tacrine has been researched along with Cocaine Abuse in 4 studies
Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pilocarpine is a nonselective muscarinic agonist that is used clinically, but has not been well characterized for its actions during cocaine-reinforced behavior." | 1.51 | The muscarinic agonist pilocarpine modifies cocaine-reinforced and food-reinforced responding in rats: comparison with the cholinesterase inhibitor tacrine. ( Grasing, KW; Idowu, JY; Xu, H, 2019) |
| "When tacrine was administered over four days which were preceded and followed by washout periods to allow elimination of cocaine and tacrine respectively, subsequent cocaine self-administration was attenuated by more than one-half." | 1.42 | Enduring effects of tacrine on cocaine-reinforced behavior: Analysis by conditioned-place preference, temporal separation from drug reward, and reinstatement. ( Grasing, K; He, S; Yang, Y, 2015) |
| "Tacrine is a centrally acting, reversible cholinesterase inhibitor that increases synaptic levels of acetylcholine (ACh) and can potentiate the actions of dopamine (DA)." | 1.35 | Long-lasting decreases in cocaine-reinforced behavior following treatment with the cholinesterase inhibitor tacrine in rats selectively bred for drug self-administration. ( Grasing, K; He, S; Yang, Y, 2009) |
| "Tacrine is a centrally acting, reversible cholinesterase inhibitor that also inhibits monoamine oxidase (MAO) and blocks reuptake of dopamine (DA) and serotonin." | 1.35 | Dose-related effects of the acetylcholinesterase inhibitor tacrine on cocaine and food self-administration in rats. ( Grasing, K; He, S; Yang, Y, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Grasing, KW | 1 |
| Xu, H | 1 |
| Idowu, JY | 1 |
| Grasing, K | 3 |
| Yang, Y | 3 |
| He, S | 3 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Tacrine Effects on Cocaine Self-Administration and Pharmacokinetics[NCT01406522] | Phase 2 | 0 participants (Actual) | Interventional | 2012-10-31 | Withdrawn (stopped due to One of the study medications, tacrine, is no longer clinically available) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 other studies available for tacrine and Cocaine Abuse
| Article | Year |
|---|---|
The muscarinic agonist pilocarpine modifies cocaine-reinforced and food-reinforced responding in rats: comparison with the cholinesterase inhibitor tacrine.
Topics: Animals; Cholinesterase Inhibitors; Cholinesterases; Cocaine; Cocaine-Related Disorders; Conditionin | 2019 |
Enduring effects of tacrine on cocaine-reinforced behavior: Analysis by conditioned-place preference, temporal separation from drug reward, and reinstatement.
Topics: Animals; Cholinergic Agonists; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dose-Respo | 2015 |
Long-lasting decreases in cocaine-reinforced behavior following treatment with the cholinesterase inhibitor tacrine in rats selectively bred for drug self-administration.
Topics: Algorithms; Animals; Behavior, Animal; Body Weight; Breeding; Cholinergic Agents; Cholinesterase Inh | 2009 |
Dose-related effects of the acetylcholinesterase inhibitor tacrine on cocaine and food self-administration in rats.
Topics: Animals; Appetitive Behavior; Association Learning; Cholinesterase Inhibitors; Cocaine; Cocaine-Rela | 2008 |