spironolactone has been researched along with Cocaine Abuse in 2 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Maćkowiak, M | 1 |
| Grzegorzewska, M | 1 |
| Budziszewska, B | 1 |
| Chocyk, A | 1 |
| Hess, G | 1 |
| Wedzony, K | 1 |
| Fiancette, JF | 1 |
| Balado, E | 1 |
| Piazza, PV | 1 |
| Deroche-Gamonet, V | 1 |
2 other studies available for spironolactone and Cocaine Abuse
| Article | Year |
|---|---|
Cocaine decreases the expression of PSA-NCAM protein and attenuates long-term potentiation via glucocorticoid receptors in the rat dentate gyrus.
Topics: Animals; Bromodeoxyuridine; Cell Count; Cell Proliferation; Cocaine; Cocaine-Related Disorders; Cort | 2008 |
Mifepristone and spironolactone differently alter cocaine intravenous self-administration and cocaine-induced locomotion in C57BL/6J mice.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Diuretics; Hallucinogens; Hormone Antagonists; Injectio | 2010 |