isotretinoin and Hyperuricemia

Acute gouty arthritis is a recognized complication of hyperuricemia and one of the most common forms of inflammatory arthritis in adults. Drug-induced hyperuricemia is increasingly prevalent in clinical practice. Diuretics, antitubercular medications, and immunosuppressants are the common drugs associated with hyperuricemia. Oral isotretinoin is the drug of choice for different forms of severe acne and is rarely associated with hyperuricemia. We present the case of a 30-year-old male with severe acne vulgaris who was prescribed isotretinoin and later presented with acute gout. The patient developed hyperuricemia and swelling of the right first metatarsophalangeal joint within two months of isotretinoin commencement. There was a second episode of similar joint swelling three months later, parallel to the isotretinoin rechallenge. The dose of isotretinoin was reduced with the addition of febuxostat. The patient did not develop further episodes and remained symptom-free without urate-lowering therapy.

Topics: Acne Vulgaris; Adult; Arthritis, Gouty; Febuxostat; Humans; Hyperuricemia; Isotretinoin; Male

Acne vulgaris is a chronic inflammatory disease affecting the pilosebaceous unit. Systemic isotretinoin (SI) is an effective, synthetic vitamin A derivative in the treatment of resistant acne or nodulocystic acne. This study aimed to investigate uric acid levels and laboratory parameters in patients receiving isotretinoin treatment.. This study included 114 patients who were under SI treatment of 0.2-0.5 mg/kg/day aged between 17 and 44 years old. We retrospectively evaluated total cholesterol, triglyceride, aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, creatinine, creatinine kinase, uric acid, thrombocyte (Plt), and leucocyte (WBC) levels prior and on the fourth month of the treatment from the patients' records and compared these data statistically.. The AST, creatinine kinase, cholesterol, triglyceride, and thrombocyte levels were significantly different (. SI treatment of 0.2-0.5 mg/kg/day did not make significant alterations on serum uric acid levels. Besides, all alterations occurred within normal ranges.

Topics: Acne Vulgaris; Adolescent; Adult; Dermatologic Agents; Humans; Hyperuricemia; Isotretinoin; Retrospective Studies; Uric Acid; Young Adult