Compounds > 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene
Page last updated: 2024-09-27

2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene

Description

2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene: structure given in first source; metabolite of o,p-DDD (mitotane) [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID246598
CHEMBL ID1391
CHEBI ID34211
SCHEMBL ID4906413
MeSH IDM0154869

Synonyms (57)

Synonym
BIDD:ER0459
benzene, 1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethenyl]-
nsc59908
1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethylene
2-(2-chlorophenyl)-2-(4-chlorophenyl)-1,1-dichloroethylene
3424-82-6
o,p'-dde
benzene,2-dichloro-1-(4-chlorophenyl)ethenyl]-
ethylene,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)-
1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethene
o,p-dde
nsc-59908
(o,p)-dde
2,4'-dde
2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene
2,2,o,p'-tetrachlorovinylidenebisbenzene
ethylene, 1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)-
brn 1977640
ethylene, 1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloro-
einecs 222-318-0
nsc 59908
benzene, 1-chloro-2-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-
NCIOPEN2_007858
1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)vinyl]benzene
1-chloro-2-(2,2-dichloro-1-(4-chlorophenyl)vinyl)benzene
CHEMBL1391 ,
chebi:34211 ,
1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethenyl]benzene
unii-dm084ylq1l
dm084ylq1l ,
o,p''-dde (1,1-(o,p''-dichlorodiphenyl)-2,2 dichloroethene)
bdbm50410515
AKOS015903090
2,4'-dichlorodiphenyldichloroethylene
dde, o,p'-
1-chloro-2-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)benzene
o,p'-dichlorodiphenyldichloroethylene
benzene,1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethenyl]-
SCHEMBL4906413
cas-3424-82-6
tox21_304022
NCGC00357281-01
dtxsid4022313 ,
dtxcid302313
1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)vinyl]benzene #
ZDYJWDIWLRZXDB-UHFFFAOYSA-N
2,4'-dde 10 microg/ml in cyclohexane
2,4'-dde 100 microg/ml in cyclohexane
J-019521
2,4 inverted exclamation mark -dde
FT-0704726
2,4'-(2,2-dichloroethene-1,1-diyl)bis(chlorobenzene)
Q27115908
2,4'-dde, 2-(2-chlorophenyl)-2-(4-chlorophenyl)-1,1-dichloroethene
STARBLD0009632
5-hydroxynorvaline-betaxanthin
2,4'-dde-d8

Drug Classes (1)

ClassDescription
diarylmethaneAny compound containing two aryl groups connected by a single C atom.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (13)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
SMAD family member 2Homo sapiens (human)Potency54.94100.173734.304761.8120AID1346859
SMAD family member 3Homo sapiens (human)Potency54.94100.173734.304761.8120AID1346859
AR proteinHomo sapiens (human)Potency10.94290.000221.22318,912.5098AID1259243; AID1259247
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency6.85900.000657.913322,387.1992AID1259378
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency21.68990.001022.650876.6163AID1224839
progesterone receptorHomo sapiens (human)Potency8.63490.000417.946075.1148AID1346795
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency36.95750.003041.611522,387.1992AID1159552; AID1159555
retinoid X nuclear receptor alphaHomo sapiens (human)Potency28.56410.000817.505159.3239AID1159527; AID1159531
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency31.00000.001530.607315,848.9004AID1224841; AID1224848; AID1224849; AID1259401
pregnane X nuclear receptorHomo sapiens (human)Potency30.63790.005428.02631,258.9301AID1346982
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency48.96620.057821.109761.2679AID1159526
Histone H2A.xCricetulus griseus (Chinese hamster)Potency126.79300.039147.5451146.8240AID1224845
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Androgen receptorRattus norvegicus (Norway rat)IC50 (µMol)20.41740.00101.979414.1600AID255211
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID255211Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881)2005Journal of medicinal chemistry, Sep-08, Volume: 48, Issue:18
Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (24)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (4.17)18.7374
1990's3 (12.50)18.2507
2000's10 (41.67)29.6817
2010's8 (33.33)24.3611
2020's2 (8.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials2 (8.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies2 (8.00%)4.05%
Observational0 (0.00%)0.25%
Other21 (84.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
chlordecone[no description available]medium30cyclic ketone;
organochlorine compound		insecticide;
persistent organic pollutant
hexachlorocyclohexane[no description available]medium40chlorocyclohexane
vanillin[no description available]medium10benzaldehydes;
monomethoxybenzene;
phenols		anti-inflammatory agent;
anticonvulsant;
antioxidant;
flavouring agent;
plant metabolite
2,4,5-trichlorophenoxyacetic acid[no description available]medium10chlorophenoxyacetic acid;
trichlorobenzene		defoliant;
phenoxy herbicide;
synthetic auxin
4-nonylphenol[no description available]medium20phenolsenvironmental contaminant
clomiphene[no description available]medium10tertiary amineestrogen antagonist;
estrogen receptor modulator
dichlorodiphenyl dichloroethylene[no description available]medium110chlorophenylethylene;
monochlorobenzenes		human xenobiotic metabolite;
persistent organic pollutant
dichlorodiphenyl dichloroethylene[no description available]medium111chlorophenylethylene;
monochlorobenzenes		human xenobiotic metabolite;
persistent organic pollutant
ddt[no description available]medium90benzenoid aromatic compound;
chlorophenylethane;
monochlorobenzenes;
organochlorine insecticide		bridged diphenyl acaricide;
carcinogenic agent;
endocrine disruptor;
persistent organic pollutant
benzophenone[no description available]medium10benzophenonesphotosensitizing agent;
plant metabolite
endosulfan[no description available]medium30cyclic sulfite ester;
cyclodiene organochlorine insecticide		acaricide;
agrochemical;
GABA-gated chloride channel antagonist;
persistent organic pollutant
heptachlor[no description available]medium40cyclodiene organochlorine insecticideagrochemical;
antibacterial agent;
antifungal agent;
GABA-gated chloride channel antagonist;
persistent organic pollutant
methoxychlor[no description available]medium20organochlorine insecticide
nafoxidine[no description available]medium10benzenes;
naphthalenes;
ring assembly
corticosterone[no description available]medium1011beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone		human metabolite;
mouse metabolite
prednisolone[no description available]medium1011beta-hydroxy steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone		adrenergic agent;
anti-inflammatory drug;
antineoplastic agent;
drug metabolite;
environmental contaminant;
immunosuppressive agent;
xenobiotic
estriol[no description available]medium1016alpha-hydroxy steroid;
17beta-hydroxy steroid;
3-hydroxy steroid		estrogen;
human metabolite;
human xenobiotic metabolite;
mouse metabolite
spironolactone[no description available]medium103-oxo-Delta(4) steroid;
oxaspiro compound;
steroid lactone;
thioester		aldosterone antagonist;
antihypertensive agent;
diuretic;
environmental contaminant;
xenobiotic
aldosterone[no description available]medium1011beta-hydroxy steroid;
18-oxo steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid hormone;
mineralocorticoid;
primary alpha-hydroxy ketone;
steroid aldehyde		human metabolite;
mouse metabolite
androsterone[no description available]medium1017-oxo steroid;
3alpha-hydroxy steroid;
androstanoid;
C19-steroid		androgen;
anticonvulsant;
human blood serum metabolite;
human metabolite;
human urinary metabolite;
mouse metabolite;
pheromone
17-desoxyestradiol[no description available]medium103-hydroxy steroid;
phenolic steroid;
phenols		estrogen
ethinyl estradiol[no description available]medium1017-hydroxy steroid;
3-hydroxy steroid;
terminal acetylenic compound		xenoestrogen
chlordan[no description available]medium10cyclodiene organochlorine insecticideGABA-gated chloride channel antagonist;
persistent organic pollutant
testosterone propionate[no description available]medium10steroid ester
methyltestosterone[no description available]medium1017beta-hydroxy steroid;
3-oxo-Delta(4) steroid;
enone		anabolic agent;
androgen;
antineoplastic agent
androstenedione[no description available]medium1017-oxo steroid;
3-oxo-Delta(4) steroid;
androstanoid		androgen;
Daphnia magna metabolite;
human metabolite;
mouse metabolite
norethindrone[no description available]medium1017beta-hydroxy steroid;
3-oxo-Delta(4) steroid;
terminal acetylenic compound;
tertiary alcohol		progestin;
synthetic oral contraceptive
norethynodrel[no description available]medium10oxo steroid
medroxyprogesterone acetate[no description available]medium1020-oxo steroid;
3-oxo-Delta(4) steroid;
acetate ester;
corticosteroid;
steroid ester		adjuvant;
androgen;
antineoplastic agent;
antioxidant;
female contraceptive drug;
inhibitor;
progestin;
synthetic oral contraceptive
dichlorodiphenyldichloroethane[no description available]medium20chlorophenylethane;
monochlorobenzenes;
organochlorine insecticide		xenobiotic metabolite
bisphenol a[no description available]medium10bisphenolendocrine disruptor;
environmental contaminant;
xenobiotic;
xenoestrogen
p-tert-amylphenol[no description available]medium10alkylbenzene
2-sec-butylphenol[no description available]medium10phenols
4-phenylphenol[no description available]medium10hydroxybiphenyls
propylparaben[no description available]medium10benzoate ester;
paraben;
phenols		antifungal agent;
antimicrobial agent
butylphen[no description available]medium10phenolsallergen
methylparaben[no description available]medium10parabenantifungal agent;
antimicrobial food preservative;
neuroprotective agent;
plant metabolite
monobenzone[no description available]medium10benzyl etherallergen;
dermatologic drug;
melanin synthesis inhibitor
3-chlorophenol[no description available]medium10monochlorophenol
2,4-dihydroxybenzophenone[no description available]medium10benzophenones
cyproterone acetate[no description available]medium1020-oxo steroid;
3-oxo-Delta(4) steroid;
acetate ester;
chlorinated steroid;
steroid ester		androgen antagonist;
geroprotector;
progestin
epitestosterone[no description available]medium1017alpha-hydroxy steroid;
3-oxo-Delta(4) steroid;
androstanoid		androgen antagonist;
human metabolite
flavanone[no description available]medium10flavanones
androstenediol[no description available]medium1017beta-hydroxy steroid;
3beta-hydroxy-Delta(5)-steroid		androgen;
human metabolite;
mouse metabolite;
radiation protective agent
dihydrotestosterone[no description available]medium1017beta-hydroxy steroid;
17beta-hydroxyandrostan-3-one;
3-oxo-5alpha-steroid		androgen;
Daphnia magna metabolite;
human metabolite;
mouse metabolite
flavone[no description available]medium10flavonesmetabolite;
nematicide
4-cumylphenol[no description available]medium10diarylmethane
o,p'-ddt[no description available]medium80diarylmethane
4-hydroxybenzophenone[no description available]medium10benzophenones
4-chloro-2-cresol[no description available]medium10monochlorobenzenes;
phenols
4-octylphenol[no description available]medium10phenolsmetabolite;
surfactant;
xenoestrogen
2,4,2',4'-tetrachlorobiphenyl[no description available]medium10dichlorobenzene;
tetrachlorobiphenyl
ac 45594[no description available]medium10aromatic ether
promegestone[no description available]medium1020-oxo steroid;
3-oxo-Delta(4) steroid		antineoplastic agent;
progesterone receptor agonist;
progestin
2,4'-dichlorobiphenyl[no description available]medium10dichlorobiphenyl;
monochlorobenzenes
4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol[no description available]medium10stilbenoid
taleranol[no description available]medium10macrolide
bisphenol b[no description available]medium10bisphenol
alfatradiol[no description available]medium1017alpha-hydroxy steroid;
3-hydroxy steroid;
estradiol		estrogen;
geroprotector
4,4'-Dihydroxybenzophenone[no description available]medium10benzophenones
6-hydroxyflavone[no description available]medium10hydroxyflavonoid
2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane[no description available]medium10bisphenol
1,1-Dichloro-2,2-bis(4-hydroxyphenyl)ethylene[no description available]medium10diarylmethane
equol[no description available]medium10hydroxyisoflavans
androstan-3-ol[no description available]medium103-hydroxy steroidandrogen
3,3',5,5'-tetrachlorobiphenyl-4,4'-diol[no description available]medium10dichlorobenzene;
hydroxybiphenyls
3,3'-Dihydroxyhexestrol[no description available]medium10stilbenoid
4-hydroxy-2',3',4'-5'-tetrachlorobiphenyl[no description available]medium10biphenyls;
tetrachlorobenzene
Zearalanone[no description available]medium10macrolide;
resorcinols
4-androstene-3,17-diol[no description available]medium103-hydroxy steroidandrogen
4'-hydroxyflavanone[no description available]medium104'-hydroxyflavanones;
monohydroxyflavanone
2-hydroxyestradiol[no description available]medium1017beta-hydroxy steroid;
2-hydroxy steroid		carcinogenic agent;
human metabolite;
metabolite;
mouse metabolite;
prodrug
mibolerone[no description available]medium1017beta-hydroxy steroid;
3-oxo-Delta(4) steroid		anabolic agent;
androgen
metribolone[no description available]medium1017beta-hydroxy steroid;
3-oxo steroid;
anabolic androgenic steroid		androgen
diethylstilbestrol[no description available]medium10olefinic compound;
polyphenol		antifungal agent;
antineoplastic agent;
autophagy inducer;
calcium channel blocker;
carcinogenic agent;
EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitor;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
endocrine disruptor;
xenoestrogen
chalcone[no description available]medium10chalconeEC 3.2.1.1 (alpha-amylase) inhibitor
isoeugenol[no description available]medium10isoeugenol
tamoxifen[no description available]medium10stilbenoid;
tertiary amino compound		angiogenesis inhibitor;
antineoplastic agent;
bone density conservation agent;
EC 1.2.3.1 (aldehyde oxidase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
estrogen antagonist;
estrogen receptor antagonist;
estrogen receptor modulator
6-hydroxyflavanone[no description available]medium10monohydroxyflavanonefungal xenobiotic metabolite
dimethylstilbestrol[no description available]medium10stilbenoid
genistein[no description available]medium107-hydroxyisoflavonesantineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor
coumestrol[no description available]medium10coumestans;
delta-lactone;
polyphenol		anti-inflammatory agent;
antioxidant;
plant metabolite
7-hydroxyflavone[no description available]medium10hydroxyflavonoid
4-hydroxyestradiol[no description available]medium104-hydroxy steroidmetabolite
4-hydroxychalcone[no description available]medium10chalcones;
phenols		antihypertensive agent;
plant metabolite
4'-hydroxychalcone[no description available]medium10chalcones;
phenols		anti-inflammatory agent;
antineoplastic agent
4,4'-dihydroxystilbene[no description available]medium10stilbene-4,4'-diol
4-hydroxystilbene[no description available]medium10stilben-4-ol
dieldrin[no description available]medium10epoxide;
organochlorine compound;
organochlorine insecticide		carcinogenic agent;
xenobiotic
mitotane[no description available]medium220diarylmethane
mitotane[no description available]medium222diarylmethane
aldrin[no description available]medium20
2,2-(2-chlorophenyl-4'-chlorophenyl)acetic acid[no description available]medium61
2,4,4'-trichlorobiphenyl[no description available]medium10
2,3,3',4,4'-pentachlorobiphenyl[no description available]medium10dichlorobenzene;
pentachlorobiphenyl;
trichlorobenzene
sucrose[no description available]medium11glycosyl glycosidealgal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent
2,3,7,8-tetrachlorodibenzofuran[no description available]medium10polychlorinated dibenzofuran
benzofurans[no description available]medium10
endosulfan sulfate[no description available]medium10
hexachlorobenzene[no description available]medium20aromatic fungicide;
chlorobenzenes		antifungal agrochemical;
carcinogenic agent;
persistent organic pollutant
dimethyl sulfoxide[no description available]medium10sulfoxide;
volatile organic compound		alkylating agent;
antidote;
Escherichia coli metabolite;
geroprotector;
MRI contrast agent;
non-narcotic analgesic;
polar aprotic solvent;
radical scavenger
fura-2[no description available]medium10
thapsigargin[no description available]medium10butyrate ester;
organic heterotricyclic compound;
sesquiterpene lactone		calcium channel blocker;
EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor
4-tert-octylphenol[no description available]medium10alkylbenzene
b 844-39[no description available]low00diarylmethane
3-[(4-chlorophenyl)-phenylmethoxy]-8-methyl-8-azabicyclo[3.2.1]octane[no description available]low00diarylmethane
adiphenine[no description available]low00diarylmethane
3-(2'-aminobenzhydryloxy)tropane[no description available]low00diarylmethane
2,2-bis(4-glycidyloxyphenyl)propane[no description available]low00diarylmethane
benproperine[no description available]low00diarylmethane
cogentin[no description available]low00diarylmethane
bifemelane[no description available]low00diarylmethane
bisacodyl[no description available]low00diarylmethane
chlorcyclizine[no description available]low00diarylmethane
cifenline[no description available]low00diarylmethane
clidinium[no description available]low00diarylmethane
clofedanol[no description available]low00diarylmethane;
tertiary amino compound		antitussive
clofoctol[no description available]low00diarylmethane
cloperastine[no description available]low00diarylmethane
r 59022[no description available]low00diarylmethane
dichlorophen[no description available]low00bridged diphenyl fungicide;
diarylmethane
fendiline[no description available]low00diarylmethane
1-[bis(4-fluorophenyl)methyl]-4-(3-phenylprop-2-enyl)piperazine[no description available]low00diarylmethane
fluspirilene[no description available]low00diarylmethane
homochlorocyclizine[no description available]low00diarylmethane
isopropamide iodide[no description available]low00diarylmethane
lidoflazine[no description available]low00diarylmethane
lomerizine[no description available]low00diarylmethane
manidipine[no description available]low00diarylmethane
meclizine[no description available]low00diarylmethane
mepenzolate[no description available]low00diarylmethane
methadone[no description available]low00benzenes;
diarylmethane;
ketone;
tertiary amino compound
no 711[no description available]low00diarylmethane
oxatomide[no description available]low00benzimidazoles;
diarylmethane;
N-alkylpiperazine		anti-allergic agent;
anti-inflammatory agent;
geroprotector;
H1-receptor antagonist;
serotonergic antagonist
pipenzolate[no description available]low00diarylmethane
piperidolate[no description available]low00diarylmethane
proadifen[no description available]low00diarylmethane
propiverine[no description available]low00diarylmethane
aurin[no description available]low00diarylmethane
dpi 201-106[no description available]low00diarylmethane
terfenadine[no description available]low00diarylmethane
mepenzolate bromide[no description available]low00diarylmethane
chlorphenoxamine[no description available]low00diarylmethaneanticoronaviral agent
chlorfenethol[no description available]low00diarylmethane
diphenadione[no description available]low00beta-triketone;
diarylmethane
phenyltoloxamine[no description available]low00diarylmethane
n,n,n',n'-tetramethyl-4,4'-methylenedianiline[no description available]low00diarylmethane
diphenan[no description available]low00diarylmethane
diphenylmethane[no description available]low00diarylmethane
2,2'-methylenebis(4-methyl-6-tert-butylphenol)[no description available]low00diarylmethane
piperidolate hydrochloride[no description available]low00diarylmethane
benactyzine[no description available]low00diarylmethane
prenylamine[no description available]low00diarylmethane
isomethadone[no description available]low00diarylmethane
pipradrol[no description available]low00diarylmethane
normethadone[no description available]low00diarylmethane
captodiamine[no description available]low00diarylmethane
methadyl acetate[no description available]low00diarylmethane
benzomethamine[no description available]low00diarylmethane
chlorobenzilate[no description available]low00diarylmethane
dimenhydrinate[no description available]low00diarylmethane
poldine[no description available]low00diarylmethane
thiphenamil[no description available]low00diarylmethane
4,4'-bisphenol f[no description available]low00bisphenol;
diarylmethane		environmental food contaminant;
xenoestrogen
4,4'-methylene bis(2-methylaniline)[no description available]low00diarylmethane
dipipanone[no description available]low00diarylmethane
diphenamid[no description available]low00diarylmethane
paracymethadol[no description available]low00diarylmethane
bisphenol a-glycidyl methacrylate[no description available]low00diarylmethane
azacyclonol[no description available]low00diarylmethane
dimenoxadol[no description available]low00diarylmethane
amphenone b[no description available]low00diarylmethane
propinox[no description available]low00diarylmethane
embramine[no description available]low00diarylmethane
chlorophacinone[no description available]low00beta-triketone;
diarylmethane
aminopentamide[no description available]low00diarylmethane
octocrylene[no description available]low00diarylmethane
terodiline[no description available]low00diarylmethane
tofenacin[no description available]low00diarylmethane
pipoxolan[no description available]low00diarylmethane
penfluridol[no description available]low00diarylmethane
emepronium[no description available]low00diarylmethane
levomethadyl acetate hydrochloride[no description available]low00diarylmethane
flumecinol[no description available]low00diarylmethane
setastine[no description available]low00diarylmethane
progabide[no description available]low00diarylmethane
beclobrate[no description available]low00diarylmethane
cetirizine dihydrochloride[no description available]low00diarylmethane
niguldipine[no description available]low00diarylmethane
mandrax[no description available]low00diarylmethane
droprenylamine[no description available]low00diarylmethane
quifenadine[no description available]low00diarylmethane
carebastine[no description available]low00diarylmethane
lercanidipine[no description available]low00diarylmethane
diphenidol hydrochloride[no description available]low00diarylmethane
dioxadrol[no description available]low00diarylmethane
budipine[no description available]low00diarylmethane
epicainide[no description available]low00diarylmethane
butinoline[no description available]low00diarylmethane
denaverine[no description available]low00diarylmethane
lifarizine[no description available]low00diarylmethane
fenpiverinium[no description available]low00diarylmethane
2,2-methylenebis(4-chloro-3-methyl-isopropylphenol)[no description available]low00diarylmethane
amperozide[no description available]low00diarylmethane;
monofluorobenzenes;
N-alkylpiperazine;
secondary carboxamide;
ureas		anxiolytic drug;
dopamine uptake inhibitor;
geroprotector;
second generation antipsychotic;
serotonergic antagonist
2,2'-bisphenol f[no description available]low00diarylmethane
3-hydroxy-2,2-diphenylpropanoic acid[no description available]low00diarylmethane
bisphenol f diglycidyl ether[no description available]low00aromatic ether;
diarylmethane;
epoxide
n-(4,4-diphenyl-3-butenyl)nipecotic acid[no description available]low00diarylmethane
methylene bis(methylanthranilate)[no description available]low00diarylmethane
tesmilifene[no description available]low00diarylmethane
pd 123177[no description available]low00diarylmethane
bw 373u86[no description available]low00diarylmethane
gilutensin hydrochloride[no description available]low00diarylmethane
4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-n,n-diethylbenzamide[no description available]low00diarylmethane
ae0047[no description available]low00diarylmethane
lercanidipine hydrochloride[no description available]low00diarylmethane
cloperastine hydrochloride[no description available]low00diarylmethane
1,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane[no description available]low00diarylmethane
2-[(4,6-dimethyl-2-pyrimidinyl)oxy]-3-methoxy-3,3-diphenylpropanoic acid[no description available]low00diarylmethane
ci 966[no description available]low00diarylmethane
Difeterol[no description available]low00diarylmethane
1,1-bis(4-hydroxyphenyl)cyclohexane[no description available]low00diarylmethane
N-[2-(dimethylamino)ethyl]-2,2-diphenylacetamide[no description available]low00diarylmethane
propiverine hydrochloride[no description available]low00diarylmethane
gw 3965[no description available]low00diarylmethane
1,1-Bis(4-hydroxyphenyl)ethane[no description available]low00diarylmethane
uk 78282[no description available]low00diarylmethane
r 59949[no description available]low00diarylmethane
4-[1-(4-hydroxyphenyl)ethenyl]phenol[no description available]low00diarylmethane
5-[4-(diphenylmethyl)-1-piperazinyl]-2-(2-methoxyphenyl)-4-oxazolecarbonitrile[no description available]low00diarylmethane
flunarizine[no description available]low00diarylmethane
N-[4-[oxo-[(1-oxo-2,2-diphenylethyl)hydrazo]methyl]phenyl]propanamide[no description available]low00diarylmethane
[4-(diphenylmethyl)-1-piperazinyl]-[5-thiophen-2-yl-7-(trifluoromethyl)-3-pyrazolo[1,5-a]pyrimidinyl]methanone[no description available]low00diarylmethane
benztropine[no description available]low00diarylmethane
3-[[[(1-oxo-2,2-diphenylethyl)amino]-sulfanylidenemethyl]amino]benzoic acid[no description available]low00diarylmethane
3-bromo-5-[[4-[hydroxy(diphenyl)methyl]-1-piperidinyl]-oxomethyl]-2-pyranone[no description available]low00diarylmethane
2-(5-bromo-3-nitro-1,2,4-triazol-1-yl)-N-(diphenylmethyl)acetamide[no description available]low00diarylmethane
1,1-bis(4-chlorophenyl)-2-[(3-methoxyphenyl)methylamino]ethanol[no description available]low00diarylmethane
cinnarizine[no description available]low00diarylmethane;
N-alkylpiperazine;
olefinic compound		anti-allergic agent;
antiemetic;
calcium channel blocker;
geroprotector;
H1-receptor antagonist;
histamine antagonist;
muscarinic antagonist
levocetirizine[no description available]low00diarylmethane
amn082[no description available]low00benzenes;
diamine;
diarylmethane;
secondary amino compound		metabotropic glutamate receptor agonist;
neuroprotective agent
N-[2-[tert-butyl(methyl)amino]ethyl]-N-methyl-2,2-diphenylacetamide[no description available]low00diarylmethane
N-(4-fluorophenyl)-4-[hydroxy(diphenyl)methyl]-1-piperidinecarbothioamide[no description available]low00diarylmethane
4-oxo-3-[(1-oxo-2,2-diphenylethyl)amino]-2-sulfanylidene-1H-quinazoline-7-carboxylic acid methyl ester[no description available]low00diarylmethane
2,2-diphenylacetic acid (2,6-dimethylphenyl) ester[no description available]low00diarylmethane
1-ethyl-3-[(1-oxo-2,2-diphenylethyl)amino]thiourea[no description available]low00diarylmethane
2-(phenylmethyl)benzoic acid [2-[4-(difluoromethylthio)anilino]-2-oxoethyl] ester[no description available]low00diarylmethane
2-[2-[bis(4-methoxyphenyl)methylidene]hydrazinyl]benzoic acid[no description available]low00diarylmethane
N-[4-bromo-2-[[(2-hydrazinyl-2-oxoethyl)amino]-phenylmethyl]phenyl]-3-(4-morpholinyl)propanamide[no description available]low00diarylmethane
N-(4-ethoxyphenyl)-4-[hydroxy(diphenyl)methyl]-1-piperidinecarbothioamide[no description available]low00diarylmethane
4-[hydroxy(diphenyl)methyl]-N-(2-phenylethyl)-1-piperidinecarbothioamide[no description available]low00diarylmethane
3-(5-chloro-2-hydroxyphenyl)-3-phenyl-N-[(4-propan-2-yloxyphenyl)methyl]propanamide[no description available]low00diarylmethane
adrafinil[no description available]low00diarylmethane
zamifenacin[no description available]low00diarylmethane
2-(cyclohexylamino)-N-[(diphenylmethylene)amino]propanamide[no description available]low00diarylmethane
3-[[4-(diphenylmethyl)-1-piperazinyl]-oxomethyl]-7,8,9,10-tetrahydro-6H-azepino[2,1-b]quinazolin-12-one[no description available]low00diarylmethane
3-[bis(4-fluorophenyl)methoxy]-8-methyl-8-azabicyclo[3.2.1]octane[no description available]low00diarylmethane
flunarizine hydrochloride[no description available]low00diarylmethane
(2-amino-5-chlorophenyl)(phenyl)methanone oxime[no description available]low00diarylmethane
imidafenacin[no description available]low00diarylmethane
2-(3,3-diphenylpropylamino)acetamide[no description available]low00diarylmethane
cgk 733[no description available]low00diarylmethane
dexniguldipine[no description available]low00diarylmethane
lu 208075[no description available]low00diarylmethane
fesoterodine[no description available]low00diarylmethane
3-(diphenylmethylene)-1-[4-(4-phenyl-1-piperazinyl)butyl]pyrrolidine-2,5-dione[no description available]low00diarylmethane
pnu 200577[no description available]low00diarylmethane
gc 1 compound[no description available]low00diarylmethane
tas 301[no description available]low00diarylmethane
1,5-anhydro-1-(5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl)-1-thioglucitol[no description available]low00diarylmethane
[4-(diphenylmethyl)-1-piperazinyl]-(5-methyl-4-nitro-3-isoxazolyl)methanone[no description available]low00diarylmethane
1-(1,4-dioxan-2-yl)-N-[[3-(diphenylmethyl)-1,2,4-oxadiazol-5-yl]methyl]-N-methylmethanamine[no description available]low00diarylmethane
1-[4-(3-chlorophenyl)-1-piperazinyl]-3-(diphenylmethyl)oxy-2-propanol[no description available]low00diarylmethane
(8R)-3-[3-[[2-(4-chlorophenoxy)-1-oxoethyl]amino]phenyl]-7-(1-oxo-3,3-diphenylpropyl)-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide[no description available]low00diarylmethane
3-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)-1-(3-methyl-1-piperidinyl)-1-propanone[no description available]low00diarylmethane
2-[[[4-[[(diphenylmethyl)amino]-oxomethyl]-1H-imidazol-5-yl]-oxomethyl]amino]acetic acid tert-butyl ester[no description available]low00diarylmethane;
tert-butyl ester
pf 04971729[no description available]low00diarylmethane
ML-210[no description available]low00C-nitro compound;
diarylmethane;
isoxazoles;
monochlorobenzenes;
N-acylpiperazine;
N-alkylpiperazine;
tertiary carboxamide		antineoplastic agent;
EC 1.11.1.9 (glutathione peroxidase) inhibitor;
ferroptosis inducer;
prodrug
ConditionIndicatedRelationship StrengthStudiesTrials
Adrenal Cancer0low10
Adrenal Cortex Cancer0medium41
Adrenal Cortex Neoplasms0medium41
Adrenal Gland Cancer0low10
Adrenal Gland Neoplasms0low10
Adrenal Neoplasm0low10
Adrenocortical Cancer0medium41
Adrenocortical Carcinoma0low30
Ambiguous Genitalia0low10
Body Weight0low10
Cancer of Adrenal Cortex0medium41
Cancer of the Adrenal Cortex0medium41
Cancer of the Adrenal Gland0low10
Carcinoma, Adrenal Cortical0low30
Carcinoma, Adrenocortical0low30
Cushing Syndrome0low10
Cushing's Syndrome0low10
Disorders of Sex Development0low10
Disorders of Sexual Development0low10
Genital Ambiguity0low10
Hermaphroditism0low10
Hypercortisolism0low10
Intersex Conditions0low10
Intersexuality0low10
Neoplasms, Adrenal Cortex0medium41
Neoplasms, Adrenal Gland0low10
Pregnancy0low20
Pseudohermaphroditism0low10
Sensitivity and Specificity0low20
Sex Development Disorders0low10
Sex Differentiation Disorders0low10
Sexual Development Disorders0low10
Sexual Differentiation Disorders0low10

Research Highlights

Safety/Toxicity (1)

ArticleYear
Toxicity of o,p'-DDE to medaka d-rR strain after a one-time embryonic exposure by in ovo nanoinjection: an early through juvenile life cycle assessment.
Chemosphere, Volume: 53, Issue: 8		2003
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Pharmacokinetics (1)

ArticleYear
[Identification of two interference peaks during dioxin analysis for biological samples].
Se pu = Chinese journal of chromatography, Volume: 32, Issue: 9		2014
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (2)

ArticleYear
Cross-sectional and longitudinal associations of dichlorodiphenyltrichloroethane (DDT) metabolites exposure with lung function alternation in the Chinese general adults.
The Science of the total environment, Dec-20, Volume: 905		2023
Toxicity of o,p'-DDE to medaka d-rR strain after a one-time embryonic exposure by in ovo nanoinjection: an early through juvenile life cycle assessment.
Chemosphere, Volume: 53, Issue: 8		2003
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]