| Assay ID | Title | Year | Journal | Article |
|---|
| AID1347057 | CD47-SIRPalpha protein protein interaction - LANCE assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7
| Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID1347405 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS LOPAC collection | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347059 | CD47-SIRPalpha protein protein interaction - Alpha assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7
| Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID504836 | Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in human glioma: Validation | 2002 | The Journal of biological chemistry, Apr-19, Volume: 277, Issue:16
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347049 | Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot screen | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347045 | Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot counterscreen GloSensor control cell line | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID1347410 | qHTS for inhibitors of adenylyl cyclases using a fission yeast platform: a pilot screen against the NCATS LOPAC library | 2019 | Cellular signalling, 08, Volume: 60 | A fission yeast platform for heterologous expression of mammalian adenylyl cyclases and high throughput screening. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347050 | Natriuretic polypeptide receptor (hNpr2) antagonism - Pilot subtype selectivity assay | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID1347151 | Optimization of GU AMC qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588378 | qHTS for Inhibitors of ATXN expression: Validation | | | |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID588349 | qHTS for Inhibitors of ATXN expression: Validation of Cytotoxic Assay | | | |
| AID1347058 | CD47-SIRPalpha protein protein interaction - HTRF assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7
| Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID30885 | Compound was tested for inhibitory activity against ACAT from U937 microsome in human | 1999 | Bioorganic & medicinal chemistry letters, Jul-19, Volume: 9, Issue:14
| Polyunsaturated fatty acid anilides as inhibitors of acyl-coA: cholesterol acyltransferase (ACAT). |
| AID31658 | Ability to inhibit rabbit liver Acyl coenzyme A:cholesterol acyltransferase 1 | 1995 | Journal of medicinal chemistry, Aug-04, Volume: 38, Issue:16
| Potent inhibitors of acyl-CoA:cholesterol acyltransferase. Structure-activity relationships of novel N-(4-oxochroman-8-yl)amides. |
| AID1396704 | Selectivity ratio of IC50 for inhibition of SOAT2 in New Zealand white rabbit intestinal microsomes to IC50 for inhibition of SOAT1 in arterial homogenates isolated from 1% cholesterol fed New Zealand white rabbit | | | |
| AID30883 | Compound was tested for inhibitory activity against ACAT from Caco-2 microsome in human | 1999 | Bioorganic & medicinal chemistry letters, Jul-19, Volume: 9, Issue:14
| Polyunsaturated fatty acid anilides as inhibitors of acyl-coA: cholesterol acyltransferase (ACAT). |
| AID173230 | Percent change in total cholesterol in cholic acid (0.5%)-cholesterol (1.5%)-peanut oil (5.5%)-fed rats | 1994 | Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
| Inhibitors of acyl-CoA:cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 8. Incorporation of amide or amine functionalities into a series of disubstituted ureas and carbamates. Effects on ACAT inhibition in vitro and efficacy in vivo. |
| AID165651 | Change in total cholesterol(TC) versus (T0)- at which drug intervention begins at a dose of 5 mg/kg in chronic cholesterol-fed rabbit model | 1996 | Journal of medicinal chemistry, Jun-07, Volume: 39, Issue:12
| Inhibitors of acyl-CoA:cholesterol O-acyltransferase. synthesis and pharmacological activity of (+/-)-2-dodecyl-alpha-phenyl-N-(2,4,6-trimethoxyphenyl)-2H-tetrazole-5- acetamide and structurally related tetrazole amide derivatives. |
| AID167455 | Dose response in cholesterol fed rabbit after oral administration | 1996 | Journal of medicinal chemistry, Jun-07, Volume: 39, Issue:12
| Inhibitors of acyl-CoA:cholesterol O-acyltransferase. synthesis and pharmacological activity of (+/-)-2-dodecyl-alpha-phenyl-N-(2,4,6-trimethoxyphenyl)-2H-tetrazole-5- acetamide and structurally related tetrazole amide derivatives. |
| AID645241 | Cytotoxicity against monkey MA104 cells after 24 hrs | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Novel triacsin C analogs as potential antivirals against rotavirus infections. |
| AID171225 | Serum total cholesterol-lowering activity in the cholesterol-fed rat expressed as the ratio of the observed reduction to the difference between the control and normal levels 100 (3 mg/kg po) | 1995 | Journal of medicinal chemistry, Aug-04, Volume: 38, Issue:16
| Potent inhibitors of acyl-CoA:cholesterol acyltransferase. Structure-activity relationships of novel N-(4-oxochroman-8-yl)amides. |
| AID167789 | Percent change in lesion coverage relative to control in the thoracic aorta at dose 25 mg/Kg in rabbits | 1996 | Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
| Heterocyclic amides: inhibitors of acyl-CoA:cholesterol O-acyl transferase with hypocholesterolemic activity in several species and antiatherosclerotic activity in the rabbit. |
| AID31675 | In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver microsomes | 1996 | Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
| Heterocyclic amides: inhibitors of acyl-CoA:cholesterol O-acyl transferase with hypocholesterolemic activity in several species and antiatherosclerotic activity in the rabbit. |
| AID31670 | Inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase 1 obtained from rat liver microsomes | 1996 | Journal of medicinal chemistry, Mar-15, Volume: 39, Issue:6
| Potent inhibitors of acyl-CoA:cholesterol acyltransferase. 2. Structure-activity relationships of novel N-(2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)amides. |
| AID84307 | In vivo effect on cholesteryl esters in cholesterol-fed hamsters at a dose of 50(mpk) | 1995 | Journal of medicinal chemistry, May-12, Volume: 38, Issue:10
| Substituted (1,2-diarylethyl)amide acyl-CoA:cholesterol acyltransferase inhibitors: effect of polar groups on in vitro and in vivo activity. |
| AID15686 | Calculated partition coefficient (clogP) | 1994 | Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
| Inhibitors of acyl-CoA:cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 8. Incorporation of amide or amine functionalities into a series of disubstituted ureas and carbamates. Effects on ACAT inhibition in vitro and efficacy in vivo. |
| AID84848 | In vivo dose effecting the cholesteryl esters in cholesterol-fed hamsters at a dose of 50(mpk) | 1995 | Journal of medicinal chemistry, May-12, Volume: 38, Issue:10
| Substituted (1,2-diarylethyl)amide acyl-CoA:cholesterol acyltransferase inhibitors: effect of polar groups on in vitro and in vivo activity. |
| AID193851 | Total cholesterol lowering activity tested by administered orally to cholesterol fed rats at dose 3(mg/kg) once a day for 3 days | 1996 | Journal of medicinal chemistry, Mar-15, Volume: 39, Issue:6
| Potent inhibitors of acyl-CoA:cholesterol acyltransferase. 2. Structure-activity relationships of novel N-(2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)amides. |
| AID166497 | Percent change in plasma triglyceride levels at dose 25 mg/Kg in rabbits | 1996 | Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
| Heterocyclic amides: inhibitors of acyl-CoA:cholesterol O-acyl transferase with hypocholesterolemic activity in several species and antiatherosclerotic activity in the rabbit. |
| AID704241 | Induction of ABCA1 mRNA expression in human HuH7 cells after 24 hrs | 2012 | Journal of medicinal chemistry, Oct-25, Volume: 55, Issue:20
| Inhibition of Acyl-CoA: cholesterol acyltransferase (ACAT), overexpression of cholesterol transporter gene, and protection of amyloid β (Aβ) oligomers-induced neuronal cell death by tricyclic pyrone molecules. |
| AID31050 | Compound was tested for inhibitory activity against ACAT from rabbit intestine | 1999 | Bioorganic & medicinal chemistry letters, Jul-19, Volume: 9, Issue:14
| Polyunsaturated fatty acid anilides as inhibitors of acyl-coA: cholesterol acyltransferase (ACAT). |
| AID30880 | Compound was tested for inhibitory activity against ACAT from canine liver | 1999 | Bioorganic & medicinal chemistry letters, Jul-19, Volume: 9, Issue:14
| Polyunsaturated fatty acid anilides as inhibitors of acyl-coA: cholesterol acyltransferase (ACAT). |
| AID193692 | Percent change in high density lipoprotein (HDL-cholesterol in cholesterol-fed rats. | 1992 | Journal of medicinal chemistry, May-01, Volume: 35, Issue:9
| Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents. |
| AID84332 | Compound was tested for the change in liver cholesteryl ester (CE) levels by the inhibition of ACAT in hamster at 50 mg/kg p.o. | 1981 | Journal of medicinal chemistry, May, Volume: 24, Issue:5
| New analgesic drugs derived from phencyclidine. |
| AID30878 | Compound was tested for inhibitory activity against ACAT from canine adrenal gland | 1999 | Bioorganic & medicinal chemistry letters, Jul-19, Volume: 9, Issue:14
| Polyunsaturated fatty acid anilides as inhibitors of acyl-coA: cholesterol acyltransferase (ACAT). |
| AID1396706 | Inhibition of ACAT1 in mouse J774 cells assessed as reduction in esterified cholesterol accumulation after 18 hrs in presence of 25-hydroxycholesterol | | | |
| AID704242 | Induction of ABCA1 mRNA expression in human MC65 cells after 24 hrs | 2012 | Journal of medicinal chemistry, Oct-25, Volume: 55, Issue:20
| Inhibition of Acyl-CoA: cholesterol acyltransferase (ACAT), overexpression of cholesterol transporter gene, and protection of amyloid β (Aβ) oligomers-induced neuronal cell death by tricyclic pyrone molecules. |
| AID31660 | Inhibition of rabbit small-intestinal Acyl coenzyme A:cholesterol acyltransferase 1 | 1995 | Journal of medicinal chemistry, Aug-04, Volume: 38, Issue:16
| Potent inhibitors of acyl-CoA:cholesterol acyltransferase. Structure-activity relationships of novel N-(4-oxochroman-8-yl)amides. |
| AID704246 | Inhibition of ACAT activity in human MC65 cells using NBD-cholesterol staining after 48 hrs by fluorescence assay | 2012 | Journal of medicinal chemistry, Oct-25, Volume: 55, Issue:20
| Inhibition of Acyl-CoA: cholesterol acyltransferase (ACAT), overexpression of cholesterol transporter gene, and protection of amyloid β (Aβ) oligomers-induced neuronal cell death by tricyclic pyrone molecules. |
| AID645239 | Antiviral activity against Rotavirus SA11 in MA104 cells assessed as inhibition of viral replication after 24 hrs by immunofluorescent assay and Western blotting analysis | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Novel triacsin C analogs as potential antivirals against rotavirus infections. |
| AID31210 | In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase, in intestinal microsomes isolated from cholesterol-fed rabbits | 1992 | Journal of medicinal chemistry, May-01, Volume: 35, Issue:9
| Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents. |
| AID84311 | In vivo effect on serum cholesterol level of cholesterol-fed hamsters at a dose of 50(mpk) | 1995 | Journal of medicinal chemistry, May-12, Volume: 38, Issue:10
| Substituted (1,2-diarylethyl)amide acyl-CoA:cholesterol acyltransferase inhibitors: effect of polar groups on in vitro and in vivo activity. |
| AID31664 | In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay | 1995 | Journal of medicinal chemistry, May-12, Volume: 38, Issue:10
| Substituted (1,2-diarylethyl)amide acyl-CoA:cholesterol acyltransferase inhibitors: effect of polar groups on in vitro and in vivo activity. |
| AID84837 | Effective dose evaluated in hamster cholesterol absorption assay | 1994 | Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
| 2-Azetidinones as inhibitors of cholesterol absorption. |
| AID165652 | Change in total cholesterol(TC) versus progression control (PC) with out drug intervention in chronic cholesterol-fed rabbit model at a dose of 25 mg/kg | 1996 | Journal of medicinal chemistry, Jun-07, Volume: 39, Issue:12
| Inhibitors of acyl-CoA:cholesterol O-acyltransferase. synthesis and pharmacological activity of (+/-)-2-dodecyl-alpha-phenyl-N-(2,4,6-trimethoxyphenyl)-2H-tetrazole-5- acetamide and structurally related tetrazole amide derivatives. |
| AID9848 | Oral bioactivity expressed as %inhibition after 4 hours of drug administration (dose 25 mg/kg) in rabbit bioassay | 1996 | Journal of medicinal chemistry, Jun-07, Volume: 39, Issue:12
| Inhibitors of acyl-CoA:cholesterol O-acyltransferase. synthesis and pharmacological activity of (+/-)-2-dodecyl-alpha-phenyl-N-(2,4,6-trimethoxyphenyl)-2H-tetrazole-5- acetamide and structurally related tetrazole amide derivatives. |
| AID31049 | Compound was tested for inhibitory activity against ACAT from rabbit adrenal gland | 1999 | Bioorganic & medicinal chemistry letters, Jul-19, Volume: 9, Issue:14
| Polyunsaturated fatty acid anilides as inhibitors of acyl-coA: cholesterol acyltransferase (ACAT). |
| AID31536 | Inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase 1 obtained from rabbit intestine microsomes | 1996 | Journal of medicinal chemistry, Mar-15, Volume: 39, Issue:6
| Potent inhibitors of acyl-CoA:cholesterol acyltransferase. 2. Structure-activity relationships of novel N-(2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)amides. |
| AID704243 | Neuroprotective activity in tetracycline-stimulated human MC65 cells assessed as protection against APP-induced cell death up to 50 uM by MTT assay | 2012 | Journal of medicinal chemistry, Oct-25, Volume: 55, Issue:20
| Inhibition of Acyl-CoA: cholesterol acyltransferase (ACAT), overexpression of cholesterol transporter gene, and protection of amyloid β (Aβ) oligomers-induced neuronal cell death by tricyclic pyrone molecules. |
| AID30884 | Compound was tested for inhibitory activity against ACAT from HepG2 microsome in human | 1999 | Bioorganic & medicinal chemistry letters, Jul-19, Volume: 9, Issue:14
| Polyunsaturated fatty acid anilides as inhibitors of acyl-coA: cholesterol acyltransferase (ACAT). |
| AID30879 | Compound was tested for inhibitory activity against ACAT from canine intestine | 1999 | Bioorganic & medicinal chemistry letters, Jul-19, Volume: 9, Issue:14
| Polyunsaturated fatty acid anilides as inhibitors of acyl-coA: cholesterol acyltransferase (ACAT). |
| AID180289 | Inhibitory activity against foam cell formation (acetyl-LDL-induced cholesteryl ester accumulation) in rat peritoneal macrophages | 1996 | Journal of medicinal chemistry, Mar-15, Volume: 39, Issue:6
| Potent inhibitors of acyl-CoA:cholesterol acyltransferase. 2. Structure-activity relationships of novel N-(2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)amides. |
| AID31051 | Compound was tested for inhibitory activity against ACAT from rabbit liver | 1999 | Bioorganic & medicinal chemistry letters, Jul-19, Volume: 9, Issue:14
| Polyunsaturated fatty acid anilides as inhibitors of acyl-coA: cholesterol acyltransferase (ACAT). |
| AID31522 | Inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) | 1981 | Journal of medicinal chemistry, May, Volume: 24, Issue:5
| New analgesic drugs derived from phencyclidine. |
| AID86169 | Percent reduction in plasma cholesterol was evaluated by hamster cholesterol absorption assay at the particular dose of 10 (mg/kg/day) | 1994 | Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
| 2-Azetidinones as inhibitors of cholesterol absorption. |
| AID166494 | Percent change in plasma total cholesterol at dose 25 mg/Kg in rabbits | 1996 | Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
| Heterocyclic amides: inhibitors of acyl-CoA:cholesterol O-acyl transferase with hypocholesterolemic activity in several species and antiatherosclerotic activity in the rabbit. |
| AID225478 | IC50 is the concentration that inhibits 50% of the enzyme activity was evaluated by measuring the ability to inhibit acetyl-LDL-induced cholesteryl ester accumulation in rat peritoneal macrophages. | 1995 | Journal of medicinal chemistry, Aug-04, Volume: 38, Issue:16
| Potent inhibitors of acyl-CoA:cholesterol acyltransferase. Structure-activity relationships of novel N-(4-oxochroman-8-yl)amides. |
| AID86173 | Percent reduction of hepatic cholesteryl esters was evaluated by hamster cholesterol absorption assay at the particular dose of 10 (mg/kg/day) | 1994 | Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
| 2-Azetidinones as inhibitors of cholesterol absorption. |
| AID31518 | Inhibition of Acyl coenzyme A:cholesterol acyltransferase in microsomal ACAT assay at 10 uM | 1994 | Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
| 2-Azetidinones as inhibitors of cholesterol absorption. |
| AID9847 | Percent change in total cholesterol(TC) versus (T0)- at which drug intervention begins at a dose of 25 mg/kg in the chronic cholesterol-fed rabbit model | 1996 | Journal of medicinal chemistry, Jun-07, Volume: 39, Issue:12
| Inhibitors of acyl-CoA:cholesterol O-acyltransferase. synthesis and pharmacological activity of (+/-)-2-dodecyl-alpha-phenyl-N-(2,4,6-trimethoxyphenyl)-2H-tetrazole-5- acetamide and structurally related tetrazole amide derivatives. |
| AID176198 | Effective dose to lower nonHDL-C in a cholesterol fed rat model in vivo | 1996 | Journal of medicinal chemistry, Jun-07, Volume: 39, Issue:12
| Inhibitors of acyl-CoA:cholesterol O-acyltransferase. synthesis and pharmacological activity of (+/-)-2-dodecyl-alpha-phenyl-N-(2,4,6-trimethoxyphenyl)-2H-tetrazole-5- acetamide and structurally related tetrazole amide derivatives. |
| AID1396699 | Inhibition of rabbit intestinal ACAT2 | | | |
| AID31366 | Concentration required for 50% inhibition of Acyl coenzyme A:cholesterol acyltransferase activity using microsomal ACAT assay | 1994 | Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
| 2-Azetidinones as inhibitors of cholesterol absorption. |
| AID165653 | Change in total cholesterol(TC) versus progression control (PC) with out drug intervention in chronic cholesterol-fed rabbit model at a dose of 5 mg/kg | 1996 | Journal of medicinal chemistry, Jun-07, Volume: 39, Issue:12
| Inhibitors of acyl-CoA:cholesterol O-acyltransferase. synthesis and pharmacological activity of (+/-)-2-dodecyl-alpha-phenyl-N-(2,4,6-trimethoxyphenyl)-2H-tetrazole-5- acetamide and structurally related tetrazole amide derivatives. |
| AID84340 | Compound was tested for the change in serum cholesterol (SC) levels by the inhibition of ACAT in hamster at 50 mg/kg p.o. | 1981 | Journal of medicinal chemistry, May, Volume: 24, Issue:5
| New analgesic drugs derived from phencyclidine. |
| AID31211 | In vitro inhibition of rat intestinal acyl coenzyme A:cholesterol acyltransferase using [1-14C]oleolyl-CoA | 1994 | Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
| Inhibitors of acyl-CoA:cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 8. Incorporation of amide or amine functionalities into a series of disubstituted ureas and carbamates. Effects on ACAT inhibition in vitro and efficacy in vivo. |
| AID1396702 | Inhibition of SOAT1 in arterial homogenates isolated from 1% cholesterol fed New Zealand white rabbit assessed as reduction in cholesteryl oleate formation incubated for 5 mins in presence of [14C]-oleoyl-CoA and BSA complex by TLC method | | | |
| AID1396703 | Inhibition of SOAT2 in New Zealand white rabbit intestinal microsomes assessed as reduction in cholesteryl oleate formation incubated for 5 mins in presence of [14C]-oleoyl-CoA and BSA complex by TLC method | | | |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |