Page last updated: 2024-11-13

allisartan isoproxil

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

allisartan isoproxil: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID24748496
SCHEMBL ID761436
MeSH IDM0592573

Synonyms (14)

Synonym
SCHEMBL761436
((ISOPROPOXYCARBONYL)OXY)METHYL 1-((2'-(2H-TETRAZOL-5-YL)-[1,1'-BIPHENYL]-4-YL)METHYL)-2-BUTYL-4-CHLORO-1H-IMIDAZOLE-5-CARBOXYLATE
SB16810
947331-05-7
allisartan isoproxil
propan-2-yloxycarbonyloxymethyl 2-butyl-5-chloro-3-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylate
((isopropoxycarbonyl)oxy)methyl 1-((2'-(1h-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-chloro-1h-imidazole-5-carboxylate
unii-di4662mk4n
di4662mk4n ,
1h-imidazole-5-carboxylic acid, 2-butyl-4-chloro-1-((2'-(2h-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-, (((1-methylethoxy)carbonyl)oxy)methyl ester
allisartan isoproxil [who-dd]
HY-111032
CS-0034002
AKOS040747792

Research Excerpts

Overview

Allisartan isoproxil is a selective nonpeptide angiotensin II (AT1) receptor blocker developed by China. This study aimed to assess its clinical efficacy for essential hypertension (EH)

ExcerptReferenceRelevance
"Allisartan isoproxil is a selective nonpeptide angiotensin II (AT1) receptor blocker developed by China, this study aimed to assess its clinical efficacy for essential hypertension (EH)."( Efficacy of Allisartan Isoproxil in the Treatment of Mild-to-Moderate Essential Hypertension.
Chen, Y; Lu, X; Sun, N; Wang, H; Wang, L; Xi, Y; Yang, F, 2023
)
2.73
"Allisartan isoproxil is a new nonpeptide angiotensin II receptor blocker (ARB) precursor drug that is used to treat hypertension and reduce the risk of heart disease. "( Allisartan isoproxil attenuates oxidative stress and inflammation through the SIRT1/Nrf2/NF‑κB signalling pathway in diabetic cardiomyopathy rats.
Chen, M; Jin, Q; Li, X; Wang, K; Zhu, Q, 2021
)
3.51
"Allisartan isoproxil (ALL) is a new angiotensin II receptor blocker and a new antihypertensive drug discovered and developed in China."( Allisartan isoproxil reduces mortality of stroke-prone rats and protects against cerebrovascular, cardiac, and aortic damage.
Cheng, MH; Fu, FH; Ling, QS; Liu, AJ; Liu, JG; Miao, CY; Tian, JS; Zhang, SL, 2021
)
2.79
"Allisartan isoproxil (ALS-3) is a selective, nonpeptide blocker of the angiotensin II type 1 receptor. "( A 26-week repeated-dose toxicity study of allisartan isoproxil in Sprague-Dawley rats.
Cheng, Y; Gong, L; Liu, Y; Lu, H; Qiao, J; Ren, J; Sun, J; Wang, H; Zhu, L, 2013
)
2.1

Toxicity

ExcerptReferenceRelevance
" Based on these results, we concluded that a dose of 20 mg/kg/day was the no observed adverse effect level."( A 26-week repeated-dose toxicity study of allisartan isoproxil in Sprague-Dawley rats.
Cheng, Y; Gong, L; Liu, Y; Lu, H; Qiao, J; Ren, J; Sun, J; Wang, H; Zhu, L, 2013
)
0.65
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (36.36)24.3611
2020's7 (63.64)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 38.40

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index38.40 (24.57)
Research Supply Index2.71 (2.92)
Research Growth Index4.97 (4.65)
Search Engine Demand Index44.23 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (38.40)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials3 (27.27%)5.53%
Reviews1 (9.09%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (63.64%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]