chlorthalidone has been researched along with Hyperuricemia in 5 studies
Chlorthalidone: A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.
Hyperuricemia: Excessive URIC ACID or urate in blood as defined by its solubility in plasma at 37 degrees C; greater than 0.42mmol per liter (7.0mg/dL) in men or 0.36mmol per liter (6.0mg/dL) in women. This condition is caused by overproduction of uric acid or impaired renal clearance. Hyperuricemia can be acquired, drug-induced or genetically determined (LESCH-NYHAN SYNDROME). It is associated with HYPERTENSION and GOUT.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To survey the prevalence of hyperuricacidemia and serum uric acid (SUA) changes and electrolyte changes after 6 weeks antihypertensive treatment with thiazide diuretics, losartan or losartan+hydrochlorothiazide (Hyzaar) in patients with essential hypertension (EH)." | 9.13 | [Serum uric acid prevalence and changes post various antihypertensive agents in patients with essential hypertension]. ( Chen, H; Gui, W; Lu, LH; Wu, XY; Yang, LQ; Yu, L, 2008) |
| "To survey the prevalence of hyperuricacidemia and serum uric acid (SUA) changes and electrolyte changes after 6 weeks antihypertensive treatment with thiazide diuretics, losartan or losartan+hydrochlorothiazide (Hyzaar) in patients with essential hypertension (EH)." | 5.13 | [Serum uric acid prevalence and changes post various antihypertensive agents in patients with essential hypertension]. ( Chen, H; Gui, W; Lu, LH; Wu, XY; Yang, LQ; Yu, L, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (60.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Agarwal, R | 1 |
| Sinha, AD | 1 |
| Pappas, MK | 1 |
| Ammous, F | 1 |
| Chen, H | 1 |
| Yang, LQ | 1 |
| Yu, L | 1 |
| Wu, XY | 1 |
| Lu, LH | 1 |
| Gui, W | 1 |
| BRYANT, JM | 1 |
| YU, TF | 1 |
| BERGER, L | 1 |
| SCHVARTZ, N | 1 |
| TOROSDAG, S | 1 |
| FLETCHER, L | 1 |
| SCHWARTZ, MS | 1 |
| QUAN, RB | 1 |
| SMILO, RP | 1 |
| BEISEL, WR | 1 |
| FORSHAM, PH | 1 |
| SPERBER, RJ | 1 |
| FISCH, S | 1 |
| DEGRAFF, AC | 1 |
| FREUDENTHAL, RR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| DD-study: Diet or Diuretics for Salt-sensitivity in Chronic Kidney Disease[NCT02875886] | Phase 4 | 28 participants (Actual) | Interventional | 2016-09-30 | Completed | ||
| Chlortalidone and Bumetanide in Advanced Chronic Kidney Disease: HEBE-CKD Trial[NCT03923933] | Phase 2 | 34 participants (Actual) | Interventional | 2019-06-18 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | mmHg (Mean) |
|---|---|
| Placebo | -3.4 |
| Treatment Grup | -13.5 |
Decrease in extracellular water measured by bioelectrical impedance analysis (NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | litres (Mean) |
|---|---|
| Placebo | -0.15 |
| Treatment Grup | 2.55 |
Decrease in extracellular water / total body water ratio measured by bioelectrical impedance analysis (NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | percentage of ECW/TBW (Mean) |
|---|---|
| Placebo | -0.24 |
| Treatment Grup | -2.92 |
decrease in blood pressure compared wit baseline measure (mmhg) (NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | mmHg (Mean) |
|---|---|
| Placebo | -5.4 |
| Treatment Grup | -18.1 |
(NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | mmHg (Mean) |
|---|---|
| Placebo | -10 |
| Treatment Grup | -26.1 |
Increase in the fractional excretion of sodium compared with the baseline measure (NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | percentage of sodium excreted (Mean) |
|---|---|
| Placebo | -0.348 |
| Treatment Grup | 0.598 |
Measured by bioelectrical impedance analysis, compared to the initial measurement (NCT03923933)
Timeframe: Change from Basal to day 28
| Intervention | litres (Mean) |
|---|---|
| Placebo | -0.075 |
| Treatment Grup | -4.36 |
2 trials available for chlorthalidone and Hyperuricemia
| Article | Year |
|---|---|
Chlorthalidone for poorly controlled hypertension in chronic kidney disease: an interventional pilot study.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure Monitoring, Ambulatory; Chlo | 2014 |
Chlorthalidone for poorly controlled hypertension in chronic kidney disease: an interventional pilot study.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure Monitoring, Ambulatory; Chlo | 2014 |
Chlorthalidone for poorly controlled hypertension in chronic kidney disease: an interventional pilot study.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure Monitoring, Ambulatory; Chlo | 2014 |
Chlorthalidone for poorly controlled hypertension in chronic kidney disease: an interventional pilot study.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure Monitoring, Ambulatory; Chlo | 2014 |
[Serum uric acid prevalence and changes post various antihypertensive agents in patients with essential hypertension].
Topics: Aged; Antihypertensive Agents; Chlorthalidone; Drug Therapy, Combination; Female; Humans; Hypertensi | 2008 |
3 other studies available for chlorthalidone and Hyperuricemia
| Article | Year |
|---|---|
Hyperuricemia induced by the administration of chlorthalidone and other sulfonamide diuretics.
Topics: Chlorthalidone; Diuretics; Humans; Hypertension; Hyperuricemia; Sulfanilamide; Sulfanilamides; Sulfo | 1962 |
Reversal of thiazide-induced transient hyperuricemia by uricosuric agents.
Topics: Chlorthalidone; Humans; Hydrochlorothiazide; Hyperuricemia; Probenecid; Pyrazoles; Thiazides; Uric A | 1962 |
CORRECTION OF DIURETIC-INDUCED HYPOKALEMIA AND HYPERURICEMIA.
Topics: Bicarbonates; Blood Chemical Analysis; Chlorthalidone; Diuretics; Drug Therapy; Geriatrics; Hydrochl | 1965 |