mazindol has been researched along with Cocaine Abuse in 3 studies
Mazindol: Tricyclic anorexigenic agent unrelated to and less toxic than AMPHETAMINE, but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Potential medications for cocaine abusers include: anticocaine catalytic antibodies, which could serve as circulating peripheral blockers of cocaine that prevents its action in the brain; and 3-phenyltropane cocaine analogs, which could serve as potent, selective, and long-lasting substitutes that reduce drug-seeking." | 3.71 | Anticocaine catalytic antibodies have no affinity for RTI compounds: implications for treatment. ( Bharat, N; Carroll, FI; Kuhar, MJ; Landry, DW, 2001) |
| "Mazindol, therefore, is an attractive scaffold for both understanding the molecular determinants of serotonin/dopamine transporter selectivity and for the development of novel drug abuse treatments." | 1.40 | Binding of mazindol and analogs to the human serotonin and dopamine transporters. ( Jensen, HH; Koldsø, H; Møller, PT; Schiøtt, B; Schjøth-Eskesen, C; Severinsen, K; Sinning, S; Thorup, KA; Wiborg, O, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Severinsen, K | 1 |
| Koldsø, H | 1 |
| Thorup, KA | 1 |
| Schjøth-Eskesen, C | 1 |
| Møller, PT | 1 |
| Wiborg, O | 1 |
| Jensen, HH | 1 |
| Sinning, S | 1 |
| Schiøtt, B | 1 |
| Ukairo, OT | 1 |
| Ramanujapuram, S | 1 |
| Surratt, CK | 1 |
| Kuhar, MJ | 1 |
| Carroll, FI | 1 |
| Bharat, N | 1 |
| Landry, DW | 1 |
3 other studies available for mazindol and Cocaine Abuse
| Article | Year |
|---|---|
Binding of mazindol and analogs to the human serotonin and dopamine transporters.
Topics: Binding Sites; Cells, Cultured; Cocaine-Related Disorders; Dopamine Plasma Membrane Transport Protei | 2014 |
Fluctuation of the dopamine uptake inhibition potency of cocaine, but not amphetamine, at mammalian cells expressing the dopamine transporter.
Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Benztropine; Binding, Competitive; Brain; Brain | 2007 |
Anticocaine catalytic antibodies have no affinity for RTI compounds: implications for treatment.
Topics: Adrenergic Uptake Inhibitors; Antibodies, Catalytic; Antibody Affinity; Brain; Carrier Proteins; Coc | 2001 |