mianserin has been researched along with Cocaine Abuse in 4 studies
Mianserin: A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
mianserin : A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Prior findings concerning the use of mirtazapine in the treatment of a variety of substance use disorders and its antagonistic actions at the serotonin 5-HT(2A) receptor suggest that this drug may have efficacy in the treatment of cocaine dependence in the presence of a depressive disorder." | 5.16 | The efficacy of mirtazapine in the treatment of cocaine dependence with comorbid depression. ( Afshar, M; Ciraulo, DA; Colaneri, LS; Devine, E; Knapp, CM; Putnam, MA; Sarid-Segal, O; Tozier, L; Waters, ME, 2012) |
| "Cocaine abuse and dependence are a global public health problem." | 3.85 | Synergistic interactions between mirtazapine and prazosin prevent the induction and expression of behavioral sensitization to cocaine in rats. ( Barbosa-Méndez, S; Matus-Ortega, M; Salazar-Juárez, A, 2017) |
| "Mirtazapine is an antidepressant implicated in reducing behavioral alterations induced by drugs of abuse." | 1.46 | Dose- and time-dependent effects of mirtazapine on the expression of cocaine-induced behavioral sensitization in rats. ( Barbosa-Méndez, S; Flores-Zamora, A; Jurado, N; Matus-Ortega, M; Salazar-Juárez, A, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barbosa-Méndez, S | 2 |
| Matus-Ortega, M | 2 |
| Flores-Zamora, A | 1 |
| Jurado, N | 1 |
| Salazar-Juárez, A | 2 |
| Afshar, M | 1 |
| Knapp, CM | 1 |
| Sarid-Segal, O | 1 |
| Devine, E | 1 |
| Colaneri, LS | 1 |
| Tozier, L | 1 |
| Waters, ME | 1 |
| Putnam, MA | 1 |
| Ciraulo, DA | 1 |
| Fisfalen, ME | 1 |
| Hsiung, RC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Clinical Studies on Anti-addictive Therapeutic Effects of Mirtazapine in Human Subjects Addicted to Cocaine.[NCT01949571] | Phase 2 | 64 participants (Actual) | Interventional | 2007-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for mianserin and Cocaine Abuse
| Article | Year |
|---|---|
The efficacy of mirtazapine in the treatment of cocaine dependence with comorbid depression.
Topics: Adult; Antidepressive Agents, Tricyclic; Cocaine; Cocaine-Related Disorders; Depressive Disorder; Do | 2012 |
3 other studies available for mianserin and Cocaine Abuse
| Article | Year |
|---|---|
Dose- and time-dependent effects of mirtazapine on the expression of cocaine-induced behavioral sensitization in rats.
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Dos | 2017 |
Synergistic interactions between mirtazapine and prazosin prevent the induction and expression of behavioral sensitization to cocaine in rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Analysis of Variance; Anesthetics, Local; Animals; Cocaine; | 2017 |
Glucose dysregulation and mirtazapine-induced weight gain.
Topics: Adult; Antidepressive Agents, Tricyclic; Blood Glucose; Body Mass Index; Cocaine-Related Disorders; | 2003 |