3-hydroxybenzoylecgonine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

3-hydroxybenzoylecgonine: contributes to the immunoreactivity for benzoylecgonine in the meconium of cocaine-exposed fetuses [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	448357
MeSH ID	M0225770

Synonyms (19)

Synonym
(1r,2r,3s,5s)-3-(3-hydroxybenzoyl)oxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid
OBE ,
3-(3-hydroxy-benzoyloxy)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid
129944-99-6
3-hydroxybenzoylecgonine
8-azabicyclo(3.2.1)octane-2-carboxylic acid, 3-((3-hydroxybenzoyl)oxy)-8-methyl-, (1r-(exo,exo))-
unii-xd3fi6u4bp
(1r-(exo,exo))-3-((3-hydroxybenzoyl)oxy)-8-methyl-8-azabicyclo(3.2.1)octane-2-carboxylic acid
xd3fi6u4bp ,
AKOS022180600
m-hydroxybenzoylecgonine, analytical standard
(1r,2r,3s,5s)-3-(3-hydroxybenzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid
DTXSID40926533
meta-hydroxybenzoylecgonine
Q27464080
(1r,2r,3s,5s)-3-((3-hydroxybenzoyl)oxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid
3'-hydroxybenzoylecgonine
3-hydroxylbenzoylecgonine
(1r,2r,3s,5s)-3-((3-hydroxybenzoyl)oxy)-8-methyl-8-azabicyclo(3.2.1)octane-2-carboxylic acid

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	2 (25.00)	18.2507
2000's	5 (62.50)	29.6817
2010's	1 (12.50)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.16

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.16 (24.57)
Research Supply Index	2.20 (2.92)
Research Growth Index	4.36 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.16)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
ecgonine methyl ester ecgonine methyl ester: major metabolite of cocaine; RN given refers to parent cpd (1R-(exo,exo))-isomer. ecgonine methyl ester : The O-debenzoyl analogue of cocaine.	2.05	1	methyl ester; tertiary amino compound; tropane alkaloid	analgesic; central nervous system depressant; metabolite; mouse metabolite; opioid analgesic; peripheral nervous system drug
benzoylnorecgonine [no description available]	2.72	3
anhydroecgonine methyl ester anhydroecgonine methyl ester: structure given in first source	2.05	1	N-alkylpyrrolidine
ecgonine ecgonine: RN given refers to (1R-(exo,exo))-isomer; structure. ecgonine : A tropane alkaloid that consists of tropane bearing carboxy and hydroxy substituents at positions 2 and 3 respectively and having (1R,2R,3S,5S)-configuration. It is both a metabolite of and a precursor to cocaine.	2.05	1	tropane alkaloid
cocaine Cocaine: An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.. cocaine : A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.	3.52	8	benzoate ester; methyl ester; tertiary amino compound; tropane alkaloid	adrenergic uptake inhibitor; central nervous system stimulant; dopamine uptake inhibitor; environmental contaminant; local anaesthetic; mouse metabolite; plant metabolite; serotonin uptake inhibitor; sodium channel blocker; sympathomimetic agent; vasoconstrictor agent; xenobiotic
benzoylecgonine benzoylecgonine: cocaine is benzoyl methyl ecgonine; RN given refers to (1R-(exo,exo))-isomer; structure. ecgonine benzoate : A benzoate ester metabolite of cocaine formed by hydrolysis of the methyl ester group, catalysed by carboxylesterases.	3.12	5	benzoate ester; tropane alkaloid	epitope; human xenobiotic metabolite; marine xenobiotic metabolite; plant metabolite
norcocaine norcocaine: N-demethylated cocaine; RN given refers to (1R-(exo,exo))-isomer	2.05	1	benzoate ester

Condition	Relationship Strength	Studies
Cocaine Abuse [description not available]	2.7	3
Cocaine-Related Disorders Disorders related or resulting from use of cocaine.	2.7	3
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	2	1

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