chicoric-acid and Hyperuricemia

chicoric-acid has been researched along with Hyperuricemia* in 1 studies

Other Studies

1 other study(ies) available for chicoric-acid and Hyperuricemia

Article	Year
Chicoric Acid Attenuated Renal Tubular Injury in HFD-Induced Chronic Kidney Disease Mice through the Promotion of Mitophagy via the Nrf2/PINK/Parkin Pathway. Journal of agricultural and food chemistry, 2022, Mar-09, Volume: 70, Issue:9 As the main factor in the pathogenesis of chronic kidney disease (CKD), the excessive apoptosis of renal tubular epithelial cells (RTECs) and its underlying mechanism of action are worth further investigation. Chicoric acid (CA), a major active constituent of the Uyghur folk medicine chicory, was recorded to possess a renal protective effect. The precise effect of CA on renal tubular injury in obesity-related CKD remains unknown. In the current study, CA was proven to ameliorate metabolic disorders including overweight, hyperglycemia, hyperlipidemia, and hyperuricemia in high fat diet (HFD)-fed mice. Furthermore, the reverse effect of CA on renal histological changes and functional damage was confirmed. Topics: Animals; Caffeic Acids; Diet, High-Fat; Hyperuricemia; Mice; Mice, Inbred C57BL; Mitochondria; Mitophagy; NF-E2-Related Factor 2; Renal Insufficiency, Chronic; Succinates; Ubiquitin-Protein Ligases	2022

Article

Year

Chicoric Acid Attenuated Renal Tubular Injury in HFD-Induced Chronic Kidney Disease Mice through the Promotion of Mitophagy via the Nrf2/PINK/Parkin Pathway.

Journal of agricultural and food chemistry, 2022, Mar-09, Volume: 70, Issue:9

As the main factor in the pathogenesis of chronic kidney disease (CKD), the excessive apoptosis of renal tubular epithelial cells (RTECs) and its underlying mechanism of action are worth further investigation. Chicoric acid (CA), a major active constituent of the Uyghur folk medicine chicory, was recorded to possess a renal protective effect. The precise effect of CA on renal tubular injury in obesity-related CKD remains unknown. In the current study, CA was proven to ameliorate metabolic disorders including overweight, hyperglycemia, hyperlipidemia, and hyperuricemia in high fat diet (HFD)-fed mice. Furthermore, the reverse effect of CA on renal histological changes and functional damage was confirmed.

Topics: Animals; Caffeic Acids; Diet, High-Fat; Hyperuricemia; Mice; Mice, Inbred C57BL; Mitochondria; Mitophagy; NF-E2-Related Factor 2; Renal Insufficiency, Chronic; Succinates; Ubiquitin-Protein Ligases

2022