adenine has been researched along with Hyperuricemia in 14 studies
Hyperuricemia: Excessive URIC ACID or urate in blood as defined by its solubility in plasma at 37 degrees C; greater than 0.42mmol per liter (7.0mg/dL) in men or 0.36mmol per liter (6.0mg/dL) in women. This condition is caused by overproduction of uric acid or impaired renal clearance. Hyperuricemia can be acquired, drug-induced or genetically determined (LESCH-NYHAN SYNDROME). It is associated with HYPERTENSION and GOUT.
| Excerpt | Relevance | Reference |
|---|---|---|
| "After oral administration of Dioscin in potassium oxonate (PO) induced hyperuricemia rats and adenine-PO induced hyperuricemia mice models, serum uric acid and creatinine levels, clearance of uric acid and creatinine, fractional excretion of uric acid, and renal pathological lesions were determined were used to evaluate the antihyperuricemic effects." | 7.88 | Effect and mechanism of dioscin from Dioscorea spongiosa on uric acid excretion in animal model of hyperuricemia. ( Chen, Q; Jin, L; Li, J; Liu, J; Wang, T; Wang, W; Yu, H; Zhang, Y, 2018) |
| " Hyperuricemia and renal failure in rats were induced by adenine and ethambutol hydrochloride intragastrically, and then Que was given for 3 weeks." | 7.77 | [Preventive and therapeutic effects of quercetin on hyperuricemia and renal injury in rats]. ( Fu, R; He, W; Yao, F; Zhang, R, 2011) |
| "Hyperuricemia is an important risk factor of chronic kidney disease, metabolic syndrome and cardiovascular disease." | 5.56 | The Time-Feature of Uric Acid Excretion in Hyperuricemia Mice Induced by Potassium Oxonate and Adenine. ( Bao, R; Chen, Q; Liu, L; Liu, M; Wang, D; Wang, T; Wen, S; Yu, H; Zhang, Y, 2020) |
| " Because compound 22 was poorly absorbed orally in rats (F = 0." | 5.43 | Identification of Adenine and Benzimidazole Nucleosides as Potent Human Concentrative Nucleoside Transporter 2 Inhibitors: Potential Treatment for Hyperuricemia and Gout. ( Hiratochi, M; Isaji, M; Itoh, F; Kikuchi, N; Kuramochi, Y; Shuto, S; Tatani, K; Watanabe, S; Yamauchi, Y, 2016) |
| "Hyperuricemia is an independent risk factor for chronic kidney disease and cardiovascular disease." | 5.42 | Chinese Herbal Formulas Si-Wu-Tang and Er-Miao-San Synergistically Ameliorated Hyperuricemia and Renal Impairment in Rats Induced by Adenine and Potassium Oxonate. ( Gui, D; Guo, Y; Jiang, Q; Wang, N, 2015) |
| "A hyperuricemic rat model induced by adenine and ethambutol was established to investigate the anti-hyperuricemia activity and its mechanism of the flavonoid extract from saffron floral bio-residues." | 4.31 | [Anti-hyperuricemia activity and its mechanism of flavonoid extract from saffron floral bio-residues]. ( Chen, N; Li, H; Meng, J; Yang, B; Yang, YF, 2023) |
| "After oral administration of Dioscin in potassium oxonate (PO) induced hyperuricemia rats and adenine-PO induced hyperuricemia mice models, serum uric acid and creatinine levels, clearance of uric acid and creatinine, fractional excretion of uric acid, and renal pathological lesions were determined were used to evaluate the antihyperuricemic effects." | 3.88 | Effect and mechanism of dioscin from Dioscorea spongiosa on uric acid excretion in animal model of hyperuricemia. ( Chen, Q; Jin, L; Li, J; Liu, J; Wang, T; Wang, W; Yu, H; Zhang, Y, 2018) |
| "This work aims to explore the amelioration of fucoidan on adenine-induced hyperuricemia and hepatorental damage." | 3.88 | Production Inhibition and Excretion Promotion of Urate by Fucoidan from ( Li, Y; Liu, H; Luo, P; Zhang, D, 2018) |
| " Hyperuricemia and renal failure in rats were induced by adenine and ethambutol hydrochloride intragastrically, and then Que was given for 3 weeks." | 3.77 | [Preventive and therapeutic effects of quercetin on hyperuricemia and renal injury in rats]. ( Fu, R; He, W; Yao, F; Zhang, R, 2011) |
| "Hyperuricemia is an important risk factor of chronic kidney disease, metabolic syndrome and cardiovascular disease." | 1.56 | The Time-Feature of Uric Acid Excretion in Hyperuricemia Mice Induced by Potassium Oxonate and Adenine. ( Bao, R; Chen, Q; Liu, L; Liu, M; Wang, D; Wang, T; Wen, S; Yu, H; Zhang, Y, 2020) |
| "Hyperuricemia is an independent risk factor for chronic kidney disease (CKD)." | 1.56 | Pharmacological inhibition of fatty acid-binding protein 4 alleviated kidney inflammation and fibrosis in hyperuricemic nephropathy. ( Feng, Y; Fu, P; Guo, F; Huang, R; Liao, D; Ma, L; Shi, M; Zeng, X, 2020) |
| "Hyperuricemia is an independent risk factor for chronic kidney disease and cardiovascular disease." | 1.42 | Chinese Herbal Formulas Si-Wu-Tang and Er-Miao-San Synergistically Ameliorated Hyperuricemia and Renal Impairment in Rats Induced by Adenine and Potassium Oxonate. ( Gui, D; Guo, Y; Jiang, Q; Wang, N, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (57.14) | 24.3611 |
| 2020's | 6 (42.86) | 2.80 |
| Authors | Studies |
|---|---|
| Li, N | 4 |
| Amatjan, M | 4 |
| He, P | 4 |
| Zhang, B | 4 |
| Mai, X | 4 |
| Jiang, Q | 5 |
| Xie, H | 4 |
| Shao, X | 4 |
| Chen, N | 1 |
| Li, H | 1 |
| Meng, J | 1 |
| Yang, YF | 1 |
| Yang, B | 1 |
| Kang, L | 1 |
| Miao, JX | 1 |
| Cao, LH | 1 |
| Miao, YY | 1 |
| Miao, MS | 1 |
| Liu, HJ | 1 |
| Xiang, LL | 1 |
| Song, YG | 1 |
| Wen, S | 1 |
| Wang, D | 1 |
| Yu, H | 2 |
| Liu, M | 1 |
| Chen, Q | 2 |
| Bao, R | 1 |
| Liu, L | 1 |
| Zhang, Y | 2 |
| Wang, T | 2 |
| Shi, M | 1 |
| Guo, F | 1 |
| Liao, D | 1 |
| Huang, R | 1 |
| Feng, Y | 2 |
| Zeng, X | 1 |
| Ma, L | 1 |
| Fu, P | 1 |
| Sun, F | 1 |
| Gao, Y | 1 |
| Yang, J | 1 |
| Wu, G | 1 |
| Lin, S | 1 |
| Hu, J | 1 |
| Jin, L | 1 |
| Liu, J | 1 |
| Wang, W | 1 |
| Li, J | 1 |
| Bao, J | 1 |
| Shi, Y | 1 |
| Tao, M | 1 |
| Liu, N | 1 |
| Zhuang, S | 1 |
| Yuan, W | 1 |
| Zhang, D | 1 |
| Liu, H | 1 |
| Luo, P | 1 |
| Li, Y | 1 |
| Nishizawa, K | 1 |
| Yoda, N | 1 |
| Morokado, F | 1 |
| Komori, H | 1 |
| Nakanishi, T | 1 |
| Tamai, I | 1 |
| Guo, Y | 1 |
| Gui, D | 1 |
| Wang, N | 1 |
| Tatani, K | 1 |
| Hiratochi, M | 1 |
| Kikuchi, N | 1 |
| Kuramochi, Y | 1 |
| Watanabe, S | 1 |
| Yamauchi, Y | 1 |
| Itoh, F | 1 |
| Isaji, M | 1 |
| Shuto, S | 1 |
| Yao, F | 1 |
| Zhang, R | 1 |
| Fu, R | 1 |
| He, W | 1 |
14 other studies available for adenine and Hyperuricemia
| Article | Year |
|---|---|
Integration of network pharmacology and intestinal flora to investigate the mechanism of action of Chinese herbal
Topics: Adenine; Animals; China; Cichorium intybus; Ethambutol; Gastrointestinal Microbiome; Hyperuricemia; | 2022 |
Integration of network pharmacology and intestinal flora to investigate the mechanism of action of Chinese herbal
Topics: Adenine; Animals; China; Cichorium intybus; Ethambutol; Gastrointestinal Microbiome; Hyperuricemia; | 2022 |
Integration of network pharmacology and intestinal flora to investigate the mechanism of action of Chinese herbal
Topics: Adenine; Animals; China; Cichorium intybus; Ethambutol; Gastrointestinal Microbiome; Hyperuricemia; | 2022 |
Integration of network pharmacology and intestinal flora to investigate the mechanism of action of Chinese herbal
Topics: Adenine; Animals; China; Cichorium intybus; Ethambutol; Gastrointestinal Microbiome; Hyperuricemia; | 2022 |
A Novel Approach Based on Gut Microbiota Analysis and Network Pharmacology to Explain the Mechanisms of Action of
Topics: Adenine; Animals; Cichorium intybus; Creatinine; Drugs, Chinese Herbal; Ethambutol; Gastrointestinal | 2023 |
[Anti-hyperuricemia activity and its mechanism of flavonoid extract from saffron floral bio-residues].
Topics: Adenine; Amino Acids; Animals; Antioxidants; Crocus; Ethambutol; Flavonoids; Hyperuricemia; Kidney; | 2023 |
Total glucosides of herbaceous peony (Paeonia lactiflora Pall.) flower attenuate adenine- and ethambutol-induced hyperuricaemia in rats.
Topics: Adenine; Animals; Biomarkers; Disease Models, Animal; Down-Regulation; Ethambutol; Flowers; Glucosid | 2020 |
The Time-Feature of Uric Acid Excretion in Hyperuricemia Mice Induced by Potassium Oxonate and Adenine.
Topics: Adenine; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Chromatography, High Pres | 2020 |
Pharmacological inhibition of fatty acid-binding protein 4 alleviated kidney inflammation and fibrosis in hyperuricemic nephropathy.
Topics: Adenine; Animals; Biphenyl Compounds; Cytokines; Fatty Acid-Binding Proteins; Fibrosis; Hepatitis A | 2020 |
Taurine decreased uric acid levels in hyperuricemic rats and alleviated kidney injury.
Topics: Acute Kidney Injury; Adenine; Administration, Oral; Animals; Ethambutol; Hyperuricemia; Male; Rats; | 2017 |
Effect and mechanism of dioscin from Dioscorea spongiosa on uric acid excretion in animal model of hyperuricemia.
Topics: Adenine; Animals; Biomarkers; Creatinine; Dioscorea; Diosgenin; Disease Models, Animal; Dose-Respons | 2018 |
Pharmacological inhibition of autophagy by 3-MA attenuates hyperuricemic nephropathy.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Proteins; Cell Line; Disease Models, Animal; Extracel | 2018 |
Production Inhibition and Excretion Promotion of Urate by Fucoidan from
Topics: Adenine; Animals; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Drug Evaluation, Preclini | 2018 |
Changes of drug pharmacokinetics mediated by downregulation of kidney organic cation transporters Mate1 and Oct2 in a rat model of hyperuricemia.
Topics: Adenine; Animals; Antiporters; Cephalexin; Creatinine; Disease Models, Animal; Down-Regulation; Huma | 2019 |
Chinese Herbal Formulas Si-Wu-Tang and Er-Miao-San Synergistically Ameliorated Hyperuricemia and Renal Impairment in Rats Induced by Adenine and Potassium Oxonate.
Topics: Adenine; Administration, Oral; Animals; Benzbromarone; Creatinine; Drug Synergism; Drugs, Chinese He | 2015 |
Identification of Adenine and Benzimidazole Nucleosides as Potent Human Concentrative Nucleoside Transporter 2 Inhibitors: Potential Treatment for Hyperuricemia and Gout.
Topics: Adenine; Animals; Benzimidazoles; Gout; Humans; Hyperuricemia; Male; Membrane Transport Proteins; Nu | 2016 |
[Preventive and therapeutic effects of quercetin on hyperuricemia and renal injury in rats].
Topics: Adenine; Animals; Antioxidants; Blood Urea Nitrogen; Creatinine; Ethambutol; Hyperuricemia; Kidney D | 2011 |