cortisol 21-sulfate
Description
Cortisol 21-sulfate, also known as cortisol sulfate, is a steroid hormone produced in the adrenal glands. It is a water-soluble form of cortisol, which allows it to be readily transported in the blood. Cortisol 21-sulfate is synthesized from cortisol through the action of the enzyme sulfotransferase. It is primarily produced in the liver and is thought to be involved in regulating cortisol levels in the blood. The exact role of cortisol 21-sulfate in the body is not fully understood, but it is believed to be involved in a number of physiological processes, including inflammation, immune responses, and stress responses. Cortisol 21-sulfate is studied because it is a potential biomarker for various diseases and conditions. For example, elevated levels of cortisol 21-sulfate have been linked to Cushing's syndrome, a disorder characterized by excessive cortisol production. Studies on cortisol 21-sulfate may provide insights into the regulation of cortisol metabolism and its role in various physiological processes, including stress, immunity, and inflammation.'
cortisol 21-sulfate: RN given refers to (11beta)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
cortisol 21-sulfate : A steroid sulfate obtained by the formal condensation of hydroxy group at position 21 of cortisol with sulfuric acid. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 102172 |
| CHEBI ID | 16473 |
| SCHEMBL ID | 2803362 |
| MeSH ID | M0074489 |
Synonyms (31)
| Synonym |
|---|
| CHEBI:16473 |
| 11,17-dihydroxy-4-pregnene-3,20-dione-21-yl-sulfate |
| 11beta,17-dihydroxy-3,20-dioxopregn-4-en-21-yl hydrogen sulfate |
| (11beta)-11,17-dihydroxy-21-(sulfooxy)pregn-4-ene-3,20-dione |
| cortisol-21-sulfate |
| cortisol sulfate |
| cortisol 21-sulfate |
| 1253-43-6 |
| LMST05020020 |
| [2-[(8s,9s,10r,11s,13s,14s,17r)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] hydrogen sulfate |
| f(k)s cpd |
| SCHEMBL2803362 |
| 4-pregnen-11,17,21-triol-3,20-dione 21-sulfate |
| 11,17-dihydroxy-4-pregnene-3,20-dione-21-yl-sulfuric acid |
| cortisol 21-sulphate |
| cortisol-21-sulphate |
| cortisol 21-sulfate, 1,2-t2-labeled |
| cortisol-21-sulfuric acid |
| (11beta)-11,17-dihydroxy-21-(sulphooxy)pregn-4-ene-3,20-dione |
| (11b)-11,17-dihydroxy-21-(sulphooxy)pregn-4-ene-3,20-dione |
| 11,17-dihydroxy-4-pregnene-3,20-dione-21-yl-sulphate |
| cortisol 21-sulphuric acid |
| cortisol 21-sulfuric acid |
| 11,17-dihydroxy-4-pregnene-3,20-dione-21-yl-sulphuric acid |
| ss441 compound |
| (11b)-11,17-dihydroxy-21-(sulfooxy)pregn-4-ene-3,20-dione |
| cortisol 21-sulfate, 4-(14)c-labeled |
| cortisol-21-sulphuric acid |
| Q27101928 |
| CS-0144518 |
| HY-N8460 |
Roles (1)
| Role | Description |
|---|---|
| human metabolite | Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens). |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
Drug Classes (7)
| Class | Description |
|---|---|
| cortisol ester | |
| steroid sulfate | A sulfuric ester obtained by the formal condensation of a hydroxy group of any steroid with sulfuric acid. |
| 11beta-hydroxy steroid | Any 11-hydroxy steroid in which the hydroxy group at position 11 has beta- configuration. |
| 17alpha-hydroxy steroid | The alpha-stereoisomer of 17-hydroxy steroid. |
| 20-oxo steroid | An oxo steroid carrying an oxo group at position 20. |
| 3-oxo-Delta(4) steroid | A 3-oxo steroid conjugated to a C=C double bond at the alpha,beta position. |
| tertiary alpha-hydroxy ketone | An alpha-hydroxy ketone in which the carbonyl group and the hydroxy group are linked by a carbon bearing two organyl groups. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
Research
Studies (8)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 4 (50.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 12.02
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.02) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 8 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||