lorazepam and Cocaine Abuse

lorazepam has been researched along with Cocaine Abuse in 7 studies

Lorazepam: A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.

Research

Studies (7)

Authors

Clinical Trials (4)

Trial Overview

Trial Outcomes

Change in Cue Reactivity

Serial visual analogue scale (VAS) scores for craving elicited by cocaine cue: units on a scale (0-200), high is worse. Scores are obtained at baseline and at 24 hours after the infusion. (NCT01790490)
Timeframe: Baseline and 24 hours after infusion

Change in Motivation to Quit

Motivation score obtained from the University of Rhode Island Change Assessment (URICA). Scores are obtained at baseline and at 24 hours after each infusion. The scores are 0-13, with higher scores indicating greater motivation. The analysis is within-subject. Scores included below are means; higher scores represent higher motivation to quit than do lower scores. (NCT01790490)
Timeframe: Baseline and 24 hours post-infusion

Average MINDS Score

Minnesota Detoxification Scale (MINDS) min score 0, max score 46. The higher the score, the worse the symptoms of AWS/AWD. (NCT01362205)
Timeframe: up to 28 days

Number of Ventilator Free Days After Randomization.

A ventilator day is counted for any use of invasive mechanical ventilation during a calendar day (NCT01362205)
Timeframe: up to 28 days

Resource Utilization Costs Associated With This Hospitalization Billed by Facility.

(NCT01362205)
Timeframe: Up to 28 days

Resource Utilization Costs Associated With This Hospitalization Billed by Physicians.

(NCT01362205)
Timeframe: up to 28 Days

Scores at Hospital Discharge on the Beck Anxiety Inventory

The Beck Anxiety Inventory is a validated questionnaire used to measure severity of anxiety (min score 0, max score 63). The higher the score the greater the severity of anxiety. A score of 30-63 indicates severe anxiety, 17-29 moderate anxiety, 10-16 mild anxiety and 0-9 minimal anxiety. (NCT01362205)
Timeframe: Up to 28 days.

Scores at Hospital Discharge on the Beck Depression Inventory.

The Beck Depression Inventory is a validated questionnaire used to measure severity of depression (min score 0, max score 63). The higher the score the greater the severity of depression. A score of 30-63 indicates severe depression, 19-29 moderate depression, 10-18 mild depression and 0-9 minimal depression. (NCT01362205)
Timeframe: Up to 28 days.

Scores at Hospital Discharge on the Mini Mental Exam.

The Mini Mental State Examination or Folstein test is a validated 30-point questionnaire used to measure cognitive impairment (min score 0, max score 30). A score of 24 points (out of a max of 30) indicates normal cognition, less than or equal to 9 points indicates severe impairment, 10-18 indicates moderate impairment and 19-23 mild impairment. (NCT01362205)
Timeframe: up to 28 days

Scores at Hospital Discharge on the PTSD Civilian Checklist

PTSD checklist consists of 17 questions graded on a scale of 1 to 5. The PTSD score is comprised from the sum of the scores 17 questions. The PTSD score has possible values from to 17 to 85 with higher values indicating greater symptom severity. (NCT01362205)
Timeframe: Up to 28 days

The Length in Days of the Hospital Stay

A hospital day is counted for any time on a calendar day the patient is admitted to the hospital. Hospital days are inclusive of ICU days. (NCT01362205)
Timeframe: up to 28 days

The Length of ICU Stay Defined as the Time Between Randomization and ICU Transfer Orders.

(NCT01362205)
Timeframe: up to 28 days in hours

The Number of CAM-ICU Negative Days After Randomization.

The Confusion Assessment Method (CAM)-ICU is a validated instrument used to detect the presence or absence of delirium in the ICU. A delirium free day is counted for any day a patient is negative by the CAM-ICU. The higher the number of CAM-ICU negative days indicates the more days a patient was able to think clearly. (NCT01362205)
Timeframe: up to 28 days

Trials

3 trials available for lorazepam and Cocaine Abuse

Other Studies

4 other studies available for lorazepam and Cocaine Abuse