Compounds > enkephalin, leucine

enkephalin, leucine and Cocaine Abuse

enkephalin, leucine has been researched along with Cocaine Abuse in 25 studies

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (4.00)18.2507
2000's17 (68.00)29.6817
2010's5 (20.00)24.3611
2020's2 (8.00)2.80

Authors

AuthorsStudies
Graham, DP; Hamon, SC; Hillhouse, M; Kosten, TR; Lawson, WB; Ling, W; Nielsen, DA; Nielsen, EM; Rotrosen, J; Saxon, AJ; Settles-Reaves, BD; Shmueli-Blumberg, D; Shores-Wilson, K; Trivedi, MH; Walker, R1
Alvarez, VA; Blegen, MB; Bocarsly, ME; Choi, IB; Dai, KZ; Dobbs, LK; Kaplan, AR; Kellendonk, C; Levitt, R; Matsui, A; Shin, JH; Simpson, EH1
Caffino, L; Candeletti, S; Caputi, FF; Fumagalli, F; Romualdi, P1
Alia-Klein, N; Beebe-Wang, N; Goldstein, RZ; Hurd, YL; Konova, AB; Moeller, SJ; Parvaz, MA; Schneider, KE1
Chavkin, C; Redila, VA1
Ho, A; Ji, F; Kreek, MJ; Levran, O; Morgello, S; Nielsen, DA; Ott, J; Shi, R; Yuferov, V1
Kreek, MJ; Levran, O; Nielsen, DA; Proudnikov, D; Yuferov, V1
Ho, A; Kreek, MJ; Nielsen, DA; Rouault, M; Yuferov, V1
Ambrose-Lanci, L; Berrettini, WH; Clarke, TK; Dackis, CA; Ferraro, TN; Kampman, KM; Lohoff, FW; O'Brien, CP; Oslin, DW; Pettinati, HM1
Ho, A; Kreek, MJ; Spangler, R; Zhou, Y1
Daunais, JB; Fagergren, P; Hurd, YL; Nader, MA; Porrino, LJ; Smith, HR1
Candeletti, S; Collins, S; D'Addario, C; Di Benedetto, M; Izenwasser, S; Romualdi, P1
Ho, A; Kreek, MJ; Mantsch, JR; Mathieu-Kia, AM; Yuferov, V1
Fagergren, P; Goiny, M; Hurd, YL; Overstreet, DH1
Bailey, A; Bendor, J; Ho, A; Kreek, MJ; Schlussman, SD; Yuferov, V; Zhou, Y1
Berrettini, WH; Dahl, JP; Ferraro, TN; Kampman, KM; Lohoff, FW; O'Brien, CP; Oslin, DW; Weller, AE1
Steiner, H; Willuhn, I1
Brambilla, R; Fasano, S; Ferguson, SM; Robinson, TE; Yang, P1
Hope, BT; Kreuter, JD; Mattson, BJ; Mitchell, TB; Simmons, DE1
Bart, G; Gordon, D; Kellogg, S; Kreek, MJ; LaForge, KS; Ott, J; Williams, TJ1
Blake, H; Comings, DE; Dietz, G; Gade-Andavolu, R; Johnson, P; Legro, RS; MacMurray, JP; Saucier, G; Verde, R1
Brené, S; Olson, L; Thorén, P; Werme, M1
Arroyo, M; Baker, WA; Everitt, BJ1
Ho, A; Jeanne Kreek, M; Spangler, R; Zhou, Y1
Bell, K; Chen, AC; Ho, A; Kellogg, S; Kreek, MJ; LaForge, KS; Leal, SM; McHugh, PF; Schluger, RP1

Reviews

1 review(s) available for enkephalin, leucine and Cocaine Abuse

ArticleYear
Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment.
    Annals of the New York Academy of Sciences, 2010, Volume: 1187

    Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Catechol O-Methyltransferase; Cocaine-Related Disorders; Enkephalins; Epigenesis, Genetic; Genetic Markers; Genetic Variation; Genome-Wide Association Study; Haplotypes; Humans; Methadone; Opioid-Related Disorders; Pharmacogenetics; Protein Precursors; Receptor, Melanocortin, Type 2; Receptor, Serotonin, 5-HT1B; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tryptophan Hydroxylase

2010

Trials

1 trial(s) available for enkephalin, leucine and Cocaine Abuse

ArticleYear
Moderation of buprenorphine therapy for cocaine dependence efficacy by variation of the Prodynorphin gene.
    European journal of clinical pharmacology, 2022, Volume: 78, Issue:6

    Topics: Buprenorphine; Buprenorphine, Naloxone Drug Combination; Cocaine; Cocaine-Related Disorders; Delayed-Action Preparations; Enkephalins; Humans; Injections, Intramuscular; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Protein Precursors

2022

Other Studies

23 other study(ies) available for enkephalin, leucine and Cocaine Abuse

ArticleYear
Dopamine D2 receptors bidirectionally regulate striatal enkephalin expression: Implications for cocaine reward.
    Cell reports, 2022, 09-27, Volume: 40, Issue:13

    Topics: Analgesics, Opioid; Animals; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Enkephalin, Methionine; Enkephalins; gamma-Aminobutyric Acid; Mice; Narcotic Antagonists; Receptors, Dopamine D1; Receptors, Dopamine D2; Reward; RNA, Messenger

2022
Short-term withdrawal from repeated exposure to cocaine during adolescence modulates dynorphin mRNA levels and BDNF signaling in the rat nucleus accumbens.
    Drug and alcohol dependence, 2019, 04-01, Volume: 197

    Topics: Animals; Brain-Derived Neurotrophic Factor; Cocaine-Related Disorders; Dynorphins; Enkephalins; Gene Expression; Male; Nociceptin Receptor; Nucleus Accumbens; Opioid Peptides; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, kappa; RNA, Messenger; Signal Transduction; Substance Withdrawal Syndrome

2019
Effects of an opioid (proenkephalin) polymorphism on neural response to errors in health and cocaine use disorder.
    Behavioural brain research, 2015, Oct-15, Volume: 293

    Topics: Adult; Brain; Cocaine-Related Disorders; Enkephalins; Female; Genetic Association Studies; Genotype; Gray Matter; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Oxygen; Polymorphism, Single Nucleotide; Protein Precursors; Psychiatric Status Rating Scales; Reaction Time; Statistics as Topic

2015
Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system.
    Psychopharmacology, 2008, Volume: 200, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Cocaine-Related Disorders; Conditioning, Operant; Disease Models, Animal; Enkephalins; Extinction, Psychological; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Protein Precursors; Receptors, Opioid, kappa; Stress, Psychological; Swimming

2008
A functional haplotype implicated in vulnerability to develop cocaine dependence is associated with reduced PDYN expression in human brain.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009, Volume: 34, Issue:5

    Topics: Alcohol-Related Disorders; Black or African American; Brain; Cocaine-Related Disorders; Enkephalins; Gene Expression; Gene Frequency; Genetic Predisposition to Disease; Haplotypes; Humans; Polymorphism, Single Nucleotide; Protein Precursors; RNA, Messenger; White People

2009
Cell-specific effects of variants of the 68-base pair tandem repeat on prodynorphin gene promoter activity.
    Addiction biology, 2011, Volume: 16, Issue:2

    Topics: Alcoholism; Alleles; Base Pairing; Cell Line; Cloning, Molecular; Cocaine-Related Disorders; Enkephalins; Genetic Variation; Genotype; HEK293 Cells; Humans; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Protein Precursors; Tandem Repeat Sequences; Transcription, Genetic; Transfection

2011
Genetic association analyses of PDYN polymorphisms with heroin and cocaine addiction.
    Genes, brain, and behavior, 2012, Volume: 11, Issue:4

    Topics: Adolescent; Adult; Alleles; Behavior, Addictive; Black or African American; Cocaine-Related Disorders; Enkephalins; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Heroin Dependence; Humans; Linkage Disequilibrium; Male; Middle Aged; Polymorphism, Single Nucleotide; Protein Precursors; Sex Factors; White People

2012
Increased CRH mRNA levels in the rat amygdala during short-term withdrawal from chronic 'binge' cocaine.
    Brain research. Molecular brain research, 2003, May-26, Volume: 114, Issue:1

    Topics: Amygdala; Animals; Brain Stem; Chronic Disease; Cocaine; Cocaine-Related Disorders; Corticosterone; Corticotropin-Releasing Hormone; Dopamine Uptake Inhibitors; Enkephalins; Frontal Lobe; Gene Expression; Hypothalamo-Hypophyseal System; Male; Pituitary-Adrenal System; Protein Precursors; Rats; Rats, Inbred F344; RNA, Messenger; Substance Withdrawal Syndrome

2003
Temporal upregulation of prodynorphin mRNA in the primate striatum after cocaine self-administration.
    The European journal of neuroscience, 2003, Volume: 17, Issue:10

    Topics: Animals; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Dopamine Uptake Inhibitors; Enkephalins; Gene Expression; Macaca mulatta; Male; Protein Precursors; RNA, Messenger; Self Administration; Up-Regulation

2003
Role of serotonin on cocaine-mediated effects on prodynorphin gene expression in the rat brain.
    Journal of molecular neuroscience : MN, 2004, Volume: 22, Issue:3

    Topics: Animals; Brain; Brain Chemistry; Carrier Proteins; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Enkephalins; Fluoxetine; Gene Expression Regulation; Male; p-Chloroamphetamine; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Serotonin; Time; Up-Regulation

2004
Effects of extended access to high versus low cocaine doses on self-administration, cocaine-induced reinstatement and brain mRNA levels in rats.
    Psychopharmacology, 2004, Volume: 175, Issue:1

    Topics: Animals; Behavior, Addictive; Brain; Cocaine; Cocaine-Related Disorders; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Dynorphins; Enkephalins; Extinction, Psychological; Male; Opioid Peptides; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Recurrence; RNA, Messenger; Self Administration; Time Factors

2004
Blunted response to cocaine in the Flinders hypercholinergic animal model of depression.
    Neuroscience, 2005, Volume: 132, Issue:4

    Topics: Acetylcholine; Animals; Chromatography, High Pressure Liquid; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Depression; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Enkephalins; In Situ Hybridization; Male; Microdialysis; Motor Activity; Nucleus Accumbens; Protein Precursors; Rats; RNA, Messenger

2005
Immediate withdrawal from chronic "binge" cocaine administration increases mu-opioid receptor mRNA levels in rat frontal cortex.
    Brain research. Molecular brain research, 2005, Jun-13, Volume: 137, Issue:1-2

    Topics: Animals; Brain Chemistry; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Down-Regulation; Drug Administration Schedule; Enkephalins; Frontal Lobe; Male; Narcotic Antagonists; Protein Precursors; Rats; Rats, Inbred F344; Receptors, Opioid, mu; RNA, Messenger; Substance Withdrawal Syndrome; Time Factors

2005
Confirmation of the association between a polymorphism in the promoter region of the prodynorphin gene and cocaine dependence.
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2005, Nov-05, Volume: 139B, Issue:1

    Topics: Adult; Black or African American; Cocaine-Related Disorders; Enkephalins; Female; Genetic Predisposition to Disease; Humans; Male; Polymorphism, Genetic; Promoter Regions, Genetic; Protein Precursors

2005
Motor-skill learning-associated gene regulation in the striatum: effects of cocaine.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2006, Volume: 31, Issue:12

    Topics: Animals; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Disease Models, Animal; Dopamine; Dynorphins; Enkephalins; Gene Expression Regulation; Learning; Male; Motor Activity; Motor Skills; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Substance P; Up-Regulation

2006
Knockout of ERK1 enhances cocaine-evoked immediate early gene expression and behavioral plasticity.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2006, Volume: 31, Issue:12

    Topics: Animals; Behavior, Animal; Brain; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Corpus Striatum; Disease Models, Animal; Dopamine Uptake Inhibitors; Enkephalins; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Genes, Immediate-Early; Limbic System; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Proto-Oncogene Proteins c-fos; Ventral Tegmental Area

2006
Cocaine-induced locomotor activity and Fos expression in nucleus accumbens are sensitized for 6 months after repeated cocaine administration outside the home cage.
    The European journal of neuroscience, 2006, Volume: 24, Issue:3

    Topics: Animals; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug Administration Schedule; Drug Interactions; Enkephalins; GABA Agonists; Gene Expression; Male; Motor Activity; Neostriatum; Nucleus Accumbens; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Time; Time Factors; Up-Regulation

2006
Prodynorphin gene promoter repeat associated with cocaine/alcohol codependence.
    Addiction biology, 2007, Volume: 12, Issue:3-4

    Topics: Alcoholism; Alleles; Base Pairing; Black People; Cocaine-Related Disorders; Comorbidity; DNA; Enkephalins; Female; Gene Frequency; Genotype; Hispanic or Latino; Humans; Male; Polymerase Chain Reaction; Promoter Regions, Genetic; Protein Precursors; Tandem Repeat Sequences; White People

2007
The proenkephalin gene (PENK) and opioid dependence.
    Neuroreport, 1999, Apr-06, Volume: 10, Issue:5

    Topics: Adult; Alcohol-Related Disorders; Alleles; Amphetamine-Related Disorders; Cocaine-Related Disorders; Dinucleotide Repeats; Enkephalins; Female; Gene Frequency; Heroin Dependence; Humans; Male; Protein Precursors; Substance-Related Disorders; White People

1999
Running and cocaine both upregulate dynorphin mRNA in medial caudate putamen.
    The European journal of neuroscience, 2000, Volume: 12, Issue:8

    Topics: Analgesics, Opioid; Animals; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Dynorphins; Enkephalins; Gene Expression; In Situ Hybridization; Male; Morphine; Naloxone; Narcotic Antagonists; Neostriatum; Rats; Rats, Inbred F344; Rats, Inbred Lew; RNA, Messenger; Running; Species Specificity; Substance P

2000
Cocaine self-administration in rats differentially alters mRNA levels of the monoamine transporters and striatal neuropeptides.
    Brain research. Molecular brain research, 2000, Nov-10, Volume: 83, Issue:1-2

    Topics: Animals; Brain Chemistry; Carrier Proteins; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Enkephalins; Gene Expression; Injections, Intravenous; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine Plasma Membrane Transport Proteins; Nucleus Accumbens; Rats; Rats, Inbred Strains; RNA, Messenger; Self Administration; Serotonin Plasma Membrane Transport Proteins; Substance P; Substance Withdrawal Syndrome; Symporters

2000
Hypothalamic CRH mRNA levels are differentially modulated by repeated 'binge' cocaine with or without D(1) dopamine receptor blockade.
    Brain research. Molecular brain research, 2001, Oct-19, Volume: 94, Issue:1-2

    Topics: Amygdala; Animals; Benzazepines; Cocaine; Cocaine-Related Disorders; Corticotropin-Releasing Hormone; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dopamine Uptake Inhibitors; Enkephalins; Frontal Lobe; Gene Expression; Hypothalamus; Male; Olfactory Bulb; Protein Precursors; Rats; Rats, Inbred F344; Receptors, Dopamine D1; RNA, Messenger; Sulpiride

2001
Potentially functional polymorphism in the promoter region of prodynorphin gene may be associated with protection against cocaine dependence or abuse.
    American journal of medical genetics, 2002, May-08, Volume: 114, Issue:4

    Topics: Alleles; Base Sequence; Cocaine-Related Disorders; DNA; Enkephalins; Gene Frequency; Humans; Molecular Sequence Data; Polymorphism, Genetic; Promoter Regions, Genetic; Protein Precursors; Repetitive Sequences, Nucleic Acid

2002