gamma-aminobutyric acid has been researched along with Cocaine Abuse in 62 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Tiagabine significantly reduced cocaine taking behavior compared to placebo or gabapentin among methadone-stabilized cocaine abusers." | 5.12 | Clinical efficacy of gabapentin versus tiagabine for reducing cocaine use among cocaine dependent methadone-treated patients. ( Desai, R; Gonsai, K; González, G; Kosten, TR; Oliveto, A; Poling, J; Sofuoglu, M, 2007) |
| "Low dopamine D2 receptor (D2R) availability in the striatum can predispose for cocaine abuse; though how low striatal D2Rs facilitate cocaine reward is unclear." | 4.12 | Dopamine D2 receptors bidirectionally regulate striatal enkephalin expression: Implications for cocaine reward. ( Alvarez, VA; Blegen, MB; Bocarsly, ME; Choi, IB; Dai, KZ; Dobbs, LK; Kaplan, AR; Kellendonk, C; Levitt, R; Matsui, A; Shin, JH; Simpson, EH, 2022) |
| "Cocaine dependence is a major public health problem with no available robustly effective pharmacotherapy." | 2.79 | Clinical efficacy of sertraline alone and augmented with gabapentin in recently abstinent cocaine-dependent patients with depressive symptoms. ( Cargile, C; Chopra, MP; Guise, JB; Kosten, TR; Mancino, MJ; McGaugh, J; Oliveto, A; Sanders, N; Thostenson, J; Williams, DK, 2014) |
| "Gabapentin showed poor treatment retention and ineffectiveness in reducing cocaine use." | 2.73 | Clinical efficacy of gabapentin versus tiagabine for reducing cocaine use among cocaine dependent methadone-treated patients. ( Desai, R; Gonsai, K; González, G; Kosten, TR; Oliveto, A; Poling, J; Sofuoglu, M, 2007) |
| "Gabapentin is an anticonvulsant medication that increases human brain GABA levels." | 2.72 | A randomized placebo-controlled trial of gabapentin for cocaine dependence. ( Aharonovich, E; Bisaga, A; Garawi, F; Levin, FR; Nunes, EV; Raby, WN; Rubin, E, 2006) |
| "Gabapentin appeared to be a safe and efficacious medication to reduce cocaine usage in a community sample of psychiatric patients." | 2.71 | Gabapentin reduces cocaine use among addicts from a community clinic sample. ( Coomaraswamy, S; Raby, WN, 2004) |
| "Gabapentin was hypothesized to reduce cocaine use by restoring inhibitory GABAergic feedback on ascending dopaminergic projections to nucleus accumbens neurons." | 2.71 | Gabapentin reduces cocaine use among addicts from a community clinic sample. ( Coomaraswamy, S; Raby, WN, 2004) |
| "Pramipexole-treated subjects had significantly increased brain GABA levels compared to placebo (p=0." | 2.71 | Prefrontal GABA levels in cocaine-dependent subjects increase with pramipexole and venlafaxine treatment. ( Ciraulo, DA; Hennen, J; Jensen, JE; Ke, Y; Knapp, C; Kwak, T; Meyer, AA; Nassar, LE; Renshaw, PF; Sarid-Segal, O; Streeter, CC, 2005) |
| "CD subjects enrolled in a treatment trial for cocaine dependence were recruited for this proton (1H) magnetic resonance spectroscopy (MRS) study." | 2.71 | Prefrontal GABA levels in cocaine-dependent subjects increase with pramipexole and venlafaxine treatment. ( Ciraulo, DA; Hennen, J; Jensen, JE; Ke, Y; Knapp, C; Kwak, T; Meyer, AA; Nassar, LE; Renshaw, PF; Sarid-Segal, O; Streeter, CC, 2005) |
| "Problematic compounds may cause seizures either acutely or on withdrawal: Their use may reduce effectiveness of antiepileptic drugs, or may simply promote and enhance chaotic lifestyles." | 2.48 | Alcohol and drugs in epilepsy: pathophysiology, presentation, possibilities, and prevention. ( Borland, W; Leach, JP; Mohanraj, R, 2012) |
| "In contrast, immunotherapies for cocaine addiction are based on the blockade of cocaine effects peripherally, and as a result, prevent or at least slow the entry of cocaine into the brain." | 2.43 | Novel approaches to the treatment of cocaine addiction. ( Kosten, TR; Sofuoglu, M, 2005) |
| " Since corticomesolimbic dopaminergic neurons interact with other neurotransmitters that modulate the effects of dopamine in the nucleus accumbens, would it not be possible to control these dopaminergic effects more reliably with a medication that acts contemporaneously on more than one neuromodulator of dopaminergic function? Further, since the long-term use of either alcohol or cocaine results in neuronal adaptations as a result of sensitisation, would the chances of effective therapy not be bolstered by administering a medication that was also able to mitigate these chronic effects? Thus, a new conceptual approach is needed." | 2.43 | Recent advances in the development of treatments for alcohol and cocaine dependence: focus on topiramate and other modulators of GABA or glutamate function. ( Johnson, BA, 2005) |
| "Smoking polysubstance users were more impulsive than smokers, and both groups were more impulsive than controls." | 1.46 | Prefrontal Glx and GABA concentrations and impulsivity in cigarette smokers and smoking polysubstance users. ( Goudriaan, AE; Homberg, JR; Kaag, AM; Reneman, L; Schmaal, L; Schulte, MHJ; van den Brink, W; van Wingen, GA; Wiers, RW, 2017) |
| "Cocaine addiction is a chronically relapsing disorder that is associated with harmful consequences." | 1.43 | Glutamatergic and neurometabolic alterations in chronic cocaine users measured with (1) H-magnetic resonance spectroscopy. ( Baumgartner, MR; Henning, A; Herdener, M; Hulka, LM; Preller, KH; Quednow, BB; Scheidegger, M; Seifritz, E; Vonmoos, M, 2016) |
| "4 mg/kg) produced a downward shift in the cocaine dose-response curve under a fixed ratio schedule of reinforcement and decreased the cocaine breaking point." | 1.42 | On the role of adenosine (A)₂A receptors in cocaine-induced reward: a pharmacological and neurochemical analysis in rats. ( Filip, M; Fuxe, K; Gołembiowska, K; Kamińska, K; Suder, A; Wydra, K, 2015) |
| "Gabapentin is a gamma-aminobutyric acid (GABA) analogue, with GABAmimetic pharmacological properties." | 1.35 | Effects of gabapentin on cocaine self-administration, cocaine-triggered relapse and cocaine-enhanced nucleus accumbens dopamine in rats. ( Ashby, CR; Gagare, PD; Gardner, EL; Li, J; Li, X; Peng, XQ; Pratihar, D; Ramachandran, PV; Xi, ZX, 2008) |
| " Initial studies examined the dose-response effects of injection of baclofen (0." | 1.33 | Injections of baclofen into the ventral medial prefrontal cortex block the initiation, but not the expression, of cocaine sensitization in rats. ( Beyer, CE; Steketee, JD, 2005) |
| "In the first series of experiments, three dose-response curves were generated that examined the effect of three doses of baclofen (1." | 1.31 | Effect of baclofen on cocaine self-administration in rats reinforced under fixed-ratio 1 and progressive-ratio schedules. ( Brebner, K; Phelan, R; Roberts, DC, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (6.45) | 18.2507 |
| 2000's | 40 (64.52) | 29.6817 |
| 2010's | 15 (24.19) | 24.3611 |
| 2020's | 3 (4.84) | 2.80 |
| Authors | Studies |
|---|---|
| Dai, KZ | 1 |
| Choi, IB | 1 |
| Levitt, R | 1 |
| Blegen, MB | 1 |
| Kaplan, AR | 1 |
| Matsui, A | 1 |
| Shin, JH | 1 |
| Bocarsly, ME | 1 |
| Simpson, EH | 1 |
| Kellendonk, C | 1 |
| Alvarez, VA | 1 |
| Dobbs, LK | 1 |
| Velasquez-Martinez, MC | 1 |
| Santos-Vera, B | 1 |
| Velez-Hernandez, ME | 1 |
| Vazquez-Torres, R | 1 |
| Jimenez-Rivera, CA | 1 |
| Freese, L | 1 |
| Fraga de Souza, M | 1 |
| Schüler Nin, M | 1 |
| Calleti, G | 1 |
| Flores Peres, V | 1 |
| Gomez, R | 1 |
| Maria Tannhauser Barros, H | 1 |
| Schulte, MHJ | 1 |
| Kaag, AM | 1 |
| Wiers, RW | 1 |
| Schmaal, L | 1 |
| van den Brink, W | 1 |
| Reneman, L | 1 |
| Homberg, JR | 1 |
| van Wingen, GA | 1 |
| Goudriaan, AE | 1 |
| Li, Y | 1 |
| Yu, L | 1 |
| Zhao, L | 1 |
| Zeng, F | 1 |
| Liu, QS | 1 |
| Enoch, MA | 1 |
| Baghal, B | 1 |
| Yuan, Q | 1 |
| Goldman, D | 1 |
| Kallupi, M | 2 |
| Wee, S | 1 |
| Edwards, S | 2 |
| Whitfield, TW | 1 |
| Oleata, CS | 1 |
| Luu, G | 1 |
| Schmeichel, BE | 1 |
| Koob, GF | 1 |
| Roberto, M | 1 |
| Bocklisch, C | 1 |
| Pascoli, V | 1 |
| Wong, JC | 1 |
| House, DR | 1 |
| Yvon, C | 1 |
| de Roo, M | 1 |
| Tan, KR | 1 |
| Lüscher, C | 2 |
| Mancino, MJ | 1 |
| McGaugh, J | 1 |
| Chopra, MP | 1 |
| Guise, JB | 1 |
| Cargile, C | 1 |
| Williams, DK | 1 |
| Thostenson, J | 1 |
| Kosten, TR | 4 |
| Sanders, N | 1 |
| Oliveto, A | 2 |
| Wydra, K | 1 |
| Gołembiowska, K | 1 |
| Suder, A | 1 |
| Kamińska, K | 1 |
| Fuxe, K | 1 |
| Filip, M | 2 |
| Hulka, LM | 1 |
| Scheidegger, M | 1 |
| Vonmoos, M | 1 |
| Preller, KH | 1 |
| Baumgartner, MR | 1 |
| Herdener, M | 1 |
| Seifritz, E | 1 |
| Henning, A | 1 |
| Quednow, BB | 1 |
| Sotomayor-Zárate, R | 1 |
| Abarca, J | 1 |
| Araya, KA | 1 |
| Renard, GM | 1 |
| Andrés, ME | 1 |
| Gysling, K | 1 |
| Keralapurath, MM | 1 |
| Briggs, SB | 1 |
| Wagner, JJ | 1 |
| Engblom, D | 1 |
| Bilbao, A | 1 |
| Sanchis-Segura, C | 1 |
| Dahan, L | 1 |
| Perreau-Lenz, S | 1 |
| Balland, B | 1 |
| Parkitna, JR | 1 |
| Luján, R | 1 |
| Halbout, B | 1 |
| Mameli, M | 1 |
| Parlato, R | 1 |
| Sprengel, R | 1 |
| Schütz, G | 1 |
| Spanagel, R | 1 |
| Steffensen, SC | 1 |
| Taylor, SR | 1 |
| Horton, ML | 1 |
| Barber, EN | 1 |
| Lyle, LT | 1 |
| Stobbs, SH | 1 |
| Allison, DW | 1 |
| Xi, ZX | 4 |
| Gardner, EL | 4 |
| Lu, H | 1 |
| Cheng, PL | 1 |
| Lim, BK | 1 |
| Khoshnevisrad, N | 1 |
| Poo, MM | 1 |
| Miguéns, M | 1 |
| Botreau, F | 1 |
| Olías, O | 1 |
| Del Olmo, N | 1 |
| Coria, SM | 1 |
| Higuera-Matas, A | 1 |
| Ambrosio, E | 1 |
| Horey, JT | 1 |
| Mariani, JJ | 1 |
| Cheng, WY | 1 |
| Bisaga, A | 3 |
| Sullivan, M | 1 |
| Nunes, E | 1 |
| Levin, FR | 2 |
| de Guglielmo, G | 1 |
| Cippitelli, A | 1 |
| Somaini, L | 1 |
| Gerra, G | 1 |
| Li, H | 1 |
| Stopponi, S | 1 |
| Ubaldi, M | 1 |
| Ciccocioppo, R | 1 |
| Leach, JP | 1 |
| Mohanraj, R | 1 |
| Borland, W | 1 |
| Hotsenpiller, G | 1 |
| Wolf, ME | 1 |
| Ramamoorthy, S | 1 |
| Shen, H | 1 |
| Lake, R | 1 |
| Samuvel, DJ | 1 |
| Kalivas, PW | 3 |
| Raby, WN | 3 |
| Coomaraswamy, S | 1 |
| Ke, Y | 2 |
| Streeter, CC | 2 |
| Nassar, LE | 2 |
| Sarid-Segal, O | 2 |
| Hennen, J | 2 |
| Yurgelun-Todd, DA | 1 |
| Awad, LA | 1 |
| Rendall, MJ | 1 |
| Gruber, SA | 1 |
| Nason, A | 1 |
| Mudrick, MJ | 1 |
| Blank, SR | 1 |
| Meyer, AA | 2 |
| Knapp, C | 2 |
| Ciraulo, DA | 2 |
| Renshaw, PF | 2 |
| Todtenkopf, MS | 1 |
| Stellar, JR | 1 |
| Williams, EA | 1 |
| Zahm, DS | 1 |
| Kikusui, T | 1 |
| Faccidomo, S | 1 |
| Miczek, KA | 1 |
| Sofuoglu, M | 3 |
| Mathon, DS | 1 |
| Lesscher, HM | 1 |
| Gerrits, MA | 1 |
| Kamal, A | 1 |
| Pintar, JE | 1 |
| Schuller, AG | 1 |
| Spruijt, BM | 1 |
| Burbach, JP | 1 |
| Smidt, MP | 1 |
| van Ree, JM | 1 |
| Ramakers, GM | 1 |
| Steketee, JD | 3 |
| Beyer, CE | 1 |
| Berger, SP | 1 |
| Winhusen, TM | 1 |
| Somoza, EC | 1 |
| Harrer, JM | 1 |
| Mezinskis, JP | 1 |
| Leiderman, DB | 1 |
| Montgomery, MA | 1 |
| Goldsmith, RJ | 1 |
| Bloch, DA | 1 |
| Singal, BM | 1 |
| Elkashef, A | 1 |
| Jayaram, P | 1 |
| Perrotti, LI | 1 |
| Bolaños, CA | 1 |
| Choi, KH | 1 |
| Russo, SJ | 1 |
| Ulery, PG | 1 |
| Wallace, DL | 1 |
| Self, DW | 1 |
| Nestler, EJ | 1 |
| Barrot, M | 1 |
| Jensen, JE | 1 |
| Kwak, T | 1 |
| Haney, M | 2 |
| Hart, C | 1 |
| Collins, ED | 1 |
| Foltin, RW | 2 |
| Aharonovich, E | 2 |
| Garawi, F | 1 |
| Rubin, E | 2 |
| Nunes, EV | 2 |
| Hasin, DS | 1 |
| Brooks, AC | 1 |
| Liu, X | 1 |
| Johnson, BA | 1 |
| Frankowska, M | 1 |
| Gołda, A | 1 |
| Zaniewska, M | 1 |
| Vetulani, J | 1 |
| Przegaliński, E | 1 |
| Buxhoeveden, DP | 1 |
| Hasselrot, U | 1 |
| Buxhoeveden, NE | 1 |
| Booze, RM | 1 |
| Mactutus, CF | 1 |
| Gilbert, JG | 1 |
| Peng, XQ | 2 |
| Pak, AC | 1 |
| Li, X | 2 |
| González, G | 1 |
| Desai, R | 1 |
| Poling, J | 1 |
| Gonsai, K | 1 |
| Hart, CL | 1 |
| Vosburg, SK | 1 |
| Weerts, EM | 1 |
| Froestl, W | 1 |
| Kaminski, BJ | 1 |
| Griffiths, RR | 1 |
| Sundaresan, K | 1 |
| Ziemann, U | 1 |
| Stanley, J | 1 |
| Boutros, N | 1 |
| You, ZB | 1 |
| Wang, B | 1 |
| Zitzman, D | 1 |
| Azari, S | 1 |
| Wise, RA | 1 |
| Li, J | 1 |
| Ramachandran, PV | 1 |
| Gagare, PD | 1 |
| Pratihar, D | 1 |
| Ashby, CR | 2 |
| Torregrossa, MM | 2 |
| Tang, XC | 1 |
| Vescovi, PP | 1 |
| Di Gennaro, C | 1 |
| Dewey, SL | 1 |
| Morgan, AE | 1 |
| Horan, B | 1 |
| Kushner, SA | 1 |
| Logan, J | 1 |
| Volkow, ND | 1 |
| Fowler, JS | 1 |
| Brodie, JD | 1 |
| Wickelgren, I | 1 |
| Jung, BJ | 1 |
| Dawson, R | 1 |
| Sealey, SA | 1 |
| Peris, J | 1 |
| Brebner, K | 1 |
| Phelan, R | 1 |
| Roberts, DC | 1 |
| Myrick, H | 1 |
| Henderson, S | 1 |
| Brady, KT | 1 |
| Malcolm, R | 1 |
| Stanwood, GD | 1 |
| Washington, RA | 1 |
| Shumsky, JS | 1 |
| Levitt, P | 1 |
| Kozell, LB | 1 |
| Meshul, CK | 1 |
| Hyman, SE | 1 |
| Yamaguchi, M | 1 |
| Suzuki, T | 1 |
| Abe, S | 1 |
| Baba, A | 1 |
| Hori, T | 1 |
| Okado, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Efficacy of Strategic Memory Training Coupled With Non-invasive Brain Stimulation Techniques in Healthy Aging Population and Subjective Cognitive Decline Patients: a Randomized-controlled Study[NCT05929872] | 56 participants (Anticipated) | Interventional | 2023-07-30 | Not yet recruiting | |||
| Treatment of Crack-cocaine Addiction Through Cognitive Neuromodulation of the Prefrontal Cortex Produced by Transcranial Direct Current Stimulation.[NCT01337297] | Phase 1/Phase 2 | 20 participants (Actual) | Interventional | 2011-06-30 | Completed | ||
| Neural Mechanistic Explanations for Differential Drug Abuse Treatment Outcomes[NCT01678833] | 7 participants (Actual) | Observational | 2012-07-19 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
abstinence to the use of crack-cocaine up to 3 months after the completion of two-weeks of treatment sessions with active-tDCS or sham-tDCS. (NCT01337297)
Timeframe: Two days after the end of tDCS treatment (one session every other day, 5 sessions), that is, on the 12nd day from the beginning.
| Intervention | percentage of participants (Number) |
|---|---|
| Active-tDCS | 71.4 |
| Sham-tDCS | 16.6 |
6 reviews available for gamma-aminobutyric acid and Cocaine Abuse
| Article | Year |
|---|---|
Hypothesis-driven medication discovery for the treatment of psychostimulant addiction.
Topics: Animals; Brain; Cannabinoid Receptor Modulators; Central Nervous System Stimulants; Cocaine-Related | 2008 |
Alcohol and drugs in epilepsy: pathophysiology, presentation, possibilities, and prevention.
Topics: Alcohol Drinking; Alcohol Withdrawal Seizures; Alcoholism; Amphetamine-Related Disorders; Benzodiaze | 2012 |
Novel approaches to the treatment of cocaine addiction.
Topics: Adrenergic Agents; Animals; Brain; Cocaine-Related Disorders; Disulfiram; Dopamine; Dopamine Agents; | 2005 |
Recent advances in the development of treatments for alcohol and cocaine dependence: focus on topiramate and other modulators of GABA or glutamate function.
Topics: Alcoholism; Animals; Cocaine-Related Disorders; Fructose; gamma-Aminobutyric Acid; Glutamic Acid; Hu | 2005 |
Emerging pharmacological strategies in the fight against cocaine addiction.
Topics: Adrenergic beta-Antagonists; Animals; Benzhydryl Compounds; Brain; Central Nervous System Stimulants | 2006 |
Cortical mechanisms of cocaine sensitization.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Dopamine; Dopamine Uptake Inhibitors; gamma-Aminobutyri | 2005 |
11 trials available for gamma-aminobutyric acid and Cocaine Abuse
| Article | Year |
|---|---|
Clinical efficacy of sertraline alone and augmented with gabapentin in recently abstinent cocaine-dependent patients with depressive symptoms.
Topics: Adult; Amines; Cocaine-Related Disorders; Cognitive Behavioral Therapy; Combined Modality Therapy; C | 2014 |
Comparison of substance use milestones in cannabis- and cocaine-dependent patients.
Topics: Adult; Age of Onset; Amines; Antidepressive Agents, Second-Generation; Bupropion; Cocaine-Related Di | 2012 |
Gabapentin reduces cocaine use among addicts from a community clinic sample.
Topics: Acetates; Adult; Amines; Cocaine-Related Disorders; Cyclohexanecarboxylic Acids; Diagnosis, Dual (Ps | 2004 |
A medication screening trial evaluation of reserpine, gabapentin and lamotrigine pharmacotherapy of cocaine dependence.
Topics: Adult; Amines; Anticonvulsants; Antipsychotic Agents; Cocaine-Related Disorders; Cyclohexanecarboxyl | 2005 |
Prefrontal GABA levels in cocaine-dependent subjects increase with pramipexole and venlafaxine treatment.
Topics: Adult; Antidepressive Agents, Second-Generation; Antioxidants; Benzothiazoles; Cocaine-Related Disor | 2005 |
Smoked cocaine discrimination in humans: effects of gabapentin.
Topics: Administration, Inhalation; Adult; Amines; Arousal; Cocaine; Cocaine-Related Disorders; Cyclohexanec | 2005 |
A randomized placebo-controlled trial of gabapentin for cocaine dependence.
Topics: Adult; Amines; Cocaine-Related Disorders; Cyclohexanecarboxylic Acids; Double-Blind Method; Excitato | 2006 |
Clinical efficacy of gabapentin versus tiagabine for reducing cocaine use among cocaine dependent methadone-treated patients.
Topics: Adult; Amines; Anti-Anxiety Agents; Cocaine-Related Disorders; Cognitive Behavioral Therapy; Combine | 2007 |
Gabapentin does not reduce smoked cocaine self-administration: employment of a novel self-administration procedure.
Topics: Adult; Affect; Ambulatory Care; Amines; Arousal; Blood Pressure; Choice Behavior; Cocaine; Cocaine-R | 2007 |
Failure of gammahydroxy butyric acid to stimulate growth hormone secretion in cocaine addicts.
Topics: Adult; Case-Control Studies; Cocaine-Related Disorders; gamma-Aminobutyric Acid; Human Growth Hormon | 1997 |
Gabapentin in the treatment of cocaine dependence: a case series.
Topics: Acetates; Adolescent; Adult; Amines; Anticonvulsants; Behavior, Addictive; Cocaine-Related Disorders | 2001 |
45 other studies available for gamma-aminobutyric acid and Cocaine Abuse
| Article | Year |
|---|---|
Dopamine D2 receptors bidirectionally regulate striatal enkephalin expression: Implications for cocaine reward.
Topics: Analgesics, Opioid; Animals; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Enkephalin, Methio | 2022 |
Alpha-1 Adrenergic Receptors Modulate Glutamate and GABA Neurotransmission onto Ventral Tegmental Dopamine Neurons during Cocaine Sensitization.
Topics: Action Potentials; Animals; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopaminergic | 2020 |
Elevated GABA levels in the medial prefrontal cortex and lower estrogen levels abolish cocaine sensitization behavior in ovariectomized female rats.
Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Upta | 2020 |
Prefrontal Glx and GABA concentrations and impulsivity in cigarette smokers and smoking polysubstance users.
Topics: Cigarette Smoking; Cocaine-Related Disorders; gamma-Aminobutyric Acid; Glutamic Acid; Gyrus Cinguli; | 2017 |
Resveratrol modulates cocaine-induced inhibitory synaptic plasticity in VTA dopamine neurons by inhibiting phosphodiesterases (PDEs).
Topics: Aging; Animals; Cocaine; Cocaine-Related Disorders; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases | 2017 |
A factor analysis of global GABAergic gene expression in human brain identifies specificity in response to chronic alcohol and cocaine exposure.
Topics: Adolescent; Adult; Alcoholics; Alcoholism; Cerebellum; Cocaine; Cocaine-Related Disorders; Ethanol; | 2013 |
Kappa opioid receptor-mediated dysregulation of gamma-aminobutyric acidergic transmission in the central amygdala in cocaine addiction.
Topics: Amygdala; Animals; Cocaine; Cocaine-Related Disorders; gamma-Aminobutyric Acid; Inhibitory Postsynap | 2013 |
Cocaine disinhibits dopamine neurons by potentiation of GABA transmission in the ventral tegmental area.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Dopaminergic Neurons; gamma-Aminobutyric Acid; Mice; Mi | 2013 |
On the role of adenosine (A)₂A receptors in cocaine-induced reward: a pharmacological and neurochemical analysis in rats.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Basal Forebrain; Behavior, Animal; Cocaine; Coca | 2015 |
Glutamatergic and neurometabolic alterations in chronic cocaine users measured with (1) H-magnetic resonance spectroscopy.
Topics: Adult; Aspartic Acid; Case-Control Studies; Choline; Cocaine-Related Disorders; Creatine; gamma-Amin | 2016 |
Exposure to repeated immobilization stress inhibits cocaine-induced increase in dopamine extracellular levels in the rat ventral tegmental area.
Topics: Animals; Bicuculline; Cocaine; Cocaine-Related Disorders; Corticotropin-Releasing Hormone; Dopamine; | 2015 |
Cocaine self-administration induces changes in synaptic transmission and plasticity in ventral hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; CA1 Region, Hippocampal; Cocaine; | 2017 |
Glutamate receptors on dopamine neurons control the persistence of cocaine seeking.
Topics: Animals; Behavior, Animal; Cocaine-Related Disorders; Conditioning, Operant; Dopamine; Excitatory Am | 2008 |
Cocaine disinhibits dopamine neurons in the ventral tegmental area via use-dependent blockade of GABA neuron voltage-sensitive sodium channels.
Topics: Action Potentials; Animals; Cocaine; Cocaine-Related Disorders; Dopamine; Dopamine Plasma Membrane T | 2008 |
Elevated BDNF after cocaine withdrawal facilitates LTP in medial prefrontal cortex by suppressing GABA inhibition.
Topics: Animals; Animals, Newborn; Biophysics; Brain-Derived Neurotrophic Factor; Carbazoles; Cocaine; Cocai | 2010 |
Genetic differences in the modulation of accumbal glutamate and γ-amino butyric acid levels after cocaine-induced reinstatement.
Topics: Analysis of Variance; Animals; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine | 2013 |
Pregabalin reduces cocaine self-administration and relapse to cocaine seeking in the rat.
Topics: Adrenergic alpha-2 Receptor Antagonists; Analysis of Variance; Animals; Anticonvulsants; Cocaine; Co | 2013 |
Baclofen attenuates conditioned locomotion to cues associated with cocaine administration and stabilizes extracellular glutamate levels in rat nucleus accumbens.
Topics: Animals; Baclofen; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Cues; Disease Mo | 2003 |
GABA transmission in the nucleus accumbens is altered after withdrawal from repeated cocaine.
Topics: Animals; Binding, Competitive; Chronic Disease; Cocaine; Cocaine-Related Disorders; Disease Models, | 2003 |
Frontal lobe GABA levels in cocaine dependence: a two-dimensional, J-resolved magnetic resonance spectroscopy study.
Topics: Adult; Cocaine-Related Disorders; Female; Frontal Lobe; gamma-Aminobutyric Acid; Humans; Magnetic Re | 2004 |
Differential distribution of parvalbumin immunoreactive neurons in the striatum of cocaine sensitized rats.
Topics: Animals; Cell Count; Cocaine; Cocaine-Related Disorders; Drug Administration Schedule; Drug Toleranc | 2004 |
Repeated maternal separation: differences in cocaine-induced behavioral sensitization in adult male and female mice.
Topics: Animals; Arousal; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Dopamine Pl | 2005 |
Increased gabaergic input to ventral tegmental area dopaminergic neurons associated with decreased cocaine reinforcement in mu-opioid receptor knockout mice.
Topics: Afferent Pathways; Animals; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine; ga | 2005 |
Injections of baclofen into the ventral medial prefrontal cortex block the initiation, but not the expression, of cocaine sensitization in rats.
Topics: Animals; Baclofen; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Dose-Response Re | 2005 |
Effects of cocaine-induced behavioural sensitization on GABA transmission within rat medial prefrontal cortex.
Topics: Analysis of Variance; Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Cocaine; Coca | 2005 |
DeltaFosB accumulates in a GABAergic cell population in the posterior tail of the ventral tegmental area after psychostimulant treatment.
Topics: Animals; Cocaine; Cocaine-Related Disorders; gamma-Aminobutyric Acid; Kinetics; Male; Morphine; Prot | 2005 |
Cognitive deficits predict low treatment retention in cocaine dependent patients.
Topics: Adult; Amines; Cocaine-Related Disorders; Cognition Disorders; Cognitive Behavioral Therapy; Cyclohe | 2006 |
Cognitive deficits predict low treatment retention in cocaine dependent patients.
Topics: Adult; Amines; Cocaine-Related Disorders; Cognition Disorders; Cognitive Behavioral Therapy; Cyclohe | 2006 |
Cognitive deficits predict low treatment retention in cocaine dependent patients.
Topics: Adult; Amines; Cocaine-Related Disorders; Cognition Disorders; Cognitive Behavioral Therapy; Cyclohe | 2006 |
Cognitive deficits predict low treatment retention in cocaine dependent patients.
Topics: Adult; Amines; Cocaine-Related Disorders; Cognition Disorders; Cognitive Behavioral Therapy; Cyclohe | 2006 |
Various GABA-mimetic drugs differently affect cocaine-evoked hyperlocomotion and sensitization.
Topics: Amines; Animals; Behavior, Animal; Brain; Cocaine; Cocaine-Related Disorders; Cyclohexanecarboxylic | 2006 |
Microanatomy in 21 day rat brains exposed prenatally to cocaine.
Topics: Animals; Brain; Cell Differentiation; Cocaine; Cocaine-Related Disorders; Dendrites; Disease Models, | 2006 |
Cannabinoid CB1 receptor antagonist AM251 inhibits cocaine-primed relapse in rats: role of glutamate in the nucleus accumbens.
Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Dopamine; Extracellular Space; gamma- | 2006 |
Attenuation of cocaine-seeking by GABA B receptor agonists baclofen and CGP44532 but not the GABA reuptake inhibitor tiagabine in baboons.
Topics: Animals; Appetitive Behavior; Baclofen; Cocaine-Related Disorders; GABA Antagonists; GABA-B Receptor | 2007 |
Cortical inhibition and excitation in abstinent cocaine-dependent patients: a transcranial magnetic stimulation study.
Topics: Adult; Brain; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Evoked Potentials, Mot | 2007 |
A role for conditioned ventral tegmental glutamate release in cocaine seeking.
Topics: Animals; Behavior, Addictive; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Conditioning, Ps | 2007 |
Effects of gabapentin on cocaine self-administration, cocaine-triggered relapse and cocaine-enhanced nucleus accumbens dopamine in rats.
Topics: Amines; Animals; Anti-Anxiety Agents; Cocaine; Cocaine-Related Disorders; Cyclohexanecarboxylic Acid | 2008 |
Neurotensin in the ventral pallidum increases extracellular gamma-aminobutyric acid and differentially affects cue- and cocaine-primed reinstatement.
Topics: Animals; Brain; Cocaine; Cocaine-Related Disorders; gamma-Aminobutyric Acid; Male; Motor Activity; N | 2008 |
The glutamatergic projection from the prefrontal cortex to the nucleus accumbens core is required for cocaine-induced decreases in ventral pallidal GABA.
Topics: Animals; Basal Ganglia; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake | 2008 |
A novel strategy for the treatment of cocaine addiction.
Topics: 4-Aminobutyrate Transaminase; Animals; Brain; Catalepsy; Cocaine; Cocaine-Related Disorders; Conditi | 1998 |
Drug may suppress the craving for nicotine.
Topics: Animals; Behavior, Animal; Brain; Cocaine-Related Disorders; Conditioning, Psychological; Dopamine; | 1998 |
Endogenous GABA release is reduced in the striatum of cocaine-sensitized rats.
Topics: Animals; Cocaine-Related Disorders; Corpus Striatum; gamma-Aminobutyric Acid; Glutamate Decarboxylas | 1999 |
Effect of baclofen on cocaine self-administration in rats reinforced under fixed-ratio 1 and progressive-ratio schedules.
Topics: Animals; Baclofen; Cocaine; Cocaine-Related Disorders; Dopamine; gamma-Aminobutyric Acid; Male; Rats | 2000 |
Gabapentin therapy for cocaine cravings.
Topics: Acetates; Adult; Amines; Anticonvulsants; Behavior, Addictive; Cocaine-Related Disorders; Cyclohexan | 2000 |
Prenatal cocaine exposure produces consistent developmental alterations in dopamine-rich regions of the cerebral cortex.
Topics: Animals; Animals, Newborn; Axons; Cerebral Cortex; Cocaine; Cocaine-Related Disorders; Dendrites; Do | 2001 |
The effects of acute or repeated cocaine administration on nerve terminal glutamate within the rat mesolimbic system.
Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Drug Administration Schedule; gamma-A | 2001 |
A 28-year-old man addicted to cocaine.
Topics: Acetates; Adult; Amines; Brain; Cocaine-Related Disorders; Cost of Illness; Crack Cocaine; Cyclohexa | 2001 |
Repeated cocaine administration increases GABA(B(1)) subunit mRNA in rat brain.
Topics: Animals; Brain; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Drug Administration | 2002 |