metyrapone has been researched along with Cocaine Abuse in 9 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although cocaine dependence affects an estimated 1." | 2.77 | Effects of the combination of metyrapone and oxazepam on cocaine craving and cocaine taking: a double-blind, randomized, placebo-controlled pilot study. ( Casso, S; DeMuth, G; Fox, BS; Goeders, NE; Hefti, F; Kablinger, AS; Lindner, MA; McCarthy, BG; McNair, LA, 2012) |
| "Allopregnanolone and THDOC were measured using liquid chromatography-mass spectroscopy (LC-MS/MS) in the prefrontal cortex and amygdala in the brains from these rats." | 1.42 | A therapeutic combination of metyrapone and oxazepam increases brain levels of GABA-active neurosteroids and decreases cocaine self-administration in male rats. ( Dhungana, S; Goeders, NE; Guerin, GF; Runyon, SP; Schmoutz, CD, 2015) |
| "Metyrapone pretreatment dose-dependently decreased cocaine self-administration as demonstrated previously." | 1.40 | Role of GABA-active neurosteroids in the efficacy of metyrapone against cocaine addiction. ( Goeders, NE; Guerin, GF; Schmoutz, CD, 2014) |
| "Corticosterone levels were significantly different at the end of the 15-min session, but not following the 2-h session." | 1.39 | Combinations of oxazepam and metyrapone attenuate cocaine and methamphetamine cue reactivity. ( Cornett, EM; Goeders, NE; Guerin, GF; Keller, CM, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 6 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Keller, CM | 2 |
| Goeders, NE | 7 |
| Cornett, EM | 1 |
| Guerin, GF | 5 |
| Schmoutz, CD | 3 |
| Runyon, SP | 1 |
| Dhungana, S | 1 |
| Maćkowiak, M | 1 |
| Grzegorzewska, M | 1 |
| Budziszewska, B | 1 |
| Chocyk, A | 1 |
| Hess, G | 1 |
| Wedzony, K | 1 |
| Kablinger, AS | 1 |
| Lindner, MA | 1 |
| Casso, S | 1 |
| Hefti, F | 1 |
| DeMuth, G | 1 |
| Fox, BS | 1 |
| McNair, LA | 1 |
| McCarthy, BG | 1 |
| Schluger, JH | 1 |
| Borg, L | 1 |
| Ho, A | 1 |
| Kreek, MJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 1b, Randomized, Double-Blinded, Multiple-Dose, Placebo Controlled, Crossover Study To Evaluate The Safety, Tolerability And Pharmacokinetic Effects Of A Metyrapone And Oxazepam Combination (EMB-001) When Co-Administered With Cocaine[NCT02856854] | Phase 1 | 18 participants (Actual) | Interventional | 2016-07-31 | Completed | ||
| A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Study to Evaluate the Safety and Efficacy of EMB 001 in Subjects With Moderate-to-Severe Cocaine Use Disorder[NCT04501874] | Phase 2 | 82 participants (Actual) | Interventional | 2020-07-29 | Completed | ||
| Efficacy and Safety of Combination EMB-001 as a Potential Smoking Cessation Treatment[NCT04933916] | Phase 1/Phase 2 | 16 participants (Actual) | Interventional | 2021-06-10 | Terminated (stopped due to Business decision) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metyrapone and Cocaine Abuse
| Article | Year |
|---|---|
The combination of metyrapone and oxazepam for the treatment of cocaine and other drug addictions.
Topics: Animals; Anti-Anxiety Agents; Cocaine-Related Disorders; Humans; Metyrapone; Oxazepam; Stress, Psych | 2014 |
1 trial available for metyrapone and Cocaine Abuse
| Article | Year |
|---|---|
Effects of the combination of metyrapone and oxazepam on cocaine craving and cocaine taking: a double-blind, randomized, placebo-controlled pilot study.
Topics: Adult; Cocaine; Cocaine-Related Disorders; Diagnostic and Statistical Manual of Mental Disorders; Do | 2012 |
Effects of the combination of metyrapone and oxazepam on cocaine craving and cocaine taking: a double-blind, randomized, placebo-controlled pilot study.
Topics: Adult; Cocaine; Cocaine-Related Disorders; Diagnostic and Statistical Manual of Mental Disorders; Do | 2012 |
Effects of the combination of metyrapone and oxazepam on cocaine craving and cocaine taking: a double-blind, randomized, placebo-controlled pilot study.
Topics: Adult; Cocaine; Cocaine-Related Disorders; Diagnostic and Statistical Manual of Mental Disorders; Do | 2012 |
Effects of the combination of metyrapone and oxazepam on cocaine craving and cocaine taking: a double-blind, randomized, placebo-controlled pilot study.
Topics: Adult; Cocaine; Cocaine-Related Disorders; Diagnostic and Statistical Manual of Mental Disorders; Do | 2012 |
Effects of the combination of metyrapone and oxazepam on cocaine craving and cocaine taking: a double-blind, randomized, placebo-controlled pilot study.
Topics: Adult; Cocaine; Cocaine-Related Disorders; Diagnostic and Statistical Manual of Mental Disorders; Do | 2012 |
Effects of the combination of metyrapone and oxazepam on cocaine craving and cocaine taking: a double-blind, randomized, placebo-controlled pilot study.
Topics: Adult; Cocaine; Cocaine-Related Disorders; Diagnostic and Statistical Manual of Mental Disorders; Do | 2012 |
Effects of the combination of metyrapone and oxazepam on cocaine craving and cocaine taking: a double-blind, randomized, placebo-controlled pilot study.
Topics: Adult; Cocaine; Cocaine-Related Disorders; Diagnostic and Statistical Manual of Mental Disorders; Do | 2012 |
Effects of the combination of metyrapone and oxazepam on cocaine craving and cocaine taking: a double-blind, randomized, placebo-controlled pilot study.
Topics: Adult; Cocaine; Cocaine-Related Disorders; Diagnostic and Statistical Manual of Mental Disorders; Do | 2012 |
Effects of the combination of metyrapone and oxazepam on cocaine craving and cocaine taking: a double-blind, randomized, placebo-controlled pilot study.
Topics: Adult; Cocaine; Cocaine-Related Disorders; Diagnostic and Statistical Manual of Mental Disorders; Do | 2012 |
7 other studies available for metyrapone and Cocaine Abuse
| Article | Year |
|---|---|
Lack of effect of the combination of metyrapone and oxazepam on brain dopamine.
Topics: Animals; Brain; Cocaine; Cocaine-Related Disorders; Corticosterone; Dopamine; Dopamine Uptake Inhibi | 2019 |
Combinations of oxazepam and metyrapone attenuate cocaine and methamphetamine cue reactivity.
Topics: Amphetamine-Related Disorders; Analysis of Variance; Animals; Central Nervous System Stimulants; Coc | 2013 |
Role of GABA-active neurosteroids in the efficacy of metyrapone against cocaine addiction.
Topics: 5-alpha Reductase Inhibitors; Animals; Bicuculline; Cocaine; Cocaine-Related Disorders; Conditioning | 2014 |
A therapeutic combination of metyrapone and oxazepam increases brain levels of GABA-active neurosteroids and decreases cocaine self-administration in male rats.
Topics: Animals; Brain; Cocaine; Cocaine-Related Disorders; Desoxycorticosterone; Disease Models, Animal; Do | 2015 |
Cocaine decreases the expression of PSA-NCAM protein and attenuates long-term potentiation via glucocorticoid receptors in the rat dentate gyrus.
Topics: Animals; Bromodeoxyuridine; Cell Count; Cell Proliferation; Cocaine; Cocaine-Related Disorders; Cort | 2008 |
Effects of the combination of metyrapone and oxazepam on cocaine and food self-administration in rats.
Topics: Animals; Cocaine-Related Disorders; Conditioning, Operant; Corticosterone; Dose-Response Relationshi | 2008 |
Altered HPA axis responsivity to metyrapone testing in methadone maintained former heroin addicts with ongoing cocaine addiction.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Cocaine-Related Disorders; Female; Heroin Dependence | 2001 |