baclofen has been researched along with Cocaine Abuse in 34 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| ") or placebo conditions (N = 35; identical in appearance and dosage rate) using a 2-group, experimental, 16-week double-blind design featuring thrice-weekly cognitive-behavioral drug counseling groups." | 2.71 | Randomized placebo-controlled trial of baclofen for cocaine dependence: preliminary effects for individuals with chronic patterns of cocaine use. ( Charuvastra, VC; Hsieh, YC; Kintaudi, PC; Ling, W; Rotheram-Fuller, EJ; Shoptaw, S; Yang, X, 2003) |
| "Cocaine dependence is characterized by compulsive drug seeking and high vulnerability to relapse." | 2.47 | Promising medications for cocaine dependence treatment. ( Amore, M; Ciccocioppo, R; Donnini, C; Gerra, G; Gerra, ML; Kalluppi, M; Malagoli, M; Raggi, MA; Saracino, MA; Somaini, L, 2011) |
| "Baclofen is a GABA(B) receptor agonist that in preclinical and early pilot clinical trials has shown promise for the treatment of cocaine dependence." | 1.35 | Multi-center trial of baclofen for abstinence initiation in severe cocaine-dependent individuals. ( Alathari, H; Beresford, T; Biswas, K; Chiang, N; Childress, AR; Collins, J; Elkashef, A; Fudala, PJ; Gorgon, L; Gruber, V; Kahn, R; Li, SH; Liberto, J; McSherry, F; Montoya, I; Shoptaw, S; Stock, C; Wallace, C; Watson, D, 2009) |
| " Separate groups of rats received bilateral intra-VTA injections of the GABA-A antagonist picrotoxin (34 ng/side, n = 7; 68 ng/side, n = 8), GABA-A agonist muscimol (14 ng/side, n = 8), GABA-B agonist baclofen (56 ng/side, n = 7; 100 ng/side, n = 6), picrotoxin (68 ng/side) co-injected with the GABA-B antagonist 2-hydroxysaclofen (100 ng/side, n = 7; 2 microg/side, n = 8) or artificial cerebrospinal fluid (aCSF, n = 6) to assess the effects of the various compounds on the cocaine self-administration dose-response curve." | 1.35 | Contribution of ventral tegmental GABA receptors to cocaine self-administration in rats. ( Backes, EN; Hemby, SE, 2008) |
| " Initial studies examined the dose-response effects of injection of baclofen (0." | 1.33 | Injections of baclofen into the ventral medial prefrontal cortex block the initiation, but not the expression, of cocaine sensitization in rats. ( Beyer, CE; Steketee, JD, 2005) |
| " A smoked cocaine dose-response curve (0, 12, 25, 50 mg) was determined twice: on days 3-4 and days 6-7 of each baclofen maintenance condition." | 1.33 | Effects of baclofen on cocaine self-administration: opioid- and nonopioid-dependent volunteers. ( Foltin, RW; Haney, M; Hart, CL, 2006) |
| "In the first series of experiments, three dose-response curves were generated that examined the effect of three doses of baclofen (1." | 1.31 | Effect of baclofen on cocaine self-administration in rats reinforced under fixed-ratio 1 and progressive-ratio schedules. ( Brebner, K; Phelan, R; Roberts, DC, 2000) |
| "In the first series of experiments, dose-response curves were generated to examine the effect of CGP56433A (0." | 1.31 | The GABA(B) antagonist CGP56433A attenuates the effect of baclofen on cocaine but not heroin self-administration in the rat. ( Brebner, K; Froestl, W; Roberts, DC, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 20 (58.82) | 29.6817 |
| 2010's | 12 (35.29) | 24.3611 |
| 2020's | 2 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Gawlińska, K | 1 |
| Jastrzębska, J | 1 |
| Gamberini, S | 1 |
| Gawliński, D | 1 |
| Pieniążek, R | 1 |
| Suder, A | 1 |
| Wydra, K | 1 |
| Frankowska, M | 2 |
| Sun, W | 1 |
| Yuill, MB | 1 |
| Pelloux, Y | 1 |
| Minier-Toribio, A | 1 |
| Hoots, JK | 1 |
| Bossert, JM | 1 |
| Shaham, Y | 1 |
| Vengeliene, V | 1 |
| Takahashi, TT | 1 |
| Dravolina, OA | 1 |
| Belozertseva, I | 1 |
| Zvartau, E | 1 |
| Bespalov, AY | 1 |
| Spanagel, R | 1 |
| Minogianis, EA | 1 |
| Servonnet, A | 1 |
| Filion, MP | 1 |
| Samaha, AN | 1 |
| Young, KA | 1 |
| Franklin, TR | 2 |
| Roberts, DC | 4 |
| Jagannathan, K | 1 |
| Suh, JJ | 1 |
| Wetherill, RR | 1 |
| Wang, Z | 1 |
| Kampman, KM | 1 |
| O'Brien, CP | 1 |
| Childress, AR | 2 |
| Limpens, JH | 1 |
| Damsteegt, R | 1 |
| Broekhoven, MH | 1 |
| Voorn, P | 1 |
| Vanderschuren, LJ | 1 |
| Cunningham, JJ | 1 |
| Orr, E | 1 |
| Lothian, BC | 1 |
| Morgen, J | 1 |
| Brebner, K | 3 |
| Kahn, R | 1 |
| Biswas, K | 1 |
| Shoptaw, S | 4 |
| Fudala, PJ | 1 |
| Gorgon, L | 1 |
| Montoya, I | 1 |
| Collins, J | 1 |
| McSherry, F | 1 |
| Li, SH | 1 |
| Chiang, N | 1 |
| Alathari, H | 1 |
| Watson, D | 1 |
| Liberto, J | 1 |
| Beresford, T | 1 |
| Stock, C | 1 |
| Wallace, C | 1 |
| Gruber, V | 1 |
| Elkashef, A | 1 |
| Lasseter, HC | 2 |
| Ramirez, DR | 1 |
| Xie, X | 2 |
| Fuchs, RA | 3 |
| Buffalari, DM | 1 |
| See, RE | 2 |
| Oleson, EB | 1 |
| Richardson, JM | 1 |
| Halbout, B | 1 |
| Quarta, D | 1 |
| Valerio, E | 1 |
| Heidbreder, CA | 1 |
| Hutcheson, DM | 1 |
| Somaini, L | 1 |
| Donnini, C | 1 |
| Raggi, MA | 1 |
| Amore, M | 1 |
| Ciccocioppo, R | 1 |
| Saracino, MA | 1 |
| Kalluppi, M | 1 |
| Malagoli, M | 1 |
| Gerra, ML | 1 |
| Gerra, G | 1 |
| Herdener, M | 1 |
| Oppliger, R | 1 |
| Stohler, R | 1 |
| Caflisch, C | 1 |
| Wells, AM | 1 |
| Arguello, AA | 1 |
| Blanton, MA | 1 |
| Reittinger, AM | 1 |
| Hotsenpiller, G | 1 |
| Wolf, ME | 1 |
| Yang, X | 1 |
| Rotheram-Fuller, EJ | 1 |
| Hsieh, YC | 1 |
| Kintaudi, PC | 1 |
| Charuvastra, VC | 1 |
| Ling, W | 1 |
| Di Ciano, P | 1 |
| Everitt, BJ | 1 |
| Evans, KA | 1 |
| Parker, MP | 1 |
| Kaplan, GB | 1 |
| McRoberts, RL | 1 |
| Smokler, HJ | 1 |
| Steketee, JD | 1 |
| Beyer, CE | 1 |
| Haney, M | 1 |
| Hart, CL | 1 |
| Foltin, RW | 1 |
| Lhuillier, L | 1 |
| Mombereau, C | 1 |
| Cryan, JF | 1 |
| Kaupmann, K | 1 |
| Weerts, EM | 1 |
| Froestl, W | 2 |
| Kaminski, BJ | 1 |
| Griffiths, RR | 1 |
| Rotheram-Fuller, E | 1 |
| De La Garza, R | 1 |
| Mahoney, JJ | 1 |
| Newton, TF | 1 |
| Filip, M | 1 |
| Herzig, V | 1 |
| Schmidt, WJ | 1 |
| Belin, TR | 1 |
| Backes, EN | 1 |
| Hemby, SE | 1 |
| Phelan, R | 1 |
| Druhan, JP | 1 |
| Kushner, SA | 1 |
| Unterwald, EM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Multi-Center Trial of Baclofen for the Treatment of Cocaine Dependence[NCT00082485] | Phase 2 | 160 participants (Actual) | Interventional | 2004-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for baclofen and Cocaine Abuse
| Article | Year |
|---|---|
Promising medications for cocaine dependence treatment.
Topics: Acetylcysteine; Atomoxetine Hydrochloride; Baclofen; Benzhydryl Compounds; Buprenorphine; Cocaine-Re | 2011 |
[Treating cocaine addiction].
Topics: Acetylcysteine; Alcohol Deterrents; Baclofen; Benzhydryl Compounds; Central Nervous System Stimulant | 2012 |
Markov transition models for binary repeated measures with ignorable and nonignorable missing values.
Topics: Baclofen; Cocaine-Related Disorders; GABA Agonists; Humans; Longitudinal Studies; Markov Chains; Mod | 2007 |
3 trials available for baclofen and Cocaine Abuse
| Article | Year |
|---|---|
Nipping cue reactivity in the bud: baclofen prevents limbic activation elicited by subliminal drug cues.
Topics: Adolescent; Adult; Baclofen; Cocaine-Related Disorders; Cues; Female; GABA-B Receptor Agonists; Huma | 2014 |
Randomized placebo-controlled trial of baclofen for cocaine dependence: preliminary effects for individuals with chronic patterns of cocaine use.
Topics: Adult; Baclofen; Cocaine; Cocaine-Related Disorders; Double-Blind Method; Female; GABA Agonists; Hum | 2003 |
Subjective and cardiovascular effects of cocaine during treatment with amantadine and baclofen in combination.
Topics: Adult; Amantadine; Baclofen; Blood Pressure; Cocaine-Related Disorders; Cross-Over Studies; Dopamine | 2007 |
28 other studies available for baclofen and Cocaine Abuse
| Article | Year |
|---|---|
The impact of GABA
Topics: Animals; Baclofen; Behavior, Addictive; Behavior, Animal; Brain; Central Nervous System Stimulants; | 2020 |
Role of the GABA
Topics: Animals; Baclofen; Behavior, Addictive; Central Amygdaloid Nucleus; Cocaine; Cocaine-Related Disorde | 2020 |
Opposite Effects of Basolateral Amygdala Inactivation on Context-Induced Relapse to Cocaine Seeking after Extinction versus Punishment.
Topics: Amygdala; Animals; Baclofen; Cocaine-Related Disorders; Conditioning, Operant; Extinction, Psycholog | 2018 |
Efficacy and side effects of baclofen and the novel GABA
Topics: Alcoholism; Allosteric Regulation; Animals; Baclofen; Behavior, Addictive; Cocaine; Cocaine-Related | 2018 |
Role of the orbitofrontal cortex and the dorsal striatum in incentive motivation for cocaine.
Topics: Animals; Baclofen; Behavior, Addictive; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Drug-Se | 2019 |
Pharmacological inactivation of the prelimbic cortex emulates compulsive reward seeking in rats.
Topics: Animals; Baclofen; Cerebral Cortex; Cocaine; Cocaine-Related Disorders; Decision Making; Dietary Suc | 2015 |
Effects of fendiline on cocaine-seeking behavior in the rat.
Topics: Animals; Baclofen; Behavior, Addictive; Calcium Channel Blockers; Central Nervous System Stimulants; | 2015 |
Multi-center trial of baclofen for abstinence initiation in severe cocaine-dependent individuals.
Topics: Adult; Baclofen; Behavior Therapy; Cocaine; Cocaine-Related Disorders; Combined Modality Therapy; Co | 2009 |
Involvement of the lateral orbitofrontal cortex in drug context-induced reinstatement of cocaine-seeking behavior in rats.
Topics: Animals; Baclofen; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhib | 2009 |
Inactivation of the bed nucleus of the stria terminalis in an animal model of relapse: effects on conditioned cue-induced reinstatement and its enhancement by yohimbine.
Topics: Animals; Baclofen; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Cues; Drug Therapy, Co | 2011 |
A novel IV cocaine self-administration procedure in rats: differential effects of dopamine, serotonin, and GABA drug pre-treatments on cocaine consumption and maximal price paid.
Topics: Analysis of Variance; Animals; Appetitive Behavior; Baclofen; Behavior, Animal; Central Nervous Syst | 2011 |
The GABA-B positive modulator GS39783 decreases psychostimulant conditioned-reinforcement and conditioned-reward.
Topics: Allosteric Regulation; Amphetamine; Animals; Association Learning; Baclofen; Central Nervous System | 2011 |
Extracellular signal-regulated kinase in the basolateral amygdala, but not the nucleus accumbens core, is critical for context-response-cocaine memory reconsolidation in rats.
Topics: Amygdala; Animals; Baclofen; Butadienes; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; | 2013 |
Baclofen attenuates conditioned locomotion to cues associated with cocaine administration and stabilizes extracellular glutamate levels in rat nucleus accumbens.
Topics: Animals; Baclofen; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Cues; Disease Mo | 2003 |
Contribution of the ventral tegmental area to cocaine-seeking maintained by a drug-paired conditioned stimulus in rats.
Topics: Amygdala; Analysis of Variance; Animals; Baclofen; Cocaine; Cocaine-Related Disorders; Conditioning, | 2004 |
Differential involvement of orbitofrontal cortex subregions in conditioned cue-induced and cocaine-primed reinstatement of cocaine seeking in rats.
Topics: Animals; Baclofen; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological | 2004 |
Baclofen as adjunctive treatment for a patient with cocaine dependence and schizoaffective disorder.
Topics: Alcoholism; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Baclofen; Bipolar Disord | 2004 |
Injections of baclofen into the ventral medial prefrontal cortex block the initiation, but not the expression, of cocaine sensitization in rats.
Topics: Animals; Baclofen; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Dose-Response Re | 2005 |
Effects of baclofen on cocaine self-administration: opioid- and nonopioid-dependent volunteers.
Topics: Adult; Baclofen; Cocaine; Cocaine-Related Disorders; Crack Cocaine; Dose-Response Relationship, Drug | 2006 |
GABA(B) receptor-positive modulation decreases selective molecular and behavioral effects of cocaine.
Topics: Animals; Baclofen; Behavior, Addictive; Brain; Cocaine; Cocaine-Related Disorders; Corpus Striatum; | 2007 |
Attenuation of cocaine-seeking by GABA B receptor agonists baclofen and CGP44532 but not the GABA reuptake inhibitor tiagabine in baboons.
Topics: Animals; Appetitive Behavior; Baclofen; Cocaine-Related Disorders; GABA Antagonists; GABA-B Receptor | 2007 |
Effects of GABA(B) receptor agents on cocaine priming, discrete contextual cue and food induced relapses.
Topics: Animals; Baclofen; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Cues | 2007 |
Amygdala cannulation alters expression of cocaine conditioned place preference and locomotion in rats.
Topics: Amygdala; Animals; Baclofen; Brain Mapping; Catheterization; Cocaine-Related Disorders; Conditioning | 2007 |
Contribution of ventral tegmental GABA receptors to cocaine self-administration in rats.
Topics: Animals; Baclofen; Cocaine-Related Disorders; Conditioning, Operant; Dose-Response Relationship, Dru | 2008 |
Effect of baclofen on cocaine self-administration in rats reinforced under fixed-ratio 1 and progressive-ratio schedules.
Topics: Animals; Baclofen; Cocaine; Cocaine-Related Disorders; Dopamine; gamma-Aminobutyric Acid; Male; Rats | 2000 |
Involvement of the nucleus accumbens and medial prefrontal cortex in the expression of conditioned hyperactivity to a cocaine-associated environment in rats.
Topics: Amygdala; Animals; Baclofen; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Dose-R | 2000 |
Chronic cocaine administration decreases the functional coupling of GABA(B) receptors in the rat ventral tegmental area as measured by baclofen-stimulated 35S-GTPgammaS binding.
Topics: Animals; Baclofen; Cocaine; Cocaine-Related Disorders; Dopamine; Dose-Response Relationship, Drug; G | 2001 |
The GABA(B) antagonist CGP56433A attenuates the effect of baclofen on cocaine but not heroin self-administration in the rat.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Baclofen; Benzoates; Cocaine-Rela | 2002 |