cytochrome-c-t and Hyperuricemia

Celery seeds are commonly used as condiments and in herbal teas with high medicinal value. In the present study, we investigated the contents of extracts derived under different extraction conditions and determined the optimal conditions for only extracting flavone glycosides from celery seeds. The compositional analysis identified three primary flavone glycosides in the ethanolic extract, and apiin, graveobioside A, and graveobioside B were isolated. Apigenin, luteolin, and chrsyeriol were obtained by the acid hydrolysis of flavone glycosides under high-temperature conditions. Here we investigated the inhibitory activity of apigenin and apiin on xanthine oxidase by reducing the rate of oxidative cytochrome C and found that both apigenin and apiin reduced cytochrome C production, except for low concentrations of apiin.

Topics: Allopurinol; Animals; Apigenin; Apium; Cytochromes c; Flavones; Glycosides; Hyperuricemia; Luteolin; Mice; Plant Extracts; Rats; Seeds; Teas, Herbal; Uric Acid; Xanthine Oxidase