alternariol has been researched along with Hyperuricemia* in 1 studies
1 other study(ies) available for alternariol and Hyperuricemia
| Article | Year |
|---|---|
Discovery of mycotoxin alternariol as a potential lead compound targeting xanthine oxidase.
Xanthine oxidase (XO) catalyzes the oxidation of hypoxanthine to xanthine, which is further converted to uric acid. The excessive production or reduced excretion of the purine terminal metabolite may lead to hyperuricemia. In our ongoing search for new xanthine oxidase inhibitors, 14 endophytic fungi were isolated for the first time from a medicinal plant Callicarpa kwangtungensis Chun, and the ethyl acetate extracts of their culture filtrates were screened for XO inhibitory activity. The extract from an endophytic fungus, characterized as Alternaria alternata GDZZ-J6, exhibited the most potent inhibition of XO. Further fractionation of its secondary metabolites led to the isolation of six compounds. Among them, mycotoxin alternariol (AOH), a dibenzo-α-pyrone derivative, had strong inhibitory activity on XO, and the IC Topics: Enzyme Inhibitors; Humans; Hyperuricemia; Kinetics; Lactones; Lead; Mycotoxins; Xanthine Oxidase | 2022 |