fenfluramine has been researched along with Cocaine Abuse in 8 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acute SSRI (selective serotonin reuptake inhibitor) treatment has been shown to attenuate the abuse-related effects of cocaine; however, SSRIs have had limited success in clinical trials for cocaine abuse, possibly due to neurobiological changes that occur during chronic administration." | 3.78 | Neurobiological changes mediating the effects of chronic fluoxetine on cocaine use. ( Goodman, MM; Howell, LL; Kimmel, HL; Mun, J; Nye, JA; Rice, KC; Sawyer, EK; Stehouwer, JS; Voll, RJ, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Buydens-Branchey, L | 3 |
| Branchey, M | 3 |
| Hibbeln, JR | 1 |
| Sawyer, EK | 1 |
| Mun, J | 1 |
| Nye, JA | 1 |
| Kimmel, HL | 1 |
| Voll, RJ | 1 |
| Stehouwer, JS | 1 |
| Rice, KC | 1 |
| Goodman, MM | 1 |
| Howell, LL | 1 |
| Ghitza, UE | 1 |
| Rothman, RB | 2 |
| Gorelick, DA | 1 |
| Henningfield, JE | 1 |
| Baumann, MH | 2 |
| Hudson, J | 2 |
| Rothman, M | 2 |
| Fergeson, P | 2 |
| McKernin, C | 2 |
| Elmer, GI | 1 |
| Shippenberg, TS | 1 |
| Rea, W | 1 |
| Yan, QS | 1 |
4 trials available for fenfluramine and Cocaine Abuse
| Article | Year |
|---|---|
Higher n-3 fatty acids are associated with more intense fenfluramine-induced ACTH and cortisol responses among cocaine-abusing men.
Topics: Adrenocorticotropic Hormone; Adult; Chromatography, Gas; Cocaine-Related Disorders; Criminals; Doubl | 2011 |
Serotonergic responsiveness in human cocaine users.
Topics: Adult; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Female; Fenfluramine; Humans; | 2007 |
Effect of fenfluramine challenge on cocaine craving in addicted male users.
Topics: Adult; Cocaine-Related Disorders; Compulsive Behavior; Double-Blind Method; Fenfluramine; Humans; Ma | 1998 |
Serotonergic function in cocaine addicts: prolactin responses to sequential D,L-fenfluramine challenges.
Topics: Administration, Oral; Adult; Alcoholism; Child of Impaired Parents; Cocaine-Related Disorders; Fathe | 1999 |
4 other studies available for fenfluramine and Cocaine Abuse
| Article | Year |
|---|---|
Serotonergic modulation for Dravet Syndrome treatment.
Topics: Animals; Brain; Cocaine-Related Disorders; Disease Models, Animal; Epilepsies, Myoclonic; Fenflurami | 2016 |
Neurobiological changes mediating the effects of chronic fluoxetine on cocaine use.
Topics: Animals; Brain; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine; Dose-Response | 2012 |
Phentermine and fenfluramine. Preclinical studies in animal models of cocaine addiction.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Dopamine; Dopamine Agents; | 1998 |
Reduced serotonin release and serotonin uptake sites in the rat nucleus accumbens and striatum after prenatal cocaine exposure.
Topics: Animals; Animals, Newborn; Citalopram; Cocaine; Cocaine-Related Disorders; Electric Stimulation; Fem | 2002 |