glutamic acid and Cocaine Abuse

glutamic acid has been researched along with Cocaine Abuse in 131 studies

Research

Studies (131)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	4 (3.05)	18.2507
2000's	55 (41.98)	29.6817
2010's	55 (41.98)	24.3611
2020's	17 (12.98)	2.80

Authors

Authors	Studies
Bi, GH; Gardner, EL; He, Y; Hempel, BJ; Xi, ZX; Yang, HJ; Zhang, HY	1
Caffino, L; Fumagalli, F; Homberg, JR; Mottarlini, F; Targa, G; Verheij, MMM	1
Gipson, CD; Hong, M; Khatri, SN; Maher, EE; Sadek, S; Stoops, WW; Ulangkaya, H; Woodcox, AM	1
Bernat, N; Gatterer, A; Inbar, D; Inbar, K; Kupchik, YM; Levi, LA; Nachshon, N	1
Jimenez-Rivera, CA; Santos-Vera, B; Vazquez-Torres, R; Velasquez-Martinez, MC; Velez-Hernandez, ME	1
Greenwald, MK; Khatib, D; Lundahl, LH; Stanley, JA; Woodcock, EA	1
Baumgartner, MR; Engeli, EJE; Esposito, F; Henning, A; Herdener, M; Hock, A; Hulka, LM; Kirschner, M; Nordt, C; Quednow, BB; Scheidegger, M; Seifritz, E; Zoelch, N	1
Fowles, K; Groman, SM; Hillmer, AT; Holden, D; Lee, D; Liu, H; Morris, ED; Taylor, JR	1
Calleti, G; Flores Peres, V; Fraga de Souza, M; Freese, L; Gomez, R; Maria Tannhauser Barros, H; Schüler Nin, M	1
Andres, M; Filip, M; Knackstedt, LA; Niedzielska-Andres, E; Pomierny-Chamioło, L; Przegaliński, E; Walczak, M	1
Acher, F; Befort, K; Bourdy, R; De Sa Nogueira, D; Filliol, D; McCort-Tranchepain, I; Quessada, C; Romieu, P; Zwiller, J	1
Shen, HW; Shi, J; Yu, ZP; Zhang, LY; Zhang, XQ; Zhou, YQ	1
Ersche, KD; Lim, TV; Murley, AG; Robbins, TW; Rua, C; Vaghi, MM; White, TL; Williams, GB	1
Caffino, L; Fumagalli, F; Homberg, J; Mottarlini, F; Targa, G; Verheij, MMM	1
Briand, LA; Kirkland, JM; Knouse, MC; McGrath, AG; Wickens, MM	1
Avalos, MP; Bollati, FA; Cancela, LM; De Giovanni, LN; Euliarte, PV; Guzman, AS; Mongi-Bragato, B; Rigoni, D; Sanchez, MA; Virgolini, MB	1
Boendermaker, WJ; Goudriaan, AE; Schulte, MHJ; van den Brink, W; Wiers, RW	1
Alasmari, F; Althobaiti, YS; Hammad, AM; Sari, Y	1
Bi, GH; Gao, JT; He, Y; Xi, ZX; Yang, HJ; Zhang, HY	1
Alcorn, JL; Hays, LR; Levi Bolin, B; Lile, JA; Rayapati, AO; Rush, CR; Stoops, WW	1
Goudriaan, AE; Homberg, JR; Kaag, AM; Reneman, L; Schmaal, L; Schulte, MHJ; van den Brink, W; van Wingen, GA; Wiers, RW	1
Chiu, AS; Gable, ES; Kim, J; Kippin, TE; Shin, CB; Szumlinski, KK; Templeton, TJ; Vieira, PA	1
Shin, CB; Szumlinski, KK	1
Bormans, G; Casteels, C; de Laat, B; Himmelreich, U; Leurquin-Sterk, G; Van Laere, K; Weerasekera, A	1
Knackstedt, L; Leong, KC; Logan, CN; Peris, J; Reichel, CM; Weber, RA	1
Cannazza, G; Cantacorps, L; Cheron, J; De Backer, JF; De Backer, O; de Kerchove d'Exaerde, A; Detraux, B; Faure, P; Gall, D; Gazan, A; Monlezun, S; Nassar, M; Schiffmann, SN; Valverde, O; Valverde, S; Vanopdenbosch, L; Venance, L; Zoli, M	1
Kaneda, K	1
Kamii, H; Kaneda, K; Minami, M; Taoka, N	1
Kawa, AB; Kennedy, RT; Robinson, TE; Valenta, AC	1
Ciccocioppo, R; Himes, ML; Lopresti, B; Mason, NS; Narendran, R; Paris, J; Tollefson, S	1
Filip, M; Mizera, J; Niedzielska-Andres, E; Pomierny-Chamioło, L; Sadakierska-Chudy, A	1
Gipson, CD; Kalivas, PW; Kupchik, YM; Reissner, KJ; Shen, H; Thomas, CA	1
Ortinski, PI; Pierce, RC; Turner, JR	1
Carson, RE; Grassetti, A; Huang, Y; Kegeles, LS; Lin, SF; Liu, F; Mao, X; Martinez, D; Nabulsi, N; Perez, A; Ropchan, J; Shungu, DC; Slifstein, M; Urban, NB	1
Kiyatkin, EA; Wakabayashi, KT	1
Gipson, CD; Huits, M; Kalivas, PW; Shen, HW	1
Doyle, SE; Garber, G; Lynch, WJ; Newman, J; Ramôa, C; Toor, Z	1
Filip, M; Fuxe, K; Gołembiowska, K; Kamińska, K; Suder, A; Wydra, K	1
Gipson, CD; Kalivas, PW	1
Baumgartner, MR; Henning, A; Herdener, M; Hulka, LM; Preller, KH; Quednow, BB; Scheidegger, M; Seifritz, E; Vonmoos, M	1
Andersen, SL; Brenhouse, HC; Sonntag, KC; Thompson, BS	1
Boger, HA; Haydon, PG; Kalivas, PW; Li, H; Scofield, MD; Smith, RJ	1
Cryan, JF; Glennon, J; Moloney, RD; O'Connor, RM; Vlachou, S	1
Bellivier, F; Besnard, A; Bolte, S; Caboche, J; Crettol, S; Daumas, S; Eap, CB; El Mestikawy, S; Giros, B; Gratton, A; Gutiérrez-Cuesta, J; Heck, N; Henrion, A; Herzog, E; Jamain, S; Lecca, S; Maldonado, R; Mameli, M; Marti, F; Martín-García, E; Moquin, L; Morel, LJ; Prado, MA; Prado, VF; Sakae, DY; Vanhoutte, P; Vorspan, F	1
Hill, K; Knackstedt, LA; LaCrosse, AL	1
Dong, Y	1
Bobadilla, AC; Bollati, F; Brown, RM; Cancela, LM; Esparza, MA; Garcia-Keller, C; Gipson, CD; Heinsbroek, JA; Kalivas, PW; Kupchik, YM; Roberts-Wolfe, DJ; Spencer, S	1
Kalivas, PW; Scofield, M; Spencer, S	1
Baumann, MH; Elmore, JS; Hoffman, AF; Lupica, CR; Wright, AM; Zapata, A	1
Barry, SM; Go, BS; McGinty, JF	1
Andrade Reis, T; da Silveira, DX; Fidalgo, TM; Nocito Echevarria, MA; Ruffo Capatti, G; Siciliano Soares, V	1
Crombag, HS; Ferrario, CR; Robinson, TE	1
Wise, RA	1
Abdulhameed, O; Baker, DA; Grier, MD; Kau, KS; Madayag, A; Mantsch, JR	1
Placenza, FM; Rajabi, H; Stewart, J	1
Steketee, JD; Xie, X	1
Bachtell, RK; Self, DW	1
Ghasemzadeh, MB; Mantsch, JR; Mueller, C; Seubert, C; Vasudevan, P	1
LaLumiere, RT; Uys, JD	1
Hsu, KS; Huang, CC; Lee, CC; Liang, YC; Wu, MY	1
Berglind, WJ; Kalivas, PW; LaLumiere, RT; McGinty, JF; Whitfield, TW	1
Gardner, EL; Xi, ZX	1
Ecke, LE; Suto, N; Wise, RA	1
Creton, C; Engblom, D; Halbout, B; Lüscher, C; Mameli, M; Parkitna, JR; Spanagel, R	1
Kalivas, PW; Knackstedt, LA; Melendez, RI	1
Berglind, WJ; McGinty, JF; Whitfield, TW	1
Ashby, CR; Chun, L; Gardner, EL; Li, J; Li, X; Peng, XQ; Slusher, BS; Thomas, AG; Xi, ZX	1
Ross, TJ; Salmeron, BJ; Stein, EA; Xi, ZX; Yang, S; Yang, Y	1
Casas, M; Corominas, M; Roncero, C	1
Keyghobadi, M; McKee, BL; Meshul, CK; Tozier De La Poterie, AP	1
Pierce, RC; Schmidt, HD	1
Balado, E; Berson, N; Deroche-Gamonet, V; Kasanetz, F; Lafourcade, M; Manzoni, O; Piazza, PV	1
Bonci, A; Bowers, MS; Chen, BT	1
Self, DW	1
Argyriou, AA; Giannakopoulou, F; Karanasios, P; Makridou, A; Makris, N; Vlachou, M	1
Carr, DB; Kalivas, PW; Moussawi, K; Reichel, CM; See, RE; Shen, H; Zhou, W	1
Rayport, S	1
Reissner, KJ; Uys, JD	1
Do, PH; Kalivas, PW; Moussawi, K; Reichel, CM; See, RE	1
Bellone, C; Brown, MT; Lüscher, C; Mameli, M	1
Alonso-Carrión, FJ; Bermúdez-Silva, FJ; Bilbao, A; Blanco, E; Campos-Sandoval, JA; de Fonseca, FR; Estivill-Torrús, G; Gutiérrez, A; Luque-Rojas, MJ; Márquez, J; Palomino, A; Santín, LJ; Suárez, J	1
Ambrosio, E; Botreau, F; Coria, SM; Del Olmo, N; Higuera-Matas, A; Miguéns, M; Olías, O	1
De La Garza, R; Haile, CN; Mahoney, JJ; Newton, TF	1
Ben-Shahar, OM; Bernstein, N; Carosso, GA; Cohen, A; DeMartini, J; Gordon, E; Lominac, KD; Nabhan, AN; Pagano, K; Ploense, KL; Rudy, NM; Sacramento, A; Szumlinski, KK; Woodward, N	1
Goudriaan, AE; Nederveen, A; Schmaal, L; van den Brink, W; Veltman, DJ	1
Baker, DA; Kau, KS; Kong, L; Lutgen, V; Madayag, A; Mantsch, JR	1
Li, N; Sorg, BA; Wu, WR	1
Aston-Jones, G; Harris, GC	1
Hotsenpiller, G; Wolf, ME	1
Kalivas, PW; Lake, R; Ramamoorthy, S; Samuvel, DJ; Shen, H; Xi, ZX	1
Kalivas, PW; Lapish, CC; McFarland, K	1
Baker, DA; Kalivas, PW; Lake, RW; McFarland, K; Shen, H; Tang, XC; Toda, S	1
Davidge, SB; Kalivas, PW; Lapish, CC; McFarland, K	1
Berry, T; Champtiaux, NP; Dehoff, MH; During, MJ; Frys, KA; Griffin, W; Kalivas, PW; Kang, SH; Klugmann, M; Lominac, KD; Middaugh, LD; Rohrer, J; Shealy, SE; Szumlinski, KK; Toda, S; Tu, JC; Worley, PF	1
Steketee, JD; Williams, JM	1
Abarca, C; Albrecht, U; Depner, M; Holzberg, D; Lascorz, J; Lathrop, M; Magnone, MC; Matsuda, F; Pendyala, G; Sanchis-Segura, C; Schreiber, S; Schumann, G; Soyka, M; Spanagel, R; Zghoul, T	1
Bart, G; Kreek, MJ; Yuferov, V	1
Azari, S; Shaham, Y; Wang, B; Wise, RA; You, ZB; Zitzman, D	1
Kalivas, PW; McFarland, K; Melendez, RI; Moran, MM; Seamans, JK	1
Heusner, CL; Palmiter, RD	1
Abernathy, KE; During, M; He, DY; Kalivas, PW; Klugmann, M; Lominac, KD; Oleson, EB; Ron, D; Szumlinski, KK	1
Johnson, BA	1
Anderson, SM; Famous, KR; Kumaresan, V; Pierce, RC; Schmidt, HD	1
Becker, N; Mead, AN; Stephens, DN; Zamanillo, D	1
Rebec, GV; Sun, W	1
Davidson, C; Ellinwood, EH; Lazarus, C; Lee, TH; Wetsel, WC; Zhang, X	1
Steketee, JD	1
Gardner, EL; Gilbert, JG; Li, X; Pak, AC; Peng, XQ; Xi, ZX	1
Kalivas, PW; Melendez, RI; Murphy, TH; Pacchioni, AM; Shih, A; Vallone, J	1
Ben-Shahar, O; Brake, W; Cook, M; Ettenberg, A; Heston, R; Joyce, M; Keeley, P; Nyffeler, M	1
Biswas, S; Harlan, RE; Neisewander, JL; Zavala, AR	1
Boutros, N; Stanley, J; Sundaresan, K; Ziemann, U	1
Rice, KC; Wang, B; Wise, RA; You, ZB	1
Famous, KR; Pierce, RC; Schmidt, HD	1
Bonci, A; Borgland, SL; Kharazia, VN; Sarti, F	1
Azari, S; Wang, B; Wise, RA; You, ZB; Zitzman, D	1
Anderson, SM; Bass, CE; Cha, JH; Famous, KR; Kumaresan, V; Pierce, RC; Sadri-Vakili, G; Schmidt, HD; Terwilliger, EF	1
Kalivas, PW; Shaham, Y; Thomas, MJ	1
Ferrario, CR; Kennedy, RT; Robinson, TE; Samaha, AN; Shou, M; Watson, CJ	1
Kalivas, PW; Tang, XC; Torregrossa, MM	1
Kosten, TR	1
Wickelgren, I	1
Ghasemzadeh, MB; Kalivas, PW; Lu, XY; Nelson, LC	1
Cornish, JL; Duffy, P; Kalivas, PW	1
Cornish, JL; Kalivas, PW	1
Gardner, EL; Hayes, RJ; Liu, X; Spector, JA; Vorel, SR	1
Holden, C	1
Nestler, EJ	1
Kozell, LB; Meshul, CK	1
Giorgetti, M; Hotsenpiller, G; Wolf, ME	1
Anderson, SM; Bari, AA; Jey, AR; Park, WK; Pierce, RC; Rowlett, JK; Spealman, RD	1

Reviews

21 review(s) available for glutamic acid and Cocaine Abuse

Article	Year
Cocaine use disorder: A look at metabotropic glutamate receptors and glutamate transporters. Pharmacology & therapeutics, 2021, Volume: 221 Topics: Amino Acid Transport System X-AG; Cocaine-Related Disorders; Glutamic Acid; Humans; Receptors, Metabotropic Glutamate; Recurrence	2021
Kinase interest you in treating incubated cocaine-craving? A hypothetical model for treatment intervention during protracted withdrawal from cocaine. Genes, brain, and behavior, 2018, Volume: 17, Issue:3 Topics: Animals; Behavior, Addictive; Cocaine; Cocaine-Related Disorders; Craving; Cues; Drug-Seeking Behavior; Excitatory Amino Acid Agents; Extinction, Psychological; Glutamic Acid; Humans; MAP Kinase Signaling System; Mice; Prefrontal Cortex; Protein Kinase C; Rats; Substance Withdrawal Syndrome; Withholding Treatment	2018
The contribution of neuroplasticity induced in cholinergic neurons of the laterodorsal tegmental nucleus to cocaine addiction. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 2017, Volume: 37, Issue:1 Topics: Animals; Cholinergic Neurons; Cocaine; Cocaine-Related Disorders; Glutamic Acid; Humans; Neuronal Plasticity; Synapses	2017
The role of neuroplasticity in cholinergic neurons of the laterodorsal tegmental nucleus for cocaine addiction. Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence, 2016, Volume: 51, Issue:5 Topics: Animals; Cholinergic Neurons; Cocaine-Related Disorders; Glutamic Acid; Humans; Neuronal Plasticity; Tegmentum Mesencephali	2016
Silent Synapse-Based Circuitry Remodeling in Drug Addiction. The international journal of neuropsychopharmacology, 2016, Volume: 19, Issue:5 Topics: Adaptation, Physiological; Adaptation, Psychological; Animals; Behavior, Addictive; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Drug Users; Excitatory Postsynaptic Potentials; Glutamic Acid; Humans; Neuronal Plasticity; Nucleus Accumbens; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission	2016
The good and bad news about glutamate in drug addiction. Journal of psychopharmacology (Oxford, England), 2016, Volume: 30, Issue:11 Topics: Behavior, Addictive; Cocaine-Related Disorders; Dopamine; Glutamic Acid; Humans; Neuronal Plasticity; Prefrontal Cortex; Substance-Related Disorders; Synaptic Transmission	2016
N-acetylcysteine for treating cocaine addiction - A systematic review. Psychiatry research, 2017, Volume: 251 Topics: Acetylcysteine; Animals; Cocaine-Related Disorders; Female; Free Radical Scavengers; Glutamic Acid; Humans; Male; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Recurrence; Secondary Prevention; Treatment Outcome	2017
Ventral tegmental glutamate: a role in stress-, cue-, and cocaine-induced reinstatement of cocaine-seeking. Neuropharmacology, 2009, Volume: 56 Suppl 1 Topics: Animals; Cocaine; Cocaine-Related Disorders; Cues; Glutamic Acid; Humans; Stress, Psychological; Ventral Tegmental Area	2009
Glutamate: the new frontier in pharmacotherapy for cocaine addiction. CNS & neurological disorders drug targets, 2008, Volume: 7, Issue:5 Topics: Animals; Brain; Cocaine; Cocaine-Related Disorders; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Receptors, Glutamate; Signal Transduction; Synaptic Transmission	2008
Hypothesis-driven medication discovery for the treatment of psychostimulant addiction. Current drug abuse reviews, 2008, Volume: 1, Issue:3 Topics: Animals; Brain; Cannabinoid Receptor Modulators; Central Nervous System Stimulants; Cocaine-Related Disorders; Dopamine; Dopamine Agonists; Dopamine Antagonists; Drug Evaluation, Preclinical; Excitatory Amino Acid Agonists; GABA Agonists; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Narcotic Antagonists; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Serotonin Antagonists; Serotonin Receptor Agonists; Substance-Related Disorders; Treatment Outcome; Vesicular Monoamine Transport Proteins	2008
Brain-derived neurotrophic factor and cocaine addiction. Brain research, 2010, Feb-16, Volume: 1314 Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Glutamic Acid; Humans; MAP Kinase Signaling System; Nucleus Accumbens; Prefrontal Cortex	2010
Corticotropin releasing factor and neuroplasticity in cocaine addiction. Life sciences, 2010, Jan-02, Volume: 86, Issue:1-2 Topics: Animals; Cocaine-Related Disorders; Corticotropin-Releasing Hormone; Dopamine; Glutamic Acid; Humans; Neuronal Plasticity; Stress, Physiological	2010
Cocaine-induced neuroadaptations in glutamate transmission: potential therapeutic targets for craving and addiction. Annals of the New York Academy of Sciences, 2010, Volume: 1187 Topics: Adaptation, Physiological; Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Dopamine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Models, Neurological; Neuronal Plasticity; Nucleus Accumbens; Rats; Receptors, Glutamate; Reinforcement, Psychology; Signal Transduction; Synaptic Transmission	2010
AMPA receptor synaptic plasticity induced by psychostimulants: the past, present, and therapeutic future. Neuron, 2010, Jul-15, Volume: 67, Issue:1 Topics: Animals; Central Nervous System Stimulants; Clinical Trials as Topic; Cocaine; Cocaine-Related Disorders; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Limbic System; Models, Biological; Neuronal Plasticity; Prefrontal Cortex; Receptors, AMPA; Signal Transduction; Synapses; Synaptic Transmission	2010
Glutamatergic neuroplasticity in cocaine addiction. Progress in molecular biology and translational science, 2011, Volume: 98 Topics: Animals; Cocaine-Related Disorders; Glutamic Acid; Homeostasis; Humans; Nerve Net; Neuronal Plasticity; Oxidation-Reduction	2011
Pharmacotherapeutics directed at deficiencies associated with cocaine dependence: focus on dopamine, norepinephrine and glutamate. Pharmacology & therapeutics, 2012, Volume: 134, Issue:2 Topics: Animals; Brain; Clinical Trials as Topic; Cocaine-Related Disorders; Dopamine; Glutamic Acid; Humans; Norepinephrine; Randomized Controlled Trials as Topic	2012
Recent advances in the development of treatments for alcohol and cocaine dependence: focus on topiramate and other modulators of GABA or glutamate function. CNS drugs, 2005, Volume: 19, Issue:10 Topics: Alcoholism; Animals; Cocaine-Related Disorders; Fructose; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Neuroprotective Agents; Topiramate	2005
Anatomy and pharmacology of cocaine priming-induced reinstatement of drug seeking. European journal of pharmacology, 2005, Dec-05, Volume: 526, Issue:1-3 Topics: Basal Ganglia; Cocaine; Cocaine-Related Disorders; Dopamine; Glutamic Acid; Humans; Limbic System; Models, Neurological; Neural Pathways; Recurrence; Synaptic Transmission	2005
Cortical mechanisms of cocaine sensitization. Critical reviews in neurobiology, 2005, Volume: 17, Issue:2 Topics: Animals; Cocaine; Cocaine-Related Disorders; Dopamine; Dopamine Uptake Inhibitors; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Prefrontal Cortex; Receptors, Dopamine; Receptors, GABA; Receptors, Glutamate; Synaptic Transmission	2005
Neuroplasticity in the mesolimbic dopamine system and cocaine addiction. British journal of pharmacology, 2008, Volume: 154, Issue:2 Topics: Animals; Behavior, Addictive; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cocaine-Related Disorders; Dopamine; Extracellular Signal-Regulated MAP Kinases; Glutamic Acid; Humans; Limbic System; Models, Animal; Neural Pathways; Neuronal Plasticity; Psychomotor Performance; Recurrence; Synaptic Transmission	2008
Pharmacotherapy of cerebral ischemia in cocaine dependence. Drug and alcohol dependence, 1998, Jan-01, Volume: 49, Issue:2 Topics: Aspirin; Brain; Brain Ischemia; Cerebrovascular Circulation; Cocaine; Cocaine-Related Disorders; Cognition Disorders; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Intracranial Embolism and Thrombosis; Male; Nerve Degeneration; Neuropsychological Tests; Platelet Aggregation Inhibitors; Radionuclide Imaging; Substance Withdrawal Syndrome	1998

Trials

3 trial(s) available for glutamic acid and Cocaine Abuse

Article	Year
N-acetylcysteine reduces cocaine-seeking behavior and anterior cingulate glutamate/glutamine levels among cocaine-dependent individuals. Addiction biology, 2021, Volume: 26, Issue:2 Topics: Acetylcysteine; Adult; Cocaine-Related Disorders; Cross-Over Studies; Double-Blind Method; Drug-Seeking Behavior; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Male; Middle Aged; Proton Magnetic Resonance Spectroscopy; Reward	2021
The effect of N-acetylcysteine and working memory training on glutamate concentrations in the dACC and rACC in regular cocaine users - A randomized proof of concept study. Neuroscience letters, 2021, 09-25, Volume: 762 Topics: Acetylcysteine; Adult; Cocaine-Related Disorders; Double-Blind Method; Glutamic Acid; Gyrus Cinguli; Humans; Learning; Male; Memory, Short-Term; Middle Aged; Proof of Concept Study	2021
N-acetylcysteine normalizes glutamate levels in cocaine-dependent patients: a randomized crossover magnetic resonance spectroscopy study. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012, Volume: 37, Issue:9 Topics: Acetylcysteine; Adult; Cocaine-Related Disorders; Cross-Over Studies; Glutamic Acid; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Pilot Projects	2012

Other Studies

107 other study(ies) available for glutamic acid and Cocaine Abuse

Article	Year
Elevation of Extracellular Glutamate by Blockade of Astrocyte Glutamate Transporters Inhibits Cocaine Reinforcement in Rats via a NMDA-GluN2B Receptor Mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022, 03-16, Volume: 42, Issue:11 Topics: Amino Acid Transport System X-AG; Animals; Astrocytes; Cocaine; Cocaine-Related Disorders; Female; Glutamic Acid; Male; N-Methylaspartate; Nucleus Accumbens; Rats; Receptors, N-Methyl-D-Aspartate; Self Administration	2022
Responsivity of serotonin transporter knockout rats to short and long access to cocaine: Modulation of the glutamate signalling in the nucleus accumbens shell. British journal of pharmacology, 2022, Volume: 179, Issue:14 Topics: Animals; Cocaine; Cocaine-Related Disorders; Glutamic Acid; Nucleus Accumbens; Rats; Self Administration; Serotonin Plasma Membrane Transport Proteins	2022
Oxycodone withdrawal is associated with increased cocaine self-administration and aberrant accumbens glutamate plasticity in rats. Neuropharmacology, 2024, Jan-01, Volume: 242 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics, Opioid; Animals; Cocaine; Cocaine-Related Disorders; Glutamic Acid; N-Methylaspartate; Nucleus Accumbens; Oxycodone; Rats; Rats, Sprague-Dawley; Self Administration	2024
Projection-Specific Potentiation of Ventral Pallidal Glutamatergic Outputs after Abstinence from Cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020, 02-05, Volume: 40, Issue:6 Topics: Animals; Basal Forebrain; Cocaine-Related Disorders; Female; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neural Pathways; Neuronal Plasticity; Neurons; Recurrence; Reward; Substance Withdrawal Syndrome	2020
Alpha-1 Adrenergic Receptors Modulate Glutamate and GABA Neurotransmission onto Ventral Tegmental Dopamine Neurons during Cocaine Sensitization. International journal of molecular sciences, 2020, Jan-25, Volume: 21, Issue:3 Topics: Action Potentials; Animals; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopaminergic Neurons; gamma-Aminobutyric Acid; Glutamic Acid; Male; Models, Biological; Patch-Clamp Techniques; Presynaptic Terminals; Rats; Receptors, Adrenergic, alpha-1; Signal Transduction; Ventral Tegmental Area	2020
Impaired glutamate homeostasis in the nucleus accumbens in human cocaine addiction. Molecular psychiatry, 2021, Volume: 26, Issue:9 Topics: Animals; Cocaine; Cocaine-Related Disorders; Drug-Seeking Behavior; Glutamic Acid; Homeostasis; Humans; Nucleus Accumbens; Self Administration	2021
Dysregulation of Decision Making Related to Metabotropic Glutamate 5, but Not Midbrain D Biological psychiatry, 2020, 11-15, Volume: 88, Issue:10 Topics: Animals; Cocaine; Cocaine-Related Disorders; Decision Making; Glutamic Acid; Mesencephalon; Rats; Self Administration	2020
Elevated GABA levels in the medial prefrontal cortex and lower estrogen levels abolish cocaine sensitization behavior in ovariectomized female rats. Brain research, 2020, 12-15, Volume: 1749 Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Estradiol; Female; gamma-Aminobutyric Acid; Glutamic Acid; Microdialysis; Motor Activity; Ovariectomy; Prefrontal Cortex; Rats; Rats, Wistar; Taurine	2020
LSP2-9166, an orthosteric mGlu4 and mGlu7 receptor agonist, reduces cocaine self-administration under a progressive ratio schedule in rats. Neuroscience letters, 2021, 11-01, Volume: 764 Topics: Administration, Intravenous; Aminobutyrates; Animals; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Glutamic Acid; Humans; Male; Motivation; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Reinforcement, Psychology; Self Administration; Synaptic Transmission	2021
Restoring glutamate homeostasis in the nucleus accumbens via endocannabinoid-mimetic drug prevents relapse to cocaine seeking behavior in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2021, Volume: 46, Issue:5 Topics: Animals; Cocaine; Cocaine-Related Disorders; Endocannabinoids; Extinction, Psychological; Glutamic Acid; Homeostasis; Nucleus Accumbens; Pharmaceutical Preparations; Rats; Rats, Sprague-Dawley; Recurrence; Self Administration	2021
Reduced Glutamate Turnover in the Putamen Is Linked With Automatic Habits in Human Cocaine Addiction. Biological psychiatry, 2021, 05-15, Volume: 89, Issue:10 Topics: Cocaine; Cocaine-Related Disorders; Glutamic Acid; Habits; Humans; Magnetic Resonance Imaging; Putamen	2021
Long access to cocaine self-administration dysregulates the glutamate synapse in the nucleus accumbens core of serotonin transporter knockout rats. British journal of pharmacology, 2022, Volume: 179, Issue:17 Topics: Animals; Cocaine; Cocaine-Related Disorders; Glutamic Acid; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Self Administration; Serotonin; Serotonin Plasma Membrane Transport Proteins; Synapses	2022
Sex-specific role for prefrontal cortical protein interacting with C kinase 1 in cue-induced cocaine seeking. Addiction biology, 2021, Volume: 26, Issue:5 Topics: Animals; Cell Cycle Proteins; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Drug-Seeking Behavior; Female; Glutamic Acid; Male; Mice; Nucleus Accumbens; Prefrontal Cortex; Receptors, AMPA; Self Administration; Sex Characteristics; Sucrose; Synapses	2021
CB1R activation in nucleus accumbens core promotes stress-induced reinstatement of cocaine seeking by elevating extracellular glutamate in a drug-paired context. Scientific reports, 2021, 06-21, Volume: 11, Issue:1 Topics: Animals; Behavior, Animal; Biomarkers; Cocaine; Cocaine-Related Disorders; Conditioning, Classical; Disease Models, Animal; Disease Susceptibility; Extinction, Psychological; Extracellular Space; Glutamic Acid; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Stress, Physiological	2021
Modulatory effects of Ampicillin/Sulbactam on glial glutamate transporters and metabotropic glutamate receptor 1 as well as reinstatement to cocaine-seeking behavior. Behavioural brain research, 2017, 08-14, Volume: 332 Topics: Amino Acid Transport Systems, Acidic; Ampicillin; Animals; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Excitatory Amino Acid Agents; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Genetic Predisposition to Disease; Glutamic Acid; Male; Motor Activity; Neuroglia; Nucleus Accumbens; Prefrontal Cortex; Rats; Receptors, Metabotropic Glutamate; Self Administration; Sulbactam	2017
Deletion of Type 2 Metabotropic Glutamate Receptor Decreases Sensitivity to Cocaine Reward in Rats. Cell reports, 2017, 07-11, Volume: 20, Issue:2 Topics: Animals; Cocaine; Cocaine-Related Disorders; Dopamine; Glutamic Acid; Male; Mice; Mice, Knockout; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Risk Factors	2017
N-Acetylcysteine reduces cocaine-cue attentional bias and differentially alters cocaine self-administration based on dosing order. Drug and alcohol dependence, 2017, 09-01, Volume: 178 Topics: Acetylcysteine; Animals; Attentional Bias; Cocaine; Cocaine-Related Disorders; Cues; Double-Blind Method; Glutamic Acid; Humans; Motivation; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration	2017
Prefrontal Glx and GABA concentrations and impulsivity in cigarette smokers and smoking polysubstance users. Drug and alcohol dependence, 2017, 10-01, Volume: 179 Topics: Cigarette Smoking; Cocaine-Related Disorders; gamma-Aminobutyric Acid; Glutamic Acid; Gyrus Cinguli; Humans; Impulsive Behavior; Male; Proton Magnetic Resonance Spectroscopy; Substance-Related Disorders	2017
Endogenous glutamate within the prelimbic and infralimbic cortices regulates the incubation of cocaine-seeking in rats. Neuropharmacology, 2018, Volume: 128 Topics: Amino Acids; Anesthetics, Local; Animals; Aspartic Acid; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Drug-Seeking Behavior; Excitatory Amino Acid Agents; Glutamic Acid; Male; Microdialysis; Microinjections; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration	2018
Glutamatergic Biomarkers for Cocaine Addiction: A Longitudinal Study Using MR Spectroscopy and mGluR5 PET in Self-Administering Rats. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2018, Volume: 59, Issue:6 Topics: Animals; Biomarkers; Cocaine-Related Disorders; Glutamic Acid; Magnetic Resonance Spectroscopy; Male; Nitriles; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Self Administration	2018
Regionally Specific Effects of Oxytocin on Reinstatement of Cocaine Seeking in Male and Female Rats. The international journal of neuropsychopharmacology, 2018, 07-01, Volume: 21, Issue:7 Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Cues; Disease Models, Animal; Dopamine Uptake Inhibitors; Female; Glutamic Acid; Male; Nucleus Accumbens; Oxytocin; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology	2018
Deletion of EMBO reports, 2018, Volume: 19, Issue:9 Topics: Amygdala; Animals; Behavior, Addictive; Cocaine; Cocaine-Related Disorders; Dependovirus; Dopamine; Gene Deletion; Glutamic Acid; Locomotion; Male; Mice; Mice, Knockout; Neoplasm Proteins; Neurons; Nucleus Accumbens; Prefrontal Cortex; Reinforcement, Psychology; Synaptic Transmission	2018
Incentive and dopamine sensitization produced by intermittent but not long access cocaine self-administration. The European journal of neuroscience, 2019, Volume: 50, Issue:4 Topics: Animals; Catheterization, Peripheral; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Cues; Dopamine; Dopamine Uptake Inhibitors; Glutamic Acid; Male; Motivation; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Self Administration	2019
Nociceptin Receptors Upregulated in Cocaine Use Disorder: A Positron Emission Tomography Imaging Study Using [ The American journal of psychiatry, 2019, 06-01, Volume: 176, Issue:6 Topics: Adult; Brain; Bridged Bicyclo Compounds, Heterocyclic; Case-Control Studies; Cerebellum; Cocaine-Related Disorders; Dopamine; Female; Glutamic Acid; Humans; Male; Mesencephalon; Middle Aged; Nociceptin; Nociceptin Receptor; Opioid Peptides; Positron-Emission Tomography; Receptors, Opioid; Spiro Compounds; Ventral Striatum	2019
Changes in the glutamate biomarker expression in rats vulnerable or resistant to the rewarding effects of cocaine and their reversal by ceftriaxone. Behavioural brain research, 2019, 09-16, Volume: 370 Topics: Amino Acid Transport Systems, Acidic; Animals; Biomarkers, Pharmacological; Brain; Ceftriaxone; Cocaine; Cocaine-Related Disorders; Drug-Seeking Behavior; Excitatory Amino Acid Transporter 2; Gene Expression Regulation; Glutamic Acid; Male; NF-E2-Related Factor 2; NF-kappa B; Nucleus Accumbens; Rats; Rats, Wistar; Reward; Self Administration	2019
Relapse induced by cues predicting cocaine depends on rapid, transient synaptic potentiation. Neuron, 2013, Mar-06, Volume: 77, Issue:5 Topics: Animals; Cell Count; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Cues; Dendritic Spines; Environment; GABA Agonists; Glutamic Acid; Long-Term Potentiation; Male; Microinjections; Microscopy, Confocal; Motivation; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, GABA; Recurrence; Self Administration; Synaptic Transmission	2013
Extrasynaptic targeting of NMDA receptors following D1 dopamine receptor activation and cocaine self-administration. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, May-29, Volume: 33, Issue:22 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Blotting, Western; Cocaine; Cocaine-Related Disorders; Data Interpretation, Statistical; Dopamine Agonists; Dopamine Uptake Inhibitors; Extracellular Space; Glutamic Acid; Male; Nucleus Accumbens; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Self Administration; Synapses; Up-Regulation	2013
Imaging glutamate homeostasis in cocaine addiction with the metabotropic glutamate receptor 5 positron emission tomography radiotracer [(11)C]ABP688 and magnetic resonance spectroscopy. Biological psychiatry, 2014, Jan-15, Volume: 75, Issue:2 Topics: Adult; Brain; Carbon Radioisotopes; Case-Control Studies; Choice Behavior; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Functional Neuroimaging; Glutamic Acid; Glutamine; Homeostasis; Humans; Magnetic Resonance Spectroscopy; Male; Oximes; Positron-Emission Tomography; Pyridines; Receptor, Metabotropic Glutamate 5; Self Administration; Young Adult	2014
Critical role of peripheral drug actions in experience-dependent changes in nucleus accumbens glutamate release induced by intravenous cocaine. Journal of neurochemistry, 2014, Volume: 128, Issue:5 Topics: Animals; Behavior, Animal; Biosensing Techniques; Blood-Brain Barrier; Cocaine; Cocaine-Related Disorders; Data Interpretation, Statistical; Electrochemistry; Glutamic Acid; Injections, Intravenous; Male; Nucleus Accumbens; Peripheral Nervous System; Rats; Rats, Long-Evans; Reward; Self Administration; Substance-Related Disorders	2014
Prelimbic cortex and ventral tegmental area modulate synaptic plasticity differentially in nucleus accumbens during cocaine-reinstated drug seeking. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014, Volume: 39, Issue:5 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cocaine; Cocaine-Related Disorders; Dendritic Spines; Dopamine D2 Receptor Antagonists; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Extinction, Psychological; Glutamic Acid; In Vitro Techniques; Male; Neural Pathways; Neuronal Plasticity; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Synapses; Ventral Tegmental Area	2014
A shift in the role of glutamatergic signaling in the nucleus accumbens core with the development of an addicted phenotype. Biological psychiatry, 2014, Nov-15, Volume: 76, Issue:10 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Excitatory Amino Acid Antagonists; Extinction, Psychological; Female; Glutamic Acid; Male; Motivation; Nucleus Accumbens; Phenotype; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Reinforcement Schedule; Self Administration	2014
On the role of adenosine (A)₂A receptors in cocaine-induced reward: a pharmacological and neurochemical analysis in rats. Psychopharmacology, 2015, Volume: 232, Issue:2 Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Basal Forebrain; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Male; Nucleus Accumbens; Phenethylamines; Purines; Pyrimidines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Reinforcement, Psychology; Reward; Self Administration; Triazoles	2015
More cocaine-more glutamate-more addiction. Biological psychiatry, 2014, Nov-15, Volume: 76, Issue:10 Topics: Animals; Cocaine; Cocaine-Related Disorders; Female; Glutamic Acid; Male; Motivation; Nucleus Accumbens	2014
Glutamatergic and neurometabolic alterations in chronic cocaine users measured with (1) H-magnetic resonance spectroscopy. Addiction biology, 2016, Volume: 21, Issue:1 Topics: Adult; Aspartic Acid; Case-Control Studies; Choline; Cocaine-Related Disorders; Creatine; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Inositol; Magnetic Resonance Imaging; Male; Middle Aged; Prefrontal Cortex; Proton Magnetic Resonance Spectroscopy	2016
Extinction and reinstatement to cocaine-associated cues in male and female juvenile rats and the role of D1 dopamine receptor. Neuropharmacology, 2015, Volume: 95 Topics: Animals; Behavior, Addictive; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Cues; Dopamine Uptake Inhibitors; Extinction, Psychological; Female; Glutamic Acid; Male; Neurons; Prefrontal Cortex; Rats, Sprague-Dawley; Receptors, Dopamine D1; Repetition Priming; Sex Characteristics; Spatial Behavior	2015
Gq-DREADD Selectively Initiates Glial Glutamate Release and Inhibits Cue-induced Cocaine Seeking. Biological psychiatry, 2015, Oct-01, Volume: 78, Issue:7 Topics: Animals; Astrocytes; Calcium Channels, N-Type; Central Nervous System Agents; Clozapine; Cocaine; Cocaine-Related Disorders; Cues; Dietary Sucrose; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Extinction, Psychological; Genetic Therapy; Glutamic Acid; Male; Mice, Transgenic; Nucleus Accumbens; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Metabotropic Glutamate; Self Administration; SNARE Proteins	2015
Enhancing glutamatergic transmission during adolescence reverses early-life stress-induced deficits in the rewarding effects of cocaine in rats. Neuropharmacology, 2015, Volume: 99 Topics: Administration, Intravenous; Aging; Amino Acid Transport System X-AG; Animals; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Maternal Deprivation; Memantine; Rats; Receptors, N-Methyl-D-Aspartate; Reward; Riluzole; Self Administration; Stress, Psychological	2015
The absence of VGLUT3 predisposes to cocaine abuse by increasing dopamine and glutamate signaling in the nucleus accumbens. Molecular psychiatry, 2015, Volume: 20, Issue:11 Topics: Action Potentials; Adult; Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dopamine; Dopamine Uptake Inhibitors; Genetic Predisposition to Disease; Glutamic Acid; Humans; Mice; Mice, Transgenic; Middle Aged; Neurons; Nucleus Accumbens; Opioid-Related Disorders; Self Administration; Signal Transduction; Synaptic Potentials; Vesicular Glutamate Transport Proteins	2015
Ceftriaxone attenuates cocaine relapse after abstinence through modulation of nucleus accumbens AMPA subunit expression. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2016, Volume: 26, Issue:2 Topics: Analysis of Variance; Animals; Anti-Bacterial Agents; Area Under Curve; Ceftriaxone; Chromatography, High Pressure Liquid; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dose-Response Relationship, Drug; Excitatory Amino Acid Transporter 2; Gene Expression Regulation; Glutamic Acid; Male; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Self Administration; Time Factors	2016
Glutamatergic mechanisms of comorbidity between acute stress and cocaine self-administration. Molecular psychiatry, 2016, Volume: 21, Issue:8 Topics: Animals; Ceftriaxone; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Comorbidity; Dendritic Spines; Excitatory Amino Acid Agents; Extinction, Psychological; Glutamic Acid; Male; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Self Administration; Stress, Psychological; Synapses	2016
Enduring Loss of Serotonergic Control of Orbitofrontal Cortex Function Following Contingent and Noncontingent Cocaine Exposure. Cerebral cortex (New York, N.Y. : 1991), 2017, 12-01, Volume: 27, Issue:12 Topics: Animals; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Glutamic Acid; In Situ Hybridization; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Prefrontal Cortex; Rats, Long-Evans; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; RNA, Messenger; Self Administration; Serotonin; Tissue Culture Techniques	2017
Glutamatergic neurotransmission in the prefrontal cortex mediates the suppressive effect of intra-prelimbic cortical infusion of BDNF on cocaine-seeking. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2016, Volume: 26, Issue:12 Topics: Animals; Brain-Derived Neurotrophic Factor; Cocaine-Related Disorders; Glutamic Acid; Male; MAP Kinase Signaling System; Microinjections; Phenols; Piperidines; Prefrontal Cortex; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Self Administration; Substance Withdrawal Syndrome; Sulfonamides; Synaptic Transmission	2016
The rate of intravenous cocaine or amphetamine delivery does not influence drug-taking and drug-seeking behavior in rats. Pharmacology, biochemistry, and behavior, 2008, Volume: 90, Issue:4 Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Body Temperature; Cocaine; Cocaine-Related Disorders; Dopamine; Dose-Response Relationship, Drug; Genes, fos; Glutamic Acid; Infusions, Intravenous; Male; Motor Activity; Neostriatum; Rats; Rats, Long-Evans; Reinforcement Schedule; Self Administration; Substance Abuse, Intravenous	2008
Blunted cystine-glutamate antiporter function in the nucleus accumbens promotes cocaine-induced drug seeking. Neuroscience, 2008, Aug-13, Volume: 155, Issue:2 Topics: Animals; Antiporters; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Cystine; Dopamine Uptake Inhibitors; Extinction, Psychological; Glutamic Acid; Male; Microdialysis; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Self Administration; Synapses	2008
Effects of chronic buprenorphine treatment on levels of nucleus accumbens glutamate and on the expression of cocaine-induced behavioral sensitization in rats. Psychopharmacology, 2008, Volume: 200, Issue:3 Topics: Animals; Brain Mapping; Buprenorphine; Chromatography, High Pressure Liquid; Cocaine; Cocaine-Related Disorders; Dopamine; Dopamine Uptake Inhibitors; Glutamic Acid; Male; Microdialysis; Motor Activity; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Long-Evans	2008
Repeated exposure to cocaine alters the modulation of mesocorticolimbic glutamate transmission by medial prefrontal cortex Group II metabotropic glutamate receptors. Journal of neurochemistry, 2008, Volume: 107, Issue:1 Topics: Amino Acids; Animals; Cocaine; Cocaine-Related Disorders; Cystine; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug Administration Schedule; Excitatory Amino Acid Antagonists; Glutamic Acid; Limbic System; Male; Neural Pathways; Prefrontal Cortex; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synaptic Transmission; Synaptic Vesicles; Ventral Tegmental Area; Xanthenes	2008
Renewed cocaine exposure produces transient alterations in nucleus accumbens AMPA receptor-mediated behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, Nov-26, Volume: 28, Issue:48 Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Agonists; Dopamine Uptake Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Motor Activity; Neuronal Plasticity; Nucleus Accumbens; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Dopamine D1; Substance Withdrawal Syndrome; Synaptic Transmission	2008
Neuroadaptations in the cellular and postsynaptic group 1 metabotropic glutamate receptor mGluR5 and Homer proteins following extinction of cocaine self-administration. Neuroscience letters, 2009, Mar-13, Volume: 452, Issue:2 Topics: Actins; Adaptation, Physiological; Animals; Brain; Brain Chemistry; Carrier Proteins; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Disease Models, Animal; Disks Large Homolog 4 Protein; Dopamine Uptake Inhibitors; Extinction, Psychological; Glutamic Acid; Homer Scaffolding Proteins; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Neuronal Plasticity; Nucleus Accumbens; Presynaptic Terminals; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Self Administration; Synaptic Transmission; Synaptosomes	2009
Repeated cocaine administration decreases 5-HT(2A) receptor-mediated serotonergic enhancement of synaptic activity in rat medial prefrontal cortex. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009, Volume: 34, Issue:8 Topics: Animals; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug Administration Schedule; Drug Interactions; Excitatory Postsynaptic Potentials; Glutamic Acid; GTP-Binding Proteins; Male; Organ Culture Techniques; Patch-Clamp Techniques; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Serotonin; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Substance Withdrawal Syndrome; Synaptic Transmission	2009
A single intra-PFC infusion of BDNF prevents cocaine-induced alterations in extracellular glutamate within the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Mar-25, Volume: 29, Issue:12 Topics: Animals; Brain-Derived Neurotrophic Factor; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Extinction, Psychological; Extracellular Space; Glutamic Acid; Male; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Self Administration; Synaptic Transmission	2009
Control of within-binge cocaine-seeking by dopamine and glutamate in the core of nucleus accumbens. Psychopharmacology, 2009, Volume: 205, Issue:3 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Behavior, Addictive; Cocaine; Cocaine-Related Disorders; Dopamine; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Glutamic Acid; Male; Microdialysis; Nucleus Accumbens; Olfactory Pathways; Rats; Rats, Long-Evans; Receptors, AMPA; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Reinforcement Schedule; Self Administration	2009
Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc. Nature neuroscience, 2009, Volume: 12, Issue:8 Topics: Animals; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Glutamic Acid; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Net; Neural Pathways; Neuronal Plasticity; Nucleus Accumbens; Organ Culture Techniques; Receptors, Metabotropic Glutamate; Recurrence; Substance Withdrawal Syndrome; Synaptic Transmission; Ventral Tegmental Area	2009
Ceftriaxone restores glutamate homeostasis and prevents relapse to cocaine seeking. Biological psychiatry, 2010, Jan-01, Volume: 67, Issue:1 Topics: Analysis of Variance; Animals; Antioxidants; Ceftriaxone; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Cystine; Disease Models, Animal; Dopamine Uptake Inhibitors; Excitatory Amino Acid Transporter 2; Glutamic Acid; Male; Motor Activity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Self Administration; Time Factors; Tritium	2010
Inhibition of NAALADase by 2-PMPA attenuates cocaine-induced relapse in rats: a NAAG-mGluR2/3-mediated mechanism. Journal of neurochemistry, 2010, Volume: 112, Issue:2 Topics: Amino Acids; Analysis of Variance; Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Corpus Striatum; Dipeptides; Dopamine; Dose-Response Relationship, Drug; Extinction, Psychological; Glutamate Carboxypeptidase II; Glutamic Acid; Male; Microdialysis; Microinjections; Neuroprotective Agents; Nucleus Accumbens; Organophosphorus Compounds; Rats; Rats, Long-Evans; Receptors, Metabotropic Glutamate; Reinforcement Schedule; Self Administration; Sucrose; Sweetening Agents	2010
Lower glutamate levels in rostral anterior cingulate of chronic cocaine users - A (1)H-MRS study using TE-averaged PRESS at 3 T with an optimized quantification strategy. Psychiatry research, 2009, Dec-30, Volume: 174, Issue:3 Topics: Adult; Analysis of Variance; Aspartic Acid; Case-Control Studies; Cocaine-Related Disorders; Creatine; Female; Glutamic Acid; Gyrus Cinguli; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Protons; Spectrum Analysis; Statistics as Topic; Time Factors; Young Adult	2009
Lesion of the ventromedial nucleus of the thalamus blocks acute cocaine-induced changes in striatal glutamate. Synapse (New York, N.Y.), 2010, Volume: 64, Issue:6 Topics: Animals; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Denervation; Disease Models, Animal; Dopamine Uptake Inhibitors; Extracellular Fluid; Glutamic Acid; Male; Microdialysis; Neural Pathways; Neurosurgical Procedures; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Ventral Thalamic Nuclei	2010
Transition to addiction is associated with a persistent impairment in synaptic plasticity. Science (New York, N.Y.), 2010, Jun-25, Volume: 328, Issue:5986 Topics: Animals; Behavior, Addictive; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Glutamic Acid; Long-Term Synaptic Depression; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Self Administration; Synaptic Transmission	2010
Stress-related receptor targets for cocaine addiction. Biological psychiatry, 2010, Aug-01, Volume: 68, Issue:3 Topics: Adaptation, Physiological; Animals; Brain; Cocaine-Related Disorders; Disease Models, Animal; Glutamic Acid; Humans; Mice; Rats; Receptors, Metabotropic Glutamate; Stress, Physiological	2010
Cocaine use and abuse triggering sporadic young-onset amyotrophic lateral sclerosis. Neuro-degenerative diseases, 2011, Volume: 8, Issue:3 Topics: Adult; Age of Onset; Amyotrophic Lateral Sclerosis; Cocaine; Cocaine-Related Disorders; Glutamic Acid; Humans; Male; Motor Neurons; Nerve Degeneration; Receptors, Glutamate	2011
Reversing cocaine-induced synaptic potentiation provides enduring protection from relapse. Proceedings of the National Academy of Sciences of the United States of America, 2011, Jan-04, Volume: 108, Issue:1 Topics: Acetylcysteine; Animals; Chromatography, High Pressure Liquid; Cocaine-Related Disorders; Glutamic Acid; Homeostasis; Long-Term Potentiation; Microdialysis; Nucleus Accumbens; Patch-Clamp Techniques; Prefrontal Cortex; Rats; Receptors, Metabotropic Glutamate; Secondary Prevention; Signal Transduction; Synaptic Transmission	2011
Increased glutamatergic synaptic transmission in the amygdala of drug abusers. Biological psychiatry, 2011, Feb-01, Volume: 69, Issue:3 Topics: Amygdala; Cocaine-Related Disorders; Glutamic Acid; Heroin Dependence; Humans; Models, Neurological; Synaptic Transmission	2011
Chronic N-acetylcysteine during abstinence or extinction after cocaine self-administration produces enduring reductions in drug seeking. The Journal of pharmacology and experimental therapeutics, 2011, Volume: 337, Issue:2 Topics: Acetylcysteine; Animals; Cocaine; Cocaine-Related Disorders; Cues; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Extinction, Psychological; Glutamic Acid; Homeostasis; Male; Rats; Rats, Sprague-Dawley; Recurrence; Self Administration; Substance Withdrawal Syndrome	2011
Cocaine inverts rules for synaptic plasticity of glutamate transmission in the ventral tegmental area. Nature neuroscience, 2011, Volume: 14, Issue:4 Topics: Animals; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Glutamic Acid; Mice; Neuronal Plasticity; Organ Culture Techniques; Synaptic Transmission; Ventral Tegmental Area	2011
Attenuation of cocaine-induced conditioned locomotion is associated with altered expression of hippocampal glutamate receptors in mice lacking LPA1 receptors. Psychopharmacology, 2012, Volume: 220, Issue:1 Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Dopamine; Gene Expression Regulation; Glutamic Acid; Hippocampus; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Receptors, Glutamate; Receptors, Lysophosphatidic Acid	2012
Genetic differences in the modulation of accumbal glutamate and γ-amino butyric acid levels after cocaine-induced reinstatement. Addiction biology, 2013, Volume: 18, Issue:4 Topics: Analysis of Variance; Animals; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Electrophoresis, Capillary; Extinction, Psychological; gamma-Aminobutyric Acid; Genetic Predisposition to Disease; Glutamic Acid; Microdialysis; Nucleus Accumbens; Rats; Rats, Inbred F344; Rats, Inbred Lew; Recurrence; Self Administration; Sodium Chloride; Species Specificity	2013
Extended access to cocaine self-administration results in reduced glutamate function within the medial prefrontal cortex. Addiction biology, 2012, Volume: 17, Issue:4 Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dopamine; Dopamine Uptake Inhibitors; Glutamic Acid; Male; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Self Administration	2012
Time course of cocaine-induced behavioral and neurochemical plasticity. Addiction biology, 2014, Volume: 19, Issue:4 Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Glutamic Acid; Male; Neuronal Plasticity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Recurrence; Self Administration; Substance Withdrawal Syndrome; Time Factors	2014
Regulation of medial prefrontal cortex dopamine by alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptors. Neuroscience, 2002, Volume: 114, Issue:2 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amphetamine; Animals; Cocaine; Cocaine-Related Disorders; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Motor Activity; Neostriatum; Neurons; Potassium Chloride; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Reward; Stress, Physiological; Synaptic Transmission; Up-Regulation	2002
Critical role for ventral tegmental glutamate in preference for a cocaine-conditioned environment. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2003, Volume: 28, Issue:1 Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cocaine; Cocaine-Related Disorders; Cues; Environment; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Microinjections; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Ventral Tegmental Area	2003
Baclofen attenuates conditioned locomotion to cues associated with cocaine administration and stabilizes extracellular glutamate levels in rat nucleus accumbens. Neuroscience, 2003, Volume: 118, Issue:1 Topics: Animals; Baclofen; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Cues; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Extracellular Space; GABA Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Motor Activity; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Reward; Substance Withdrawal Syndrome; Synaptic Transmission	2003
GABA transmission in the nucleus accumbens is altered after withdrawal from repeated cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Apr-15, Volume: 23, Issue:8 Topics: Animals; Binding, Competitive; Chronic Disease; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine; Drug Administration Schedule; Extracellular Space; GABA Agonists; GABA Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Guanosine 5'-O-(3-Thiotriphosphate); Male; Microdialysis; Nucleus Accumbens; Phosphorylation; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Substance Withdrawal Syndrome; Synaptic Transmission	2003
Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug-seeking behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Apr-15, Volume: 23, Issue:8 Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Disease Models, Animal; Dopamine; Extinction, Psychological; Extracellular Space; GABA Agonists; Glutamic Acid; Male; Microdialysis; Neurons; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Recurrence; Reinforcement, Psychology; Self Administration	2003
Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse. Nature neuroscience, 2003, Volume: 6, Issue:7 Topics: Acetylcysteine; Adaptation, Physiological; Analysis of Variance; Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Corpus Striatum; Cystine; Dose-Response Relationship, Drug; Expectorants; Extinction, Psychological; Extracellular Space; Glutamic Acid; Male; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Recurrence; Reinforcement, Psychology; Self Administration; Substance Withdrawal Syndrome; Time Factors	2003
Limbic and motor circuitry underlying footshock-induced reinstatement of cocaine-seeking behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Feb-18, Volume: 24, Issue:7 Topics: Amygdala; Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Disease Models, Animal; Dopamine; Dopamine Antagonists; Efferent Pathways; Electroshock; GABA Agonists; Globus Pallidus; Glutamic Acid; Limbic System; Male; Microinjections; Motor Activity; Neostriatum; Neural Inhibition; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Recurrence; Self Administration; Septal Nuclei; Ventral Tegmental Area	2004
Homer proteins regulate sensitivity to cocaine. Neuron, 2004, Aug-05, Volume: 43, Issue:3 Topics: Animals; Carrier Proteins; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Dose-Response Relationship, Drug; Glutamic Acid; Homer Scaffolding Proteins; Locomotion; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Nucleus Accumbens; Self Administration	2004
Cocaine increases medial prefrontal cortical glutamate overflow in cocaine-sensitized rats: a time course study. The European journal of neuroscience, 2004, Volume: 20, Issue:6 Topics: Analysis of Variance; Animals; Behavior, Animal; Brain Chemistry; Chromatography, High Pressure Liquid; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Drug Administration Schedule; Glutamic Acid; Male; Microdialysis; Motor Activity; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Time Factors	2004
The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption. Nature medicine, 2005, Volume: 11, Issue:1 Topics: Acamprosate; Alcohol Deterrents; Alcohol Drinking; Alcoholism; Amino Acid Transport System X-AG; Animals; Biological Clocks; Cell Cycle Proteins; Cocaine; Cocaine-Related Disorders; Glutamic Acid; Humans; Mice; Nuclear Proteins; Period Circadian Proteins; Taurine; Time Factors; Transcription Factors	2005
Clock reset for alcoholism. Nature medicine, 2005, Volume: 11, Issue:1 Topics: Alcohol Drinking; Alcoholism; Animals; Biological Clocks; Cell Cycle Proteins; Cocaine; Cocaine-Related Disorders; Glutamic Acid; Humans; Mice; Nuclear Proteins; Period Circadian Proteins; Transcription Factors	2005
Cocaine experience establishes control of midbrain glutamate and dopamine by corticotropin-releasing factor: a role in stress-induced relapse to drug seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Jun-01, Volume: 25, Issue:22 Topics: Animals; Cocaine-Related Disorders; Corticotropin-Releasing Hormone; Dopamine; Glutamic Acid; Male; Microdialysis; Rats; Rats, Long-Evans; Recurrence; Stress, Physiological; Ventral Tegmental Area	2005
Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Jul-06, Volume: 25, Issue:27 Topics: Amino Acids; Animals; Biological Transport; Cocaine; Cocaine-Related Disorders; Consummatory Behavior; Cystine; Excitatory Amino Acid Antagonists; Extinction, Psychological; Glutamic Acid; Male; Neural Conduction; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, Presynaptic; Self Administration; Xanthenes	2005
Expression of mutant NMDA receptors in dopamine D1 receptor-containing cells prevents cocaine sensitization and decreases cocaine preference. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Jul-13, Volume: 25, Issue:28 Topics: Amino Acid Substitution; Amphetamine; Animals; Brain; Central Nervous System Stimulants; Chromosomes, Artificial, P1 Bacteriophage; Cocaine; Cocaine-Related Disorders; Conditioning, Classical; Dopamine; Exploratory Behavior; Glutamic Acid; Locomotion; Mice; Mutation, Missense; Neurons; Point Mutation; Rats; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; Reward	2005
Homer isoforms differentially regulate cocaine-induced neuroplasticity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2006, Volume: 31, Issue:4 Topics: Anesthetics, Local; Animals; Behavior, Animal; Carrier Proteins; Chromatography, High Pressure Liquid; Cocaine; Cocaine-Related Disorders; Dopamine; Gene Expression Regulation; Glutamic Acid; Homer Scaffolding Proteins; Male; Mice; Microdialysis; Motor Activity; Neuronal Plasticity; Nucleus Accumbens; Protein Isoforms; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Time Factors	2006
AMPA-receptor GluR1 subunits are involved in the control over behavior by cocaine-paired cues. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007, Volume: 32, Issue:2 Topics: Animals; Behavior, Animal; Brain; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Cues; Disease Models, Animal; Dopamine Uptake Inhibitors; Extinction, Psychological; Glutamic Acid; Learning; Male; Mice; Mice, Knockout; Reaction Time; Receptors, AMPA; Reinforcement, Psychology; Reward; Self Administration; Synaptic Transmission	2007
Neuronal substrates of relapse to cocaine-seeking behavior: role of prefrontal cortex. Journal of the experimental analysis of behavior, 2005, Volume: 84, Issue:3 Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dopamine; Electroencephalography; Evoked Potentials; Feedback; Glutamic Acid; Male; Motivation; Nerve Net; Neurons; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Recurrence; Self Administration; Substance Withdrawal Syndrome	2005
Reversal of cocaine-induced behavioral sensitization and associated phosphorylation of the NR2B and GluR1 subunits of the NMDA and AMPA receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007, Volume: 32, Issue:2 Topics: Animals; Behavior, Addictive; Brain; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine; Dopamine Agonists; Dopamine Uptake Inhibitors; Drug Therapy, Combination; Glutamic Acid; Male; Neurons; Nucleus Accumbens; Ondansetron; Pergolide; Phosphorylation; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Serotonin Antagonists; Synaptic Transmission	2007
Cannabinoid CB1 receptor antagonist AM251 inhibits cocaine-primed relapse in rats: role of glutamate in the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Aug-16, Volume: 26, Issue:33 Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Dopamine; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Male; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Recurrence; Reward	2006
Nrf2 gene deletion fails to alter psychostimulant-induced behavior or neurotoxicity. Brain research, 2007, Jan-05, Volume: 1127, Issue:1 Topics: Amino Acid Transport System y+; Animals; Brain; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Gene Expression Regulation; Glutamic Acid; Methamphetamine; Mice; Mice, Knockout; Nerve Degeneration; NF-E2-Related Factor 2; Nucleus Accumbens; Oxidative Stress; Regulatory Elements, Transcriptional	2007
Changes in levels of D1, D2, or NMDA receptors during withdrawal from brief or extended daily access to IV cocaine. Brain research, 2007, Feb-02, Volume: 1131, Issue:1 Topics: Adaptation, Physiological; Animals; Binding, Competitive; Brain Chemistry; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Drug Administration Schedule; Glutamic Acid; Injections, Intravenous; Male; Neural Pathways; Nucleus Accumbens; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome; Synaptic Transmission	2007
Fos and glutamate AMPA receptor subunit coexpression associated with cue-elicited cocaine-seeking behavior in abstinent rats. Neuroscience, 2007, Mar-16, Volume: 145, Issue:2 Topics: Animals; Biomarkers; Brain; Cocaine; Cocaine-Related Disorders; Cues; Dopamine Uptake Inhibitors; Exploratory Behavior; Glutamic Acid; Limbic System; Male; Protein Subunits; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Self Administration; Substance Withdrawal Syndrome; Synaptic Transmission; Up-Regulation	2007
Cortical inhibition and excitation in abstinent cocaine-dependent patients: a transcranial magnetic stimulation study. Neuroreport, 2007, Feb-12, Volume: 18, Issue:3 Topics: Adult; Brain; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Evoked Potentials, Motor; Excitatory Postsynaptic Potentials; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Male; Middle Aged; Motor Cortex; Neural Inhibition; Substance Withdrawal Syndrome; Synaptic Transmission; Transcranial Magnetic Stimulation	2007
Stress-induced relapse to cocaine seeking: roles for the CRF(2) receptor and CRF-binding protein in the ventral tegmental area of the rat. Psychopharmacology, 2007, Volume: 193, Issue:2 Topics: Animals; Behavior, Animal; Carrier Proteins; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Corticotropin-Releasing Hormone; Dopamine; Electroshock; Glutamic Acid; Male; Protein Binding; Rats; Rats, Long-Evans; Receptors, Corticotropin-Releasing Hormone; Recurrence; Self Administration; Stress, Psychological; Ventral Tegmental Area	2007
When administered into the nucleus accumbens core or shell, the NMDA receptor antagonist AP-5 reinstates cocaine-seeking behavior in the rat. Neuroscience letters, 2007, Jun-13, Volume: 420, Issue:2 Topics: 2-Amino-5-phosphonovalerate; Animals; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Exploratory Behavior; Glutamic Acid; Male; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Recurrence	2007
Acute cocaine exposure alters spine density and long-term potentiation in the ventral tegmental area. The European journal of neuroscience, 2007, Volume: 26, Issue:3 Topics: Action Potentials; Animals; Cell Shape; Cocaine; Cocaine-Related Disorders; Dendritic Spines; Dopamine; Dopamine Uptake Inhibitors; Glutamic Acid; Long-Term Potentiation; Lysine; Male; Organ Culture Techniques; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Staining and Labeling; Synapses; Synaptic Transmission; Ventral Tegmental Area	2007
A role for conditioned ventral tegmental glutamate release in cocaine seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, Sep-26, Volume: 27, Issue:39 Topics: Animals; Behavior, Addictive; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Disease Models, Animal; Dopamine Uptake Inhibitors; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Rats; Rats, Long-Evans; Reinforcement, Psychology; Ventral Tegmental Area	2007
CaMKII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking. Nature neuroscience, 2008, Volume: 11, Issue:3 Topics: Animals; Binding Sites; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cocaine; Cocaine-Related Disorders; Diltiazem; Dopamine; Dopamine Agonists; Dopamine Uptake Inhibitors; Glutamic Acid; Male; Nucleus Accumbens; Phosphorylation; Protein Transport; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Dopamine D1; Synaptic Transmission; Threonine	2008
The rate of intravenous cocaine administration alters c-fos mRNA expression and the temporal dynamics of dopamine, but not glutamate, overflow in the striatum. Brain research, 2008, May-13, Volume: 1209 Topics: Animals; Biomarkers; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Drug Administration Schedule; Extracellular Fluid; Gene Expression; Genes, Immediate-Early; Glutamic Acid; Injections, Intravenous; Microdialysis; Proto-Oncogene Proteins c-fos; Rats; RNA, Messenger; Time Factors; Up-Regulation	2008
The glutamatergic projection from the prefrontal cortex to the nucleus accumbens core is required for cocaine-induced decreases in ventral pallidal GABA. Neuroscience letters, 2008, Jun-20, Volume: 438, Issue:2 Topics: Animals; Basal Ganglia; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Excitatory Amino Acid Antagonists; Extracellular Fluid; GABA Agonists; gamma-Aminobutyric Acid; Globus Pallidus; Glutamic Acid; Male; Microdialysis; Neural Pathways; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Synaptic Transmission	2008
Teaching the brain to take drugs. Science (New York, N.Y.), 1998, Jun-26, Volume: 280, Issue:5372 Topics: Acamprosate; Alcohol Deterrents; Alcoholism; Animals; Behavior, Addictive; Brain; Cocaine; Cocaine-Related Disorders; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Rats; Receptors, Glutamate; Substance-Related Disorders; Synaptic Transmission; Taurine	1998
Neuroadaptations in ionotropic and metabotropic glutamate receptor mRNA produced by cocaine treatment. Journal of neurochemistry, 1999, Volume: 72, Issue:1 Topics: Adaptation, Physiological; Animals; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Dopamine Uptake Inhibitors; Gene Expression; Glutamic Acid; Male; Molecular Sequence Data; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Ventral Tegmental Area	1999
A role for nucleus accumbens glutamate transmission in the relapse to cocaine-seeking behavior. Neuroscience, 1999, Volume: 93, Issue:4 Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, Local; Animals; Behavior, Addictive; Behavior, Animal; Benzazepines; Cocaine; Cocaine-Related Disorders; Dizocilpine Maleate; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Feeding Behavior; Glutamates; Glutamic Acid; Male; Nucleus Accumbens; Procaine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Recurrence; Self Administration; Synaptic Transmission	1999
Glutamate transmission in the nucleus accumbens mediates relapse in cocaine addiction. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Aug-01, Volume: 20, Issue:15 Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Extinction, Psychological; Glutamic Acid; Male; Microinjections; Motor Activity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate; Recurrence; Self Administration; Synaptic Transmission	2000
Relapse to cocaine-seeking after hippocampal theta burst stimulation. Science (New York, N.Y.), 2001, May-11, Volume: 292, Issue:5519 Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dopamine; Electric Stimulation; Electrodes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extinction, Psychological; Glutamic Acid; Hippocampus; Injections, Intravenous; Kynurenic Acid; Medial Forebrain Bundle; Memory; N-Methylaspartate; Rats; Rats, Long-Evans; Recurrence; Reward; Self Administration; Synaptic Transmission; Theta Rhythm; Ventral Tegmental Area	2001
Drug addiction. Zapping memory center triggers drug craving. Science (New York, N.Y.), 2001, May-11, Volume: 292, Issue:5519 Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dopamine; Electric Stimulation; Extinction, Psychological; Glutamic Acid; Hippocampus; Injections, Intravenous; Medial Forebrain Bundle; Memory; Rats; Recurrence; Reward; Self Administration; Ventral Tegmental Area	2001
Neurobiology. Total recall-the memory of addiction. Science (New York, N.Y.), 2001, Jun-22, Volume: 292, Issue:5525 Topics: Animals; Brain; Calcium; Calcium Signaling; Cocaine; Cocaine-Related Disorders; Dopamine; Glutamic Acid; Hippocampus; Long-Term Potentiation; Memory; Neurons; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Ventral Tegmental Area	2001
The effects of acute or repeated cocaine administration on nerve terminal glutamate within the rat mesolimbic system. Neuroscience, 2001, Volume: 106, Issue:1 Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Drug Administration Schedule; gamma-Aminobutyric Acid; Glutamic Acid; Immunohistochemistry; Male; Microscopy, Electron; Motor Activity; Neural Pathways; Nucleus Accumbens; Prefrontal Cortex; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Ventral Tegmental Area	2001
Alterations in behaviour and glutamate transmission following presentation of stimuli previously associated with cocaine exposure. The European journal of neuroscience, 2001, Volume: 14, Issue:11 Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Dopamine Uptake Inhibitors; Extinction, Psychological; Glutamic Acid; Male; Microdialysis; Motor Activity; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Up-Regulation	2001
Cocaine administered into the medial prefrontal cortex reinstates cocaine-seeking behavior by increasing AMPA receptor-mediated glutamate transmission in the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Apr-01, Volume: 22, Issue:7 Topics: Anesthetics, Local; Animals; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Extinction, Psychological; Glutamic Acid; Male; Microinjections; Neostriatum; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Recurrence; Reinforcement, Psychology; Septum of Brain; Synaptic Transmission	2002