lidocaine and Cocaine Abuse

lidocaine has been researched along with Cocaine Abuse in 19 studies

Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.

Research

Studies (19)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Cocaine Craving

basal measures of cocaine craving will be measured by Cocaine Craving Questionnaire (CCQ) times weekly after lidocaine/saline administration. The higher the score the more craving and lower the score the less craving. The CCQ has 10 items, each item scored 1-7. Maximum score is 70, minimum score is 7. (NCT01929343)
Timeframe: cocaine craving will be measure during the 4 weeks following infusion

Cocaine Use

cocaine use will be measured by urine drug screen and participant self-report three times weekly after lidocaine/saline administration. Cocaine use will be assessed as positive (1) or negative (0) using urine drug screen for cocaine and/or by participant self-report of cocaine use. (NCT01929343)
Timeframe: cocaine use will be measure during the 4 weeks following infusion

Cue-induced Craving After Lidocaine/Saline Administration.

7 days after lidocaine/saline administration, cocaine craving will be measured during the administration of relaxation or craving script. Craving intensity will be measured by the subjective intensity of craving as reported by the participant. Measured via a visual analog scale based on 4 (out of 10) questions from the Cocaine Craving Questionnaire (1-strongly disagree to 7- strongly agree). Highest total score possible 28, lowest score possible is 4. If the score is low in the lidocaine group and high in the saline group, it would mean that lidocaine has successfully decreased the craving response relative to saline. (NCT01929343)
Timeframe: craving measured immediately following reading of the script.

Physiological Responses as Measured by EMG (Electromyography) After Lidocaine/Saline Administration.

Electromyography (frontal) will be measured during the administration of the relaxation or craving script seven days after infusion. EMG is assessed by uV (microvolts). Higher scores reflect greater amounts of EMG activity, lower scores reflect lower amounts of EMG activity. It was expected that EMG would be positively associated with cocaine craving. (NCT01929343)
Timeframe: 2 minutes during administration of script.

Physiological Responses as Measured by Galvanic Skin Response (GSR) After Lidocaine/Saline Administration.

7 days after lidocaine/saline administration, GSR will be measured during the reading of the relaxation or saline script. It is predicted that higher GSR would be associated with higher cocaine craving and lower GSR will be associated with lower cocaine craving. (NCT01929343)
Timeframe: 2 minutes during script reading.

Physiological Responses as Measured by Heart Rate After Lidocaine/Saline Administration.

7 days after lidocaine/saline administration, heart rate will be measured during the administration of a relaxation or craving script. Heart rate will be measured in beats per minute. (NCT01929343)
Timeframe: 120 seconds, during reading of the script.

Reviews

1 review available for lidocaine and Cocaine Abuse

Trials

1 trial available for lidocaine and Cocaine Abuse

Other Studies

17 other studies available for lidocaine and Cocaine Abuse