mirtazapine has been researched along with Cocaine Abuse in 9 studies
Mirtazapine: A piperazinoazepine tetracyclic compound that enhances the release of NOREPINEPHRINE and SEROTONIN through blockage of presynaptic ALPHA-2 ADRENERGIC RECEPTORS. It also blocks both 5-HT2 and 5-HT3 serotonin receptors and is a potent HISTAMINE H1 RECEPTOR antagonist. It is used for the treatment of depression, and may also be useful for the treatment of anxiety disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Prior findings concerning the use of mirtazapine in the treatment of a variety of substance use disorders and its antagonistic actions at the serotonin 5-HT(2A) receptor suggest that this drug may have efficacy in the treatment of cocaine dependence in the presence of a depressive disorder." | 5.16 | The efficacy of mirtazapine in the treatment of cocaine dependence with comorbid depression. ( Afshar, M; Ciraulo, DA; Colaneri, LS; Devine, E; Knapp, CM; Putnam, MA; Sarid-Segal, O; Tozier, L; Waters, ME, 2012) |
| "Cocaine abuse and dependence are a global public health problem." | 3.85 | Synergistic interactions between mirtazapine and prazosin prevent the induction and expression of behavioral sensitization to cocaine in rats. ( Barbosa-Méndez, S; Matus-Ortega, M; Salazar-Juárez, A, 2017) |
| " Thus, the objective of this study was to determine if dosing of mirtazapine in an enriched housing environment enhanced the mirtazapine-induced decrease on the induction and expression of cocaine-induced locomotor sensitization." | 1.62 | Mirtazapine-induced decrease in cocaine sensitization is enhanced by environmental enrichment in rats. ( Barbosa-Méndez, S; López-Morado, C; Salazar-Juárez, A, 2021) |
| "Tamoxifen was administered during the antagonism phase." | 1.56 | Mirtazapine reduces the expression of cocaine-induced locomotor sensitization in male and female Wistar rats. ( Barbosa-Méndez, S; Osorio-Santiago, KL; Salazar-Juárez, A, 2020) |
| "Mirtazapine is an antidepressant implicated in reducing behavioral alterations induced by drugs of abuse." | 1.46 | Dose- and time-dependent effects of mirtazapine on the expression of cocaine-induced behavioral sensitization in rats. ( Barbosa-Méndez, S; Flores-Zamora, A; Jurado, N; Matus-Ortega, M; Salazar-Juárez, A, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 4 (44.44) | 2.80 |
| Authors | Studies |
|---|---|
| Ciccarone, D | 1 |
| Shoptaw, S | 1 |
| Ma, L | 1 |
| Cunningham, KA | 1 |
| Anastasio, NC | 1 |
| Bjork, JM | 1 |
| Taylor, BA | 1 |
| Arias, AJ | 1 |
| Riley, BP | 1 |
| Snyder, AD | 1 |
| Moeller, FG | 1 |
| Barbosa-Méndez, S | 4 |
| Osorio-Santiago, KL | 1 |
| Salazar-Juárez, A | 4 |
| López-Morado, C | 1 |
| Matus-Ortega, M | 2 |
| Flores-Zamora, A | 1 |
| Jurado, N | 1 |
| Hairston, DR | 1 |
| de Similien, RH | 1 |
| Himelhoch, S | 1 |
| Forrester, A | 1 |
| Afshar, M | 1 |
| Knapp, CM | 1 |
| Sarid-Segal, O | 1 |
| Devine, E | 1 |
| Colaneri, LS | 1 |
| Tozier, L | 1 |
| Waters, ME | 1 |
| Putnam, MA | 1 |
| Ciraulo, DA | 1 |
| Fisfalen, ME | 1 |
| Hsiung, RC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Clinical Studies on Anti-addictive Therapeutic Effects of Mirtazapine in Human Subjects Addicted to Cocaine.[NCT01949571] | Phase 2 | 64 participants (Actual) | Interventional | 2007-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for mirtazapine and Cocaine Abuse
| Article | Year |
|---|---|
Understanding Stimulant Use and Use Disorders in a New Era.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adult; Anticonvulsants; Behavior Therapy; Bupropion; Centra | 2022 |
1 trial available for mirtazapine and Cocaine Abuse
| Article | Year |
|---|---|
The efficacy of mirtazapine in the treatment of cocaine dependence with comorbid depression.
Topics: Adult; Antidepressive Agents, Tricyclic; Cocaine; Cocaine-Related Disorders; Depressive Disorder; Do | 2012 |
7 other studies available for mirtazapine and Cocaine Abuse
| Article | Year |
|---|---|
A serotonergic biobehavioral signature differentiates cocaine use disorder participants administered mirtazapine.
Topics: Cocaine; Cocaine-Related Disorders; Gyrus Cinguli; Humans; Mirtazapine; Serotonin; Substance-Related | 2022 |
Mirtazapine reduces the expression of cocaine-induced locomotor sensitization in male and female Wistar rats.
Topics: Animals; Antidepressive Agents; Central Nervous System Sensitization; Cocaine; Cocaine-Related Disor | 2020 |
Mirtazapine-induced decrease in cocaine sensitization is enhanced by environmental enrichment in rats.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Dopamine Uptak | 2021 |
Dose- and time-dependent effects of mirtazapine on the expression of cocaine-induced behavioral sensitization in rats.
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Dos | 2017 |
Synergistic interactions between mirtazapine and prazosin prevent the induction and expression of behavioral sensitization to cocaine in rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Analysis of Variance; Anesthetics, Local; Animals; Cocaine; | 2017 |
Treatment of phantom shocks: A case report.
Topics: Antidepressive Agents; Anxiety Disorders; Cocaine-Related Disorders; Defibrillators, Implantable; De | 2019 |
Glucose dysregulation and mirtazapine-induced weight gain.
Topics: Adult; Antidepressive Agents, Tricyclic; Blood Glucose; Body Mass Index; Cocaine-Related Disorders; | 2003 |