modafinil has been researched along with Cocaine Abuse in 51 studies
Modafinil: A benzhydryl acetamide compound, central nervous system stimulant, and CYP3A4 inducing agent that is used in the treatment of NARCOLEPSY and SLEEP WAKE DISORDERS.
modafinil : A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.
2-[(diphenylmethyl)sulfinyl]acetamide : A sulfoxide that is dimethylsulfoxide in which two hydrogens attached to one of the methyl groups are replaced by phenyl groups, while one hydrogen attached to the other methyl group is replaced by a carbamoyl (aminocarbonyl) group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this double-blind, randomized, outpatient study was to evaluate the reinforcing and subjective effects of modafinil (200, 400, or 600 mg) in cocaine abusers." | 9.14 | Modafinil does not serve as a reinforcer in cocaine abusers. ( Foltin, RW; Haney, M; Hart, CL; Rubin, E; Vosburg, SK, 2010) |
| "Eleven cocaine abusers were administered methylphenidate (0, 15, 30, and 45 mg) or modafinil (0, 150, 300, and 450 mg) across four experimental sessions." | 6.73 | Effects of potential agonist-replacement therapies for stimulant dependence on inhibitory control in cocaine abusers. ( Fillmorex, MT; Hays, LR; Rush, CR; Vansickel, AR, 2008) |
| "The purpose of this double-blind, randomized, outpatient study was to evaluate the reinforcing and subjective effects of modafinil (200, 400, or 600 mg) in cocaine abusers." | 5.14 | Modafinil does not serve as a reinforcer in cocaine abusers. ( Foltin, RW; Haney, M; Hart, CL; Rubin, E; Vosburg, SK, 2010) |
| "Modafinil is used experimentally to treat ADHD, mood disorders, schizophrenia and substance-dependence." | 4.86 | [Modafinil in psychiatric disorders: the promising state reconsidered]. ( Docx, L; Dom, G; Joos, L; Sabbe, BG; Schmaal, L, 2010) |
| "This phenomenon has been termed "occult insomnia." | 2.84 | Sleep Perception and Misperception in Chronic Cocaine Users During Abstinence. ( Hodges, SE; Morgan, PT; Pittman, B, 2017) |
| "Modafinil treatment was associated with a higher mean percentage (52% vs." | 2.82 | Modafinil and sleep architecture in an inpatient-outpatient treatment study of cocaine dependence. ( Angarita, GA; Bessette, A; Canavan, S; Easton, C; Forselius, E; Hodges, S; Malison, RT; McKee, S; Mohsenin, V; Morgan, PT; Oberleitner, L; Pittman, B, 2016) |
| "Modafinil was used in a randomized double-blind placebo-controlled design and was administered as follows: 400 mg/day for 26 days, then 300 mg/day for 30 days, and 200 mg/day for 31 days." | 2.82 | Dopamine Transporter Correlates and Occupancy by Modafinil in Cocaine-Dependent Patients: A Controlled Study With High-Resolution PET and [(11)C]-PE2I. ( Artiges, E; Bordas, N; Dubois, A; Dubol, M; Karila, L; Leroy, C; Mabondo, A; Marill, C; Martinot, JL; Reynaud, M; Trichard, C, 2016) |
| "Modafinil adherence was low, with only 10% treatment completers." | 2.80 | Modafinil in the treatment of crack-cocaine dependence in the Netherlands: Results of an open-label randomised controlled feasibility trial. ( Blanken, P; Hendriks, V; Nuijten, M; van den Brink, W, 2015) |
| "Modafinil is a medication approved for narcolepsy and shift work sleep disorder." | 2.80 | A double blind, placebo controlled trial of modafinil for the treatment of cocaine dependence without co-morbid alcohol dependence. ( Dackis, C; Kampman, KM; Lynch, KG; O'Brien, CP; Pettinati, HM; Spratt, K; Wierzbicki, MR, 2015) |
| "Modafinil treatment was associated with significantly higher BART scores (p=0." | 2.79 | Preliminary evidence for normalization of risk taking by modafinil in chronic cocaine users. ( Bessette, AJ; Canavan, SV; Forselius, EL; Morgan, PT, 2014) |
| "Modafinil was promising in the first clinical trials in cocaine dependence, and was able to reduce craving in addictive disorders." | 2.78 | Neurophysiological effects of modafinil on cue-exposure in cocaine dependence: a randomized placebo-controlled cross-over study using pharmacological fMRI. ( Dom, G; Goudriaan, AE; Schmaal, L; van den Brink, W; Veltman, DJ, 2013) |
| "The present study (Cocaine Addiction Treatments to improve Control and reduce Harm; CATCH) investigates the possibilities and problems associated with new pharmacological treatments for crack dependent patients." | 2.76 | Cocaine Addiction Treatments to improve Control and reduce Harm (CATCH): new pharmacological treatment options for crack-cocaine dependence in the Netherlands. ( Blanken, P; Hendriks, V; Nuijten, M; van den Brink, W, 2011) |
| "Modafinil was associated with increased daytime sleep latency, as measured by the Multiple Sleep Latency Test, and a nearly significant decrease in subjective daytime sleepiness." | 2.75 | Normalizing effects of modafinil on sleep in chronic cocaine users. ( Malison, RT; Morgan, PT; Pace-Schott, E; Pittman, B; Stickgold, R, 2010) |
| "Modafinil was tested for efficacy in facilitating abstinence in cocaine-dependent patients, compared to placebo." | 2.74 | Modafinil for the treatment of cocaine dependence. ( Anderson, AL; Chiang, N; Ciraulo, D; Dackis, C; Elkashef, AM; Holmes, T; Kahn, R; Li, SH; Reid, MS; Roache, JD; Salloum, IM; Shemanski, L; Slee, A; Smith, EV; Somoza, E; Urschel, HC; Vocci, F, 2009) |
| "Modafinil has been reported to reduce cocaine use in a clinical sample of infrequent users (2 days/week), but the effects of modafinil on cocaine self-administration in the laboratory have not been studied." | 2.73 | Smoked cocaine self-administration is decreased by modafinil. ( Foltin, RW; Haney, M; Hart, CL; Rubin, E; Vosburg, SK, 2008) |
| "Eleven cocaine abusers were administered methylphenidate (0, 15, 30, and 45 mg) or modafinil (0, 150, 300, and 450 mg) across four experimental sessions." | 2.73 | Effects of potential agonist-replacement therapies for stimulant dependence on inhibitory control in cocaine abusers. ( Fillmorex, MT; Hays, LR; Rush, CR; Vansickel, AR, 2008) |
| "Modafinil was given open label at 0 mg, 400 mg, or 800 mg." | 2.72 | Modafinil and cocaine interactions. ( Chiang, N; Cochran, K; DeVane, CL; Donovan, JL; Elkashef, A; Hedden, S; Khan, R; Malcolm, R; Mojsiak, J; Myrick, DL; Swayngim, K; Woolson, RF, 2006) |
| "Modafinil is a novel compound that is approved for the treatment of narcolepsy." | 2.71 | Modafinil and cocaine: a double-blind, placebo-controlled drug interaction study. ( Cornish, JW; Dackis, CA; Kampman, KM; Lynch, KG; O'Brien, CP; Poole, S; Rowan, A; Samaha, FF; White, L; Yu, E, 2003) |
| "Modafinil-treated patients provided significantly more BE-negative urine samples (p=0." | 2.71 | A double-blind, placebo-controlled trial of modafinil for cocaine dependence. ( Dackis, CA; Kampman, KM; Lynch, KG; O'Brien, CP; Pettinati, HM, 2005) |
| " There were no significant changes in total AUC, clearance or elimination half-life of cocaine." | 2.71 | Modafinil influences the pharmacokinetics of intravenous cocaine in healthy cocaine-dependent volunteers. ( Chiang, CN; DeVane, CL; Donovan, JL; Elkashef, A; Malcolm, RJ; Mojsiak, J; Taylor, RM, 2005) |
| "Cocaine dependence is characterized by compulsive drug seeking and high vulnerability to relapse." | 2.47 | Promising medications for cocaine dependence treatment. ( Amore, M; Ciccocioppo, R; Donnini, C; Gerra, G; Gerra, ML; Kalluppi, M; Malagoli, M; Raggi, MA; Saracino, MA; Somaini, L, 2011) |
| "Cocaine addiction is a chronic relapsing disorder associated with severe medical and psychosocial complications." | 2.44 | Modafinil: a useful medication for cocaine addiction? Review of the evidence from neuropharmacological, experimental and clinical studies. ( Cepeda, S; Knecht, C; Martínez-Raga, J, 2008) |
| "Cocaine dependence is quite serious and is associated with numerous adverse health consequences." | 2.44 | [Current pharmacotherapies and immunotherapy in cocaine addiction]. ( Aubin, HJ; Benyamina, A; Coscas, S; Karila, L; Lépine, JP; Leroy, C; Lowenstein, W; Noble, F; Reynaud, M; Weinstein, A, 2008) |
| "Modafinil has a novel mechanism and is theorized to work in a localized manner, utilizing hypocretin, histamine, epinephrine, gamma-aminobutyric acid, and glutamate." | 2.43 | A systematic review of modafinil: Potential clinical uses and mechanisms of action. ( Ballon, JS; Feifel, D, 2006) |
| "Modafinil is a central nervous system stimulant used to promote wakefulness, and it is being evaluated clinically as an agonist medication for treating stimulant abuse." | 1.36 | Behavioral evaluation of modafinil and the abuse-related effects of cocaine in rhesus monkeys. ( Lozama, A; Mello, NK; Negus, SS; Newman, JL; Prisinzano, TE, 2010) |
| "Modafinil is a novel stimulant approved by the FDA for use in the management of excessive sleepiness associated with narcolepsy." | 1.32 | Chiral analysis of d- and l-modafinil in human serum: application to human pharmacokinetic studies. ( DeVane, CL; Donovan, JL; Malcolm, RJ; Markowitz, JS, 2003) |
| "Modafinil is a novel stimulant that is effective in the treatment of narcolepsy and excessive daytime sleepiness." | 1.31 | Discriminative-stimulus effects of modafinil in cocaine-trained humans. ( Hays, LR; Kelly, TH; Rush, CR; Wooten, AF, 2002) |
| "Modafinil is a drug that promotes wakefulness and, as such, is used to treat hypersomnia and narcolepsy." | 1.31 | Study of the addictive potential of modafinil in naive and cocaine-experienced rats. ( Bruins-Slot, L; Darnaudéry, M; Deroche-Gamonet, V; Le Moal, M; Piat, F; Piazza, PV, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 21 (41.18) | 29.6817 |
| 2010's | 29 (56.86) | 24.3611 |
| 2020's | 1 (1.96) | 2.80 |
| Authors | Studies |
|---|---|
| Haney, M | 3 |
| Rubin, E | 3 |
| Denson, RK | 1 |
| Foltin, RW | 3 |
| Sangroula, D | 1 |
| Motiwala, F | 1 |
| Wagle, B | 1 |
| Shah, VC | 1 |
| Hagi, K | 1 |
| Lippmann, S | 1 |
| Hodges, SE | 1 |
| Pittman, B | 3 |
| Morgan, PT | 5 |
| Schmitz, JM | 3 |
| Stotts, AL | 2 |
| Vujanovic, AA | 1 |
| Weaver, MF | 1 |
| Yoon, JH | 2 |
| Vincent, J | 1 |
| Green, CE | 2 |
| Susukida, R | 1 |
| Crum, RM | 1 |
| Hong, H | 1 |
| Stuart, EA | 1 |
| Mojtabai, R | 1 |
| Jordan, CJ | 1 |
| Cao, J | 1 |
| Newman, AH | 1 |
| Xi, ZX | 1 |
| Lindsay, JA | 1 |
| Rathnayaka, NS | 1 |
| Grabowski, J | 1 |
| Moeller, FG | 2 |
| Canavan, SV | 1 |
| Forselius, EL | 1 |
| Bessette, AJ | 1 |
| Nuijten, M | 3 |
| Blanken, P | 3 |
| van den Brink, W | 4 |
| Hendriks, V | 2 |
| Kampman, KM | 5 |
| Lynch, KG | 4 |
| Pettinati, HM | 3 |
| Spratt, K | 1 |
| Wierzbicki, MR | 1 |
| Dackis, C | 4 |
| O'Brien, CP | 6 |
| Angarita, GA | 1 |
| Canavan, S | 1 |
| Oberleitner, L | 1 |
| Malison, RT | 3 |
| Mohsenin, V | 1 |
| Hodges, S | 1 |
| Easton, C | 1 |
| McKee, S | 1 |
| Bessette, A | 1 |
| Forselius, E | 1 |
| Karila, L | 2 |
| Leroy, C | 2 |
| Dubol, M | 1 |
| Trichard, C | 1 |
| Mabondo, A | 1 |
| Marill, C | 1 |
| Dubois, A | 1 |
| Bordas, N | 1 |
| Martinot, JL | 1 |
| Reynaud, M | 2 |
| Artiges, E | 1 |
| Goudriaan, AE | 2 |
| Hendriks, VM | 1 |
| Anderson, AL | 1 |
| Reid, MS | 1 |
| Li, SH | 1 |
| Holmes, T | 1 |
| Shemanski, L | 1 |
| Slee, A | 1 |
| Smith, EV | 1 |
| Kahn, R | 1 |
| Chiang, N | 2 |
| Vocci, F | 1 |
| Ciraulo, D | 1 |
| Roache, JD | 1 |
| Salloum, IM | 1 |
| Somoza, E | 1 |
| Urschel, HC | 1 |
| Elkashef, AM | 1 |
| Martínez-Raga, J | 1 |
| Knecht, C | 1 |
| Cepeda, S | 1 |
| Vosburg, SK | 2 |
| Hart, CL | 2 |
| Pace-Schott, E | 1 |
| Stickgold, R | 1 |
| Steinberg, JL | 1 |
| Ma, L | 1 |
| Liu, S | 1 |
| Kjome, KL | 1 |
| Rathnayaka, N | 1 |
| Kramer, LA | 1 |
| Narayana, PA | 1 |
| Andersen, ML | 1 |
| Kessler, E | 1 |
| Murnane, KS | 1 |
| McClung, JC | 1 |
| Tufik, S | 2 |
| Howell, LL | 1 |
| Shearer, J | 1 |
| Shanahan, M | 1 |
| Darke, S | 1 |
| Rodgers, C | 1 |
| van Beek, I | 1 |
| McKetin, R | 1 |
| Mattick, RP | 1 |
| Newman, JL | 1 |
| Negus, SS | 1 |
| Lozama, A | 1 |
| Prisinzano, TE | 1 |
| Mello, NK | 1 |
| Joos, L | 1 |
| Docx, L | 1 |
| Schmaal, L | 2 |
| Sabbe, BG | 1 |
| Dom, G | 2 |
| Somaini, L | 1 |
| Donnini, C | 1 |
| Raggi, MA | 1 |
| Amore, M | 1 |
| Ciccocioppo, R | 1 |
| Saracino, MA | 1 |
| Kalluppi, M | 1 |
| Malagoli, M | 1 |
| Gerra, ML | 1 |
| Gerra, G | 1 |
| Wuo-Silva, R | 1 |
| Fukushiro, DF | 1 |
| Borçoi, AR | 1 |
| Fernandes, HA | 1 |
| Procópio-Souza, R | 1 |
| Hollais, AW | 1 |
| Santos, R | 1 |
| Ribeiro, LT | 1 |
| Corrêa, JM | 1 |
| Talhati, F | 1 |
| Saito, LP | 1 |
| Aramini, TC | 1 |
| Kameda, SR | 1 |
| Bittencourt, LR | 1 |
| Frussa-Filho, R | 1 |
| Dackis, CA | 4 |
| Plebani, JG | 1 |
| Sparkman, T | 1 |
| Veltman, DJ | 1 |
| Mariani, JJ | 1 |
| Levin, FR | 1 |
| Kalechstein, AD | 1 |
| Mahoney, JJ | 1 |
| Bennett, R | 1 |
| De la Garza, R | 1 |
| Herdener, M | 1 |
| Oppliger, R | 1 |
| Stohler, R | 1 |
| Caflisch, C | 1 |
| Mahler, SV | 1 |
| Hensley-Simon, M | 1 |
| Tahsili-Fahadan, P | 1 |
| LaLumiere, RT | 1 |
| Thomas, C | 1 |
| Fallon, RV | 1 |
| Kalivas, PW | 1 |
| Aston-Jones, G | 1 |
| Rush, CR | 3 |
| Kelly, TH | 2 |
| Hays, LR | 3 |
| Wooten, AF | 2 |
| Donovan, JL | 3 |
| Malcolm, RJ | 2 |
| Markowitz, JS | 1 |
| DeVane, CL | 3 |
| Yu, E | 1 |
| Samaha, FF | 1 |
| Cornish, JW | 1 |
| Rowan, A | 1 |
| Poole, S | 1 |
| White, L | 1 |
| O'Brien, C | 1 |
| Mojsiak, J | 2 |
| Chiang, CN | 1 |
| Elkashef, A | 2 |
| Taylor, RM | 1 |
| Umanoff, DF | 1 |
| Sofuoglu, M | 1 |
| Kosten, TR | 1 |
| Kruszewski, SP | 1 |
| Ballon, JS | 1 |
| Feifel, D | 1 |
| Kampman, K | 1 |
| Malcolm, R | 1 |
| Swayngim, K | 1 |
| Khan, R | 1 |
| Myrick, DL | 1 |
| Hedden, S | 1 |
| Cochran, K | 1 |
| Woolson, RF | 1 |
| Weinstein, A | 1 |
| Benyamina, A | 1 |
| Coscas, S | 1 |
| Noble, F | 1 |
| Lowenstein, W | 1 |
| Aubin, HJ | 1 |
| Lépine, JP | 1 |
| Vansickel, AR | 1 |
| Fillmorex, MT | 1 |
| Baker, RW | 1 |
| Deroche-Gamonet, V | 1 |
| Darnaudéry, M | 1 |
| Bruins-Slot, L | 1 |
| Piat, F | 1 |
| Le Moal, M | 1 |
| Piazza, PV | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Screening Medications for Cocaine Cessation and Relapse Prevention[NCT00218023] | Phase 2 | 101 participants (Actual) | Interventional | 2006-03-31 | Completed | ||
| Randomised Placebo-Controlled Trial of Modafinil for Methamphetamine Dependence[NCT00123370] | Phase 2 | 87 participants (Anticipated) | Interventional | 2006-07-31 | Active, not recruiting | ||
| Randomised Placebo-Controlled Trial of Modafinil for Cocaine Dependence[NCT00123383] | Phase 2 | 10 participants (Anticipated) | Interventional | 2005-07-31 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Cocaine use was determined by assessing for the presence of benzoylecgonine in urine. (NCT00218023)
Timeframe: 3 times per week (Monday, Wednesday, and Friday) for 12 weeks
| Intervention | Mean % of cocaine-positive urines (Mean) |
|---|---|
| Modafinil Plus MI, CM, and CBT | 31 |
| Levodopa/Carbidopa Plus MI, CM, and CBT | 28 |
| Naltrexone HCl Plus MI, CM, and CBT | 47 |
| Placebo Plus MI, CM, and CBT | 35 |
Cocaine use was determined by assessing for the presence of benzoylecgonine in urine. (NCT00218023)
Timeframe: 3 times per week (Monday, Wednesday, and Friday) for 12 weeks
| Intervention | Mean % of cocaine-positive urines (Mean) |
|---|---|
| Modafinil Plus MI, CM, and CBT | 88 |
| Levodopa/Carbidopa Plus MI, CM, and CBT | 49 |
| Naltrexone HCl Plus MI, CM, and CBT | 62 |
| Placebo Plus MI, CM, and CBT | 91 |
12 reviews available for modafinil and Cocaine Abuse
| Article | Year |
|---|---|
Modafinil Treatment of Cocaine Dependence: A Systematic Review and Meta-Analysis.
Topics: Benzhydryl Compounds; Cocaine-Related Disorders; Humans; Modafinil | 2017 |
Comparing pharmacological treatments for cocaine dependence: Incorporation of methods for enhancing generalizability in meta-analytic studies.
Topics: Adult; Anti-Anxiety Agents; Buspirone; Central Nervous System Stimulants; Cocaine-Related Disorders; | 2018 |
Progress in agonist therapy for substance use disorders: Lessons learned from methadone and buprenorphine.
Topics: Analgesics, Opioid; Buprenorphine; Central Nervous System Stimulants; Cocaine-Related Disorders; Dex | 2019 |
Modafinil: a useful medication for cocaine addiction? Review of the evidence from neuropharmacological, experimental and clinical studies.
Topics: Animals; Benzhydryl Compounds; Brain; Central Nervous System Stimulants; Cocaine; Cocaine-Related Di | 2008 |
[Modafinil in psychiatric disorders: the promising state reconsidered].
Topics: Attention Deficit Disorder with Hyperactivity; Benzhydryl Compounds; Central Nervous System Stimulan | 2010 |
Promising medications for cocaine dependence treatment.
Topics: Acetylcysteine; Atomoxetine Hydrochloride; Baclofen; Benzhydryl Compounds; Buprenorphine; Cocaine-Re | 2011 |
Psychostimulant treatment of cocaine dependence.
Topics: Amphetamines; Animals; Benzhydryl Compounds; Bupropion; Central Nervous System Stimulants; Clinical | 2012 |
[Treating cocaine addiction].
Topics: Acetylcysteine; Alcohol Deterrents; Baclofen; Benzhydryl Compounds; Central Nervous System Stimulant | 2012 |
Glutamatergic agents for cocaine dependence.
Topics: Animals; Benzhydryl Compounds; Central Nervous System Stimulants; Clinical Trials as Topic; Cocaine- | 2003 |
Emerging pharmacological strategies in the fight against cocaine addiction.
Topics: Adrenergic beta-Antagonists; Animals; Benzhydryl Compounds; Brain; Central Nervous System Stimulants | 2006 |
A systematic review of modafinil: Potential clinical uses and mechanisms of action.
Topics: Animals; Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Benzhydryl Compounds; | 2006 |
[Current pharmacotherapies and immunotherapy in cocaine addiction].
Topics: Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Dopamin | 2008 |
25 trials available for modafinil and Cocaine Abuse
| Article | Year |
|---|---|
Sleep Perception and Misperception in Chronic Cocaine Users During Abstinence.
Topics: Adult; Benzhydryl Compounds; Cocaine-Related Disorders; Double-Blind Method; Female; Humans; Male; M | 2017 |
A sequential multiple assignment randomized trial for cocaine cessation and relapse prevention: Tailoring treatment to the individual.
Topics: Adolescent; Adult; Behavior Therapy; Central Nervous System Stimulants; Cocaine-Related Disorders; F | 2018 |
A two-phased screening paradigm for evaluating candidate medications for cocaine cessation or relapse prevention: modafinil, levodopa-carbidopa, naltrexone.
Topics: Adolescent; Adult; Benzhydryl Compounds; Carbidopa; Central Nervous System Stimulants; Cocaine-Relat | 2014 |
Preliminary evidence for normalization of risk taking by modafinil in chronic cocaine users.
Topics: Adult; Benzhydryl Compounds; Chronic Disease; Cocaine-Related Disorders; Cognition; Cohort Studies; | 2014 |
Modafinil in the treatment of crack-cocaine dependence in the Netherlands: Results of an open-label randomised controlled feasibility trial.
Topics: Benzhydryl Compounds; Cocaine-Related Disorders; Cognitive Behavioral Therapy; Crack Cocaine; Cytoch | 2015 |
A double blind, placebo controlled trial of modafinil for the treatment of cocaine dependence without co-morbid alcohol dependence.
Topics: Adolescent; Adult; Alcoholism; Benzhydryl Compounds; Cocaine; Cocaine-Related Disorders; Cognitive B | 2015 |
Modafinil and sleep architecture in an inpatient-outpatient treatment study of cocaine dependence.
Topics: Adult; Benzhydryl Compounds; Cocaine-Related Disorders; Cognitive Behavioral Therapy; Combined Modal | 2016 |
Dopamine Transporter Correlates and Occupancy by Modafinil in Cocaine-Dependent Patients: A Controlled Study With High-Resolution PET and [(11)C]-PE2I.
Topics: Adult; Benzhydryl Compounds; Brain; Cocaine-Related Disorders; Craving; Decision Making; Depression; | 2016 |
Impulsivity and attentional bias as predictors of modafinil treatment outcome for retention and drug use in crack-cocaine dependent patients: Results of a randomised controlled trial.
Topics: Attention; Attentional Bias; Behavior, Addictive; Benzhydryl Compounds; Cocaine-Related Disorders; C | 2016 |
Modafinil for the treatment of cocaine dependence.
Topics: Adult; Alcoholism; Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine-Related Disorder | 2009 |
Modafinil does not serve as a reinforcer in cocaine abusers.
Topics: Adult; Benzhydryl Compounds; Blood Pressure; Central Nervous System Stimulants; Choice Behavior; Coc | 2010 |
Normalizing effects of modafinil on sleep in chronic cocaine users.
Topics: Adult; Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; | 2010 |
Working memory fMRI activation in cocaine-dependent subjects: association with treatment response.
Topics: Adult; Amphetamine; Analysis of Variance; Benzhydryl Compounds; Brain; Brain Mapping; Carbidopa; Cen | 2010 |
A cost-effectiveness analysis of modafinil therapy for psychostimulant dependence.
Topics: Adult; Amphetamine-Related Disorders; Benzhydryl Compounds; Central Nervous System Stimulants; Cocai | 2010 |
A cost-effectiveness analysis of modafinil therapy for psychostimulant dependence.
Topics: Adult; Amphetamine-Related Disorders; Benzhydryl Compounds; Central Nervous System Stimulants; Cocai | 2010 |
A cost-effectiveness analysis of modafinil therapy for psychostimulant dependence.
Topics: Adult; Amphetamine-Related Disorders; Benzhydryl Compounds; Central Nervous System Stimulants; Cocai | 2010 |
A cost-effectiveness analysis of modafinil therapy for psychostimulant dependence.
Topics: Adult; Amphetamine-Related Disorders; Benzhydryl Compounds; Central Nervous System Stimulants; Cocai | 2010 |
Cocaine Addiction Treatments to improve Control and reduce Harm (CATCH): new pharmacological treatment options for crack-cocaine dependence in the Netherlands.
Topics: Benzhydryl Compounds; Clinical Protocols; Cocaine-Related Disorders; Cognitive Behavioral Therapy; C | 2011 |
A double-blind, placebo-controlled trial of modafinil for cocaine dependence.
Topics: Adult; Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; | 2012 |
Neurophysiological effects of modafinil on cue-exposure in cocaine dependence: a randomized placebo-controlled cross-over study using pharmacological fMRI.
Topics: Adult; Analysis of Variance; Behavior, Addictive; Benzhydryl Compounds; Brain; Cocaine-Related Disor | 2013 |
Modafinil, but not escitalopram, improves working memory and sustained attention in long-term, high-dose cocaine users.
Topics: Adult; Benzhydryl Compounds; Black or African American; Citalopram; Cocaine-Related Disorders; Cogni | 2013 |
Modafinil and cocaine: a double-blind, placebo-controlled drug interaction study.
Topics: Adult; Benzhydryl Compounds; Blood Pressure; Body Temperature; Central Nervous System Stimulants; Co | 2003 |
A double-blind, placebo-controlled trial of modafinil for cocaine dependence.
Topics: Adult; Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine-Related Disorders; Double-Bl | 2005 |
Modafinil influences the pharmacokinetics of intravenous cocaine in healthy cocaine-dependent volunteers.
Topics: Administration, Oral; Adult; Anesthetics, Local; Area Under Curve; Benzhydryl Compounds; Central Ner | 2005 |
Modafinil and cocaine interactions.
Topics: Benzhydryl Compounds; Blood Pressure; Cocaine; Cocaine-Related Disorders; Drug Interactions; Humans; | 2006 |
Smoked cocaine self-administration is decreased by modafinil.
Topics: Adult; Benzhydryl Compounds; Blood Pressure; Cocaine; Cocaine-Related Disorders; Cross-Over Studies; | 2008 |
Effects of potential agonist-replacement therapies for stimulant dependence on inhibitory control in cocaine abusers.
Topics: Adult; Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; | 2008 |
Acute behavioral and physiological effects of modafinil in drug abusers.
Topics: Adult; Behavior; Benzhydryl Compounds; Blood Pressure; Central Nervous System Stimulants; Cocaine-Re | 2002 |
14 other studies available for modafinil and Cocaine Abuse
| Article | Year |
|---|---|
Modafinil reduces smoked cocaine self-administration in humans: effects vary as a function of cocaine 'priming' and cost.
Topics: Adult; Alcoholism; Benzhydryl Compounds; Cocaine; Cocaine-Related Disorders; Cues; Double-Blind Meth | 2021 |
Normalizing effects of modafinil on cocaine-induced sleep abnormalities.
Topics: Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Double- | 2010 |
Dopamine transporter-related effects of modafinil in rhesus monkeys.
Topics: Animals; Benzhydryl Compounds; Caudate Nucleus; Cocaine-Related Disorders; Corpus Striatum; Dopamine | 2010 |
Behavioral evaluation of modafinil and the abuse-related effects of cocaine in rhesus monkeys.
Topics: Animals; Behavior, Animal; Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine; Cocaine | 2010 |
Addictive potential of modafinil and cross-sensitization with cocaine: a pre-clinical study.
Topics: Animals; Benzhydryl Compounds; Brain; Central Nervous System Sensitization; Central Nervous System S | 2011 |
Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors.
Topics: Amino Acid Transport System y+; Amino Acids; Analysis of Variance; Animals; Benzhydryl Compounds; Co | 2014 |
Discriminative-stimulus effects of modafinil in cocaine-trained humans.
Topics: Adult; Analysis of Variance; Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine; Cocai | 2002 |
Chiral analysis of d- and l-modafinil in human serum: application to human pharmacokinetic studies.
Topics: Benzhydryl Compounds; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Cocai | 2003 |
Trial of modafinil for cocaine dependence.
Topics: Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine-Related Disorders; Humans; Modafini | 2005 |
Euphorigenic and abusive properties of modafinil.
Topics: Affective Symptoms; Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine-Related Disorde | 2006 |
Does modafinil produce euphoria?
Topics: Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine-Related Disorders; Euphoria; Humans | 2006 |
Chest tightness and palpitations associated with modafinil and consumption of free glutamate.
Topics: Adult; Arrhythmias, Cardiac; Benzhydryl Compounds; Chest Pain; Cocaine-Related Disorders; Eating; Gl | 2008 |
The search for medications to treat stimulant dependence.
Topics: Amphetamine-Related Disorders; Benzhydryl Compounds; Brain; Bupropion; Cocaine; Cocaine-Related Diso | 2008 |
Study of the addictive potential of modafinil in naive and cocaine-experienced rats.
Topics: Animals; Behavior, Addictive; Benzhydryl Compounds; Cocaine; Cocaine-Related Disorders; Conditioning | 2002 |