oxadiazoles has been researched along with Hyperuricemia* in 3 studies
3 other study(ies) available for oxadiazoles and Hyperuricemia
| Article | Year |
|---|---|
Novel 3-[4-alkoxy-3-(1H-tetrazol-1-yl) phenyl]-1,2,4-oxadiazol-5(4H)-ones as promising xanthine oxidase inhibitors: Design, synthesis and biological evaluation.
Topics: Drug Design; Enzyme Inhibitors; Hyperuricemia; Inhibitory Concentration 50; Kinetics; Molecular Docking Simulation; Oxadiazoles; Structure-Activity Relationship; Uric Acid; Xanthine Oxidase | 2020 |
Design, synthesis and biological evaluation of 1-alkyl-5/6-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1H-indole-3-carbonitriles as novel xanthine oxidase inhibitors.
Topics: Allopurinol; Animals; Catalytic Domain; Cattle; Drug Design; Enzyme Assays; Enzyme Inhibitors; Hyperuricemia; Indoles; Kinetics; Male; Molecular Docking Simulation; Molecular Structure; Oxadiazoles; Oxonic Acid; Protein Binding; Rats, Sprague-Dawley; Structure-Activity Relationship; Xanthine Oxidase | 2020 |
[Design, synthesis and biological evaluation of oxadiazole derivatives as xanthine oxidase inhibitors].
Xanthine oxidase (XO) is an important target for the treatment of hyperuricemia and gout. Based on the two known non-purine xanthine oxidase inhibitors, febuxostat and topiroxostat, 14 oxadiazole derivatives have been designed and synthesized. These compounds have been evaluated against XO and five of them exhibited significant inhibitory activities at the concentrations below 10 μmol·L(-1). Topics: Drug Design; Enzyme Inhibitors; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Oxadiazoles; Xanthine Oxidase | 2016 |