xanthine has been researched along with Hyperuricemia in 17 studies
7H-xanthine : An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-7 is protonated.
9H-xanthine : An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-9 is protonated.
Hyperuricemia: Excessive URIC ACID or urate in blood as defined by its solubility in plasma at 37 degrees C; greater than 0.42mmol per liter (7.0mg/dL) in men or 0.36mmol per liter (6.0mg/dL) in women. This condition is caused by overproduction of uric acid or impaired renal clearance. Hyperuricemia can be acquired, drug-induced or genetically determined (LESCH-NYHAN SYNDROME). It is associated with HYPERTENSION and GOUT.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study, we report a case of cystinuria with xanthine stones and hyperuricemia." | 8.31 | Declaration: Novel SLC3A1 mutation in a cystinuria patient with xanthine stones: a case report. ( Bai, P; Chen, B; Chen, Y; Duan, B; Huang, H; Jia, Y; Lai, L; Qin, J; Wang, H; Wang, T; Xing, J; Zhang, W, 2023) |
| "The associations of obesity with hypoxanthine, xanthine and plasma XOR activity were investigated in 484 participants (men/women: 224/260) of the Tanno-Sobetsu Study." | 7.96 | Differential regulation of hypoxanthine and xanthine by obesity in a general population. ( Furuhashi, M; Higashiura, Y; Koyama, M; Matsumoto, M; Miura, T; Moniwa, N; Murase, T; Nakamura, T; Ohnishi, H; Saitoh, S; Sakai, A; Shimamoto, K; Tanaka, M, 2020) |
| "To further explore the possibility of xanthine and hypoxanthine to be gout biomarkers as substitutes for uric acid." | 7.91 | Study on the diagnosis of gout with xanthine and hypoxanthine. ( Deng, B; Deng, M; Fei, X; Huang, Z; Wang, Y; Ye, L, 2019) |
| "X-linked hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency in an inherited disorder of purine metabolism is usually associated with the clinical manifestations of hyperuricemia." | 7.81 | Hyperuricemia and gout due to deficiency of hypoxanthine-guanine phosphoribosyltransferase in female carriers: New insight to differential diagnosis. ( Kostalova, E; Musalkova, D; Pavelka, K; Stiburkova, B; Vlaskova, H, 2015) |
| "During its development, ticagrelor, a drug designed to prevent thrombotic events in patients with acute coronary syndromes, was found to have an association with mild hyperuricemia." | 5.16 | Evaluation and characterization of the effects of ticagrelor on serum and urinary uric acid in healthy volunteers. ( Butler, K; Teng, R, 2012) |
| "In this study, we report a case of cystinuria with xanthine stones and hyperuricemia." | 4.31 | Declaration: Novel SLC3A1 mutation in a cystinuria patient with xanthine stones: a case report. ( Bai, P; Chen, B; Chen, Y; Duan, B; Huang, H; Jia, Y; Lai, L; Qin, J; Wang, H; Wang, T; Xing, J; Zhang, W, 2023) |
| "The associations of obesity with hypoxanthine, xanthine and plasma XOR activity were investigated in 484 participants (men/women: 224/260) of the Tanno-Sobetsu Study." | 3.96 | Differential regulation of hypoxanthine and xanthine by obesity in a general population. ( Furuhashi, M; Higashiura, Y; Koyama, M; Matsumoto, M; Miura, T; Moniwa, N; Murase, T; Nakamura, T; Ohnishi, H; Saitoh, S; Sakai, A; Shimamoto, K; Tanaka, M, 2020) |
| "With co-treatment of potassium oxonate (PO) and xanthine sodium salt (XSS), a zebrafish larva model of acute hyperuricemia has been constructed for the first time." | 3.91 | A zebrafish (danio rerio) model for high-throughput screening food and drugs with uric acid-lowering activity. ( Li, Q; Wang, F; Xing, C; Zhang, Y, 2019) |
| "To further explore the possibility of xanthine and hypoxanthine to be gout biomarkers as substitutes for uric acid." | 3.91 | Study on the diagnosis of gout with xanthine and hypoxanthine. ( Deng, B; Deng, M; Fei, X; Huang, Z; Wang, Y; Ye, L, 2019) |
| "Whether renal dysfunction influences the hypouricemic effect of febuxostat, a xanthine oxidase (XO) inhibitor, in patients with hyperuricemia due to overproduction or underexcretion of uric acid (UA) remains unclear." | 3.83 | Modeling and Simulation for Estimating the Influence of Renal Dysfunction on the Hypouricemic Effect of Febuxostat in Hyperuricemic Patients Due to Overproduction or Underexcretion of Uric Acid. ( Echizen, H; Hirai, T; Kimura, T, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (41.18) | 29.6817 |
| 2010's | 8 (47.06) | 24.3611 |
| 2020's | 2 (11.76) | 2.80 |
| Authors | Studies |
|---|---|
| Rocić, B | 1 |
| Vucić-Lovrencić, M | 1 |
| Poje, N | 1 |
| Poje, M | 1 |
| Bertuzzi, F | 1 |
| Bai, P | 1 |
| Zhang, W | 1 |
| Lai, L | 1 |
| Huang, H | 1 |
| Qin, J | 1 |
| Duan, B | 1 |
| Wang, H | 1 |
| Chen, Y | 1 |
| Jia, Y | 1 |
| Xing, J | 1 |
| Wang, T | 1 |
| Chen, B | 1 |
| Furuhashi, M | 1 |
| Koyama, M | 1 |
| Higashiura, Y | 1 |
| Murase, T | 1 |
| Nakamura, T | 1 |
| Matsumoto, M | 1 |
| Sakai, A | 1 |
| Ohnishi, H | 1 |
| Tanaka, M | 1 |
| Saitoh, S | 1 |
| Moniwa, N | 1 |
| Shimamoto, K | 1 |
| Miura, T | 1 |
| Zhang, Y | 1 |
| Li, Q | 1 |
| Wang, F | 1 |
| Xing, C | 1 |
| Jacomelli, G | 1 |
| Baldini, E | 1 |
| Mugnaini, C | 1 |
| Micheli, V | 1 |
| Bernardini, G | 1 |
| Santucci, A | 1 |
| Wang, Y | 1 |
| Deng, M | 1 |
| Deng, B | 1 |
| Ye, L | 1 |
| Fei, X | 1 |
| Huang, Z | 1 |
| Kostalova, E | 1 |
| Pavelka, K | 1 |
| Vlaskova, H | 1 |
| Musalkova, D | 1 |
| Stiburkova, B | 1 |
| Nishino, T | 1 |
| Okamoto, K | 1 |
| Hirai, T | 1 |
| Kimura, T | 1 |
| Echizen, H | 1 |
| Feng, J | 1 |
| Li, X | 1 |
| Yang, X | 1 |
| Zhang, C | 1 |
| Yuan, Y | 1 |
| Pu, J | 1 |
| Zhao, Y | 1 |
| Xie, Y | 1 |
| Yuan, H | 1 |
| Bu, Y | 1 |
| Liao, F | 1 |
| Butler, K | 1 |
| Teng, R | 1 |
| Ichida, K | 1 |
| Yamaguchi, Y | 1 |
| Matsumura, T | 1 |
| Yamamoto, T | 2 |
| Yamazaki, T | 2 |
| Ueda, T | 1 |
| Hosoya, T | 1 |
| Ohno, I | 1 |
| Uetake, D | 1 |
| Saikawa, H | 1 |
| Moriwaki, Y | 1 |
| Takahashi, S | 1 |
| Vella, M | 1 |
| Karydi, M | 1 |
| Coraci, G | 1 |
| Oriti, R | 1 |
| Melloni, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Investigation of Aging Men With Renal Stones: The Role of Bone Demineralization (Metabolic and Hormonal Assessment)[NCT01246531] | 42 participants (Actual) | Observational | 2008-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for xanthine and Hyperuricemia
| Article | Year |
|---|---|
Mechanistic insights into xanthine oxidoreductase from development studies of candidate drugs to treat hyperuricemia and gout.
Topics: Catalytic Domain; Coenzymes; Enzyme Inhibitors; Gout; Humans; Hyperuricemia; Metalloproteins; Molybd | 2015 |
[Xanthine dehydrogenase (xanthine oxidase)].
Topics: Allopurinol; Animals; Enzyme Inhibitors; Flavin-Adenine Dinucleotide; Free Radicals; Humans; Hyperur | 2003 |
[Effect of ethanol on uric acid level].
Topics: Acetaldehyde; Animals; Erythrocytes; Ethanol; Gout; Humans; Hyperuricemia; Purines; Pyrazinamide; Ur | 2003 |
[Secondary hyperuricemia in burn and trauma].
Topics: Animals; Burns; Humans; Hyperuricemia; Superoxides; Uric Acid; Wounds and Injuries; Xanthine; Xanthi | 2003 |
[Purine metabolism in patients with renal failure].
Topics: Allopurinol; Antimetabolites; Glomerulonephritis; Humans; Hyperuricemia; Hypoxanthine; Kidney; Kidne | 2004 |
Effect of ethanol on metabolism of purine bases (hypoxanthine, xanthine, and uric acid).
Topics: Acetyl Coenzyme A; Alcohol Dehydrogenase; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondr | 2005 |
Pathophysiology and clinical aspects of urinary lithiasis.
Topics: Calcium; Cystine; Cystinuria; Drug-Related Side Effects and Adverse Reactions; Humans; Hypercalciuri | 2007 |
1 trial available for xanthine and Hyperuricemia
| Article | Year |
|---|---|
Evaluation and characterization of the effects of ticagrelor on serum and urinary uric acid in healthy volunteers.
Topics: Adenosine; Adult; Cross-Over Studies; Humans; Hyperuricemia; Hypoxanthine; Male; Middle Aged; Purine | 2012 |
9 other studies available for xanthine and Hyperuricemia
| Article | Year |
|---|---|
Uric acid may inhibit glucose-induced insulin secretion via binding to an essential arginine residue in rat pancreatic beta-cells.
Topics: Animals; Arginine; Glucose; Hyperuricemia; In Vitro Techniques; Insulin; Insulin Secretion; Islets o | 2005 |
Declaration: Novel SLC3A1 mutation in a cystinuria patient with xanthine stones: a case report.
Topics: Amino Acid Transport Systems; Codon, Nonsense; Cystinuria; Female; Genetic Testing; Humans; Hyperuri | 2023 |
Differential regulation of hypoxanthine and xanthine by obesity in a general population.
Topics: Adipose Tissue; Aged; Alanine Transaminase; Biomarkers; Body Mass Index; Enzyme Inhibitors; Female; | 2020 |
A zebrafish (danio rerio) model for high-throughput screening food and drugs with uric acid-lowering activity.
Topics: Allopurinol; Animals; Anserine; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughpu | 2019 |
Inhibiting PNP for the therapy of hyperuricemia in Lesch-Nyhan disease: Preliminary in vitro studies with analogues of immucillin-G.
Topics: Allopurinol; Cells, Cultured; Enzyme Inhibitors; Humans; Hyperuricemia; Hypoxanthine; Hypoxanthine P | 2019 |
Study on the diagnosis of gout with xanthine and hypoxanthine.
Topics: Blood Chemical Analysis; Chromatography, High Pressure Liquid; Gout; Humans; Hyperuricemia; Hypoxant | 2019 |
Hyperuricemia and gout due to deficiency of hypoxanthine-guanine phosphoribosyltransferase in female carriers: New insight to differential diagnosis.
Topics: Adult; Child; Diagnosis, Differential; Female; Gout; Heterozygote; Humans; Hyperuricemia; Hypoxanthi | 2015 |
Modeling and Simulation for Estimating the Influence of Renal Dysfunction on the Hypouricemic Effect of Febuxostat in Hyperuricemic Patients Due to Overproduction or Underexcretion of Uric Acid.
Topics: Computer Simulation; Febuxostat; Gout Suppressants; Humans; Hyperuricemia; Models, Biological; Renal | 2016 |
A new practical system for evaluating the pharmacological properties of uricase as a potential drug for hyperuricemia.
Topics: Animals; Bacillus; Gout; Half-Life; Hyperuricemia; Male; Polyethylene Glycols; Rabbits; Rats; Rats, | 2010 |