amantadine and Cocaine Abuse studies

amant: an antiviral compound consisting of an adamantane derivative chemically linked to a water-solube polyanioic matrix; structure in first source

Research Excerpts

Excerpt	Relevance	Reference
"Amantadine-treated participants were retained significantly longer than placebo."	2.70	A screening trial of amantadine as a medication for cocaine dependence. ( Charuvastra, C; Kintaudi, PC; Ling, W; Shoptaw, S, 2002)
"Among subjects with severe cocaine withdrawal symptoms at the start of treatment, those who received amantadine used significantly less cocaine during the trial than did subjects who received placebo."	2.69	Amantadine in the treatment of cocaine-dependent patients with severe withdrawal symptoms. ( Alterman, AI; Cornish, J; Kampman, KM; O'Brien, CP; Volpicelli, JR, 2000)
" There is a wide and well documented range of consequences associated to chronic use of cocaine, such as medical, psychological and social problems."	2.46	WITHDRAWN: Dopamine agonists for cocaine dependence. ( Farrell, M; Lima Reisser, AA; Silva de Lima, M; Soares, B, 2010)
" There is a wide and well documented range of consequences associated to chronic use of this drug, such as medical, psychological and social problems, including the spread of infectious diseases (e."	2.42	Dopamine agonists for cocaine dependence. ( Farrell, M; Lima, MS; Reisser, AA; Soares, BG, 2003)
" There is a wide and well documented range of consequences associated to chronic use of this drug, such as medical, psychological and social problems, including the spread of infectious diseases (e."	2.41	Dopamine agonists for cocaine dependence. ( Farrell, M; Lima, MS; Reisser, AA; Soares, BG, 2001)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (8.33)	18.2507
2000's	8 (66.67)	29.6817
2010's	3 (25.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Minozzi, S	2
Amato, L	2
Pani, PP	2
Solimini, R	2
Vecchi, S	2
De Crescenzo, F	1
Zuccaro, P	2
Davoli, M	2
Soares, B	1
Lima Reisser, AA	1
Farrell, M	3
Silva de Lima, M	1
Soares, BG	2
Lima, MS	2
Reisser, AA	2
Collins, ED	1
Vosburg, SK	1
Hart, CL	1
Haney, M	1
Foltin, RW	1
Kampman, KM	2
Dackis, C	1
Lynch, KG	1
Pettinati, H	1
Tirado, C	1
Gariti, P	1
Sparkman, T	1
Atzram, M	1
O'Brien, CP	2
Rotheram-Fuller, E	1
De La Garza, R	1
Mahoney, JJ	1
Shoptaw, S	2
Newton, TF	1
Morris, K	1
Volpicelli, JR	1
Alterman, AI	1
Cornish, J	1
Pérez de los Cobos, J	1
Duro, P	1
Trujols, J	1
Tejero, A	1
Batlle, F	1
Ribalta, E	1
Casas, M	1
Kintaudi, PC	1
Charuvastra, C	1
Ling, W	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
A Double-Blind, Placebo Controlled Trial of Propranolol and Amantadine for the Treatment of Cocaine Dependent Subjects With Severe Cocaine Withdrawal Symptoms[NCT00158132]	Phase 2	199 participants (Actual)	Interventional	1999-09-30	Completed
Rapid Evaluation of Cocaine Pharmacotherapies (Amantadine)[NCT00000301]	Phase 2	0 participants	Interventional	1996-03-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Dopamine agonists for the treatment of cocaine dependence. The Cochrane database of systematic reviews, 2015, May-27, Issue:5 Topics: Amantadine; Antidepressive Agents; Bromocriptine; Cocaine-Related Disorders; Depression; Dopamine Ag	2015
WITHDRAWN: Dopamine agonists for cocaine dependence. The Cochrane database of systematic reviews, 2010, Feb-17, Issue:2 Topics: Amantadine; Bromocriptine; Cocaine-Related Disorders; Dopamine Agonists; Humans; Randomized Controll	2010
Dopamine agonists for the treatment of cocaine dependence. The Cochrane database of systematic reviews, 2011, Dec-07, Issue:12 Topics: Amantadine; Bromocriptine; Cocaine-Related Disorders; Depression; Dopamine Agonists; Humans; Levodop	2011
Dopamine agonists for cocaine dependence. The Cochrane database of systematic reviews, 2003, Issue:2 Topics: Amantadine; Bromocriptine; Cocaine-Related Disorders; Dopamine Agonists; Humans; Randomized Controll	2003
Dopamine agonists for cocaine dependence. The Cochrane database of systematic reviews, 2001, Issue:4 Topics: Amantadine; Bromocriptine; Cocaine-Related Disorders; Dopamine; Humans; Randomized Controlled Trials	2001

Article	Year
Amantadine does not modulate reinforcing, subjective, or cardiovascular effects of cocaine in humans. Pharmacology, biochemistry, and behavior, 2003, Volume: 76, Issue:3-4 Topics: Adult; Amantadine; Cocaine; Cocaine-Related Disorders; Crack Cocaine; Dopamine Agents; Dose-Response	2003
A double-blind, placebo-controlled trial of amantadine, propranolol, and their combination for the treatment of cocaine dependence in patients with severe cocaine withdrawal symptoms. Drug and alcohol dependence, 2006, Nov-08, Volume: 85, Issue:2 Topics: Adrenergic beta-Antagonists; Adult; Amantadine; Analgesics, Non-Narcotic; Cocaine; Cocaine-Related D	2006
Subjective and cardiovascular effects of cocaine during treatment with amantadine and baclofen in combination. Psychiatry research, 2007, Aug-30, Volume: 152, Issue:2-3 Topics: Adult; Amantadine; Baclofen; Blood Pressure; Cocaine-Related Disorders; Cross-Over Studies; Dopamine	2007
Amantadine in the treatment of cocaine-dependent patients with severe withdrawal symptoms. The American journal of psychiatry, 2000, Volume: 157, Issue:12 Topics: Amantadine; Ambulatory Care; Cocaine; Cocaine-Related Disorders; Dopamine Agents; Double-Blind Metho	2000
Methadone tapering plus amantadine to detoxify heroin-dependent inpatients with or without an active cocaine use disorder: two randomised controlled trials. Drug and alcohol dependence, 2001, Jul-01, Volume: 63, Issue:2 Topics: Adolescent; Adult; Amantadine; Cocaine-Related Disorders; Comorbidity; Dose-Response Relationship, D	2001
A screening trial of amantadine as a medication for cocaine dependence. Drug and alcohol dependence, 2002, May-01, Volume: 66, Issue:3 Topics: Adult; Amantadine; Cocaine-Related Disorders; Dopamine Agents; Double-Blind Method; Female; Humans;	2002

amantadine and Cocaine Abuse

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