methylphenidate has been researched along with Cocaine Abuse in 68 studies
Methylphenidate: A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE.
methylphenidate : A racemate comprising equimolar amounts of the two threo isomers of methyl phenyl(piperidin-2-yl)acetate. A central stimulant and indirect-acting sympathomimetic, is used (generally as the hydrochloride salt) in the treatment of hyperactivity disorders in children and for the treatment of narcolepsy.
methyl phenyl(piperidin-2-yl)acetate : A amino acid ester that is methyl phenylacetate in which one of the hydrogens alpha to the carbonyl group is replaced by a piperidin-2-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Imaging studies in cocaine abusers show decreases in striatal dopamine levels, which we hypothesize may enhance conditioned responses since tonic dopamine levels modulate phasic dopamine release." | 9.14 | Methylphenidate attenuates limbic brain inhibition after cocaine-cues exposure in cocaine abusers. ( Alia-Klein, N; Fowler, JS; Goldstein, RZ; Jayne, M; Logan, J; Pradhan, K; Telang, F; Tomasi, D; Volkow, ND; Wang, GJ; Wong, C, 2010) |
| " Interestingly, imaging studies have reported blunted dopamine increases in striatum (assessed as reduced binding of [(11)C]raclopride to D2/D3 receptors) in detoxified cocaine abusers." | 7.80 | Stimulant-induced dopamine increases are markedly blunted in active cocaine abusers. ( Alexoff, DL; Du, C; Fowler, JS; Jayne, M; Logan, J; Tomasi, D; Volkow, ND; Wang, GJ; Wong, C; Yin, P, 2014) |
| "Attention deficit hyperactivity disorder (ADHD) is prevalent in adult cocaine abusers." | 7.73 | Response to cocaine, alone and in combination with methylphenidate, in cocaine abusers with ADHD. ( Collins, SL; Evans, SM; Foltin, RW; Kleber, HD; Levin, FR, 2006) |
| "Attention-deficit/hyperactivity disorder (ADHD) is common among cocaine abusers seeking treatment." | 7.70 | Methylphenidate treatment for cocaine abusers with adult attention-deficit/hyperactivity disorder: a pilot study. ( Evans, SM; Kleber, HD; Levin, FR; McDowell, DM, 1998) |
| "Eleven cocaine abusers were administered methylphenidate (0, 15, 30, and 45 mg) or modafinil (0, 150, 300, and 450 mg) across four experimental sessions." | 6.73 | Effects of potential agonist-replacement therapies for stimulant dependence on inhibitory control in cocaine abusers. ( Fillmorex, MT; Hays, LR; Rush, CR; Vansickel, AR, 2008) |
| "Methylphenidate's effects were significant for increases in metabolism in the superior cingulate, right thalamus, and cerebellum." | 5.30 | Association of methylphenidate-induced craving with changes in right striato-orbitofrontal metabolism in cocaine abusers: implications in addiction. ( Angrist, B; Ding, YS; Fowler, JS; Gatley, SJ; Hitzemann, R; Logan, J; Pappas, N; Volkow, ND; Wang, GJ, 1999) |
| "We combined neural measures from three separate procedures (two inhibitory control tasks differing in their degree of emotional salience and resting-state functional connectivity) during methylphenidate (20 mg oral, versus randomized and counterbalanced placebo) and correlated these aggregated responses with cocaine use disorder diagnosis (22 cocaine abusers, 21 controls), symptoms of attention deficit hyperactivity disorder, and working memory capacity." | 5.22 | Abnormal response to methylphenidate across multiple fMRI procedures in cocaine use disorder: feasibility study. ( Goldstein, RZ; Konova, AB; Moeller, SJ; Parvaz, MA; Tomasi, D, 2016) |
| " Imaging studies in cocaine abusers show decreases in striatal dopamine levels, which we hypothesize may enhance conditioned responses since tonic dopamine levels modulate phasic dopamine release." | 5.14 | Methylphenidate attenuates limbic brain inhibition after cocaine-cues exposure in cocaine abusers. ( Alia-Klein, N; Fowler, JS; Goldstein, RZ; Jayne, M; Logan, J; Pradhan, K; Telang, F; Tomasi, D; Volkow, ND; Wang, GJ; Wong, C, 2010) |
| " Here we evaluate how expectation affects the response to the stimulant drug methylphenidate in 25 cocaine abusers." | 5.10 | Expectation enhances the regional brain metabolic and the reinforcing effects of stimulants in cocaine abusers. ( Ding, YS; Fowler, JS; Ma, Y; Maynard, L; Swanson, JM; Telang, F; Vaska, P; Volkow, ND; Wang, GJ; Wong, C; Zhu, W, 2003) |
| " COMT, D4 receptor, and BDNF polymorphisms are linked to methamphetamine abuse and psychosis." | 4.85 | Pharmacogenetic treatments for drug addiction: cocaine, amphetamine and methamphetamine. ( Haile, CN; Kosten, TA; Kosten, TR, 2009) |
| "Past research with the spontaneously hypertensive rat (SHR) model of attention deficit/hyperactivity disorder showed that adolescent methylphenidate treatment enhanced cocaine abuse risk in SHR during adulthood." | 3.81 | Methylphenidate treatment beyond adolescence maintains increased cocaine self-administration in the spontaneously hypertensive rat model of attention deficit/hyperactivity disorder. ( Baskin, BM; Dwoskin, LP; Kantak, KM, 2015) |
| " Interestingly, imaging studies have reported blunted dopamine increases in striatum (assessed as reduced binding of [(11)C]raclopride to D2/D3 receptors) in detoxified cocaine abusers." | 3.80 | Stimulant-induced dopamine increases are markedly blunted in active cocaine abusers. ( Alexoff, DL; Du, C; Fowler, JS; Jayne, M; Logan, J; Tomasi, D; Volkow, ND; Wang, GJ; Wong, C; Yin, P, 2014) |
| "Attention deficit hyperactivity disorder (ADHD) is prevalent in adult cocaine abusers." | 3.73 | Response to cocaine, alone and in combination with methylphenidate, in cocaine abusers with ADHD. ( Collins, SL; Evans, SM; Foltin, RW; Kleber, HD; Levin, FR, 2006) |
| "Attention-deficit/hyperactivity disorder (ADHD) is common among cocaine abusers seeking treatment." | 3.70 | Methylphenidate treatment for cocaine abusers with adult attention-deficit/hyperactivity disorder: a pilot study. ( Evans, SM; Kleber, HD; Levin, FR; McDowell, DM, 1998) |
| "Cocaine addiction is associated with altered resting-state functional connectivity among regions of the mesocorticolimbic dopamine pathways." | 2.78 | Effects of methylphenidate on resting-state functional connectivity of the mesocorticolimbic dopamine pathways in cocaine addiction. ( Goldstein, RZ; Konova, AB; Moeller, SJ; Tomasi, D; Volkow, ND, 2013) |
| "Methylphenidate was well tolerated with similar retention rates compared with the placebo." | 2.78 | A randomized, controlled, pilot trial of methylphenidate and cognitive-behavioral group therapy for cocaine dependence in heroin prescription. ( Boss, J; Bürki, C; Dürsteler-MacFarland, KM; Farronato, NS; Kuntze, MF; Petitjean, SA; Strasser, J; Wiesbeck, GA, 2013) |
| "Eleven cocaine abusers were administered methylphenidate (0, 15, 30, and 45 mg) or modafinil (0, 150, 300, and 450 mg) across four experimental sessions." | 2.73 | Effects of potential agonist-replacement therapies for stimulant dependence on inhibitory control in cocaine abusers. ( Fillmorex, MT; Hays, LR; Rush, CR; Vansickel, AR, 2008) |
| "Methylphenidate's efficacy was assessed by both objective and subjective measures." | 2.71 | An open-label pilot study of methylphenidate in the treatment of cocaine dependent patients with adult attention deficit/hyperactivity disorder. ( Barrett, JA; Bridge, TP; Ciraulo, DA; Harrer, JM; Mezinskis, JP; Montgomery, MA; Rotrosen, JP; Somoza, EC; Vanderburg, DG; Winhusen, TM; Wulsin, LR, 2004) |
| "Methylphenidate did not increase cocaine craving nor ratings suggesting abuse potential (i." | 2.69 | Laboratory measures of methylphenidate effects in cocaine-dependent patients receiving treatment. ( Creson, DL; Grabowski, J; Rhoades, HM; Roache, JD; Schmitz, JM, 2000) |
| "Adolescents tend to have shorter substance use histories therefore they often experience emergency/acute care health treatment resulting from substance use related trauma and/or overdose." | 2.43 | Adolescent substance use: brief interventions by emergency care providers. ( Burke, PJ; O'Sullivan, J; Vaughan, BL, 2005) |
| " Participants (N = 12; 33% female) completed a within-subject, outpatient, acute dosing study." | 1.56 | Acute methylphenidate administration reduces cocaine-cue attentional bias. ( Alcorn, JL; Lile, JA; Rush, CR; Stoops, WW; Strickland, JC, 2020) |
| "The SHR successfully model ADHD and cocaine abuse comorbidity and show differential effects of adolescent ADHD medications on cocaine intake and cue reactivity during adulthood." | 1.40 | Cocaine-seeking behavior in a genetic model of attention-deficit/hyperactivity disorder following adolescent methylphenidate or atomoxetine treatments. ( Baskin, BB; Dwoskin, LP; Harvey, RC; Jordan, CJ; Kantak, KM, 2014) |
| ") dose-response curves were determined, self-administration sessions were suspended and MPD (0." | 1.39 | Effects of chronic methylphenidate on cocaine self-administration under a progressive-ratio schedule of reinforcement in rhesus monkeys. ( Czoty, PW; Gould, RW; Martelle, SE; Nader, MA, 2013) |
| "In a second sample of 14 cocaine abusers and 15 controls, administration of an indirect dopamine agonist, methylphenidate, reversed these midbrain responses in both groups, possibly indicating normalization of response in cocaine abusers because of restoration of dopamine signaling but degradation of response in healthy controls owing to excessive dopamine signaling." | 1.38 | Dopaminergic involvement during mental fatigue in health and cocaine addiction. ( Goldstein, RZ; Honorio, J; Moeller, SJ; Tomasi, D; Volkow, ND, 2012) |
| " Compared with WKY and WIS rats, SHRs with previous methylphenidate treatment acquired cocaine self-administration faster, identified cocaine as a highly efficacious reinforcer by displaying an upward shift in the cocaine dose-response function, and showed the greatest motivation to self-administer cocaine by exhibiting the highest progressive ratio breakpoints." | 1.37 | Methylphenidate treatment in adolescent rats with an attention deficit/hyperactivity disorder phenotype: cocaine addiction vulnerability and dopamine transporter function. ( Deaciuc, A; Dwoskin, LP; Harvey, RC; Kantak, KM; Sen, S, 2011) |
| "Aripiprazole was not found to be self-administered in the tested dose range (0." | 1.35 | Aripiprazole blocks acute self-administration of cocaine and is not self-administered in mice. ( Brennum, LT; Fink-Jensen, A; Hee Bengtsen, C; Petersen, JH; Sager, TN; Sørensen, G; Thomsen, M; Thøgersen, P; Woldbye, DP; Wörtwein, G, 2008) |
| "Methylphenidate (MP) and amphetamine, which are the mainstay for the treatment of ADHD, have raised concerns because of their reinforcing effects and the fear that their chronic use during childhood or adolescence could induce changes in the brain that could facilitate drug abuse in adulthood." | 1.34 | Effects of chronic oral methylphenidate on cocaine self-administration and striatal dopamine D2 receptors in rodents. ( Benveniste, H; Michaelides, M; Thanos, PK; Volkow, ND; Wang, GJ, 2007) |
| "Methylphenidate's effects were significant for increases in metabolism in the superior cingulate, right thalamus, and cerebellum." | 1.30 | Association of methylphenidate-induced craving with changes in right striato-orbitofrontal metabolism in cocaine abusers: implications in addiction. ( Angrist, B; Ding, YS; Fowler, JS; Gatley, SJ; Hitzemann, R; Logan, J; Pappas, N; Volkow, ND; Wang, GJ, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (5.88) | 18.2507 |
| 2000's | 27 (39.71) | 29.6817 |
| 2010's | 34 (50.00) | 24.3611 |
| 2020's | 3 (4.41) | 2.80 |
| Authors | Studies |
|---|---|
| Tschudi, L | 1 |
| Fischer, SKM | 1 |
| Perlov, E | 1 |
| Baumgartner, MR | 1 |
| Soyka, M | 1 |
| Müller, TJ | 1 |
| Seifritz, E | 1 |
| Mutschler, J | 1 |
| Angarita, GA | 1 |
| Pittman, B | 1 |
| Nararajan, A | 1 |
| Mayerson, TF | 1 |
| Parate, A | 1 |
| Marlin, B | 1 |
| Gueorguieva, RR | 1 |
| Potenza, MN | 1 |
| Ganesan, D | 1 |
| Malison, RT | 3 |
| Alcorn, JL | 1 |
| Strickland, JC | 1 |
| Lile, JA | 1 |
| Stoops, WW | 1 |
| Rush, CR | 3 |
| Baskin, BM | 2 |
| Nic Dhonnchadha, BÁ | 1 |
| Dwoskin, LP | 4 |
| Kantak, KM | 4 |
| Zanettini, C | 1 |
| Wilkinson, DS | 1 |
| Katz, JL | 1 |
| Jordan, CJ | 2 |
| Cao, J | 1 |
| Newman, AH | 1 |
| Xi, ZX | 2 |
| Czoty, PW | 1 |
| Martelle, SE | 1 |
| Gould, RW | 1 |
| Nader, MA | 2 |
| Crunelle, CL | 1 |
| van den Brink, W | 1 |
| Veltman, DJ | 1 |
| van Emmerik-van Oortmerssen, K | 1 |
| Dom, G | 1 |
| Schoevers, RA | 1 |
| Booij, J | 1 |
| Konova, AB | 3 |
| Moeller, SJ | 6 |
| Tomasi, D | 8 |
| Volkow, ND | 15 |
| Goldstein, RZ | 9 |
| Matuskey, D | 2 |
| Luo, X | 2 |
| Zhang, S | 1 |
| Morgan, PT | 2 |
| Abdelghany, O | 2 |
| Li, CS | 2 |
| Harvey, RC | 2 |
| Baskin, BB | 1 |
| Wang, GJ | 10 |
| Logan, J | 4 |
| Alexoff, DL | 1 |
| Jayne, M | 5 |
| Fowler, JS | 8 |
| Wong, C | 7 |
| Yin, P | 1 |
| Du, C | 1 |
| Imbert, B | 1 |
| Labrune, N | 1 |
| Lancon, C | 1 |
| Simon, N | 1 |
| Chen, LY | 1 |
| Crum, RM | 1 |
| Strain, EC | 1 |
| Martins, SS | 1 |
| Mojtabai, R | 1 |
| Stewart, JL | 1 |
| May, AC | 1 |
| Tapert, SF | 1 |
| Paulus, MP | 1 |
| Parvaz, MA | 2 |
| Olivares, EL | 1 |
| Kendler, KS | 1 |
| Neale, MC | 1 |
| Gillespie, NA | 1 |
| Song, R | 1 |
| Li, X | 1 |
| Lu, GY | 1 |
| Peng, XQ | 1 |
| He, Y | 1 |
| Bi, GH | 1 |
| Sheng, SP | 1 |
| Yang, HJ | 1 |
| Zhang, H | 1 |
| Li, J | 1 |
| Froimowitz, M | 1 |
| Gardner, EL | 1 |
| Woicik, PA | 3 |
| Telang, F | 6 |
| Haile, CN | 1 |
| Kosten, TR | 1 |
| Kosten, TA | 1 |
| Pradhan, K | 1 |
| Alia-Klein, N | 2 |
| Chang, JL | 1 |
| Rounsaville, BJ | 1 |
| Ding, YS | 4 |
| Maloney, T | 1 |
| Shan, J | 1 |
| Honorio, J | 3 |
| Samaras, D | 1 |
| Wang, R | 1 |
| Sen, S | 1 |
| Deaciuc, A | 1 |
| Martinez, D | 1 |
| Carpenter, KM | 1 |
| Liu, F | 1 |
| Slifstein, M | 1 |
| Broft, A | 1 |
| Friedman, AC | 1 |
| Kumar, D | 1 |
| Van Heertum, R | 1 |
| Kleber, HD | 3 |
| Nunes, E | 2 |
| Broos, N | 1 |
| Diergaarde, L | 1 |
| Schoffelmeer, AN | 1 |
| Pattij, T | 1 |
| De Vries, TJ | 1 |
| Wetzell, B | 1 |
| Riley, AL | 1 |
| Grau-López, L | 1 |
| Roncero, C | 1 |
| Navarro, MC | 1 |
| Casas, M | 1 |
| Mariani, JJ | 1 |
| Levin, FR | 6 |
| Gill, KE | 1 |
| Pierre, PJ | 1 |
| Daunais, J | 1 |
| Bennett, AJ | 1 |
| Martelle, S | 1 |
| Gage, HD | 1 |
| Swanson, JM | 3 |
| Porrino, LJ | 1 |
| Herdener, M | 1 |
| Oppliger, R | 1 |
| Stohler, R | 1 |
| Caflisch, C | 1 |
| Dürsteler-MacFarland, KM | 1 |
| Farronato, NS | 1 |
| Strasser, J | 1 |
| Boss, J | 1 |
| Kuntze, MF | 1 |
| Petitjean, SA | 1 |
| Bürki, C | 1 |
| Wiesbeck, GA | 1 |
| Schubiner, H | 1 |
| Saules, KK | 1 |
| Arfken, CL | 1 |
| Johanson, CE | 1 |
| Schuster, CR | 1 |
| Lockhart, N | 1 |
| Edwards, A | 1 |
| Donlin, J | 1 |
| Pihlgren, E | 1 |
| Ma, Y | 3 |
| Zhu, W | 1 |
| Maynard, L | 1 |
| Vaska, P | 1 |
| Volkow, N | 1 |
| Somoza, EC | 1 |
| Winhusen, TM | 1 |
| Bridge, TP | 1 |
| Rotrosen, JP | 1 |
| Vanderburg, DG | 1 |
| Harrer, JM | 1 |
| Mezinskis, JP | 1 |
| Montgomery, MA | 1 |
| Ciraulo, DA | 1 |
| Wulsin, LR | 1 |
| Barrett, JA | 1 |
| Pereira, RR | 1 |
| van de Wetering, BJ | 1 |
| Hitzemann, R | 2 |
| Kalivas, P | 1 |
| Collins, SL | 1 |
| Foltin, RW | 1 |
| Evans, SM | 4 |
| Burke, PJ | 1 |
| O'Sullivan, J | 1 |
| Vaughan, BL | 1 |
| Guerriero, RM | 1 |
| Hayes, MM | 1 |
| Dhaliwal, SK | 1 |
| Ren, JQ | 1 |
| Kosofsky, BE | 1 |
| Brooks, DJ | 3 |
| Garawi, F | 2 |
| Ukairo, OT | 1 |
| Ramanujapuram, S | 1 |
| Surratt, CK | 1 |
| Kim, DI | 1 |
| Deutsch, HM | 2 |
| Ye, X | 2 |
| Schweri, MM | 2 |
| Hennink, M | 1 |
| Abbas, Z | 1 |
| Choudhri, Y | 1 |
| Diener, T | 1 |
| Lloyd, K | 1 |
| Archibald, CP | 1 |
| Cule, S | 1 |
| Bisaga, A | 1 |
| Raby, W | 1 |
| Aharonovich, E | 1 |
| Rubin, E | 1 |
| Mariani, J | 1 |
| Nunes, EV | 1 |
| Thanos, PK | 1 |
| Michaelides, M | 1 |
| Benveniste, H | 1 |
| Childress, AR | 1 |
| Kollins, SH | 1 |
| Vansickel, AR | 1 |
| Fillmorex, MT | 1 |
| Hays, LR | 1 |
| Sørensen, G | 1 |
| Sager, TN | 1 |
| Petersen, JH | 1 |
| Brennum, LT | 1 |
| Thøgersen, P | 1 |
| Hee Bengtsen, C | 1 |
| Thomsen, M | 1 |
| Wörtwein, G | 1 |
| Fink-Jensen, A | 1 |
| Woldbye, DP | 1 |
| Grabowski, J | 2 |
| Roache, JD | 2 |
| Schmitz, JM | 2 |
| Rhoades, H | 1 |
| Creson, D | 1 |
| Korszun, A | 1 |
| McDowell, DM | 2 |
| Morris, K | 1 |
| Angrist, B | 1 |
| Gatley, SJ | 1 |
| Pappas, N | 1 |
| Creson, DL | 1 |
| Rhoades, HM | 1 |
| Castaneda, R | 1 |
| Levy, R | 1 |
| Hardy, M | 1 |
| Trujillo, M | 1 |
| Shi, Q | 1 |
| Liu, Z | 1 |
| Baker, RW | 1 |
| Robbins, TW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Imaging the Neurobiology of a Behavioral Treatment for Cocaine Dependence[NCT00376558] | 50 participants (Actual) | Interventional | 2006-07-31 | Completed | |||
| Methylphenidate Treatment for Cocaine Abuse and ADHD[NCT00136734] | Phase 1 | 124 participants (Actual) | Interventional | 1998-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The relationship between Methylphenidate-induced Dopamine Release in the Striatum (Measured by Displacement of [11C]-Raclopride by Oral Methylphenidate) and Treatment Response (Measured Using Community Reinforcement Approach and Contingency Management) was studied. Dopamine Function was assessed by evaluation of endogenous Dopamine release over the course of treatment (i.e., at 3 months as compared to baseline). Endogenous Dopamine release is inversely related to the change in binding potential (delta BPND) of [11C]raclopride, in that a negative delta BPND, or increased displacement of [11C]raclopride, reflects an increase in the release of endogenous dopamine over the course of treatment. (NCT00376558)
Timeframe: baseline and 3 months
| Intervention | ratio (Mean) |
|---|---|
| Cocaine Users | -13.7 |
| Control Subjects | -5.8 |
measurement of abstinence, measured as vouchers earned and clinical appointments attended using CRA (NCT00376558)
Timeframe: 2x/week for 24 weeks
| Intervention | dollars (Mean) |
|---|---|
| Cocaine Abuser Undergoing CM With CRA Treatment | 650 |
6 reviews available for methylphenidate and Cocaine Abuse
| Article | Year |
|---|---|
Progress in agonist therapy for substance use disorders: Lessons learned from methadone and buprenorphine.
Topics: Analgesics, Opioid; Buprenorphine; Central Nervous System Stimulants; Cocaine-Related Disorders; Dex | 2019 |
Pharmacogenetic treatments for drug addiction: cocaine, amphetamine and methamphetamine.
Topics: Amphetamine; Amphetamine-Related Disorders; Cocaine-Related Disorders; Disulfiram; Dopamine Uptake I | 2009 |
Psychostimulant treatment of cocaine dependence.
Topics: Amphetamines; Animals; Benzhydryl Compounds; Bupropion; Central Nervous System Stimulants; Clinical | 2012 |
[Treating cocaine addiction].
Topics: Acetylcysteine; Alcohol Deterrents; Baclofen; Benzhydryl Compounds; Central Nervous System Stimulant | 2012 |
Adolescent substance use: brief interventions by emergency care providers.
Topics: Adolescent; Adolescent Behavior; Attention Deficit Disorder with Hyperactivity; Chest Pain; Cocaine- | 2005 |
ADHD, substance use disorders, and psychostimulant treatment: current literature and treatment guidelines.
Topics: Amphetamine; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child | 2008 |
15 trials available for methylphenidate and Cocaine Abuse
| Article | Year |
|---|---|
Effects of methylphenidate on resting-state functional connectivity of the mesocorticolimbic dopamine pathways in cocaine addiction.
Topics: Adult; Brain; Cocaine-Related Disorders; Connectome; Cross-Over Studies; Dopamine; Dopamine Uptake I | 2013 |
Abnormal response to methylphenidate across multiple fMRI procedures in cocaine use disorder: feasibility study.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Brain; Cocaine-Related Disorders; Cognition; C | 2016 |
Methylphenidate attenuates limbic brain inhibition after cocaine-cues exposure in cocaine abusers.
Topics: Adult; Blood Pressure; Brain; Brain Chemistry; Cocaine; Cocaine-Related Disorders; Cues; Dopamine; D | 2010 |
A randomized, controlled, pilot trial of methylphenidate and cognitive-behavioral group therapy for cocaine dependence in heroin prescription.
Topics: Adult; Analgesics, Opioid; Central Nervous System Stimulants; Chi-Square Distribution; Cocaine-Relat | 2013 |
Double-blind placebo-controlled trial of methylphenidate in the treatment of adult ADHD patients with comorbid cocaine dependence.
Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; | 2002 |
Expectation enhances the regional brain metabolic and the reinforcing effects of stimulants in cocaine abusers.
Topics: Adult; Brain; Central Nervous System Stimulants; Cocaine-Related Disorders; Conditioning, Psychologi | 2003 |
An open-label pilot study of methylphenidate in the treatment of cocaine dependent patients with adult attention deficit/hyperactivity disorder.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cocaine-Rel | 2004 |
Treatment of cocaine dependent treatment seekers with adult ADHD: double-blind comparison of methylphenidate and placebo.
Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; | 2007 |
Stimulant-induced enhanced sexual desire as a potential contributing factor in HIV transmission.
Topics: Administration, Oral; Adult; Central Nervous System Stimulants; Cocaine-Related Disorders; Comorbidi | 2007 |
Effects of major depressive disorder and attention-deficit/hyperactivity disorder on the outcome of treatment for cocaine dependence.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cocaine-Rel | 2008 |
Effects of potential agonist-replacement therapies for stimulant dependence on inhibitory control in cocaine abusers.
Topics: Adult; Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; | 2008 |
Replacement medication for cocaine dependence: methylphenidate.
Topics: Adult; Central Nervous System Stimulants; Cocaine-Related Disorders; Female; Humans; Male; Methylphe | 1997 |
Laboratory measures of methylphenidate effects in cocaine-dependent patients receiving treatment.
Topics: Adult; Affect; Analysis of Variance; Central Nervous System Stimulants; Cocaine-Related Disorders; D | 2000 |
Behavioral pharmacological similarities between methylphenidate and cocaine in cocaine abusers.
Topics: Adult; Behavior; Blood Pressure; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorde | 2001 |
Bupropion treatment for cocaine abuse and adult attention-deficit/hyperactivity disorder.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Bupropion; Cocaine-Related Disorders; Comorbid | 2002 |
47 other studies available for methylphenidate and Cocaine Abuse
| Article | Year |
|---|---|
Concomitant Drug Use among Opioid-Dependent Patients with and without Attention Deficit Hyperactivity Disorder: Does Methylphenidate Merit a Trial?
Topics: Amphetamine; Analgesics, Opioid; Attention Deficit Disorder with Hyperactivity; Central Nervous Syst | 2023 |
Discriminating cocaine use from other sympathomimetics using wearable electrocardiographic (ECG) sensors.
Topics: Cocaine; Cocaine-Related Disorders; Electrocardiography; Humans; Methylphenidate; Sympathomimetics; | 2023 |
Acute methylphenidate administration reduces cocaine-cue attentional bias.
Topics: Adult; Attention; Attentional Bias; Blood Pressure; Cocaine-Related Disorders; Cues; Dopamine Uptake | 2020 |
Blockade of α2-adrenergic receptors in prelimbic cortex: impact on cocaine self-administration in adult spontaneously hypertensive rats following adolescent atomoxetine treatment.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic Uptake Inhibitors; Age Factors; Animals; Atomoxe | 2017 |
Behavioral economic analysis of the effects of N-substituted benztropine analogs on cocaine self-administration in rats.
Topics: Animals; Behavior, Animal; Benztropine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Econo | 2018 |
Effects of chronic methylphenidate on cocaine self-administration under a progressive-ratio schedule of reinforcement in rhesus monkeys.
Topics: Animals; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Dextroamphetamine; D | 2013 |
Low dopamine transporter occupancy by methylphenidate as a possible reason for reduced treatment effectiveness in ADHD patients with cocaine dependence.
Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Brain; Central Nervous System Stim | 2013 |
Methylphenidate remediates error-preceding activation of the default mode brain regions in cocaine-addicted individuals.
Topics: Adult; Central Nervous System Stimulants; Cerebral Cortex; Cocaine-Related Disorders; Cognition Diso | 2013 |
Cocaine-seeking behavior in a genetic model of attention-deficit/hyperactivity disorder following adolescent methylphenidate or atomoxetine treatments.
Topics: Animals; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Central Nervous S | 2014 |
Stimulant-induced dopamine increases are markedly blunted in active cocaine abusers.
Topics: Brain; Brain Mapping; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Cohort | 2014 |
Use of extended-release methylphenidate (concerta) in treatment of cocaine dependence in a patient presenting with attention deficit hyperactivity disorder.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cocaine-Rel | 2014 |
Methylphenidate treatment beyond adolescence maintains increased cocaine self-administration in the spontaneously hypertensive rat model of attention deficit/hyperactivity disorder.
Topics: Age Factors; Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulan | 2015 |
Effects of chronic and acute stimulants on brain functional connectivity hubs.
Topics: Brain; Brain Mapping; Central Nervous System Stimulants; Chronic Disease; Cocaine; Cocaine-Related D | 2015 |
Patterns of concurrent substance use among adolescent nonmedical ADHD stimulant users.
Topics: Adolescent; Amphetamines; Analgesics, Opioid; Central Nervous System Stimulants; Child; Cocaine-Rela | 2015 |
Hyperactivation to pleasant interoceptive stimuli characterizes the transition to stimulant addiction.
Topics: Adult; Amphetamine-Related Disorders; Behavior, Addictive; Brain; Case-Control Studies; Cocaine-Rela | 2015 |
The Genetic and Environmental Association Between Parental Monitoring and Risk of Cannabis, Stimulants, and Cocaine Initiation in a Sample of Male Twins: Does Parenting Matter?
Topics: Adolescent; Adult; Child; Cocaine-Related Disorders; Humans; Male; Marijuana Abuse; Methylphenidate; | 2016 |
CTDP-32476: A Promising Agonist Therapy for Treatment of Cocaine Addiction.
Topics: Animals; Behavior, Animal; Cocaine-Related Disorders; Dopamine Plasma Membrane Transport Proteins; D | 2017 |
Liking and wanting of drug and non-drug rewards in active cocaine users: the STRAP-R questionnaire.
Topics: Adult; Age of Onset; Behavior, Addictive; Case-Control Studies; Cocaine-Related Disorders; Dopamine | 2010 |
Biological markers of the effects of intravenous methylphenidate on improving inhibitory control in cocaine-dependent patients.
Topics: Adult; Biomarkers; Brain Mapping; Cocaine-Related Disorders; Female; Frontal Lobe; Humans; Impulsive | 2010 |
Oral methylphenidate normalizes cingulate activity in cocaine addiction during a salient cognitive task.
Topics: Administration, Oral; Adult; Case-Control Studies; Cocaine-Related Disorders; Cognition; Dopamine Up | 2010 |
Oral methylphenidate normalizes cingulate activity and decreases impulsivity in cocaine addiction during an emotionally salient cognitive task.
Topics: Administration, Oral; Adult; Brain Mapping; Cocaine-Related Disorders; Cognition; Dopamine Uptake In | 2011 |
Methylphenidate treatment in adolescent rats with an attention deficit/hyperactivity disorder phenotype: cocaine addiction vulnerability and dopamine transporter function.
Topics: Age Factors; Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Addictive; Cocaine-Re | 2011 |
Imaging dopamine transmission in cocaine dependence: link between neurochemistry and response to treatment.
Topics: Adult; Case-Control Studies; Central Nervous System Stimulants; Cocaine-Related Disorders; Corpus St | 2011 |
Trait impulsive choice predicts resistance to extinction and propensity to relapse to cocaine seeking: a bidirectional investigation.
Topics: Analysis of Variance; Animals; Benzazepines; Choice Behavior; Cocaine; Cocaine-Related Disorders; Co | 2012 |
Adolescent exposure to methylphenidate has no effect on the aversive properties of cocaine in adulthood.
Topics: Animals; Avoidance Learning; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Cocaine-R | 2012 |
Psychosis induced by the interaction between disulfiram and methylphenidate may be dose dependent.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Cocaine-Related Disorders; Disulfiram; Dopamin | 2012 |
Chronic treatment with extended release methylphenidate does not alter dopamine systems or increase vulnerability for cocaine self-administration: a study in nonhuman primates.
Topics: Animals; Central Nervous System Stimulants; Chemistry, Pharmaceutical; Cocaine-Related Disorders; Co | 2012 |
Long-term safety of stimulant use for ADHD: findings from nonhuman primates.
Topics: Amphetamine; Animals; Behavior, Animal; Central Nervous System Stimulants; Cocaine-Related Disorders | 2012 |
Dopaminergic involvement during mental fatigue in health and cocaine addiction.
Topics: Adult; Brain; Case-Control Studies; Caudate Nucleus; Cocaine-Related Disorders; Cognition Disorders; | 2012 |
Methylphenidate enhances executive function and optimizes prefrontal function in both health and cocaine addiction.
Topics: Adult; Association Learning; Central Nervous System Stimulants; Cocaine-Related Disorders; Cognition | 2014 |
Drug dependence and addiction, III: Expectation and brain function in drug abuse.
Topics: Behavior, Addictive; Brain; Central Nervous System Stimulants; Cocaine-Related Disorders; Glucose; H | 2004 |
[Caffeine, cannabis and cocaine: from automedication to 'automutilation' in adults with ADHD].
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Caffeine; Central Nervous System Stimulants; C | 2004 |
Activation of orbital and medial prefrontal cortex by methylphenidate in cocaine-addicted subjects but not in controls: relevance to addiction.
Topics: Adult; Behavior, Addictive; Brain Mapping; Carbon Isotopes; Central Nervous System Stimulants; Cocai | 2005 |
Response to cocaine, alone and in combination with methylphenidate, in cocaine abusers with ADHD.
Topics: Administration, Oral; Adrenergic Agents; Adult; Attention Deficit Disorder with Hyperactivity; Choic | 2006 |
Preadolescent methylphenidate versus cocaine treatment differ in the expression of cocaine-induced locomotor sensitization during adolescence and adulthood.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Cocaine; Cocaine-Rel | 2006 |
Fluctuation of the dopamine uptake inhibition potency of cocaine, but not amphetamine, at mammalian cells expressing the dopamine transporter.
Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Benztropine; Binding, Competitive; Brain; Brain | 2007 |
Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate.
Topics: Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Citalopram; Cocaine; Cocaine-Related Disord | 2007 |
Risk behaviours for infection with HIV and hepatitis C virus among people who inject drugs in Regina, Saskatchewan.
Topics: Adult; Chlamydia Infections; Cocaine-Related Disorders; Condoms; Cross-Sectional Studies; Female; Go | 2007 |
Effects of chronic oral methylphenidate on cocaine self-administration and striatal dopamine D2 receptors in rodents.
Topics: Animals; Body Weight; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Dopamin | 2007 |
Dopamine increases in striatum do not elicit craving in cocaine abusers unless they are coupled with cocaine cues.
Topics: Adult; Blood Pressure; Brain; Brain Chemistry; Cocaine-Related Disorders; Cues; Dopamine; Dopamine A | 2008 |
Aripiprazole blocks acute self-administration of cocaine and is not self-administered in mice.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Brain; Central Nervous System Stimulants; Cocaine; Coca | 2008 |
Methylphenidate treatment for cocaine abusers with adult attention-deficit/hyperactivity disorder: a pilot study.
Topics: Adult; Ambulatory Care; Attention Deficit Disorder with Hyperactivity; Behavior Therapy; Cocaine; Co | 1998 |
Seeking ways to crack cocaine addiction.
Topics: Amantadine; Clinical Trials as Topic; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Humans; | 1998 |
Association of methylphenidate-induced craving with changes in right striato-orbitofrontal metabolism in cocaine abusers: implications in addiction.
Topics: Adult; Behavior, Addictive; Brain Chemistry; Carbon Radioisotopes; Cerebral Cortex; Cocaine-Related | 1999 |
Long-acting stimulants for the treatment of attention-deficit disorder in cocaine-dependent adults.
Topics: Adult; Algorithms; Amphetamines; Antidepressive Agents, Second-Generation; Attention Deficit Disorde | 2000 |
Synthesis and pharmacology of site specific cocaine abuse treatment agents: a new synthetic methodology for methylphenidate analogs based on the Blaise reaction.
Topics: Animals; Biochemistry; Cocaine; Cocaine-Related Disorders; Dopamine; Dopamine Uptake Inhibitors; Dru | 2001 |
ADHD and addiction.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Cocaine-Related Disorders; Dopamine Uptake I | 2002 |