Page last updated: 2024-10-21

urea and Hyperuricemia

urea has been researched along with Hyperuricemia in 20 studies

pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.

Hyperuricemia: Excessive URIC ACID or urate in blood as defined by its solubility in plasma at 37 degrees C; greater than 0.42mmol per liter (7.0mg/dL) in men or 0.36mmol per liter (6.0mg/dL) in women. This condition is caused by overproduction of uric acid or impaired renal clearance. Hyperuricemia can be acquired, drug-induced or genetically determined (LESCH-NYHAN SYNDROME). It is associated with HYPERTENSION and GOUT.

Research Excerpts

ExcerptRelevanceReference
"Hyperuricemia is associated with aortic dissection and cardiovascular diseases."5.72Post-operative uric acid: a predictor for 30-days mortality of acute type A aortic dissection repair. ( Chen, X; Hu, Q; Huang, L; Lin, G; Luo, W; Ma, S; Wu, D; Xu, Q, 2022)
"Hyperuricemia is defined by the European Rheumatology Society as a uric acid level greater than 6 mg/dl (60 mg/l or 360 μmol/l)."4.02Creation of an adequate animal model of hyperuricemia (acute and chronic hyperuricemia); study of its reversibility and its maintenance. ( Affes, H; Charfi, S; Dhouibi, R; Hammami, S; Jamoussi, K; Ksouda, K; Marekchi, R; Moalla, D; Sahnoun, Z; Salem, MB; Zeghal, KM, 2021)
" Significant changes of biochemical parameters in cases of hypertensive disorders in pregnancy are increased levels of blood glucose, urea, creatinine, uric acid (hyperuricemia), transaminases, and LDH."3.79Correlation of biochemical parameters and neonatal outcome in patients with gestational hypertension. ( Aksam, S; Kocijancic, A; Kocijancic, DM; Plecas, D; Plesinac, S, 2013)
"Hyperuricemia is associated with aortic dissection and cardiovascular diseases."1.72Post-operative uric acid: a predictor for 30-days mortality of acute type A aortic dissection repair. ( Chen, X; Hu, Q; Huang, L; Lin, G; Luo, W; Ma, S; Wu, D; Xu, Q, 2022)
"Triuret was also found to be elevated in the urine of subjects with preeclampsia, a pregnancy-specific hypertensive syndrome that is associated with oxidative stress, whereas very little triuret is produced in normal healthy volunteers."1.35Reactions of peroxynitrite with uric acid: formation of reactive intermediates, alkylated products and triuret, and in vivo production of triuret under conditions of oxidative stress. ( Angerhofer, A; Gersch, C; Henderson, GN; Imaram, W; Johnson, RJ; Karumanchi, SA; Kim, KM; Palii, SP, 2009)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19904 (20.00)18.7374
1990's0 (0.00)18.2507
2000's3 (15.00)29.6817
2010's4 (20.00)24.3611
2020's9 (45.00)2.80

Authors

AuthorsStudies
ALRashdi, BM1
Elgebaly, HA1
Germoush, MO1
Qarmush, MM1
Azab, MS1
Alruhaimi, RS1
Ahmeda, AF1
Abukhalil, MH1
Kamel, EM1
Arab, HH1
Alzoghaibi, MA1
Alotaibi, MF1
Mahmoud, AM1
Huang, L2
He, X2
Peng, W1
Xu, B1
Xu, H1
Wang, Y2
Xu, W1
Chen, W1
Wang, S1
Zhou, L1
Liu, N1
Xu, Y1
Lu, W1
Wang, M1
Zhuoma, D1
Yuan, R1
Pu, Z1
Zeren, L1
Wang, J1
Tan, M1
Huang, S1
Ma, S1
Xu, Q1
Hu, Q1
Wu, D1
Lin, G1
Chen, X1
Luo, W1
Li, N4
Amatjan, M4
He, P4
Zhang, B4
Mai, X4
Jiang, Q4
Xie, H4
Shao, X4
Huang, XF1
He, Q1
Shi, HH1
Hu, HP1
Lu, L1
Huang, RM1
Zhang, XY1
Xu, YQ1
Wahba, NS1
Abdel-Ghany, RH1
Ghareib, SA1
Abdel-Aal, M1
Alsemeh, AE1
Dhouibi, R1
Affes, H1
Salem, MB1
Moalla, D1
Marekchi, R1
Charfi, S1
Hammami, S1
Sahnoun, Z1
Jamoussi, K1
Zeghal, KM1
Ksouda, K1
Kemter, E1
Prueckl, P1
Sklenak, S1
Rathkolb, B1
Habermann, FA1
Hans, W1
Gailus-Durner, V1
Fuchs, H1
Hrabě de Angelis, M1
Wolf, E1
Aigner, B1
Wanke, R1
Zhang, YF1
He, F1
Ding, HH1
Dai, W1
Zhang, Q1
Luan, H1
Lv, YM1
Zeng, HB1
Gersch, C1
Palii, SP1
Imaram, W1
Kim, KM1
Karumanchi, SA1
Angerhofer, A1
Johnson, RJ1
Henderson, GN1
Kocijancic, DM1
Plesinac, S1
Plecas, D1
Aksam, S1
Kocijancic, A1
Krauss, M1
Schaller, S1
Borchers, S1
Findeisen, R1
Lippert, J1
Kuepfer, L1
Huang, CT1
Chen, ML1
Huang, LL1
Mao, IF1
MCKECHNIE, JK1
ALPERIN, JB1
LEVIN, WC1
HOEFNAGEL, D1
KRAKOFF, IH1
MEYER, RL1
Ganson, NJ1
Kelly, SJ1
Scarlett, E1
Sundy, JS1
Hershfield, MS1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Alternative Haemodiafiltration in Summer Season for Chronic Kidney Disease Patients[NCT05861219]100 participants (Anticipated)Interventional2023-06-21Not yet recruiting
Using of the Skin as a Third Spare Kidney for Patients With Chronic Renal Failure[NCT03810989]86 participants (Anticipated)Interventional2019-06-01Not yet recruiting
A Phase II Multidose Study of Intravenous PEG-uricase in Patients With Refractory Gout[NCT00111657]Phase 230 participants (Actual)Interventional2004-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Development of Antibodies to PEG-uricase

Number of patients who developed antibodies to PEG-uricase (NCT00111657)
Timeframe: baseline, then prior to infusions and 7 wks after last infusion

Interventionparticipants (Number)
Pegloticase15

Infusion 1: Maximum Concentration (Cmax) Value

The highest drug concentration in the blood after the first infusion of study drug. (NCT00111657)
Timeframe: 2 hours

InterventionmU/mL (Mean)
Single Arm - Pegloticase25.6

Infusion 1: Minimum Concentration (Cmin)

The lowest drug concentration in the blood after the first infusion of study drug. (NCT00111657)
Timeframe: 21 days after the infusion

InterventionmU/mL (Mean)
Single Arm - Pegloticase4.9

Reduction in Plasma Uric Acid to Less Than 6 mg/dL.

(NCT00111657)
Timeframe: Baseline to Day 105

InterventionParticipants (Number)
Single Arm17

Clinical Response: Number of Swollen and Tender Joints

Count of tenderness and swelling of 68 joints (NCT00111657)
Timeframe: Basline and day 134

Interventionjoints (Median)
Number of Tender joints at baselineNumber of Tender joints at day 134Number of Swollen jonts at baselineNumber of Swollen jonts at day 134
Pegloticase13296

Reviews

1 review available for urea and Hyperuricemia

ArticleYear
Effect of uric-acid-lowering therapy on progression of chronic kidney disease: a meta-analysis.
    Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2014, Volume: 34, Issue:4

    Topics: Blood Pressure; Creatinine; Disease Progression; Female; Glomerular Filtration Rate; Humans; Hyperur

2014

Trials

1 trial available for urea and Hyperuricemia

ArticleYear
Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene glycol) (PEG), in a phase I trial of subcutaneous PEGylated urate oxidase.
    Arthritis research & therapy, 2006, Volume: 8, Issue:1

    Topics: Adult; Aged; Carbon Radioisotopes; Female; Gout; Humans; Hyperuricemia; Immunoglobulin G; Male; Midd

2006

Other Studies

18 other studies available for urea and Hyperuricemia

ArticleYear
A flavonoid-rich fraction of Monolluma quadrangula inhibits xanthine oxidase and ameliorates potassium oxonate-induced hyperuricemia in rats.
    Environmental science and pollution research international, 2022, Volume: 29, Issue:42

    Topics: Animals; Catalase; Creatinine; Cytokines; Flavonoids; Hyperuricemia; Inflammation; Kidney; Molecular

2022
Hyperuricemia induces liver injury by upregulating HIF-1α and inhibiting arginine biosynthesis pathway in mouse liver and human L02 hepatocytes.
    Biochemical and biophysical research communications, 2022, 08-30, Volume: 617, Issue:Pt 2

    Topics: Animals; Arginine; Argininosuccinate Synthase; Hepatocytes; Humans; Hyperuricemia; Hypoxia-Inducible

2022
Ethanol extract of Nepeta angustifoia C. Y. Wu ameliorates hyperuricemia in fructose-induced mice.
    Pakistan journal of pharmaceutical sciences, 2022, Volume: 35, Issue:4

    Topics: Animals; Creatinine; Drugs, Chinese Herbal; Ethanol; Fructose; Hyperuricemia; Kidney; Mice; Nepeta;

2022
Post-operative uric acid: a predictor for 30-days mortality of acute type A aortic dissection repair.
    BMC cardiovascular disorders, 2022, 09-15, Volume: 22, Issue:1

    Topics: Aortic Dissection; Creatinine; Fibrinogen; Humans; Hyperuricemia; Retrospective Studies; Urea; Uric

2022
Integration of network pharmacology and intestinal flora to investigate the mechanism of action of Chinese herbal
    Pharmaceutical biology, 2022, Volume: 60, Issue:1

    Topics: Adenine; Animals; China; Cichorium intybus; Ethambutol; Gastrointestinal Microbiome; Hyperuricemia;

2022
Integration of network pharmacology and intestinal flora to investigate the mechanism of action of Chinese herbal
    Pharmaceutical biology, 2022, Volume: 60, Issue:1

    Topics: Adenine; Animals; China; Cichorium intybus; Ethambutol; Gastrointestinal Microbiome; Hyperuricemia;

2022
Integration of network pharmacology and intestinal flora to investigate the mechanism of action of Chinese herbal
    Pharmaceutical biology, 2022, Volume: 60, Issue:1

    Topics: Adenine; Animals; China; Cichorium intybus; Ethambutol; Gastrointestinal Microbiome; Hyperuricemia;

2022
Integration of network pharmacology and intestinal flora to investigate the mechanism of action of Chinese herbal
    Pharmaceutical biology, 2022, Volume: 60, Issue:1

    Topics: Adenine; Animals; China; Cichorium intybus; Ethambutol; Gastrointestinal Microbiome; Hyperuricemia;

2022
A Novel Approach Based on Gut Microbiota Analysis and Network Pharmacology to Explain the Mechanisms of Action of
    Drug design, development and therapy, 2023, Volume: 17

    Topics: Adenine; Animals; Cichorium intybus; Creatinine; Drugs, Chinese Herbal; Ethambutol; Gastrointestinal

2023
[Mediating effects of obesity and metabolic factors in hyperuricemia and prehypertension].
    Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi, 2023, Oct-10, Volume: 44, Issue:10

    Topics: Body Mass Index; Cholesterol; Cholesterol, LDL; Creatinine; Humans; Hyperuricemia; Nitrogen; Obesity

2023
Vitamin D3 potentiates the renoprotective effects of vildagliptin in a rat model of fructose/salt-induced insulin resistance.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2020, Mar-01, Volume: 144

    Topics: AMP-Activated Protein Kinases; Animals; Blood Glucose; Cholecalciferol; Creatinine; Dipeptidyl-Pepti

2020
Creation of an adequate animal model of hyperuricemia (acute and chronic hyperuricemia); study of its reversibility and its maintenance.
    Life sciences, 2021, Mar-01, Volume: 268

    Topics: Animals; Antioxidants; Biomarkers; Chronic Disease; Creatinine; Disease Models, Animal; Hyperuricemi

2021
Type of uromodulin mutation and allelic status influence onset and severity of uromodulin-associated kidney disease in mice.
    Human molecular genetics, 2013, Oct-15, Volume: 22, Issue:20

    Topics: Age of Onset; Alleles; Animals; Body Weight; Cystatins; Disease Models, Animal; Disease Progression;

2013
Reactions of peroxynitrite with uric acid: formation of reactive intermediates, alkylated products and triuret, and in vivo production of triuret under conditions of oxidative stress.
    Nucleosides, nucleotides & nucleic acids, 2009, Volume: 28, Issue:2

    Topics: Antioxidants; Female; Humans; Hyperuricemia; Oxidants; Oxidative Stress; Peroxynitrous Acid; Pre-Ecl

2009
Correlation of biochemical parameters and neonatal outcome in patients with gestational hypertension.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2013, Volume: 35, Issue:1

    Topics: Apgar Score; Blood Glucose; Case-Control Studies; Creatinine; Female; HELLP Syndrome; Humans; Hypert

2013
Integrating cellular metabolism into a multiscale whole-body model.
    PLoS computational biology, 2012, Volume: 8, Issue:10

    Topics: Acetaminophen; Allopurinol; Ammonia; Chemical and Drug Induced Liver Injury; Computational Biology;

2012
Uric acid and urea in human sweat.
    The Chinese journal of physiology, 2002, Sep-30, Volume: 45, Issue:3

    Topics: Adult; Gout; Humans; Hyperuricemia; Kidney; Male; Middle Aged; Sweat; Urea; Uric Acid

2002
Uric acid and urea in human sweat.
    The Chinese journal of physiology, 2002, Sep-30, Volume: 45, Issue:3

    Topics: Adult; Gout; Humans; Hyperuricemia; Kidney; Male; Middle Aged; Sweat; Urea; Uric Acid

2002
Uric acid and urea in human sweat.
    The Chinese journal of physiology, 2002, Sep-30, Volume: 45, Issue:3

    Topics: Adult; Gout; Humans; Hyperuricemia; Kidney; Male; Middle Aged; Sweat; Urea; Uric Acid

2002
Uric acid and urea in human sweat.
    The Chinese journal of physiology, 2002, Sep-30, Volume: 45, Issue:3

    Topics: Adult; Gout; Humans; Hyperuricemia; Kidney; Male; Middle Aged; Sweat; Urea; Uric Acid

2002
GOUT, HYPERURICAEMIA AND CARBOHYDRATE METABOLISM.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1964, Mar-14, Volume: 38

    Topics: Carbohydrate Metabolism; Cholesterol; Glucose Tolerance Test; Gout; Humans; Hypertension; Hyperurice

1964
EXTREME HYPERURICEMIA ASSOCIATED WITH PREDNISONE THERAPY FOR ACUTE LYMPHOBLASTIC LEUKEMIA.
    Texas state journal of medicine, 1964, Volume: 60

    Topics: Adolescent; Blood; Blood Urea Nitrogen; Humans; Hyperuricemia; Leukemia; Leukemia, Lymphoid; Lymphoc

1964
THE SYNDROME OF ATHETOID CEREBRAL PALSY, MENTAL DEFICIENCY, SELF-MUTILATION AND HYPERURICEMIA.
    Journal of mental deficiency research, 1965, Volume: 9

    Topics: Athetosis; Blood Chemical Analysis; Blood Urea Nitrogen; Cerebral Palsy; Child; Genetics, Medical; H

1965
PREVENTION OF HYPERURICEMIA IN LEUKEMIA AND LYMPHOMA: USE OF ALOPURINOL, A XANTHINE OXIDASE INHIBITOR.
    JAMA, 1965, Jul-05, Volume: 193

    Topics: Adolescent; Antineoplastic Agents; Blood; Blood Urea Nitrogen; Drug Therapy; Geriatrics; Humans; Hyp

1965