ketoconazole has been researched along with Cocaine Abuse in 4 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To explore the treatment implications of these findings, ketoconazole's (600-900 mg daily) ability to reduce heroin and cocaine use was compared with placebo in 39 methadone maintained patients with a history of cocaine abuse or dependence during a 12-week double blind trial." | 5.10 | Ketoconazole increases cocaine and opioid use in methadone maintained patients. ( Feingold, A; Gonsai, K; Kosten, TR; Oliveto, A; Sevarino, KA, 2002) |
| "Pretreatment with ketoconazole reversed the conditioned reinforcer-induced reinstatement of extinguished cocaine-seeking behavior and also attenuated the conditioned increases in plasma corticosterone observed during reinstatement." | 1.31 | Potential role for the hypothalamo-pituitary-adrenal axis in the conditioned reinforcer-induced reinstatement of extinguished cocaine seeking in rats. ( Clampitt, DM; Goeders, NE, 2002) |
| "Ketoconazole is an FDA-approved antifungal agent that also blocks the synthesis of adrenocorticosteroids and functions as a glucocorticoid receptor antagonist." | 1.30 | Ketoconazole does not block cocaine discrimination or the cocaine-induced reinstatement of cocaine-seeking behavior. ( Goeders, NE; Mantsch, JR, 1999) |
| "Pretreatment with ketoconazole (25 mg/kg, i." | 1.30 | Ketoconazole reduces low dose cocaine self-administration in rats. ( Goeders, NE; Guerin, GF; Peltier, RL, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mantsch, JR | 1 |
| Goeders, NE | 3 |
| Peltier, RL | 1 |
| Guerin, GF | 1 |
| Kosten, TR | 1 |
| Oliveto, A | 1 |
| Sevarino, KA | 1 |
| Gonsai, K | 1 |
| Feingold, A | 1 |
| Clampitt, DM | 1 |
1 trial available for ketoconazole and Cocaine Abuse
| Article | Year |
|---|---|
Ketoconazole increases cocaine and opioid use in methadone maintained patients.
Topics: Analysis of Variance; Antifungal Agents; Chi-Square Distribution; Cocaine-Related Disorders; Double- | 2002 |
3 other studies available for ketoconazole and Cocaine Abuse
| Article | Year |
|---|---|
Ketoconazole does not block cocaine discrimination or the cocaine-induced reinstatement of cocaine-seeking behavior.
Topics: Animals; Antifungal Agents; Catheterization; Cocaine; Cocaine-Related Disorders; Corticosterone; Dis | 1999 |
Ketoconazole reduces low dose cocaine self-administration in rats.
Topics: Animals; Arousal; Cocaine-Related Disorders; Corticosterone; Dose-Response Relationship, Drug; Hypot | 1998 |
Potential role for the hypothalamo-pituitary-adrenal axis in the conditioned reinforcer-induced reinstatement of extinguished cocaine seeking in rats.
Topics: Analysis of Variance; Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Corticoste | 2002 |