Page last updated: 2024-12-09

2-mercaptothiazoline

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID2723699
CHEMBL ID2398099
SCHEMBL ID34680
MeSH IDM0046437

Synonyms (71)

Synonym
2(3h)-thiazolethione, 4,5-dihydro-
4,5-dihydrothiazole-2-thiol
inchi=1/c3h5ns2/c5-3-4-1-2-6-3/h1-2h2,(h,4,5
thiazolidine,2-thione
4,5-dihydro-2-mercaptothiazole
2-thiozolidinethione
metabasal
nsc-680
thyroidan
2-thiazolidenethione
thiazolidine-2-thione
2-thiothiazolidone
2-mercapto-2-thiazoline
1,3-thiazolidine-2-thione
2-mercaptothiazoline ,
wln: t5m cs bhj bsh
2-mercapto-.delta.2-thiazoline
mercaptothiazoline
nsc680
2(3h)-thiazolethione,5-dihydro-
2-thiazolidinethione
96-53-7
2-thiazoline-2-thiol
2-thiazoline-2-thiol, 98%
2-thiazolethiol, dihydro-
ai3-00986
einecs 202-512-1
nsc 680
dihydro-2-thiazolethiol
tetrahydrothiazole-2-thione
einecs 246-918-7
dihydrothiazole-2-thiol
usaf a-10211
sancelent 2mt
wr 305
thiazoline-2-thiol
M0065
AKOS000119225
A845606
AKOS003622202
upa7y8938q ,
unii-upa7y8938q
CHEMBL2398099
25377-76-8
FT-0612775
STL264201
4,5-dihydro-1,3-thiazole-2-thiol
BBL027511
SCHEMBL34680
AKOS025243618
2-mercapto-1,3-thiazoline
4,5-dihydro-2-mercapto-thiazole
mercapto-thiazoline
DTXSID3059133
W-100141
134469-06-0
2-thiazolidine thione
4,5-dihydro-thiazole-2-thiol
4,5-dihydro-1,3-thiazole-2-thiol #
thiazolidin-2-thione
mfcd00126013
F0001-2300
2-mercapto-4,5-dihydro-thiazole
E77124
VS-08557
.delta.2-thiazoline-2-thiol
1,3-thiazolidin-2-thione; 1,3-thiazolidine-2-thione
AMY23225
CS-0008464
EN300-21459
SY353155

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" In conclusion, this work reports at least four compounds (5b, 5e, 5g and 6e) with potential anti-tumor effect against glioblastoma multiform cell presenting activity at low concentrations and safe profile of cytotoxicity."( Thiazolidin-4-ones from 4-(methylthio)benzaldehyde and 4-(methylsulfonyl)benzaldehyde: Synthesis, antiglioma activity and cytotoxicity.
Azambuja, JH; Braganhol, E; Cunico, W; da Silva, CEH; da Silva, DS; de Carvalho, TR; Frizzo, CP; Soares, MSP; Spanevello, RM; Zimmer, GC, 2016
)
0.43
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID756686Activation of AMPKalpha in rat L6 cells assessed as phosphorylation at Thr172 after 40 mins to 24 hrs by Western blot analysis2013Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13
Synthesis and mechanism of hypoglycemic activity of benzothiazole derivatives.
AID756690Activation of AMPK in rat L6 cells assessed as increase of [3H]dGlc uptake at 100 uM after 5 hrs relative to control2013Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13
Synthesis and mechanism of hypoglycemic activity of benzothiazole derivatives.
AID756681Activation of AMPK in rat L6 cells assessed as increase of [3H]dGlc uptake at 100 uM after 5 hrs in presence of insulin2013Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13
Synthesis and mechanism of hypoglycemic activity of benzothiazole derivatives.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (33)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (3.03)18.7374
1990's2 (6.06)18.2507
2000's13 (39.39)29.6817
2010's14 (42.42)24.3611
2020's3 (9.09)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 27.31

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index27.31 (24.57)
Research Supply Index3.56 (2.92)
Research Growth Index5.17 (4.65)
Search Engine Demand Index27.81 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (27.31)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other34 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]