doxazosin has been researched along with Cocaine Abuse in 3 studies
Doxazosin: A prazosin-related compound that is a selective alpha-1-adrenergic blocker.
doxazosin : A member of the class of quinazolines that is quinazoline substituted by an amino group at position 4, methoxy groups at positions 6 and 7 and a piperazin-1-yl group at position 2 which in turn is substituted by a 2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl group at position 4. An antihypertensive agent, it is used in the treatment of high blood pressure.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Doxazosin treatment was well tolerated and doxazosin alone produced minimal changes in heart rate and blood pressure." | 2.77 | Noradrenergic α₁ receptor antagonist treatment attenuates positive subjective effects of cocaine in humans: a randomized trial. ( Brown, G; De La Garza, R; Haile, CN; Kosten, TR; Mahoney, JJ; Newton, TF, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, X | 1 |
| Nielsen, DA | 1 |
| Domingo, CB | 1 |
| Shorter, DI | 1 |
| Nielsen, EM | 1 |
| Kosten, TR | 3 |
| Newton, TF | 1 |
| De La Garza, R | 1 |
| Brown, G | 1 |
| Mahoney, JJ | 1 |
| Haile, CN | 1 |
| Shorter, D | 1 |
| Lindsay, JA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effects of Doxazosin on the Cardiovascular and Subjective Effects of Cocaine[NCT01062945] | Phase 1 | 13 participants (Actual) | Interventional | 2010-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for doxazosin and Cocaine Abuse
| Article | Year |
|---|---|
Pharmacogenetics of Dopamine β-Hydroxylase in cocaine dependence therapy with doxazosin.
Topics: Adrenergic alpha-1 Receptor Antagonists; Cocaine-Related Disorders; Dopamine beta-Hydroxylase; Doubl | 2019 |
Noradrenergic α₁ receptor antagonist treatment attenuates positive subjective effects of cocaine in humans: a randomized trial.
Topics: Adolescent; Adrenergic alpha-1 Receptor Antagonists; Adult; Blood Pressure; Cocaine; Cocaine-Related | 2012 |
The alpha-1 adrenergic antagonist doxazosin for treatment of cocaine dependence: A pilot study.
Topics: Adrenergic alpha-1 Receptor Antagonists; Aged; Cocaine-Related Disorders; Double-Blind Method; Doxaz | 2013 |