dextroamphetamine has been researched along with Cocaine Abuse in 33 studies
Dextroamphetamine: The d-form of AMPHETAMINE. It is a central nervous system stimulant and a sympathomimetic. It has also been used in the treatment of narcolepsy and of attention deficit disorders and hyperactivity in children. Dextroamphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulating release of monamines, and inhibiting monoamine oxidase. It is also a drug of abuse and a psychotomimetic.
(S)-amphetamine : A 1-phenylpropan-2-amine that has S configuration.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Agonist medications have been proven effective in treating opioid and nicotine dependence; results from clinical studies suggest that the indirect dopamine agonist d-amphetamine may reduce cocaine abuse." | 3.76 | Effects of chronic d-amphetamine administration on the reinforcing strength of cocaine in rhesus monkeys. ( Czoty, PW; Martelle, JL; Nader, MA, 2010) |
| " After oral administration, tmax values (coefficient of variation %) were 6." | 2.87 | Pharmacokinetics of Sustained-Release Oral Dexamphetamine Sulfate in Cocaine and Heroin-Dependent Patients. ( Beijnen, JH; Blanken, P; Hendriks, VM; Herbrink, M; Huitema, ADR; Janmohamed, A; Nuijen, B; Nuijten, M; van den Brink, W, 2018) |
| "The present study (Cocaine Addiction Treatments to improve Control and reduce Harm; CATCH) investigates the possibilities and problems associated with new pharmacological treatments for crack dependent patients." | 2.76 | Cocaine Addiction Treatments to improve Control and reduce Harm (CATCH): new pharmacological treatment options for crack-cocaine dependence in the Netherlands. ( Blanken, P; Hendriks, V; Nuijten, M; van den Brink, W, 2011) |
| " These effects were not clinically significant and no unexpected or serious adverse events were observed." | 2.74 | Cocaine effects during D-amphetamine maintenance: a human laboratory analysis of safety, tolerability and efficacy. ( Hays, LR; Rush, CR; Stoops, WW, 2009) |
| " In the multistage dosing design, subjects initially received placebo (PBO) or 15 to 30 mg of dextroamphetamine sulfate, sustained-release capsules." | 2.70 | Dextroamphetamine for cocaine-dependence treatment: a double-blind randomized clinical trial. ( Creson, D; Daruzska, LA; Grabowski, J; Moeller, FG; Rhoades, H; Schmitz, J; Stotts, A, 2001) |
| ") dose-response curves were determined, self-administration sessions were suspended and MPD (0." | 1.39 | Effects of chronic methylphenidate on cocaine self-administration under a progressive-ratio schedule of reinforcement in rhesus monkeys. ( Czoty, PW; Gould, RW; Martelle, SE; Nader, MA, 2013) |
| "Cocaine dependence is a pervasive disorder with high rates of relapse." | 1.38 | Cocaine hydrolase encoded in viral vector blocks the reinstatement of cocaine seeking in rats for 6 months. ( Anker, JJ; Brimijoin, S; Carroll, ME; Gao, Y; Geng, L; Parks, RJ; Zlebnik, NE, 2012) |
| " After determining a dose-response curve for cocaine (0." | 1.37 | Prolonged attenuation of the reinforcing strength of cocaine by chronic d-amphetamine in rhesus monkeys. ( Czoty, PW; Gould, RW; Martelle, JL; Nader, MA, 2011) |
| " Experiment 2: rats were trained to self-administer cocaine under a PR schedule and initial dose-response curves were determined before implantation of D-amphetamine mini-pumps." | 1.35 | Decreased reinforcing effects of cocaine following 2 weeks of continuous D-amphetamine treatment in rats. ( Chiodo, KA; Roberts, DC, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 13 (39.39) | 29.6817 |
| 2010's | 16 (48.48) | 24.3611 |
| 2020's | 4 (12.12) | 2.80 |
| Authors | Studies |
|---|---|
| D'Amour-Horvat, V | 1 |
| Cox, SML | 1 |
| Dagher, A | 1 |
| Kolivakis, T | 1 |
| Jaworska, N | 1 |
| Leyton, M | 1 |
| Ndiaye, NA | 1 |
| Allain, F | 1 |
| Samaha, AN | 1 |
| Blanken, P | 4 |
| Nuijten, M | 4 |
| van den Brink, W | 4 |
| Hendriks, VM | 3 |
| Herbrink, M | 1 |
| Nuijen, B | 2 |
| Huitema, ADR | 1 |
| Beijnen, JH | 1 |
| Janmohamed, A | 1 |
| Jordan, CJ | 1 |
| Cao, J | 1 |
| Newman, AH | 1 |
| Xi, ZX | 1 |
| Lile, JA | 1 |
| Johnson, AR | 1 |
| Banks, ML | 2 |
| Hatton, KW | 1 |
| Hays, LR | 3 |
| Nicholson, KL | 1 |
| Poklis, JL | 2 |
| Rayapati, AO | 1 |
| Rush, CR | 4 |
| Stoops, WW | 3 |
| Negus, SS | 5 |
| Czoty, PW | 3 |
| Martelle, SE | 1 |
| Gould, RW | 2 |
| Nader, MA | 3 |
| Comer, SD | 1 |
| Mogali, S | 1 |
| Saccone, PA | 1 |
| Askalsky, P | 1 |
| Martinez, D | 1 |
| Walker, EA | 1 |
| Jones, JD | 1 |
| Vosburg, SK | 1 |
| Cooper, ZD | 1 |
| Roux, P | 1 |
| Sullivan, MA | 1 |
| Manubay, JM | 1 |
| Rubin, E | 1 |
| Pines, A | 1 |
| Berkower, EL | 1 |
| Haney, M | 1 |
| Foltin, RW | 1 |
| Hutsell, BA | 1 |
| Blough, BE | 1 |
| Chen, LY | 1 |
| Crum, RM | 1 |
| Strain, EC | 1 |
| Martins, SS | 1 |
| Mojtabai, R | 1 |
| van de Wetering, B | 1 |
| Dürsteler, KM | 1 |
| Vogel, M | 1 |
| Reed, SC | 1 |
| Evans, SM | 1 |
| Chiodo, KA | 2 |
| Läck, CM | 1 |
| Roberts, DC | 2 |
| Trigo, JM | 1 |
| Orejarena, MJ | 1 |
| Maldonado, R | 1 |
| Robledo, P | 1 |
| Martelle, JL | 2 |
| Sevak, RJ | 1 |
| Greenwald, MK | 1 |
| Lundahl, LH | 1 |
| Steinmiller, CL | 1 |
| Hendriks, V | 1 |
| Anker, JJ | 1 |
| Brimijoin, S | 1 |
| Gao, Y | 1 |
| Geng, L | 1 |
| Zlebnik, NE | 1 |
| Parks, RJ | 1 |
| Carroll, ME | 1 |
| Thomsen, M | 1 |
| Barrett, AC | 1 |
| Caine, SB | 1 |
| Mello, NK | 2 |
| Vanderschuren, LJ | 1 |
| Beemster, P | 1 |
| Schoffelmeer, AN | 1 |
| Ledford, CC | 1 |
| Fuchs, RA | 1 |
| See, RE | 1 |
| Shearer, J | 1 |
| Wodak, A | 1 |
| van Beek, I | 1 |
| Mattick, RP | 1 |
| Lewis, J | 1 |
| Fillmore, MT | 1 |
| Marczinski, CA | 1 |
| Grabowski, J | 2 |
| Rhoades, H | 2 |
| Stotts, A | 2 |
| Cowan, K | 1 |
| Kopecky, C | 1 |
| Dougherty, A | 1 |
| Moeller, FG | 2 |
| Hassan, S | 1 |
| Schmitz, J | 2 |
| Daruzska, LA | 1 |
| Creson, D | 1 |
| Covington, HE | 1 |
| Miczek, KA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy and Safety of 24 Weeks Sustained-release Dexamphetamine in Patients With Moderate to Severe Cocaine Use Disorder With Comorbid Opioid Use Disorder - A Multicenter Randomized, Double-blind, Placebo-controlled Study[NCT05529927] | Phase 2 | 204 participants (Anticipated) | Interventional | 2024-03-31 | Not yet recruiting | ||
| Reducing Cocaine/Heroin Abuse With SR-Amphetamine and Buprenorphine: Study 1[NCT00429767] | 16 participants (Anticipated) | Observational | 2007-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for dextroamphetamine and Cocaine Abuse
| Article | Year |
|---|---|
D-amphetamine maintenance therapy reduces cocaine use in female rats.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Dextroamphetamine; Drug-Seeking Behavior; Extinction, P | 2022 |
Progress in agonist therapy for substance use disorders: Lessons learned from methadone and buprenorphine.
Topics: Analgesics, Opioid; Buprenorphine; Central Nervous System Stimulants; Cocaine-Related Disorders; Dex | 2019 |
12 trials available for dextroamphetamine and Cocaine Abuse
| Article | Year |
|---|---|
Clinical effects beyond cocaine use of sustained-release dexamphetamine for the treatment of cocaine dependent patients with comorbid opioid dependence: secondary analysis of a double-blind, placebo-controlled randomized trial.
Topics: Adult; Central Nervous System Stimulants; Cocaine-Related Disorders; Delayed-Action Preparations; De | 2020 |
Pharmacokinetics of Sustained-Release Oral Dexamphetamine Sulfate in Cocaine and Heroin-Dependent Patients.
Topics: Administration, Oral; Adult; Central Nervous System Stimulants; Chromatography, Liquid; Cocaine-Rela | 2018 |
Effects of acute oral naltrexone on the subjective and physiological effects of oral D-amphetamine and smoked cocaine in cocaine abusers.
Topics: Administration, Oral; Adult; Cardiovascular System; Central Nervous System Stimulants; Cocaine; Coca | 2013 |
Sustained-release dexamfetamine in the treatment of chronic cocaine-dependent patients on heroin-assisted treatment: a randomised, double-blind, placebo-controlled trial.
Topics: Administration, Oral; Central Nervous System Stimulants; Chronic Disease; Cocaine-Related Disorders; | 2016 |
Cocaine effects during D-amphetamine maintenance: a human laboratory analysis of safety, tolerability and efficacy.
Topics: Administration, Intranasal; Adult; Blood Pressure; Body Temperature; Central Nervous System Stimulan | 2009 |
Cocaine choice in humans during D-amphetamine maintenance.
Topics: Adult; Behavior, Addictive; Choice Behavior; Cocaine; Cocaine-Related Disorders; Dextroamphetamine; | 2010 |
Sustained release d-amphetamine reduces cocaine but not 'speedball'-seeking in buprenorphine-maintained volunteers: a test of dual-agonist pharmacotherapy for cocaine/heroin polydrug abusers.
Topics: Adolescent; Adult; Buprenorphine; Choice Behavior; Cocaine; Cocaine-Related Disorders; Delayed-Actio | 2010 |
Cocaine Addiction Treatments to improve Control and reduce Harm (CATCH): new pharmacological treatment options for crack-cocaine dependence in the Netherlands.
Topics: Benzhydryl Compounds; Clinical Protocols; Cocaine-Related Disorders; Cognitive Behavioral Therapy; C | 2011 |
Pilot randomized double blind placebo-controlled study of dexamphetamine for cocaine dependence.
Topics: Adult; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Dextroamphetamine; Dou | 2003 |
Effects of d-amphetamine on behavioral control in stimulant abusers: the role of prepotent response tendencies.
Topics: Adult; Amphetamine-Related Disorders; Analysis of Variance; Behavior Control; Central Nervous System | 2003 |
Agonist-like or antagonist-like treatment for cocaine dependence with methadone for heroin dependence: two double-blind randomized clinical trials.
Topics: Adolescent; Adult; Blood Pressure; Cocaine; Cocaine-Related Disorders; Cognitive Behavioral Therapy; | 2004 |
Dextroamphetamine for cocaine-dependence treatment: a double-blind randomized clinical trial.
Topics: Adult; Behavior Therapy; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Dela | 2001 |
19 other studies available for dextroamphetamine and Cocaine Abuse
| Article | Year |
|---|---|
Cocaine cue-induced mesocorticolimbic activation in cocaine users: Effects of personality traits, lifetime drug use, and acute stimulant ingestion.
Topics: Adult; Brain; Cocaine; Cocaine-Related Disorders; Craving; Cues; Dextroamphetamine; Female; Humans; | 2022 |
Pharmacological validation of a translational model of cocaine use disorder: Effects of d-amphetamine maintenance on choice between intravenous cocaine and a nondrug alternative in humans and rhesus monkeys.
Topics: Administration, Intravenous; Adolescent; Adult; Animals; Choice Behavior; Cocaine; Cocaine-Related D | 2020 |
Effects of chronic methylphenidate on cocaine self-administration under a progressive-ratio schedule of reinforcement in rhesus monkeys.
Topics: Animals; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Dextroamphetamine; D | 2013 |
Preclinical Assessment of Lisdexamfetamine as an Agonist Medication Candidate for Cocaine Addiction: Effects in Rhesus Monkeys Trained to Discriminate Cocaine or to Self-Administer Cocaine in a Cocaine Versus Food Choice Procedure.
Topics: Animals; Choice Behavior; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dextroamphetami | 2015 |
Patterns of concurrent substance use among adolescent nonmedical ADHD stimulant users.
Topics: Adolescent; Amphetamines; Analgesics, Opioid; Central Nervous System Stimulants; Child; Cocaine-Rela | 2015 |
Effective drug therapy for cocaine dependence: a milestone.
Topics: Central Nervous System Stimulants; Cocaine-Related Disorders; Crack Cocaine; Dextroamphetamine; Fema | 2016 |
The effects of oral d-amphetamine on impulsivity in smoked and intranasal cocaine users.
Topics: Administration, Inhalation; Administration, Intranasal; Adult; Affect; Central Nervous System Stimul | 2016 |
Cocaine self-administration reinforced on a progressive ratio schedule decreases with continuous D-amphetamine treatment in rats.
Topics: Animals; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; De | 2008 |
MDMA reinstates cocaine-seeking behaviour in mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Conditioning, O | 2009 |
Decreased reinforcing effects of cocaine following 2 weeks of continuous D-amphetamine treatment in rats.
Topics: Animals; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; De | 2009 |
Effects of chronic d-amphetamine administration on the reinforcing strength of cocaine in rhesus monkeys.
Topics: Animals; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Co | 2010 |
Prolonged attenuation of the reinforcing strength of cocaine by chronic d-amphetamine in rhesus monkeys.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Dextroamphetamine; Disease Models, Animal; Dopamine Upt | 2011 |
Cocaine hydrolase encoded in viral vector blocks the reinstatement of cocaine seeking in rats for 6 months.
Topics: Animals; Butyrylcholinesterase; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorder | 2012 |
Cocaine versus food choice procedure in rats: environmental manipulations and effects of amphetamine.
Topics: Animals; Central Nervous System Stimulants; Choice Behavior; Cocaine-Related Disorders; Conditioning | 2013 |
Effects of chronic d-amphetamine treatment on cocaine- and food-maintained responding under a progressive-ratio schedule in rhesus monkeys.
Topics: Animals; Behavior, Animal; Body Weight; Central Nervous System Stimulants; Cocaine-Related Disorders | 2003 |
Effects of chronic d-amphetamine treatment on cocaine- and food-maintained responding under a second-order schedule in rhesus monkeys.
Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dextroamphetam | 2003 |
On the role of noradrenaline in psychostimulant-induced psychomotor activity and sensitization.
Topics: Amphetamine-Related Disorders; Animals; Central Nervous System Stimulants; Clonidine; Cocaine; Cocai | 2003 |
Potentiated reinstatement of cocaine-seeking behavior following D-amphetamine infusion into the basolateral amygdala.
Topics: Amygdala; Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Cues | 2003 |
Repeated social-defeat stress, cocaine or morphine. Effects on behavioral sensitization and intravenous cocaine self-administration "binges".
Topics: Animals; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Co | 2001 |