Page last updated: 2024-12-07

18-hydroxy-19-norcorticosterone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

18-hydroxy-19-norcorticosterone (18-OH-19-norcorticosterone) is a **synthetic steroid** that is structurally similar to the natural hormone **corticosterone**.

Here's why it's important in research:

* **Selective Mineralocorticoid Receptor (MR) Agonist:** 18-OH-19-norcorticosterone is a potent and selective agonist of the MR, meaning it binds to and activates the MR. This makes it a valuable tool for studying the role of the MR in various physiological processes.
* **Potential Therapeutic Applications:** Due to its selectivity for MR, 18-OH-19-norcorticosterone has potential therapeutic applications in conditions like:
* **Heart failure:** MR activation plays a role in heart failure progression. 18-OH-19-norcorticosterone might be useful in managing heart failure by targeting specific MR-mediated pathways.
* **Kidney disease:** MR activation can contribute to salt and water retention in kidney disease. Selective MR agonists like 18-OH-19-norcorticosterone could potentially be used to modulate these effects.
* **Neurological disorders:** MR signaling is involved in various brain functions. 18-OH-19-norcorticosterone might be explored as a potential treatment for conditions like Alzheimer's disease and anxiety.
* **Understanding MR Pharmacology:** 18-OH-19-norcorticosterone is a valuable tool for studying the pharmacology of the MR. Its selectivity allows researchers to differentiate the effects of MR activation from those of other steroid receptors like the glucocorticoid receptor (GR).

**Research using 18-OH-19-norcorticosterone is ongoing to better understand its potential therapeutic benefits and to refine its use in research settings.**

It's important to note that 18-OH-19-norcorticosterone is still under investigation, and its clinical applications are not yet fully established. More research is needed to determine its safety and efficacy in humans.

18-hydroxy-19-norcorticosterone: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID130685
MeSH IDM0146210

Synonyms (7)

Synonym
111594-84-4
18-hydroxy-19-norcorticosterone
19-norpregn-4-ene-3,20-dione, 11,18,21-trihydroxy-, (11beta)-
18-oh-19-nc
(8s,9s,10r,11s,13r,14s,17s)-11-hydroxy-17-(2-hydroxyacetyl)-13-(hydroxymethyl)-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-one
DTXSID40912234
11,18,21-trihydroxy-19-norpregn-4-ene-3,20-dione
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (33.33)18.7374
1990's6 (66.67)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.31

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.31 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.62 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.31)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]