substance-Related Disorders; Tobacco Use Disorder	2005
Anticraving medications for relapse prevention: a possible new class of psychoactive medications. The American journal of psychiatry, 2005, Volume: 162, Issue:8 Topics: Alcoholism; Behavior, Addictive; Bupropion; Cocaine-Related Disorders; Disulfiram; Humans; Naltrexone; Nicotine; Psychotherapy; Psychotropic Drugs; Secondary Prevention; Substance-Related Disorders; Tobacco Use Disorder	2005
Contingency management: utility in the treatment of drug abuse disorders. Clinical pharmacology and therapeutics, 2008, Volume: 83, Issue:4 Topics: Behavior Therapy; Buprenorphine; Cocaine-Related Disorders; Humans; Motivation; Naltrexone; Narcotic Antagonists; Patient Compliance; Receptors, Opioid, mu; Reinforcement, Psychology; Reward; Substance Abuse Detection; Substance Abuse Treatment Centers; Substance-Related Disorders; Treatment Outcome	2008
Interactions between kappa opioid agonists and cocaine. Preclinical studies. Annals of the New York Academy of Sciences, 2000, Volume: 909 Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Discrimination Learning; Humans; Naloxone; Naltrexone; Receptors, Opioid, kappa; Self Administration	2000

Trials

22 trial(s) available for naltrexone and Cocaine Abuse

Article	Year
Moderation of buprenorphine therapy for cocaine dependence efficacy by variation of the Prodynorphin gene. European journal of clinical pharmacology, 2022, Volume: 78, Issue:6 Topics: Buprenorphine; Buprenorphine, Naloxone Drug Combination; Cocaine; Cocaine-Related Disorders; Delayed-Action Preparations; Enkephalins; Humans; Injections, Intramuscular; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Protein Precursors	2022
Effects of acute oral naltrexone on the subjective and physiological effects of oral D-amphetamine and smoked cocaine in cocaine abusers. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2013, Volume: 38, Issue:12 Topics: Administration, Oral; Adult; Cardiovascular System; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Cross-Over Studies; Dextroamphetamine; Dopamine Uptake Inhibitors; Double-Blind Method; Female; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Smoking	2013
A two-phased screening paradigm for evaluating candidate medications for cocaine cessation or relapse prevention: modafinil, levodopa-carbidopa, naltrexone. Drug and alcohol dependence, 2014, Mar-01, Volume: 136 Topics: Adolescent; Adult; Benzhydryl Compounds; Carbidopa; Central Nervous System Stimulants; Cocaine-Related Disorders; Cognitive Behavioral Therapy; Data Interpretation, Statistical; Diagnostic and Statistical Manual of Mental Disorders; Dopamine Agents; Female; Humans; Levodopa; Male; Middle Aged; Modafinil; Motivational Interviewing; Naltrexone; Narcotic Antagonists; Neuropsychological Tests; Patient Compliance; Secondary Prevention; Treatment Outcome; Young Adult	2014
Employment-based reinforcement of adherence to oral naltrexone in unemployed injection drug users: 12-month outcomes. Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors, 2015, Volume: 29, Issue:2 Topics: Adult; Cocaine-Related Disorders; Drug Users; Employment; Female; Follow-Up Studies; Humans; Injections; Male; Medication Adherence; Middle Aged; Naltrexone; Opioid-Related Disorders; Reinforcement, Psychology; Secondary Prevention; Treatment Outcome; Unemployment	2015
Buprenorphine + naloxone plus naltrexone for the treatment of cocaine dependence: the Cocaine Use Reduction with Buprenorphine (CURB) study. Addiction (Abingdon, England), 2016, Volume: 111, Issue:8 Topics: Administration, Oral; Adult; Analgesics, Opioid; Buprenorphine, Naloxone Drug Combination; Cocaine-Related Disorders; Cognitive Behavioral Therapy; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Injections, Intramuscular; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Treatment Outcome	2016
Effects of naltrexone are influenced by childhood adversity during negative emotional processing in addiction recovery. Translational psychiatry, 2017, 03-07, Volume: 7, Issue:3 Topics: Adult; Adult Survivors of Child Adverse Events; Alcoholism; Amygdala; Brain; Case-Control Studies; Cocaine-Related Disorders; Cross-Over Studies; Cues; Double-Blind Method; Female; Functional Neuroimaging; Gyrus Cinguli; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Neural Pathways; Opioid-Related Disorders; Prefrontal Cortex; Substance-Related Disorders; Young Adult	2017
Combined effects of alcohol and hepatitis C: a secondary analysis of alcohol use biomarkers and high-risk behaviors from two medication trials for alcohol dependence. Addictive behaviors, 2010, Volume: 35, Issue:2 Topics: Adult; Alanine Transaminase; Alcoholism; Aspartate Aminotransferases; Cocaine-Related Disorders; Female; gamma-Glutamyltransferase; Hepatitis C; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Risk Factors; Risk-Taking; Transferrin	2010
Working memory fMRI activation in cocaine-dependent subjects: association with treatment response. Psychiatry research, 2010, Mar-30, Volume: 181, Issue:3 Topics: Adult; Amphetamine; Analysis of Variance; Benzhydryl Compounds; Brain; Brain Mapping; Carbidopa; Central Nervous System Stimulants; Cocaine-Related Disorders; Cognitive Behavioral Therapy; Dopamine Agents; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Mathematics; Memory Disorders; Memory, Short-Term; Middle Aged; Modafinil; Naltrexone; Narcotic Antagonists; Neuropsychological Tests; Oxygen	2010
Risk-taking propensity as a predictor of induction onto naltrexone treatment for opioid dependence. The Journal of clinical psychiatry, 2012, Volume: 73, Issue:8 Topics: Administration, Oral; Adult; Baltimore; Cocaine-Related Disorders; Conditioning, Operant; Female; Heroin Dependence; Humans; Male; Medication Adherence; Middle Aged; Naltrexone; Narcotic Antagonists; Odds Ratio; Opioid-Related Disorders; Patient Acceptance of Health Care; Personality Assessment; Psychometrics; Rehabilitation, Vocational; Risk-Taking; Sheltered Workshops; Substance Abuse Detection; Substance Abuse, Intravenous	2012
Cocaine use reduction with buprenorphine (CURB): rationale, design, and methodology. Contemporary clinical trials, 2013, Volume: 34, Issue:2 Topics: Administration, Sublingual; Adolescent; Adult; Aged; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Cocaine-Related Disorders; Cognitive Behavioral Therapy; Combined Modality Therapy; Double-Blind Method; Drug Combinations; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Treatment Outcome; Young Adult	2013
Employment-based reinforcement of adherence to oral naltrexone treatment in unemployed injection drug users. Experimental and clinical psychopharmacology, 2013, Volume: 21, Issue:1 Topics: Administration, Oral; Adolescent; Adult; Aged; Cocaine-Related Disorders; Employment; Female; Humans; Male; Medication Adherence; Middle Aged; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Patient Dropouts; Reinforcement, Psychology; Substance Abuse, Intravenous; Substance-Related Disorders; Workplace	2013
Effects of naltrexone and isradipine, alone or in combination, on cocaine responses in humans. Pharmacology, biochemistry, and behavior, 2003, Volume: 75, Issue:4 Topics: Adult; Area Under Curve; Behavior, Addictive; Blood Pressure; Cocaine-Related Disorders; Double-Blind Method; Drug Therapy, Combination; Female; Heart Rate; Humans; Isradipine; Male; Naltrexone	2003
Short-term efficacy of Disulfiram or Naltrexone in reducing positive urinalysis for both cocaine and cocaethylene in cocaine abusers: a pilot study. Pharmacological research, 2007, Volume: 55, Issue:2 Topics: Adult; Cocaine; Cocaine-Related Disorders; Cognitive Behavioral Therapy; Combined Modality Therapy; Disulfiram; Humans; Naltrexone; Narcotic Antagonists; Patient Compliance; Pilot Projects; Time Factors; Treatment Outcome	2007
Naltrexone and disulfiram in patients with alcohol dependence and current depression. Journal of clinical psychopharmacology, 2007, Volume: 27, Issue:2 Topics: Alcohol Deterrents; Alcoholism; Bipolar Disorder; Cocaine-Related Disorders; Comorbidity; Connecticut; Depressive Disorder, Major; Disulfiram; Double-Blind Method; Drug Therapy, Combination; Female; gamma-Glutamyltransferase; Gastrointestinal Diseases; Humans; Male; Massachusetts; Middle Aged; Naltrexone; Narcotic Antagonists; Psychiatric Status Rating Scales; Psychotic Disorders; Schizophrenia; Stress Disorders, Post-Traumatic; Treatment Outcome; Veterans	2007
Family history and antisocial traits moderate naltrexone's effects on heavy drinking in alcoholics. Experimental and clinical psychopharmacology, 2007, Volume: 15, Issue:3 Topics: Adult; Age of Onset; Alcohol Drinking; Alcoholism; Antisocial Personality Disorder; Cocaine-Related Disorders; Comorbidity; Double-Blind Method; Family; Female; Genetic Predisposition to Disease; Humans; Male; Marijuana Abuse; Naltrexone	2007
Gender differences with high-dose naltrexone in patients with co-occurring cocaine and alcohol dependence. Journal of substance abuse treatment, 2008, Volume: 34, Issue:4 Topics: Adolescent; Adult; Aged; Alcoholism; Cocaine-Related Disorders; Cognitive Behavioral Therapy; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Sex Factors	2008
A double blind, placebo-controlled trial that combines disulfiram and naltrexone for treating co-occurring cocaine and alcohol dependence. Addictive behaviors, 2008, Volume: 33, Issue:5 Topics: Adolescent; Adult; Aged; Alcohol Deterrents; Alcoholism; Cocaine-Related Disorders; Disulfiram; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Treatment Outcome	2008
Effects of naltrexone on cue-elicited craving for alcohol and cocaine. Drug and alcohol dependence, 1997, Volume: 49, Issue:1 Topics: Adolescent; Adult; Affect; Alcoholism; Cocaine-Related Disorders; Double-Blind Method; Female; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Psychiatric Status Rating Scales; Severity of Illness Index; Surveys and Questionnaires; Time Factors; Visual Perception	1997
Naltrexone treatment of comorbid alcohol and cocaine use disorders. Psychopharmacology, 1998, Volume: 139, Issue:1-2 Topics: Adult; Alcohol Deterrents; Alcohol Drinking; Alcoholism; Cocaine-Related Disorders; Compliance; Double-Blind Method; Female; Humans; Male; Naltrexone	1998
Dynorphin A1-13 causes elevation of serum levels of prolactin through an opioid receptor mechanism in humans: gender differences and implications for modulation of dopaminergic tone in the treatment of addictions. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 288, Issue:1 Topics: Adult; Analgesics, Opioid; Analysis of Variance; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Dynorphins; Female; Humans; Male; Middle Aged; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments; Prolactin; Receptors, Dopamine; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sex Characteristics; Time Factors	1999
The effects of naltrexone on alcohol and cocaine use in dually addicted patients. Journal of substance abuse treatment, 1999, Volume: 16, Issue:2 Topics: Adult; Alcohol Drinking; Alcoholism; Ambulatory Care; Cocaine-Related Disorders; Combined Modality Therapy; Comorbidity; Female; Humans; Male; Naltrexone; Narcotic Antagonists; Prevalence; Psychotherapy; Treatment Outcome	1999
The validity of self-reported cocaine use in two groups of cocaine abusers. Journal of consulting and clinical psychology, 1999, Volume: 67, Issue:1 Topics: Adult; Carbamazepine; Cocaine; Cocaine-Related Disorders; Double-Blind Method; Female; Humans; Interview, Psychological; Male; Naltrexone; Predictive Value of Tests; Psychometrics; Reproducibility of Results; Self Disclosure; Substance Abuse Detection	1999

Other Studies

23 other study(ies) available for naltrexone and Cocaine Abuse

Article	Year
PPL-103: A mixed opioid partial agonist with desirable anti-cocaine properties. Progress in neuro-psychopharmacology & biological psychiatry, 2022, 12-20, Volume: 119 Topics: Analgesics, Opioid; Animals; Cocaine; Cocaine-Related Disorders; Humans; Naltrexone; Rats; Receptors, Opioid, kappa; Receptors, Opioid, mu; Self Administration	2022
Toll-like receptor 4 antagonists reduce cocaine-primed reinstatement of drug seeking. Psychopharmacology, 2023, Volume: 240, Issue:7 Topics: Animals; Cocaine; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Extinction, Psychological; Lipopolysaccharides; Naltrexone; Rats; Rats, Sprague-Dawley; Self Administration; Toll-Like Receptor 4	2023
The Persistent Challenge of Developing Addiction Pharmacotherapies. Cold Spring Harbor perspectives in medicine, 2021, 11-01, Volume: 11, Issue:11 Topics: Acamprosate; Alcohol Deterrents; Alcoholism; Bupropion; Central Nervous System Stimulants; Cocaine-Related Disorders; Drug Therapy; Humans; Naltrexone; Narcotic Antagonists; Nicotinic Agonists; Smoking Cessation Agents; Substance-Related Disorders; Varenicline	2021
Dynorphin Counteracts Orexin in the Paraventricular Nucleus of the Thalamus: Cellular and Behavioral Evidence. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018, Volume: 43, Issue:5 Topics: Animals; Behavior, Addictive; Cocaine; Cocaine-Related Disorders; Drug Interactions; Dynorphins; Excitatory Postsynaptic Potentials; Extinction, Psychological; Male; Microinjections; Miniature Postsynaptic Potentials; Naltrexone; Orexins; Paraventricular Hypothalamic Nucleus; Rats; Reward; Self Administration	2018
Kappa-opioid receptors, dynorphin, and cocaine addiction: a positron emission tomography study. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2019, Volume: 44, Issue:10 Topics: Adult; Brain; Carbon Radioisotopes; Case-Control Studies; Choice Behavior; Cocaine; Cocaine Smoking; Cocaine-Related Disorders; Dynorphins; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Neostriatum; Piperazines; Positron-Emission Tomography; Pyrrolidines; Receptors, Opioid, kappa; Stress, Psychological	2019
Kappa opioid receptors regulate stress-induced cocaine seeking and synaptic plasticity. Neuron, 2013, Mar-06, Volume: 77, Issue:5 Topics: Animals; Cocaine-Related Disorders; Dopaminergic Neurons; Drug-Seeking Behavior; Extinction, Psychological; In Vitro Techniques; Long-Term Potentiation; Microinjections; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, Opioid, kappa; Recurrence; Self Administration; Stress, Psychological; Swimming; Synapses; Ventral Tegmental Area	2013
Treatment of cocaine craving with as-needed nalmefene, a partial κ opioid receptor agonist: first clinical experience. International clinical psychopharmacology, 2015, Volume: 30, Issue:4 Topics: Adult; Behavior, Addictive; Cocaine-Related Disorders; Craving; Drug Partial Agonism; Female; Humans; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Recurrence; Time Factors; Treatment Outcome	2015
Pharmacotherapy: Quest for the quitting pill. Nature, 2015, Jun-25, Volume: 522, Issue:7557 Topics: Animals; Behavior, Addictive; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Clinical Trials as Topic; Cocaine-Related Disorders; Counseling; Dopamine; Drug Discovery; Drug Industry; Humans; Ibogaine; Lobeline; Molecular Targeted Therapy; Naloxone; Naltrexone; Oligopeptides; Opioid-Related Disorders; Pleasure; Rats; Receptors, Nicotinic; Reward; Substance-Related Disorders; Tobacco Use Disorder; Vaccines; Vesicular Monoamine Transport Proteins	2015
Synthesis and characterization of a dual kappa-delta opioid receptor agonist analgesic blocking cocaine reward behavior. ACS chemical neuroscience, 2015, Nov-18, Volume: 6, Issue:11 Topics: Analgesics, Opioid; Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Dopamine Uptake Inhibitors; Drug Evaluation, Preclinical; Male; Mice, Inbred C57BL; Mice, Knockout; Molecular Structure; Morphinans; Naltrexone; Nociception; Nuclear Receptor Subfamily 1, Group F, Member 1; Random Allocation; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reward; Spatial Behavior	2015
Combination of Levo-Tetrahydropalmatine and Low Dose Naltrexone: A Promising Treatment for Prevention of Cocaine Relapse. The Journal of pharmacology and experimental therapeutics, 2016, Volume: 357, Issue:2 Topics: Animals; Berberine Alkaloids; beta-Endorphin; Cocaine-Related Disorders; Drug Therapy, Combination; Drug-Seeking Behavior; Hypothalamus; Male; Motor Activity; Naltrexone; Narcotic Antagonists; Pro-Opiomelanocortin; Rats; Rats, Wistar; Recurrence; Self Administration; Substance Withdrawal Syndrome	2016
Negative symptoms are associated with less alcohol use, craving, and "high" in alcohol dependent patients with schizophrenia. Schizophrenia research, 2008, Volume: 105, Issue:1-3 Topics: Adult; Alcohol Drinking; Alcoholism; Behavior, Addictive; Cocaine-Related Disorders; Cognition Disorders; Comorbidity; Diagnostic and Statistical Manual of Mental Disorders; Euphoria; Female; Humans; Male; Marijuana Abuse; Naltrexone; Narcotic Antagonists; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology; Severity of Illness Index	2008
Intravenous self-administration of etonitazene alone and combined with cocaine in rhesus monkeys: comparison with heroin and antagonism by naltrexone and naloxonazine. Psychopharmacology, 2009, Volume: 204, Issue:3 Topics: Animals; Benzimidazoles; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Drug Interactions; Female; Heroin; Injections, Intravenous; Macaca mulatta; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Receptors, Opioid, mu; Reinforcement, Psychology; Self Administration; Substance Abuse, Intravenous	2009
Attenuation of cocaine-induced reinstatement of drug seeking in squirrel monkeys: kappa opioid and serotonergic mechanisms. Psychopharmacology, 2010, Volume: 210, Issue:2 Topics: Animals; Benzofurans; Citalopram; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Fluoxetine; Ligands; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa; Saimiri; Selective Serotonin Reuptake Inhibitors; Self Administration; Serotonin; Serotonin 5-HT1 Receptor Agonists	2010
Effectiveness of analogs of the kappa opioid receptor antagonist (3R)-7-hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic) to reduce U50,488-induced diure Psychopharmacology, 2010, Volume: 210, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cocaine-Related Disorders; Diuresis; Dose-Response Relationship, Drug; Male; Naltrexone; Pain; Piperidines; Rats; Rats, Long-Evans; Receptors, Opioid, kappa; Self Administration; Tetrahydroisoquinolines	2010
A combination of buprenorphine and naltrexone blocks compulsive cocaine intake in rodents without producing dependence. Science translational medicine, 2012, Aug-08, Volume: 4, Issue:146 Topics: Animals; Buprenorphine; Cocaine; Cocaine-Related Disorders; Male; Naloxone; Naltrexone; Rats; Rats, Wistar; Substance Withdrawal Syndrome	2012
Reinstatement of cocaine-seeking behavior in rats is attenuated following repeated treatment with the opioid receptor antagonist naltrexone. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2005, Volume: 15, Issue:3 Topics: Animals; Behavior, Animal; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Extinction, Psychological; Male; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid, mu; Recurrence; Substance Abuse, Intravenous	2005
Naltrexone and buprenorphine combination in the treatment of opioid dependence. Journal of psychopharmacology (Oxford, England), 2006, Volume: 20, Issue:6 Topics: Adult; Affect; Buprenorphine; Cocaine; Cocaine-Related Disorders; Female; Heroin Dependence; Humans; Liver; Male; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Psychiatric Status Rating Scales; Substance Abuse Detection; Survival Analysis	2006
Effects of naltrexone on cocaine- and sucrose-seeking behaviour in response to associated stimuli in rats. The international journal of neuropsychopharmacology, 2008, Volume: 11, Issue:1 Topics: Animals; Behavior, Animal; Cocaine-Related Disorders; Cues; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Reward; Self Administration; Sucrose	2008
Kappa agonist-induced reinstatement of cocaine seeking in squirrel monkeys: a role for opioid and stress-related mechanisms. The Journal of pharmacology and experimental therapeutics, 2007, Volume: 323, Issue:2 Topics: Animals; Behavior, Addictive; Benzofurans; Clonidine; Cocaine-Related Disorders; Corticotropin-Releasing Hormone; Male; Naltrexone; Norepinephrine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Saimiri; Self Administration; Stress, Psychological	2007
Naltrexone, naltrindole, and CTOP block cocaine-induced sensitization to seizures and death. Peptides, 1997, Volume: 18, Issue:8 Topics: Animals; Cocaine-Related Disorders; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Seizures; Somatostatin	1997
Responding for rewarding brain stimulation: cocaine and isradipine plus naltrexone. Pharmacology, biochemistry, and behavior, 1998, Volume: 61, Issue:2 Topics: Analysis of Variance; Animals; Brain; Calcium Channel Blockers; Cocaine-Related Disorders; Drug Therapy, Combination; Electric Stimulation; Fluoxetine; Isradipine; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Reward; Valproic Acid	1998
Concurrent substance use and outcome in combined behavioral and naltrexone therapy for opiate dependence. The American journal of drug and alcohol abuse, 2001, Volume: 27, Issue:3 Topics: Adolescent; Adult; Aged; Analysis of Variance; Anti-Anxiety Agents; Behavior Therapy; Benzodiazepines; Cocaine-Related Disorders; Female; Humans; Male; Marijuana Smoking; Middle Aged; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Substance Abuse Detection; Treatment Outcome	2001
Conservative management with naltrexone of an iatrogenic methadone overdose in an opiate-naive patient. Journal of clinical psychopharmacology, 2002, Volume: 22, Issue:2 Topics: Alcoholism; Cocaine-Related Disorders; Diagnosis, Dual (Psychiatry); Drug Overdose; Humans; Male; Medication Errors; Methadone; Middle Aged; Naltrexone; Schizophrenia	2002