dansyl hydrazine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Dansyl hydrazine (DNSH) is a fluorescent reagent widely used in biochemical research. It is a derivative of dansyl chloride, which is a sulfonyl chloride that reacts with primary amines to form highly fluorescent dansyl derivatives. DNSH is particularly useful for labeling aldehydes and ketones due to its reactivity with carbonyl groups. The reaction of DNSH with aldehydes or ketones produces a stable hydrazone derivative, which can then be detected and quantified using fluorescence spectroscopy. DNSH labeling is often used in studies of protein modification, enzyme kinetics, and the analysis of biological samples. The reaction of DNSH with carbonyl groups is relatively specific and can be performed under mild conditions, making it a valuable tool for studying a variety of biological processes.'

Cross-References

ID Source	ID
PubMed CID	94442
SCHEMBL ID	235824
MeSH ID	M0090312

Synonyms (34)

Synonym
5-(dimethylamino)naphthalene-1-sulfonohydrazide
OPREA1_436969
SR-01000633636-1
dansylhydrazine, 98%
5-dimethylaminonaphthalene-1-sulfonyl hydrazine
33008-06-9
dansyl hydrazine
dansylhydrazine
bdbm36661
1-naphthalenesulfonic acid, 5-(dimethylamino)-hydrazide
einecs 251-337-7
5-dimethylaminonaphthalene-1-sulphonohydrazide
CCG-43740
FT-0624414
FT-0624422
AKOS015894725
5-(dimethylamino)-1-naphthalenesulfonic hydrazide
SCHEMBL235824
1-naphthalenesulfonic acid, 5-(dimethylamino)-, hydrazide
5-(dimethylamino)-1-naphthalenesulfonohydrazide #
KPQYDVAFRDWIBW-UHFFFAOYSA-N
1-dimethylaminophthalene-5-sulphonyl hydrazine
mfcd00003986
DTXSID90186640
dansylhydrazine, bioreagent, suitable for fluorescence, >=90% (hplc)
dansylhydrazine, for lc-ms derivatization, >=95% (hplc)
J-018973
5-(dimethylamino)-1-naphthalenesulfonohydrazide
T70785
dansyl hydrazine [for hplc labeling]
AS-56735
CS-W010127
SY050086
HY-W009411

Research Excerpts

Pharmacokinetics

Excerpt	Reference	Relevance
" Tacrolimus demonstrates considerable interindividual variation in its pharmacokinetic profile."	( Measurement of tacrolimus (FK506) and its metabolites: a review of assay development and application in therapeutic drug monitoring and pharmacokinetic studies. Alak, AM, 1997)	0.3
" Due to its simplicity and sensitivity this method can be used on a routine basis for pharmacokinetic analysis of neuroactive steroids."	( High-performance liquid chromatography of the neuroactive steroids alphaxalone and pregnanolone in plasma using dansyl hydrazine as fluorescent label: application to a pharmacokinetic-pharmacodynamic study in rats. Danhof, M; Gladdines, WW; Irth, H; Smulders, CJ; van der Graaf, PH; Visser, SA, 2000)	0.52

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Thymidylate synthase	Lacticaseibacillus casei	IC50 (µMol)	511.7500	0.0090	1.9324	8.8000	AID1799451; AID1799474
Thymidylate synthase	Homo sapiens (human)	IC50 (µMol)	536.0000	0.0066	2.0637	9.5000	AID1799474
Thymidylate synthase	Escherichia coli K-12	IC50 (µMol)	536.0000	0.0066	0.9588	6.8000	AID1799474
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (24)

Process	via Protein(s)	Taxonomy
dTMP biosynthetic process	Thymidylate synthase	Homo sapiens (human)
dTTP biosynthetic process	Thymidylate synthase	Homo sapiens (human)
circadian rhythm	Thymidylate synthase	Homo sapiens (human)
response to xenobiotic stimulus	Thymidylate synthase	Homo sapiens (human)
response to toxic substance	Thymidylate synthase	Homo sapiens (human)
negative regulation of translation	Thymidylate synthase	Homo sapiens (human)
uracil metabolic process	Thymidylate synthase	Homo sapiens (human)
methylation	Thymidylate synthase	Homo sapiens (human)
response to progesterone	Thymidylate synthase	Homo sapiens (human)
response to vitamin A	Thymidylate synthase	Homo sapiens (human)
response to cytokine	Thymidylate synthase	Homo sapiens (human)
tetrahydrofolate interconversion	Thymidylate synthase	Homo sapiens (human)
response to ethanol	Thymidylate synthase	Homo sapiens (human)
response to organophosphorus	Thymidylate synthase	Homo sapiens (human)
developmental growth	Thymidylate synthase	Homo sapiens (human)
cartilage development	Thymidylate synthase	Homo sapiens (human)
response to glucocorticoid	Thymidylate synthase	Homo sapiens (human)
response to folic acid	Thymidylate synthase	Homo sapiens (human)
intestinal epithelial cell maturation	Thymidylate synthase	Homo sapiens (human)
DNA biosynthetic process	Thymidylate synthase	Homo sapiens (human)
liver regeneration	Thymidylate synthase	Homo sapiens (human)
dTMP biosynthetic process	Thymidylate synthase	Escherichia coli K-12
response to radiation	Thymidylate synthase	Escherichia coli K-12
dTMP biosynthetic process	Thymidylate synthase	Escherichia coli K-12
dTTP biosynthetic process	Thymidylate synthase	Escherichia coli K-12
regulation of translation	Thymidylate synthase	Escherichia coli K-12
nucleotide biosynthetic process	Thymidylate synthase	Escherichia coli K-12
methylation	Thymidylate synthase	Escherichia coli K-12
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (8)

Process	via Protein(s)	Taxonomy
mRNA regulatory element binding translation repressor activity	Thymidylate synthase	Homo sapiens (human)
thymidylate synthase activity	Thymidylate synthase	Homo sapiens (human)
folic acid binding	Thymidylate synthase	Homo sapiens (human)
protein homodimerization activity	Thymidylate synthase	Homo sapiens (human)
sequence-specific mRNA binding	Thymidylate synthase	Homo sapiens (human)
magnesium ion binding	Thymidylate synthase	Escherichia coli K-12
RNA binding	Thymidylate synthase	Escherichia coli K-12
thymidylate synthase activity	Thymidylate synthase	Escherichia coli K-12
methyltransferase activity	Thymidylate synthase	Escherichia coli K-12
protein homodimerization activity	Thymidylate synthase	Escherichia coli K-12
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (6)

Process	via Protein(s)	Taxonomy
nucleus	Thymidylate synthase	Homo sapiens (human)
cytoplasm	Thymidylate synthase	Homo sapiens (human)
mitochondrion	Thymidylate synthase	Homo sapiens (human)
mitochondrial inner membrane	Thymidylate synthase	Homo sapiens (human)
mitochondrial matrix	Thymidylate synthase	Homo sapiens (human)
cytosol	Thymidylate synthase	Homo sapiens (human)
mitochondrion	Thymidylate synthase	Homo sapiens (human)
cytosol	Thymidylate synthase	Homo sapiens (human)
cytoplasm	Thymidylate synthase	Escherichia coli K-12
cytosol	Thymidylate synthase	Escherichia coli K-12
cytosol	Thymidylate synthase	Escherichia coli K-12
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (5)

Assay ID	Title	Year	Journal	Article
AID1794808	Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).	2014	Journal of biomolecular screening, Jul, Volume: 19, Issue:6	A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808	Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
AID1799451	Enzyme Assay from Article 10.1016/S1074-5521(99)80077-5: \\Structure-based discovery and in-parallel optimization of novel competitive inhibitors of thymidylate synthase.\\	1999	Chemistry & biology, May, Volume: 6, Issue:5	Structure-based discovery and in-parallel optimization of novel competitive inhibitors of thymidylate synthase.
AID1799474	Inhibition Assay from Article 10.1016/S1074-5521(01)00067-9: \\Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase.\\	2001	Chemistry & biology, Oct, Volume: 8, Issue:10	Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase.
AID1159607	Screen for inhibitors of RMI FANCM (MM2) intereaction	2016	Journal of biomolecular screening, Jul, Volume: 21, Issue:6	A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (65)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	21 (32.31)	18.7374
1990's	16 (24.62)	18.2507
2000's	12 (18.46)	29.6817
2010's	12 (18.46)	24.3611
2020's	4 (6.15)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 33.92

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	33.92 (24.57)
Research Supply Index	4.19 (2.92)
Research Growth Index	4.53 (4.65)
Search Engine Demand Index	28.17 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (33.92)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (1.54%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	64 (98.46%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
acetic acid Acetic Acid: Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed). acetic acid : A simple monocarboxylic acid containing two carbons.	2.08	1	monocarboxylic acid	antimicrobial food preservative; Daphnia magna metabolite; food acidity regulator; protic solvent
carnitine [no description available]	2.25	1	amino-acid betaine	human metabolite; mouse metabolite
dimethyl sulfoxide Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.. dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.	1.96	1	sulfoxide; volatile organic compound	alkylating agent; antidote; Escherichia coli metabolite; geroprotector; MRI contrast agent; non-narcotic analgesic; polar aprotic solvent; radical scavenger
glycine [no description available]	1.96	1	alpha-amino acid; amino acid zwitterion; proteinogenic amino acid; serine family amino acid	EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor; fundamental metabolite; hepatoprotective agent; micronutrient; neurotransmitter; NMDA receptor agonist; nutraceutical
hydroxylamine amino alcohol : An alcohol containing an amino functional group in addition to the alcohol-defining hydroxy group.	1.99	1	hydroxylamines	algal metabolite; bacterial xenobiotic metabolite; EC 1.1.3.13 (alcohol oxidase) inhibitor; EC 4.2.1.22 (cystathionine beta-synthase) inhibitor; EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor; nitric oxide donor; nucleophilic reagent
taurine [no description available]	1.96	1	amino sulfonic acid; zwitterion	antioxidant; Escherichia coli metabolite; glycine receptor agonist; human metabolite; mouse metabolite; nutrient; radical scavenger; Saccharomyces cerevisiae metabolite
5-methoxytryptamine 5-Methoxytryptamine: Serotonin derivative proposed as potentiator for hypnotics and sedatives.. 5-methoxytryptamine : A member of the class of tryptamines that is the methyl ether derivative of serotonin.	2.03	1	aromatic ether; primary amino compound; tryptamines	5-hydroxytryptamine 2A receptor agonist; 5-hydroxytryptamine 2B receptor agonist; 5-hydroxytryptamine 2C receptor agonist; antioxidant; cardioprotective agent; human metabolite; mouse metabolite; neuroprotective agent; radiation protective agent; serotonergic agonist
erythrosine Fluoresceins: A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.	2.36	2
gossypol Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.	2.03	1
succinylacetone succinylacetone: inhibitor of heme biosynthesis. 4,6-dioxoheptanoic acid : A dioxo monocarboxylic acid that is heptanoic acid in which oxo groups replace the hydrogens at positions 4 and 6. It is an abnormal metabolite of the tyrosine metabolic pathway and a marker for type 1 tyrosinaemia.	2.03	1	beta-diketone; dioxo monocarboxylic acid	human metabolite
prednisolone Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.. prednisolone : A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.	1.96	1	11beta-hydroxy steroid; 17alpha-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(1),Delta(4)-steroid; C21-steroid; glucocorticoid; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	adrenergic agent; anti-inflammatory drug; antineoplastic agent; drug metabolite; environmental contaminant; immunosuppressive agent; xenobiotic
dehydroepiandrosterone Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.. dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.	2.03	1	17-oxo steroid; 3beta-hydroxy-Delta(5)-steroid; androstanoid	androgen; human metabolite; mouse metabolite
serine Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.. serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.	2	1	L-alpha-amino acid; proteinogenic amino acid; serine family amino acid; serine zwitterion; serine	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
aspartic acid Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.. aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent. L-aspartic acid : The L-enantiomer of aspartic acid.	7.1	1	aspartate family amino acid; aspartic acid; L-alpha-amino acid; proteinogenic amino acid	Escherichia coli metabolite; mouse metabolite; neurotransmitter
lysine Lysine: An essential amino acid. It is often added to animal feed.. lysine : A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6.. L-lysine : An L-alpha-amino acid; the L-isomer of lysine.	1.97	1	aspartate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; lysine; organic molecular entity; proteinogenic amino acid	algal metabolite; anticonvulsant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
phenylalanine Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.. L-phenylalanine : The L-enantiomer of phenylalanine.. phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.	1.95	1	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; phenylalanine; proteinogenic amino acid	algal metabolite; EC 3.1.3.1 (alkaline phosphatase) inhibitor; Escherichia coli metabolite; human xenobiotic metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
acetonitrile acetonitrile: RN given refers to unlabeled cpd. acetonitrile : A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by a methyl group.	2.42	2	aliphatic nitrile; volatile organic compound	EC 3.5.1.4 (amidase) inhibitor; NMR chemical shift reference compound; polar aprotic solvent
trifluoroacetic acid Trifluoroacetic Acid: A very strong halogenated derivative of acetic acid. It is used in acid catalyzed reactions, especially those where an ester is cleaved in peptide synthesis.. trifluoroacetic acid : A monocarboxylic acid that is the trifluoro derivative of acetic acid.	2.03	1	fluoroalkanoic acid	human xenobiotic metabolite; NMR chemical shift reference compound; reagent
salicylaldehyde o-hydroxybenzaldehyde: structure in first source	7.1	1	hydroxybenzaldehyde	nematicide; plant metabolite
benzoyl chloride benzoyl chloride: potential carcinogens in manufacturing process. benzoyl chloride : An acyl chloride consisting of benzene in which a hydrogen is replaced by an acyl chloride group. It is an important chemical intermediate for the manufacture of other chemicals, dyes, perfumes, herbicides and pharmaceuticals.	1.96	1	acyl chloride; benzenes	carcinogenic agent
acrolein [no description available]	2.41	2	enal	herbicide; human xenobiotic metabolite; toxin
2-methylpentane Hexanes: Six-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives. Various polyneuropathies are caused by hexane poisoning.	1.98	1	alkane
2,5-hexanedione 2,5-hexanedione: metabolite of methyl-n-butyl ketone. 2,5-hexanedione : A diketone that is hexane substituted by oxo groups at positions 2 and 5. It is a toxic metabolite of hexane and of 2-hexanone	1.98	1	diketone; methyl ketone	human xenobiotic metabolite; neurotoxin
n-hexane hexane : An unbranched alkane containing six carbon atoms.	1.98	1	alkane; volatile organic compound	neurotoxin; non-polar solvent
dodecyltrimethylammonium dodecyltrimethylammonium: used to determine thermal stability of DNA; RN given refers to parent cpd. dodecyltrimethylammonium ion : A quarternary ammonium cation having one dodecyl and three methyl substituents around the central nitrogen.	1.97	1	quaternary ammonium ion
cyclopentane Cyclopentanes: A group of alicyclic hydrocarbons with the general formula R-C5H9.. cyclopentanes : Cyclopentane and its derivatives formed by substitution.	1.96	1	cycloalkane; cyclopentanes; volatile organic compound	non-polar solvent
hydrazine diamine : Any polyamine that contains two amino groups.	5.39	59	azane; hydrazines	EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor
cyanogen bromide Cyanogen Bromide: Cyanogen bromide (CNBr). A compound used in molecular biology to digest some proteins and as a coupling reagent for phosphoroamidate or pyrophosphate internucleotide bonds in DNA duplexes.	2.4	2
malondialdehyde Malondialdehyde: The dialdehyde of malonic acid.. malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.	2.25	1	dialdehyde	biomarker
dansyl chloride dansyl chloride: RN given refers to unlabeled cpd	1.97	1	aminonaphthalene; sulfonic acid derivative
sodium hydroxide Sodium Hydroxide: A highly caustic substance that is used to neutralize acids and make sodium salts. (From Merck Index, 11th ed)	1.99	1	alkali metal hydroxide
1-aminopyrene [no description available]	1.98	1
ethyldimethylaminopropyl carbodiimide Ethyldimethylaminopropyl Carbodiimide: Carbodiimide cross-linking reagent.	1.97	1
tetrapentylammonium tetrapentylammonium: RN given refers to parent cpd	1.97	1	quaternary ammonium ion
uranium Uranium: A radioactive element of the actinide series of metals. It has an atomic symbol U, atomic number 92, and atomic weight 238.03. U-235 is used as the fissionable fuel in nuclear weapons and as fuel in nuclear power reactors.	1.96	1	actinoid atom; f-block element atom; monoatomic uranium
pregnanolone Pregnanolone: A pregnane found in the urine of pregnant women and sows. It has anesthetic, hypnotic, and sedative properties.. 3alpha-hydroxy-5beta-pregnan-20-one : The 3alpha-stereoisomer of 3-hydroxy-5beta-pregnan-20-one.	7	1	3-hydroxy-5beta-pregnan-20-one; 3alpha-hydroxy steroid	human metabolite; intravenous anaesthetic; sedative
glutamic acid Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.. glutamic acid : An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2.	7.1	1	glutamic acid; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	Escherichia coli metabolite; ferroptosis inducer; micronutrient; mouse metabolite; neurotransmitter; nutraceutical
adenosine diphosphate ribose Adenosine Diphosphate Ribose: An ester formed between the aldehydic carbon of RIBOSE and the terminal phosphate of ADENOSINE DIPHOSPHATE. It is produced by the hydrolysis of nicotinamide-adenine dinucleotide (NAD) by a variety of enzymes, some of which transfer an ADP-ribosyl group to target proteins.	1.99	1	ADP-sugar	Escherichia coli metabolite; mouse metabolite
s-adenosylmethionine acylcarnitine: structure in first source. S-adenosyl-L-methioninate : A sulfonium betaine that is a conjugate base of S-adenosyl-L-methionine obtained by the deprotonation of the carboxy group.	2.25	1	sulfonium betaine	human metabolite
metaperiodate Periodic Acid: A strong oxidizing agent.	2.9	4	iodine oxoacid
alphaxalone alphaxalone: RN given refers to (3alpha,5alpha)-isomer; structure	7	1	corticosteroid hormone
peroxyoxalate [no description available]	1.97	1
1-cyano-4-dimethylaminopyridinium 1-cyano-4-dimethylaminopyridinium: a cyanylating agent for the activation of polysaccharide resins	2.46	2
dansylethylenediamine [no description available]	1.96	1
metaperiodate metaperiodate: RN given refers to periodic acid, Na salt; structure. periodate : A monovalent inorganic anion obtained by deprotonation of periodic acid.	2.37	2	iodine oxoanion; monovalent inorganic anion
tacrolimus Tacrolimus: A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.. tacrolimus (anhydrous) : A macrolide lactam containing a 23-membered lactone ring, originally isolated from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis.	2.39	2	macrolide lactam	bacterial metabolite; immunosuppressive agent
2-butenal crotonaldehyde : An enal consisting of propene having a formyl group at the 1-position.	2.02	1	enal
ovalbumin Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.	1.96	1
sodium dodecyl sulfate Sodium Dodecyl Sulfate: An anionic surfactant, usually a mixture of sodium alkyl sulfates, mainly the lauryl; lowers surface tension of aqueous solutions; used as fat emulsifier, wetting agent, detergent in cosmetics, pharmaceuticals and toothpastes; also as research tool in protein biochemistry.. sodium dodecyl sulfate : An organic sodium salt that is the sodium salt of dodecyl hydrogen sulfate.	2.1	1	organic sodium salt	detergent; protein denaturant
2,4-dinitrophenylhydrazine 2,4-dinitrophenylhydrazine: structure. 2,4-dinitrophenylhydrazine : A C-nitro compound that is phenylhydrazine substituted at the 2- and 4-positions by nitro groups.	2.38	2	C-nitro compound; phenylhydrazines	reagent
17-ketosteroids 17-Ketosteroids: Steroids that contain a ketone group at position 17.. 17-oxo steroid : Any oxo steroid carrying the oxo group at position 17.	3.06	5
dinoprostone prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.	1.96	1	prostaglandins E	human metabolite; mouse metabolite; oxytocic
hymecromone Hymecromone: A coumarin derivative possessing properties as a spasmolytic, choleretic and light-protective agent. It is also used in ANALYTICAL CHEMISTRY TECHNIQUES for the determination of NITRIC ACID.	1.96	1	hydroxycoumarin	antineoplastic agent; hyaluronic acid synthesis inhibitor
pulmicort Budesonide: A glucocorticoid used in the management of ASTHMA, the treatment of various skin disorders, and allergic RHINITIS.. budesonide : A glucocorticoid steroid having a highly oxygenated pregna-1,4-diene structure. It is used mainly in the treatment of asthma and non-infectious rhinitis and for treatment and prevention of nasal polyposis.	2.21	1	11beta-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(1),Delta(4)-steroid; cyclic acetal; glucocorticoid; primary alpha-hydroxy ketone	anti-inflammatory drug; bronchodilator agent; drug allergen
jasmonic acid jasmonic acid: a derivative of alpha-linolenic acid that has a role in plant response to herbivory analogous to the role of prostanoids in inflammation in mammals;. jasmonic acid : An oxo monocarboxylic acid that is (3-oxocyclopentyl)acetic acid substituted by a (2Z)-pent-2-en-1-yl group at position 2 of the cyclopentane ring.	1.96	1	oxo monocarboxylic acid	jasmonates; plant metabolite
geranylgeranylacetone geranylgeranylacetone: structure in first source; RN given refers to isomeric cpd without isomeric designation; mixture of (5E,9E,13E) & (5Z,9E,13E)-isomers. teprenone : A terpene ketone in which a (9E,13E)-geranylgernayl group is bonded to one of the alpha-methyls of acetone (it is a mixture of 5E- and 5Z-geoisomers in a 3:2 ratio).	1.97	1
cysteine Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.	1.99	1	cysteinium	fundamental metabolite
abscisic acid Abscisic Acid: Abscission-accelerating plant growth substance isolated from young cotton fruit, leaves of sycamore, birch, and other plants, and from potatoes, lemons, avocados, and other fruits.. (S)-2-trans-abscisic acid : A 2-trans-abscisic acid with (S)-configuration at the chiral centre.. (+)-abscisic acid : The naturally occurring (1'S)-(+) enantiomer of abscisic acid. It is an important sesquiterpenoid plant hormone which acts as a regulator of plant responses to environmental stresses such as drought and cold.	1.96	1	2-trans-abscisic acid
oxalates Oxalates: Derivatives of OXALIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that are derived from the ethanedioic acid structure.	1.97	1
fluorescein thiosemicarbazide [no description available]	1.95	1
lipid a Lipid A: Lipid A is the biologically active component of lipopolysaccharides. It shows strong endotoxic activity and exhibits immunogenic properties.. lipid A : The glycolipid moiety of bacterial lipopolysaccharide (R can be either hydrogen or a fatty acyl group).	2.47	2	dodecanoate ester; lipid A; tetradecanoate ester	Escherichia coli metabolite
chondroitin Chondroitin: A mucopolysaccharide constituent of chondrin. (Grant & Hackh's Chemical Dictionary, 5th ed)	2.37	2
chondroitin sulfates Chondroitin Sulfates: Derivatives of chondroitin which have a sulfate moiety esterified to the galactosamine moiety of chondroitin. Chondroitin sulfate A, or chondroitin 4-sulfate, and chondroitin sulfate C, or chondroitin 6-sulfate, have the sulfate esterified in the 4- and 6-positions, respectively. Chondroitin sulfate B (beta heparin; DERMATAN SULFATE) is a misnomer and this compound is not a true chondroitin sulfate.	2.89	4
concanavalin a Concanavalin A: A MANNOSE/GLUCOSE binding lectin isolated from the jack bean (Canavalia ensiformis). It is a potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures.	1.97	1

Condition	Relationship Strength	Studies
Plasmodium falciparum Malaria [description not available]	2.1	1
Malaria, Falciparum Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.	2.1	1
Anemia, Fanconi [description not available]	2.13	1
Fanconi Anemia Congenital disorder affecting all bone marrow elements, resulting in ANEMIA; LEUKOPENIA; and THROMBOPENIA, and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes. Spontaneous CHROMOSOME BREAKAGE is a feature of this disease along with predisposition to LEUKEMIA. There are at least 7 complementation groups in Fanconi anemia: FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, and FANCL. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227650, August 20, 2004)	2.13	1
4 Hydroxyphenylpyruvate Dioxygenase Deficiency Disease [description not available]	2.03	1
Tyrosinemias A group of disorders which have in common elevations of tyrosine in the blood and urine secondary to an enzyme deficiency. Type I tyrosinemia features episodic weakness, self-mutilation, hepatic necrosis, renal tubular injury, and seizures and is caused by a deficiency of the enzyme fumarylacetoacetase. Type II tyrosinemia features INTELLECTUAL DISABILITY, painful corneal ulcers, and keratoses of the palms and plantar surfaces and is caused by a deficiency of the enzyme TYROSINE TRANSAMINASE. Type III tyrosinemia features INTELLECTUAL DISABILITY and is caused by a deficiency of the enzyme 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE. (Menkes, Textbook of Child Neurology, 5th ed, pp42-3)	2.03	1
Breast Cancer [description not available]	2.04	1
Breast Neoplasms Tumors or cancer of the human BREAST.	2.04	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.42	2
Acute Confusional Senile Dementia [description not available]	1.98	1
Benign Infantile Myoclonic Epilepsy [description not available]	1.98	1
Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.	1.98	1
Alzheimer Disease A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)	1.98	1
Epilepsies, Myoclonic A clinically diverse group of epilepsy syndromes characterized either by myoclonic seizures or by myoclonus in association with other seizure types. Myoclonic epilepsy syndromes are divided into three subtypes based on etiology: familial, cryptogenic, and symptomatic.	1.98	1
Carcinoma 256, Walker A transplantable carcinoma of the rat that originally appeared spontaneously in the mammary gland of a pregnant albino rat, and which now resembles a carcinoma in young transplants and a sarcoma in older transplants. (Stedman, 25th ed)	1.99	1
Carcinoma, Ehrlich Tumor A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.	1.99	1
Experimental Neoplasms [description not available]	1.99	1
Cushing's Syndrome [description not available]	1.97	1
Aldosteronism [description not available]	1.97	1
Cushing Syndrome A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.	1.97	1
Hyperaldosteronism A condition caused by the overproduction of ALDOSTERONE. It is characterized by sodium retention and potassium excretion with resultant HYPERTENSION and HYPOKALEMIA.	1.97	1

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