Page last updated: 2024-10-24

response to symbiotic bacterium

Definition

Target type: biologicalprocess

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism. [GOC:hb, ISBN:0198506732]

Response to symbiotic bacterium is a complex biological process that involves a multifaceted interplay between the host organism and its symbiotic partner. This interaction is characterized by a dynamic exchange of signals and resources, leading to a mutually beneficial relationship. The process typically begins with the recognition of the symbiont by the host, often mediated by specific receptors on the host cell surface. This recognition triggers a cascade of signaling events that activate specific genes and pathways within the host, ultimately leading to the establishment and maintenance of the symbiotic relationship. Key aspects of this process include:

* **Host-symbiont recognition**: This involves specific molecular interactions between the host and symbiont, often mediated by surface receptors, flagella, or secreted factors. This recognition step ensures that the host is interacting with a compatible symbiotic partner.
* **Signaling pathways**: Once recognized, the symbiont triggers signaling pathways within the host, involving molecules such as calcium, cyclic AMP, and various kinases. These pathways orchestrate the host's response to the symbiont, including changes in gene expression, cell differentiation, and nutrient exchange.
* **Nutrient exchange**: A key feature of symbiotic relationships is the exchange of nutrients between the host and symbiont. The symbiont may provide the host with essential nutrients, such as nitrogen fixation or vitamin synthesis, while the host may provide the symbiont with carbohydrates or other resources.
* **Host cell modifications**: In some cases, the host cell may undergo structural modifications to accommodate the symbiont. For example, the host may form specialized structures, such as nodules or symbiosomes, to house and support the symbiotic bacteria.
* **Immune modulation**: The host's immune system must be carefully regulated to avoid rejection of the symbiont. This involves a complex interplay between immune cells, signaling pathways, and immune-suppressive mechanisms that promote tolerance towards the symbiont.
* **Gene expression**: The interaction with the symbiont leads to changes in the host's gene expression, influencing various physiological processes, including nutrient uptake, defense responses, and developmental pathways.
* **Population dynamics**: The symbiotic relationship can influence the population dynamics of both the host and symbiont, promoting the growth and survival of both partners.

These intricate processes ensure the stability and longevity of the symbiotic relationship, providing both the host and symbiont with a variety of ecological and evolutionary benefits.'
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Proteins (3)

ProteinDefinitionTaxonomy
Platelet-activating factor receptorA mammalian-type platelet-activating factor receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25105]Homo sapiens (human)
Glutathione peroxidase 1A glutathione peroxidase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P07203]Homo sapiens (human)
Solute carrier family 22 member 5An organic cation/carnitine transporter 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O76082]Homo sapiens (human)

Compounds (45)

CompoundDefinitionClassesRoles
carnitineamino-acid betainehuman metabolite;
mouse metabolite
brotizolambrotizolam: structureorganic molecular entity
cilostamidecilostamide: selective inhibitor of cyclic AMP phosphodiesterase & platelet aggregation; structurequinolines
clotrimazoleconazole antifungal drug;
imidazole antifungal drug;
imidazoles;
monochlorobenzenes
antiinfective agent;
environmental contaminant;
xenobiotic
dephostatindephostatin: from Streptomyces sp. MJ742-NF5; structure given in first source
juglonejuglone : A hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone in which the hydrogen at position 5 has been replaced by a hydroxy group. A plant-derived 1,4-naphthoquinone with confirmed antibacterial and antitumor activities.

juglone: structure
hydroxy-1,4-naphthoquinonegeroprotector;
herbicide;
reactive oxygen species generator
loratadineloratadine : A benzocycloheptapyridine that is 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine substituted by a chloro group at position 8 and a 1-(ethoxycarbonyl)piperidin-4-ylidene group at position 11. It is a H1-receptor antagonist commonly employed in the treatment of allergic disorders.

Loratadine: A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.
benzocycloheptapyridine;
ethyl ester;
N-acylpiperidine;
organochlorine compound;
tertiary carboxamide
anti-allergic agent;
cholinergic antagonist;
geroprotector;
H1-receptor antagonist
mesalaminemesalamine : A monohydroxybenzoic acid that is salicylic acid substituted by an amino group at the 5-position.

Mesalamine: An anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed)
amino acid;
aromatic amine;
monocarboxylic acid;
monohydroxybenzoic acid;
phenols
non-steroidal anti-inflammatory drug
etoposide phosphate
nifedipineNifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.C-nitro compound;
dihydropyridine;
methyl ester
calcium channel blocker;
human metabolite;
tocolytic agent;
vasodilator agent
1,2,5,8-tetrahydroxy anthraquinone1,2,5,8-tetrahydroxy anthraquinone: structure in first source

quinalizarin : A tetrahydroxyanthraquinone having the four hydroxy groups at the 1-, 2-, 5- and 8-positions.
tetrahydroxyanthraquinoneEC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor
cephaloridinecefaloridine : A cephalosporin compound having pyridinium-1-ylmethyl and 2-thienylacetamido side-groups. A first-generation semisynthetic derivative of cephalosporin C.

Cephaloridine: A cephalosporin antibiotic.
beta-lactam antibiotic allergen;
cephalosporin;
semisynthetic derivative
antibacterial drug
purpurinpurpurin : A trihydroxyanthraquinone derived from anthracene by substitution with oxo groups at C-9 and C-10 and with hydroxy groups at C-1, C-2 and C-4.

purpurin: from Rubiaceae plants; structure in first source
trihydroxyanthraquinonebiological pigment;
histological dye;
plant metabolite
suramin sodiumsuramin sodium : An organic sodium salt that is the hexasodium salt of suramin. It is an FDA approved drug for African sleeping sickness and river blindness.organic sodium saltangiogenesis inhibitor;
antinematodal drug;
antineoplastic agent;
apoptosis inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
GABA antagonist;
GABA-gated chloride channel antagonist;
purinergic receptor P2 antagonist;
ryanodine receptor agonist;
trypanocidal drug
lithocholic acidlithocholate : A bile acid anion that is the conjugate base of lithocholic acid.

lithocholic acid : A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.

Lithocholic Acid: A bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as cholagogue and choleretic.
bile acid;
C24-steroid;
monohydroxy-5beta-cholanic acid
geroprotector;
human metabolite;
mouse metabolite
chrysophanic acidchrysophanic acid: RN given refers to parent cpd; structure in Merck, 9th ed, #2260

chrysophanol : A trihydroxyanthraquinone that is chrysazin with a methyl substituent at C-3. It has been isolated from Aloe vera and exhibits antiviral and anti-inflammatory activity.
dihydroxyanthraquinoneanti-inflammatory agent;
antiviral agent;
plant metabolite
ethidium bromideorganic bromide saltgeroprotector;
intercalator;
trypanocidal drug
daunorubicinanthracycline : Anthracyclines are polyketides that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine.

daunorubicin : A natural product found in Actinomadura roseola.

Daunorubicin: A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.
aminoglycoside antibiotic;
anthracycline;
p-quinones;
tetracenequinones
antineoplastic agent;
bacterial metabolite
cefoperazonecefoperazone : A semi-synthetic parenteral cephalosporin with a tetrazolyl moiety that confers beta-lactamase resistance.

Cefoperazone: Semisynthetic broad-spectrum cephalosporin with a tetrazolyl moiety that is resistant to beta-lactamase. It may be used to treat Pseudomonas infections.
cephalosporinantibacterial drug
sch 37370N-acetyldesloratadine: dual antagonist of platelet-activating factor and histamine
ro 24-4736Ro 24-4736: structure given in first source; platelet activating factor antagonist
daunorubicin hydrochlorideanthracycline
web 2086WEB 2086: structure given in first source; PAF antagonistorganonitrogen heterocyclic compound;
organosulfur heterocyclic compound
paceinorcein : A variable mixture of several compounds isolated from lichens, the eight most abundant being alpha-aminoorcein, alpha-hydroxyorcein, beta-aminoorcein, gamma-aminoorcein, beta-hydroxyorcein, gamma-hydroxyorcein, beta-aminoorceimine and beta-aminoorceimine (all are phenoxazine-based). It is used for the demonstration of elastic fibres as well as to stain the rough endoplasmic reticulum of hepatitis B infected liver cells.

pacein : A member of the class of benzofurans that is dibenzo[b,d]furan-3,7-dione bearing two methyl substituents at positions 1 and 9 as well as two 2,4-dihydroxy-6-methylanilino substituents at positions 2 and 8.

PAcein: structure
cv 3988CV 3988: platelet activating factor antagonist; structure given in first source
1-hexadecyl-2-acetyl-glycero-3-phosphocholine2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine : A 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine betaine which has hexadecyl as the alkyl group. PAF is a potent phospholipid activator and mediator of many leukocyte functions, including platelet aggregation, inflammation, and anaphylaxis.

Platelet Activating Factor: A phospholipid derivative formed by PLATELETS; BASOPHILS; NEUTROPHILS; MONOCYTES; and MACROPHAGES. It is a potent platelet aggregating agent and inducer of systemic anaphylactic symptoms, including HYPOTENSION; THROMBOCYTOPENIA; NEUTROPENIA; and BRONCHOCONSTRICTION.
2-acetyl-1-alkyl-sn-glycero-3-phosphocholineantihypertensive agent;
beta-adrenergic antagonist;
bronchoconstrictor agent;
hematologic agent;
vasodilator agent
mk 287MK 287: RN given refers to the trans-(-)-isomer L-680573; L-680574 is an optical enantiomer; L-668750 is the racemic mixture; structure given in first source
rupatadinerupatadine: structure given in first source; RN given refers to trihydrochloridebenzocycloheptapyridine
sdz 64-412SDZ 64-412: structure given in first source; PAF antagonist
doxorubicin hydrochlorideanthracycline
2-thiophenecarboxylic acid 2-(1,3-dioxo-2-isoindolyl)ethyl esterphthalimides
suramin sodiumsuramin(6-) : An organosulfate oxoanion that is the hexanion of suramin resulting from the deprotonation of the six sulfo groups; major species at pH 7.3.organosulfate oxoanion
cefuroxime3-(carbamoyloxymethyl)cephalosporin;
furans;
oxime O-ether
drug allergen
ceftriaxone1,2,4-triazines;
1,3-thiazoles;
cephalosporin;
oxime O-ether
antibacterial drug;
drug allergen;
EC 3.5.2.6 (beta-lactamase) inhibitor
cefepimecefepime : A cephalosporin bearing (1-methylpyrrolidinium-1-yl)methyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido groups at positions 3 and 7, respectively, of the cephem skeleton.

Cefepime: A fourth-generation cephalosporin antibacterial agent that is used in the treatment of infections, including those of the abdomen, urinary tract, respiratory tract, and skin. It is effective against PSEUDOMONAS AERUGINOSA and may also be used in the empiric treatment of FEBRILE NEUTROPENIA.
cephalosporin;
oxime O-ether
antibacterial drug
gw-5074
nf 449
ginkgolide b
ro 24-0238Ro 24-0238: PAF antagonist
ceftizoximecephalosporinantibacterial drug
l 652731
acetylcarnitineO-acetyl-L-carnitine : An O-acyl-L-carnitine where the acyl group specified is acetyl. It facilitates movement of acetyl-CoA into the matrices of mammalian mitochondria during the oxidation of fatty acids.O-acetylcarnitine;
saturated fatty acyl-L-carnitine
human metabolite;
Saccharomyces cerevisiae metabolite
lexipafantlexipafant: an imidazolyl derivative which forms part of a fused heterocyclic system
abt 299ABT 299: converted in vivo to A-85783.0; a platelet activating factor antagonist; structure in first source
orvepitant