Page last updated: 2024-10-20

purine and Hyperuricemia

purine has been researched along with Hyperuricemia in 34 studies

1H-purine : The 1H-tautomer of purine.
3H-purine : The 3H-tautomer of purine.
9H-purine : The 9H-tautomer of purine.
7H-purine : The 7H-tautomer of purine.

Hyperuricemia: Excessive URIC ACID or urate in blood as defined by its solubility in plasma at 37 degrees C; greater than 0.42mmol per liter (7.0mg/dL) in men or 0.36mmol per liter (6.0mg/dL) in women. This condition is caused by overproduction of uric acid or impaired renal clearance. Hyperuricemia can be acquired, drug-induced or genetically determined (LESCH-NYHAN SYNDROME). It is associated with HYPERTENSION and GOUT.

Research Excerpts

ExcerptRelevanceReference
" Recently it has been identified that hypertension are frequently associated with myogenic hyperuricemia converted from overproduced hypoxanthine in the skeletal muscles."8.84[Idiopathic hyperuricemia with overproduction of uric acid]. ( Hisatome, I; Igawa, O; Mizuta, E, 2008)
"Patients with system lupus erythematosus, rheumatic arthritis, chronic active hepatitis and gout were found to have considerable hyperuricemia and be decreased in aminoacides content, which are the predecessors of purine."7.73[Hyperuricemia and disorders in content of amino acids-purine precursors in patients with autoimmune diseases and gout]. ( Anan'eva, MN; Dubiaga, VV; Nikolenko, IuI; Nikolenko, VIu; Shchukin, IN; Siniachenko, OV, 2005)
"Hyperuricemia (serum urate level >7 mg/dL) is caused by accelerated generation of uric acid and/or impaired excretion in the kidney."4.84[Definition and classification of hyperuricemia]. ( Yamamoto, T, 2008)
" Although only about 10% of hyperuricemia results from overproduction of urate, purine biosynthesis has substantial impacts on the pathogenesis of hyperuricemia."4.84[Urate production and regulation]. ( Morisaki, H; Morisaki, T, 2008)
" Recently it has been identified that hypertension are frequently associated with myogenic hyperuricemia converted from overproduced hypoxanthine in the skeletal muscles."4.84[Idiopathic hyperuricemia with overproduction of uric acid]. ( Hisatome, I; Igawa, O; Mizuta, E, 2008)
" Accelerated generation of uric acid and impaired excretion in the kidney are promoted by several dietary factors, such as foods with higher content of sugars (fructose and xylitol), fat and purine bases, and by alcohol consumption, starvation and dehydration."4.84[How do we set the standard value of serum uric acid levels?]. ( Hamada, T; Hisatome, I; Igawa, O; Shigemasa, C, 2008)
"5% fat UHT milk diet or allopurinol therapy in rat experimental hyperuricemia."3.80Short communication: Effect of commercial or depurinized milk diet on plasma advanced oxidation protein products, cardiovascular markers, and bone marrow CD34+ stem cell potential in rat experimental hyperuricemia. ( Cvetkovic, T; Jevtovic, T; Jovanovic, A; Jovanovic, J; Kocic, G; Kocic, H; Sokolovic, D; Stojanovic, S; Veljkovic, A; Zivkovic, P, 2014)
" Therefore, in this study we investigated the association between hyperuricemia, prediabetes, and prehypertension in Croatian adults, as well as that between purine-rich diet and hyperuricemia, prediabetes, or prehypertension."3.78Association between hyperuricemia, prediabetes, and prehypertension in the Croatian adult population--a cross-sectional study. ( Bielen, I; Katić, M; Kranjčević, K; Lalić, DI; Marković, BB; Vrdoljak, D; Vučak, J, 2012)
"The purine contents of alcoholic beverages were determined in order to utilize them in the dietary care of gout and hyperuricemia."3.75Determination of purine contents of alcoholic beverages using high performance liquid chromatography. ( Fujimori, S; Kaneko, K; Yamanobe, T, 2009)
"Patients with system lupus erythematosus, rheumatic arthritis, chronic active hepatitis and gout were found to have considerable hyperuricemia and be decreased in aminoacides content, which are the predecessors of purine."3.73[Hyperuricemia and disorders in content of amino acids-purine precursors in patients with autoimmune diseases and gout]. ( Anan'eva, MN; Dubiaga, VV; Nikolenko, IuI; Nikolenko, VIu; Shchukin, IN; Siniachenko, OV, 2005)
"The characteristic phenomena of acute gouty arthritis are acute arthritis in a middle-aged male, associated with serum uric acid above 6 mg."3.63Diagnosis and treatment of gouty arthritis. ( TALBOTT, JH, 1953)
"Gout is among the most common causes of acute monoarticular arthritis."2.43Purine metabolism and hyperuricemic states. 'The point of view of the rheumatologist'. ( Peronato, G, 2005)
"Hyperuricemia is associated with multiple risk factor syndrome."2.42[Disorder of purine metabolism]. ( Fujimori, S, 2004)

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.94)18.7374
1990's0 (0.00)18.2507
2000's25 (73.53)29.6817
2010's6 (17.65)24.3611
2020's2 (5.88)2.80

Authors

AuthorsStudies
Fukuuchi, T2
Itahashi, I1
Takayanagi, F2
Yamaoka, N2
Kaneko, K4
Yasuda, M1
Mawatari, KI1
Fujimori, S6
Jacomelli, G1
Baldini, E1
Mugnaini, C1
Micheli, V1
Bernardini, G1
Santucci, A1
Kocic, G1
Sokolovic, D1
Jevtovic, T1
Cvetkovic, T1
Veljkovic, A1
Kocic, H1
Stojanovic, S1
Jovanovic, A1
Jovanovic, J1
Zivkovic, P1
Rong, S1
Zou, L1
Zhang, Y1
Zhang, G1
Li, X1
Li, M1
Yang, F1
Li, C1
He, Y1
Guan, H1
Guo, Y1
Wang, D1
Cui, X1
Ye, H1
Liu, F1
Pan, H1
Yang, Y1
Yamanobe, T1
Yamada, Y1
Yamada, K1
Nomura, N1
Yamano, A1
Kimura, R1
Tomida, S1
Naiki, M1
Wakamatsu, N1
Ichida, K1
Vučak, J1
Katić, M1
Bielen, I1
Vrdoljak, D1
Lalić, DI1
Kranjčević, K1
Marković, BB1
Kawasugi, K1
Takeuchi, F1
Yamamoto, T3
Iwatani, M1
Nakamura, T1
Kono, N1
Yamasaki, T1
Morisaki, T2
Ogata, E1
TALBOTT, JH1
Johnson, RJ1
Rideout, BA1
Alderman, M1
Aiyer, KJ1
Hosoya, T1
Ohno, I1
Uetake, D1
Saikawa, H1
Peronato, G1
Cameron, JS1
Simmonds, HA1
Gao, ZQ1
Deng, YY1
Wang, L1
Chen, YP1
Nikolenko, IuI1
Siniachenko, OV1
Anan'eva, MN1
Nikolenko, VIu1
Dubiaga, VV1
Shchukin, IN1
Choi, HK1
Mount, DB1
Reginato, AM1
Taniguchi, A1
Kamatani, N1
Morisaki, H1
Mizuta, E1
Igawa, O2
Hisatome, I2
Hamada, T1
Shigemasa, C1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Three Arms, Randomized, Double-blind Controlled Trial of the Efficacy of Amway Uric Acid Lowering Product on Hyperuricemia[NCT06084585]180 participants (Anticipated)Interventional2023-10-23Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

23 reviews available for purine and Hyperuricemia

ArticleYear
[Hyperuricemia and metabolic syndrome].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2010, Volume: 136, Issue:6

    Topics: Adenosine Monophosphate; Adenosine Triphosphate; Fructose; Humans; Hyperuricemia; Insulin Resistance

2010
[Phosphoribosylpyrophosphate(PRPP) synthetase].
    Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61 Suppl 1

    Topics: Humans; Hyperuricemia; Phosphoribosyl Pyrophosphate; Purine Nucleotides; Purines; Ribose-Phosphate P

2003
[Effect of foods on serum uric acid level].
    Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61 Suppl 1

    Topics: Diet; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Drinking; Food; Food Analysis; Gout; Hu

2003
[Effect of ethanol on uric acid level].
    Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61 Suppl 1

    Topics: Acetaldehyde; Animals; Erythrocytes; Ethanol; Gout; Humans; Hyperuricemia; Purines; Pyrazinamide; Ur

2003
[Hyperuricemia--definition and classification].
    Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61 Suppl 1

    Topics: Animals; Diagnosis, Differential; Humans; Hyperuricemia; Hypoxanthine Phosphoribosyltransferase; Kid

2003
[Idiopathic hyperuricemia].
    Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61 Suppl 1

    Topics: Glyceraldehyde 3-Phosphate; Humans; Hyperuricemia; Hypoxanthine Phosphoribosyltransferase; Insulin R

2003
[Diet therapy for management of hyperuricemia and gout].
    Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61 Suppl 1

    Topics: Adult; Alcoholic Beverages; Diet, Reducing; Gout; Humans; Hyperuricemia; Male; Obesity; Purines; Tem

2003
[Non-drug substance (over intake of foods which are contained purine body, fat and fructose)].
    Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61 Suppl 1

    Topics: Dietary Carbohydrates; Dietary Fats; Food Analysis; Fructose; Humans; Hyperuricemia; Purines; Uric A

2003
[Alcohol-related tissue injury and hyperuricemia].
    Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61 Suppl 1

    Topics: Acetaldehyde; Adenosine Triphosphate; Coronary Disease; Cytochrome P-450 CYP2E1; Ethanol; Humans; Hy

2003
[Animal models for abnormal purine metabolism].
    Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61 Suppl 1

    Topics: Adenine Phosphoribosyltransferase; Adenosine Deaminase; AMP Deaminase; Animals; Disease Models, Anim

2003
[Contents of purine bases in foods and alcoholic beverages].
    Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61 Suppl 1

    Topics: Alcoholic Beverages; Food Analysis; Humans; Hyperuricemia; Purines

2003
Uric acid: role in cardiovascular disease and effects of losartan.
    Current medical research and opinion, 2004, Volume: 20, Issue:3

    Topics: Angiotensin Receptor Antagonists; Antihypertensive Agents; Cardiovascular Diseases; Humans; Hyperuri

2004
[Disorder of purine metabolism].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62, Issue:6

    Topics: Humans; Hyperuricemia; Metabolic Syndrome; Purines

2004
[Purine metabolism in patients with renal failure].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 6

    Topics: Allopurinol; Antimetabolites; Glomerulonephritis; Humans; Hyperuricemia; Hypoxanthine; Kidney; Kidne

2004
Purine metabolism and hyperuricemic states. 'The point of view of the rheumatologist'.
    Contributions to nephrology, 2005, Volume: 147

    Topics: Gout; Humans; Hyperuricemia; Purines

2005
Hereditary hyperuricemia and renal disease.
    Seminars in nephrology, 2005, Volume: 25, Issue:1

    Topics: Genetic Predisposition to Disease; Humans; Hyperuricemia; Hypoxanthine Phosphoribosyltransferase; Ki

2005
[Researches on the establishment of chronic nephropathy models and the effect of TCM on these models].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2005, Volume: 25, Issue:2

    Topics: Animals; Disease Models, Animal; Drugs, Chinese Herbal; Hyperuricemia; Kidney Diseases; Mice; Phytot

2005
Pathogenesis of gout.
    Annals of internal medicine, 2005, Oct-04, Volume: 143, Issue:7

    Topics: Cardiovascular Diseases; Crystallization; Diet; Gout; Humans; Hyperuricemia; Inflammation; Insulin R

2005
[Genetic testing and gene-based testing for hyperuricemia and gout].
    Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 12

    Topics: Carrier Proteins; Genetic Diseases, Inborn; Gout; Humans; Hyperuricemia; Hypoxanthine Phosphoribosyl

2005
[Definition and classification of hyperuricemia].
    Nihon rinsho. Japanese journal of clinical medicine, 2008, Volume: 66, Issue:4

    Topics: Alcohol Drinking; Diet, Reducing; Fructose; Glucose-6-Phosphatase; Glycogen Storage Disease Type I;

2008
[Urate production and regulation].
    Nihon rinsho. Japanese journal of clinical medicine, 2008, Volume: 66, Issue:4

    Topics: Adenosine Triphosphate; Humans; Hyperuricemia; Hypoxanthine Phosphoribosyltransferase; Purines; Ribo

2008
[Idiopathic hyperuricemia with overproduction of uric acid].
    Nihon rinsho. Japanese journal of clinical medicine, 2008, Volume: 66, Issue:4

    Topics: Antihypertensive Agents; Gout; Humans; Hypertension; Hyperuricemia; Hypoxanthine; Muscle, Skeletal;

2008
[How do we set the standard value of serum uric acid levels?].
    Nihon rinsho. Japanese journal of clinical medicine, 2008, Volume: 66, Issue:4

    Topics: Alcoholic Beverages; Biomarkers; Catalase; Colorimetry; Dehydration; Diet; Humans; Hyperuricemia; Pe

2008

Other Studies

11 other studies available for purine and Hyperuricemia

ArticleYear
Determination of total purine and free purine content in milk, soymilk, and enteral nutritional supplements to assist nutritional therapy for hyperuricemia and gout.
    Nucleosides, nucleotides & nucleic acids, 2022, Volume: 41, Issue:12

    Topics: Aged; Animals; Gout; Humans; Hyperuricemia; Milk; Purines; Uric Acid

2022
Determination of total purine and purine base content of 80 food products to aid nutritional therapy for gout and hyperuricemia.
    Nucleosides, nucleotides & nucleic acids, 2020, Volume: 39, Issue:10-12

    Topics: Food Analysis; Gout; Hyperuricemia; Purines

2020
Inhibiting PNP for the therapy of hyperuricemia in Lesch-Nyhan disease: Preliminary in vitro studies with analogues of immucillin-G.
    Journal of inherited metabolic disease, 2019, Volume: 42, Issue:1

    Topics: Allopurinol; Cells, Cultured; Enzyme Inhibitors; Humans; Hyperuricemia; Hypoxanthine; Hypoxanthine P

2019
Short communication: Effect of commercial or depurinized milk diet on plasma advanced oxidation protein products, cardiovascular markers, and bone marrow CD34+ stem cell potential in rat experimental hyperuricemia.
    Journal of dairy science, 2014, Volume: 97, Issue:11

    Topics: Advanced Oxidation Protein Products; Allopurinol; Animals; Antigens, CD34; Biomarkers; Bone Marrow;

2014
Determination of purine contents in different parts of pork and beef by high performance liquid chromatography.
    Food chemistry, 2015, Mar-01, Volume: 170

    Topics: Animals; Cattle; Chromatography, High Pressure Liquid; Gout; Hyperuricemia; Meat; Purines; Red Meat;

2015
Determination of purine contents of alcoholic beverages using high performance liquid chromatography.
    Biomedical chromatography : BMC, 2009, Volume: 23, Issue:8

    Topics: Alcoholic Beverages; Chromatography, High Pressure Liquid; Gout; Guanine Deaminase; Humans; Hyperuri

2009
Molecular analysis of two enzyme genes, HPRT1 and PRPS1, causing X-linked inborn errors of purine metabolism.
    Nucleosides, nucleotides & nucleic acids, 2010, Volume: 29, Issue:4-6

    Topics: DNA Mutational Analysis; Genetic Diseases, X-Linked; Genetic Predisposition to Disease; Humans; Hype

2010
Association between hyperuricemia, prediabetes, and prehypertension in the Croatian adult population--a cross-sectional study.
    BMC cardiovascular disorders, 2012, Dec-04, Volume: 12

    Topics: Adult; Aged; Cardiovascular Diseases; Croatia; Cross-Sectional Studies; Diet; Female; Humans; Hyperu

2012
Diagnosis and treatment of gouty arthritis.
    California medicine, 1953, Volume: 79, Issue:3

    Topics: Arthritis; Arthritis, Gouty; Colchicine; Gout; Humans; Hyperuricemia; Male; Middle Aged; Probenecid;

1953
Uric acid and diet--insights into the epidemic of cardiovascular disease.
    The New England journal of medicine, 2004, Mar-11, Volume: 350, Issue:11

    Topics: Dairy Products; Diet; Dietary Proteins; Female; Gout; History, 17th Century; History, 18th Century;

2004
[Hyperuricemia and disorders in content of amino acids-purine precursors in patients with autoimmune diseases and gout].
    Likars'ka sprava, 2005, Issue:4

    Topics: Amino Acids; Autoimmune Diseases; Gout; Humans; Hyperuricemia; Lipid Peroxides; Purines; Uric Acid;

2005