valproic acid has been researched along with Cushing's Syndrome in 24 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Despite an increase in bromocriptine dosage to 30 mg daily and 24 mg/day cyproheptadine, the clinical and biochemical remission was not sustained in patient 1, and no further improvement occurred in patient 2." | 5.28 | Bromocriptine-responsive Cushing's disease associated with anterior pituitary corticotroph hyperplasia or normal pituitary gland. ( Croughs, RJ; Koppeschaar, HP; McNicol, AM; van't Verlaat, JW, 1989) |
| " Neither a single dose nor long term administration of sodium valproate resulted in a significant decrease of plasma ACTH levels in patients with Cushing's disease and Nelson's syndrome." | 2.66 | The effect of sodium valproate in Cushing's disease, Nelson's syndrome and Addison's disease. ( Allolio, B; Jaursch-Hancke, C; Kaulen, D; Reincke, M; Winkelmann, W, 1988) |
| " The effect of a long term administration of sodium valproate (600-1000 mg/day) was evaluated in 2 patients with active Cushing's disease and in 1 patient with Nelson's syndrome (3 weeks, 3, 9 months respectively); in the 2 patients with Cushing's disease ACTH and cortisol secretion, 17-hydroxy-corticosteroids (17-OHCS) urinary excretion did not change during DPA treatment." | 2.65 | Lack of ACTH lowering effect of sodium valproate in patients with ACTH hypersecretion. ( Berselli, ME; Frascatani, F; Loli, P; Muratori, F; Tagliaferri, M, 1984) |
| " Despite an increase in bromocriptine dosage to 30 mg daily and 24 mg/day cyproheptadine, the clinical and biochemical remission was not sustained in patient 1, and no further improvement occurred in patient 2." | 1.28 | Bromocriptine-responsive Cushing's disease associated with anterior pituitary corticotroph hyperplasia or normal pituitary gland. ( Croughs, RJ; Koppeschaar, HP; McNicol, AM; van't Verlaat, JW, 1989) |
| "Treatment with cyproheptadine again induced hypocorticism necessitating corticosteroid substitution therapy." | 1.27 | Sodium valproate and cyproheptadine may independently induce a remission in the same patient with Cushing's disease. ( Croughs, RJ; Koppeschaar, HP; Schwarz, F; Thijssen, JH, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (87.50) | 18.7374 |
| 1990's | 3 (12.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Koppeschaar, HP | 5 |
| Croughs, RJ | 5 |
| van't Verlaat, JW | 2 |
| Hendriks, MJ | 1 |
| Arts, CJ | 1 |
| Thijssen, JH | 4 |
| Schwarz, F | 4 |
| Allolio, B | 2 |
| Winkelmann, W | 2 |
| Kaulen, D | 2 |
| Hipp, FX | 1 |
| Mies, R | 1 |
| Cavagnini, F | 1 |
| Invitti, C | 1 |
| Polli, EE | 1 |
| Glaser, B | 1 |
| Kahana, L | 1 |
| Elias, V | 1 |
| Sheinfeld, M | 1 |
| Jones, MT | 2 |
| Gillham, B | 2 |
| Altaher, AR | 2 |
| Nicholson, SA | 1 |
| Campbell, EA | 1 |
| Watts, SM | 1 |
| Thody, A | 1 |
| Elias, AN | 2 |
| Gwinup, G | 2 |
| Valenta, LJ | 1 |
| Bergstrand, CG | 1 |
| Nilsson, KO | 1 |
| Ambrosi, B | 1 |
| Bochicchio, D | 1 |
| Riva, E | 1 |
| Faglia, G | 1 |
| Loli, P | 1 |
| Berselli, ME | 1 |
| Frascatani, F | 1 |
| Muratori, F | 1 |
| Tagliaferri, M | 1 |
| Miller, JW | 1 |
| Crapo, L | 1 |
| García Rojas, JF | 1 |
| Mangas Rojas, A | 1 |
| Barba Chacón, A | 1 |
| García Osle, M | 1 |
| Zamora Madaria, E | 1 |
| Beckers, A | 1 |
| Stevenaert, A | 1 |
| Pirens, G | 1 |
| Flandroy, P | 1 |
| Sulon, J | 1 |
| Hennen, G | 1 |
| McNicol, AM | 1 |
| Kasperlik-Załuska, A | 2 |
| Migdalska, B | 2 |
| Jeske, W | 2 |
| Wiśniewska-Woźniak, T | 2 |
| Sek, S | 1 |
| Reincke, M | 1 |
| Jaursch-Hancke, C | 1 |
| Nussey, SS | 1 |
| Price, P | 1 |
| Jenkins, JS | 1 |
| Drac-Kaniewska, J | 1 |
| Yoshida, H | 1 |
| Takeda, F | 1 |
| Kinouchi, T | 1 |
| Shimizu, N | 1 |
| López-Moreno, JM | 1 |
| Rodríguez-Portales, JA | 1 |
| Mahana, D | 1 |
| Burch, WM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open-label Study of the Efficacy and Safety of CORLUX (Mifepristone) in the Treatment of the Signs and Symptoms of Endogenous Cushing's Syndrome[NCT00569582] | Phase 3 | 50 participants (Actual) | Interventional | 2007-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Responder is defined as subject with a decrease greater than or equal to 5mm Hg in diastolic blood pressure from baseline to week 24 or last visit. (NCT00569582)
Timeframe: Baseline to Week 24
| Intervention | participants (Number) |
|---|---|
| Mifepristone | 8 |
Responder is defined as subject with a decrease greater than or equal to 25% in area under the curve for glucose on 2-hour oral glucose test from baseline to week 24 or last visit, for Cushing's patients with type-2 diabetes mellitus/impaired glucose tolerance. (NCT00569582)
Timeframe: Baseline to Week 24
| Intervention | participants (Number) |
|---|---|
| Mifepristone | 15 |
4 reviews available for valproic acid and Cushing's Syndrome
| Article | Year |
|---|---|
Treatment of Cushing's disease in children.
Topics: Adrenalectomy; Adrenocorticotropic Hormone; Aminoglutethimide; Bromocriptine; Child; Cushing Syndrom | 1982 |
The medical treatment of Cushing's syndrome.
Topics: Adrenal Cortex Neoplasms; Adrenal Glands; Aminoglutethimide; Animals; Bromocriptine; Cushing Syndrom | 1993 |
[Drug and radiotherapy of pituitary tumors].
Topics: Acromegaly; Adenoma; Adrenocorticotropic Hormone; Bromocriptine; Cushing Syndrome; Cyproheptadine; G | 1986 |
Cushing's disease. A review.
Topics: Adenoma; Adolescent; Adrenalectomy; Adult; Animals; Bromocriptine; Child; Combined Modality Therapy; | 1985 |
2 trials available for valproic acid and Cushing's Syndrome
| Article | Year |
|---|---|
Lack of ACTH lowering effect of sodium valproate in patients with ACTH hypersecretion.
Topics: Addison Disease; Adrenalectomy; Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Female; Humans | 1984 |
The effect of sodium valproate in Cushing's disease, Nelson's syndrome and Addison's disease.
Topics: Addison Disease; Adrenocorticotropic Hormone; Cushing Syndrome; Humans; Hydrocortisone; Lypressin; N | 1988 |
18 other studies available for valproic acid and Cushing's Syndrome
| Article | Year |
|---|---|
Successful treatment with sodium valproate of a patient with Cushing's disease and gross enlargement of the pituitary.
Topics: 17-Hydroxycorticosteroids; Adenoma; Adrenocorticotropic Hormone; Cushing Syndrome; Female; Humans; H | 1984 |
Valproate in Cushing's syndrome.
Topics: Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Female; Humans; Male; Middle Aged; Valproic Ac | 1982 |
Sodium valproate and heterogeneity of pituitary dependent Cushing's syndrome.
Topics: Adult; Cushing Syndrome; Female; Humans; Pituitary Gland, Anterior; Valproic Acid | 1982 |
Sodium valproate in Cushing's disease.
Topics: Adult; Cushing Syndrome; Female; Humans; Middle Aged; Valproic Acid | 1984 |
Sodium valproate and metyrapone for pituitary-dependent Cushing's disease.
Topics: Adrenal Glands; Adult; Cushing Syndrome; Drug Therapy, Combination; Female; Humans; Metyrapone; Pitu | 1984 |
Clinical and experimental studies on the role of GABA in the regulation of ACTH secretion: a review.
Topics: Adrenocorticotropic Hormone; Corticotropin-Releasing Hormone; Cushing Syndrome; gamma-Aminobutyric A | 1984 |
Effects of valproic acid, naloxone and hydrocortisone in Nelson's syndrome and cushing's disease.
Topics: Adrenalectomy; Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Female; Humans; Hydrocortisone; | 1981 |
Cortisol, valproic acid, and ACTH suppression.
Topics: Adrenocorticotropic Hormone; Animals; Cushing Syndrome; Humans; Hydrocortisone; Rats; Valproic Acid | 1982 |
Sodium valproate and cyproheptadine may independently induce a remission in the same patient with Cushing's disease.
Topics: Adrenocorticotropic Hormone; Adult; Bromocriptine; Cushing Syndrome; Cyproheptadine; Dexamethasone; | 1983 |
Effects of sodium-valproate administration on plasma ACTH levels in patients with ACTH hypersecretion.
Topics: Addison Disease; Adrenocorticotropic Hormone; Cushing Syndrome; Female; Humans; Male; Nelson Syndrom | 1983 |
[Clinical remission in Cushing's disease through treatment with sodium valproate and bromocriptine].
Topics: Bromocriptine; Chronic Disease; Cushing Syndrome; Cyproheptadine; Drug Therapy, Combination; Female; | 1991 |
Cyclical Cushing's disease and its successful control under sodium valproate.
Topics: Adolescent; Cushing Syndrome; Humans; Hydrocortisone; Male; Periodicity; Valproic Acid | 1990 |
Bromocriptine-responsive Cushing's disease associated with anterior pituitary corticotroph hyperplasia or normal pituitary gland.
Topics: Adolescent; Adrenocorticotropic Hormone; Bromocriptine; Cushing Syndrome; Cyproheptadine; Humans; Hy | 1989 |
The relationship between cortisol and ACTH in patients with Cushing's disease following neurosurgery or pharmacotherapy.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Aminoglutethimide; Cushing Syndrome; Cyproheptadine; | 1989 |
The combined use of sodium valproate and metyrapone in the treatment of Cushing's syndrome.
Topics: Adrenocorticotropic Hormone; Adult; Aged; Cortodoxone; Cushing Syndrome; Drug Therapy, Combination; | 1988 |
The effect of sodium valproate on plasma ACTH and cortisol concentrations in Cushing's disease and Nelson's syndrome.
Topics: Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Female; Hormone Antagonists; Humans; Hydrocort | 1988 |
Response to neurotransmitter modulating drugs in patients with Cushing's disease.
Topics: Adolescent; Adult; Bromocriptine; Cushing Syndrome; Cyproheptadine; Female; Humans; Hydrocortisone; | 1986 |
Fever of unexplained origin, biochemical Cushing's disease and cerebral dysrhythmia corrected by valproate sodium.
Topics: Adult; Brain; Cushing Syndrome; Electroencephalography; Female; Fever of Unknown Origin; Humans; Val | 1985 |