Page last updated: 2024-10-15

althiomycin

Description

althiomycin: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

althiomycin : A peptide antibiotic isolated from soil and enteric bacteria. It is a protein synthesis inhibitor which exhibits antibacterial activity against both Gram-positive and Gram-negative bacteria. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID135488978
CHEMBL ID152828
MeSH IDM0055237

Synonyms (5)

Synonym
NSC102809 ,
12656-40-5
althiomycin
CHEMBL152828
AKOS040746546

Research Excerpts

Overview

Althiomycin is a ribosome-inhibiting antibiotic. Its biosynthetic machinery had been elusive for decades.

ExcerptReference
"Althiomycin is a ribosome-inhibiting antibiotic whose biosynthetic machinery had been elusive for decades."( The insect pathogen Serratia marcescens Db10 uses a hybrid non-ribosomal peptide synthetase-polyketide synthase to produce the antibiotic althiomycin.
Challis, GL; Coulthurst, SJ; Gerc, AJ; Song, L; Stanley-Wall, NR, 2012
)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (3)

RoleDescription
bacterial metaboliteAny prokaryotic metabolite produced during a metabolic reaction in bacteria.
antibacterial agentA substance (or active part thereof) that kills or slows the growth of bacteria.
protein synthesis inhibitorA compound, usually an anti-bacterial agent or a toxin, which inhibits the synthesis of a protein.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (10)

ClassDescription
1,3-thiazoles
gamma-lactamA lactam in which the amide bond is contained within a five-membered ring, which includes the amide nitrogen and the carbonyl carbon.
aldoximeOximes of aldehydes RCH=NOH.
pentapeptideAny molecule that contains five amino-acid residues connected by peptide linkages.
tertiary carboxamideA carboxamide resulting from the formal condensation of a carboxylic acid with a secondary amine; formula RC(=O)NHR(1)R(2).
secondary carboxamideA carboxamide resulting from the formal condensation of a carboxylic acid with a primary amine; formula RC(=O)NHR(1).
primary alcoholA primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.
etherAn organooxygen compound with formula ROR, where R is not hydrogen.
pyrrolineAny organic heteromonocyclic compound with a structure based on a dihydropyrrole.
peptide antibioticA chemically diverse class of peptides that exhibit antimicrobial properties.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (8)

Assay IDTitleYearJournalArticle
AID69824Tested for the minimum inhibitory concentration against Escherichia coli 1852E + 3 ug/mL PMBN2002Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4
Total synthesis and semi-synthetic approaches to analogues of antibacterial natural product althiomycin.
AID206194Tested for the minimum inhibitory concentration against Staphylococcus aureus 853E2002Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4
Total synthesis and semi-synthetic approaches to analogues of antibacterial natural product althiomycin.
AID202540Tested for the minimum inhibitory concentration against Saccharomyces cerevisiae NCYC 812002Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4
Total synthesis and semi-synthetic approaches to analogues of antibacterial natural product althiomycin.
AID206315Tested for the minimum inhibitory concentration against Staphylococcus aureus col2002Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4
Total synthesis and semi-synthetic approaches to analogues of antibacterial natural product althiomycin.
AID69825Tested for the minimum inhibitory concentration against Escherichia coli 1852E PM2002Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4
Total synthesis and semi-synthetic approaches to analogues of antibacterial natural product althiomycin.
AID40924Tested for the minimum inhibitory concentration against Bacillus subtilis 66332002Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4
Total synthesis and semi-synthetic approaches to analogues of antibacterial natural product althiomycin.
AID208463Tested for the minimum inhibitory concentration against Streptococcus pneumoniae 35122002Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4
Total synthesis and semi-synthetic approaches to analogues of antibacterial natural product althiomycin.
AID66381Tested for the minimum inhibitory concentration against Enterobacter faecalis 850E2002Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4
Total synthesis and semi-synthetic approaches to analogues of antibacterial natural product althiomycin.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (33.33)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's3 (50.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]