Compounds > cortisol 21-sulfate
Page last updated: 2024-12-07

cortisol 21-sulfate

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Description

Cortisol 21-sulfate, also known as cortisol sulfate, is a steroid hormone produced in the adrenal glands. It is a water-soluble form of cortisol, which allows it to be readily transported in the blood. Cortisol 21-sulfate is synthesized from cortisol through the action of the enzyme sulfotransferase. It is primarily produced in the liver and is thought to be involved in regulating cortisol levels in the blood. The exact role of cortisol 21-sulfate in the body is not fully understood, but it is believed to be involved in a number of physiological processes, including inflammation, immune responses, and stress responses. Cortisol 21-sulfate is studied because it is a potential biomarker for various diseases and conditions. For example, elevated levels of cortisol 21-sulfate have been linked to Cushing's syndrome, a disorder characterized by excessive cortisol production. Studies on cortisol 21-sulfate may provide insights into the regulation of cortisol metabolism and its role in various physiological processes, including stress, immunity, and inflammation.'

cortisol 21-sulfate: RN given refers to (11beta)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

cortisol 21-sulfate : A steroid sulfate obtained by the formal condensation of hydroxy group at position 21 of cortisol with sulfuric acid. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID102172
CHEBI ID16473
SCHEMBL ID2803362
MeSH IDM0074489

Synonyms (31)

Synonym
CHEBI:16473
11,17-dihydroxy-4-pregnene-3,20-dione-21-yl-sulfate
11beta,17-dihydroxy-3,20-dioxopregn-4-en-21-yl hydrogen sulfate
(11beta)-11,17-dihydroxy-21-(sulfooxy)pregn-4-ene-3,20-dione
cortisol-21-sulfate
cortisol sulfate
cortisol 21-sulfate
1253-43-6
LMST05020020
[2-[(8s,9s,10r,11s,13s,14s,17r)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] hydrogen sulfate
f(k)s cpd
SCHEMBL2803362
4-pregnen-11,17,21-triol-3,20-dione 21-sulfate
11,17-dihydroxy-4-pregnene-3,20-dione-21-yl-sulfuric acid
cortisol 21-sulphate
cortisol-21-sulphate
cortisol 21-sulfate, 1,2-t2-labeled
cortisol-21-sulfuric acid
(11beta)-11,17-dihydroxy-21-(sulphooxy)pregn-4-ene-3,20-dione
(11b)-11,17-dihydroxy-21-(sulphooxy)pregn-4-ene-3,20-dione
11,17-dihydroxy-4-pregnene-3,20-dione-21-yl-sulphate
cortisol 21-sulphuric acid
cortisol 21-sulfuric acid
11,17-dihydroxy-4-pregnene-3,20-dione-21-yl-sulphuric acid
ss441 compound
(11b)-11,17-dihydroxy-21-(sulfooxy)pregn-4-ene-3,20-dione
cortisol 21-sulfate, 4-(14)c-labeled
cortisol-21-sulphuric acid
Q27101928
CS-0144518
HY-N8460
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
human metaboliteAny mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (7)

ClassDescription
cortisol ester
steroid sulfateA sulfuric ester obtained by the formal condensation of a hydroxy group of any steroid with sulfuric acid.
11beta-hydroxy steroidAny 11-hydroxy steroid in which the hydroxy group at position 11 has beta- configuration.
17alpha-hydroxy steroidThe alpha-stereoisomer of 17-hydroxy steroid.
20-oxo steroidAn oxo steroid carrying an oxo group at position 20.
3-oxo-Delta(4) steroidA 3-oxo steroid conjugated to a C=C double bond at the alpha,beta position.
tertiary alpha-hydroxy ketoneAn alpha-hydroxy ketone in which the carbonyl group and the hydroxy group are linked by a carbon bearing two organyl groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (50.00)18.7374
1990's2 (25.00)18.2507
2000's0 (0.00)29.6817
2010's2 (25.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.02

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.02 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.21 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.02)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
melatonin
[no description available]		2.1310acetamides;
tryptamines		anticonvulsant;
central nervous system depressant;
geroprotector;
hormone;
human metabolite;
immunological adjuvant;
mouse metabolite;
radical scavenger
methoxyamine
methoxyamine: analytical reagent for aldehydes and ketones; strong irritant, can probably produce methemoglobinemia; RN given refers to parent cpd; structure		2.110organooxygen compound
corticosterone
[no description available]		2.372011beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone		human metabolite;
mouse metabolite
androsterone
[no description available]		1.951017-oxo steroid;
3alpha-hydroxy steroid;
androstanoid;
C19-steroid		androgen;
anticonvulsant;
human blood serum metabolite;
human metabolite;
human urinary metabolite;
mouse metabolite;
pheromone
etiocholanolone
Etiocholanolone: The 5-beta-reduced isomer of ANDROSTERONE. Etiocholanolone is a major metabolite of TESTOSTERONE and ANDROSTENEDIONE in many mammalian species including humans. It is excreted in the URINE.. 3alpha-hydroxy-5beta-androstan-17-one : An androstanoid that is 5beta-androstane substituted by an alpha-hydroxy group at position 3 and an oxo group at position 17. It is a metabolite of testosterone in mammals.		1.951017-oxo steroid;
3alpha-hydroxy steroid;
androstanoid		human metabolite;
mouse metabolite
dehydroepiandrosterone
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.. dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.		1.951017-oxo steroid;
3beta-hydroxy-Delta(5)-steroid;
androstanoid		androgen;
human metabolite;
mouse metabolite
desoxycorticosterone
Desoxycorticosterone: A steroid metabolite that is the 11-deoxy derivative of CORTICOSTERONE and the 21-hydroxy derivative of PROGESTERONE		1.971020-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
mineralocorticoid;
primary alpha-hydroxy ketone		human metabolite;
mouse metabolite
ru-28362
11,17-dihydroxy-6-methyl-17-(1-propynyl)androsta-1,4,6-triene-3-one: glucocorticoid receptor agonist; RN given refers to (11beta,17beta)-isomer		1.9710
deoxycorticosterone sulfate
deoxycorticosterone sulfate: biosyn in human fetal kidney		1.9710
corticosterone sulfate
[no description available]		2.3720
cortisone
[no description available]		2.653011-oxo steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone		human metabolite;
mouse metabolite
17-ketosteroids
17-Ketosteroids: Steroids that contain a ketone group at position 17.. 17-oxo steroid : Any oxo steroid carrying the oxo group at position 17.		1.9510
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Prostate
[description not available]		02.1310
Prostatic Neoplasms
Tumors or cancer of the PROSTATE.		02.1310
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		01.9510
Cushing's Syndrome
[description not available]		01.9810
Aldosteronism
[description not available]		01.9810
Adrenal Cortex Diseases
Pathological processes of the ADRENAL CORTEX.		01.9810
Cushing Syndrome
A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.		01.9810
Hyperaldosteronism
A condition caused by the overproduction of ALDOSTERONE. It is characterized by sodium retention and potassium excretion with resultant HYPERTENSION and HYPOKALEMIA.		01.9810
Obesity
A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).		01.9810
Breast Cancer
[description not available]		01.9510
Breast Neoplasms
Tumors or cancer of the human BREAST.		01.9510